The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Temporal plasticity of apical progenitors in the developing mouse neocortex
Open accessAbstract
The diverse subtypes of excitatory neurons that populate the neocortex are born from apical progenitors located in the ventricular zone. During corticogenesis, apical progenitors sequentially generate deep-layer neurons followed by superficial-layer neurons directly or via the generation of intermediate progenitors. Whether neurogenic fate progression necessarily implies fate restriction in single progenitor types is unknown. Here we specifically isolated apical progenitors and intermediate progenitors, and fate-mapped their respective neuronal progeny following heterochronic transplantation into younger embryos. We find that apical progenitors are temporally plastic and can re-enter past molecular, electrophysiological and neurogenic states when exposed to an earlier-stage environment by sensing dynamic changes in extracellular Wnt. By contrast, intermediate progenitors are committed progenitors that lack such retrograde fate plasticity. These findings identify a diversity in the temporal plasticity of neocortical progenitors, revealing that some subtypes of cells can be untethered from their normal temporal progression to re-enter past developmental states.
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“By the time the apical radial glial progenitors within the prefrontal subdomains start dividing asymmetrically, the number of neurons will increase rapidly and peaks between week 13 and 16 of gestation in human (E10-E15 rodents/E43-E50 primates), specifically in the dorsal telencephalon [44–47].”
From Development of prefrontal cortex (2022) · cites this paper as [45]
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Cites
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Haubensak, W. E., Attardo, A., Denk, W. T., & Huttner, W. Β. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308600100 · Cited by 1,004
Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863
The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall
Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06046.1995 · Cited by 673
An intrinsic mechanism of corticogenesis from embryonic stem cells
Gaspard, N., Bouschet, T., Hourez, R., Dimidschstein, J., Naeije, G., van den Ameele, J., Espuny-Camacho, I., Herpoel, A., Passante, L., Schiffmann, S. N., et al. (2008) · Nature · doi:10.1038/nature07287 · Cited by 641
Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq
Cadwell, C. R., Palasantza, A., Jiang, X., Berens, P., Deng, Q., Yilmaz, M., Reimer, J., Shen, S., Bethge, M., Tolias, K. F., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3445 · Cited by 581
Differential Notch signalling distinguishes neural stem cells from intermediate progenitors
Mizutani, K., Yoon, K., Dang, L. T., Tokunaga, A., & Gaiano, N. (2007) · Nature · doi:10.1038/nature06090 · Cited by 521
Fezl Is Required for the Birth and Specification of Corticospinal Motor Neurons
Molyneaux, B. J., Arlotta, P., Hirata, T., Hibi, M., & Macklis, J. D. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.030 · Cited by 491
Pereira, J. D., Sansom, S. N., Smith, J. C., Dobenecker, M., Tarakhovsky, A., & Livesey, F. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002530107 · Cited by 465
Deterministic Progenitor Behavior and Unitary Production of Neurons in the Neocortex
Gao, P., Postiglione, M. P., Krieger, T. G., Hernandez, L., Wang, C., Han, Z., Streicher, C., Papusheva, E., Insolera, R., Chugh, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.027 · Cited by 449
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Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378
“Through close interplay between cell-autonomous events and local as well as external cues, neurons generated close to the ventricle start migrating in radial columns [45, 46, 50, 51].”
BackgroundPrefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans
Chini, M., & Hanganu-Opatz, I. L. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.017 · Cited by 253
Single-cell delineation of lineage and genetic identity in the mouse brain
Bandler, R. C., Vitali, I., Delgado, R. N., Ho, M. C., Dvoretskova, E., Molinas, J. S. I., Frazel, P. W., Mohammadkhani, M., Machold, R. P., Mädler, S. C., et al. (2021) · Nature · doi:10.1038/s41586-021-04237-0 · Cited by 206
Shifting Developmental Trajectories During Critical Periods of Brain Formation
Dehorter, N., & del Pino, I. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00283 · Cited by 143
Mossink, B., Negwer, M., Schubert, D., & Nadif Kasri, N. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03714-5 · Cited by 114
Metadata
- Authors
- Oberst, P., Fièvre, S., Baumann, N., Concetti, C., Bartolini, G., & Jabaudon, D.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Jabaudon, Denis
- ORCID
- Venue
- Nature
- Published
- 2019-08-28
- Volume
- 573
- Issue
- 7774
- Pages
- 370-374
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2970999020
- Cited by
- 121
- References
- 43
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 10 · 2023: 15 · 2022: 18 · 2021: 21 · 2020: 26 · 2019: 9
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-04-15)
- Open access
- green
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Université de Genève
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- apical progenitors, intermediate progenitor cells, neocortex development, cortical development, temporal plasticity, Wnt signaling, ventricular zone, neuronal lineage tracing
- MeSH terms
- Cell Plasticity, Animals, Cells, Cultured, Embryo, Mammalian, Neurons, Stem Cells, Time Factors, Neocortex, Mice, Neurogenesis
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