A view on drug resistance in cancer

Hallmarks of Cancer: The Next Generation

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PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

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The hallmarks of cancer

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Signatures of mutational processes in human cancer

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Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

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Cancer immunotherapy using checkpoint blockade

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

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The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.

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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

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Hyaluronan-based Multifunctional Nano-carriers for Combination Cancer Therapy

Gao, M., Deng, H., & Zhang, W. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200922113846 · Cited by 24

Phosphorylation-Dependent Conformations of the Disordered Carboxyl-Terminus Domain in the Epidermal Growth Factor Receptor

Regmi, R., Srinivasan, S., Latham, A. P., Kukshal, V., Cui, W., Zhang, B., Bose, R., & Schlau‐Cohen, G. S. (2020) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.0c02327 · Cited by 23

Duplex-Repair enables highly accurate sequencing, despite DNA damage

Xiong, K., Shea, D., Rhoades, J., Blewett, T., Liu, R., Bae, J. H., Nguyen, E., Makrigiorgos, G. M., Golub, T. R., & Adalsteinsson, V. A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab855 · Cited by 25

Yolk–Shell-Type Gold Nanoaggregates for Chemo- and Photothermal Combination Therapy for Drug-Resistant Cancers

Choe, H., Shin, M. J., Kwon, S. G., Lee, H., Kim, D. K., Choi, K. U., Kim, J., & Kim, J. H. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c10036 · Cited by 24

The Metabolism Symbiosis Between Pancreatic Cancer and Tumor Microenvironment

Li, Y., Zhang, J., Xu, J., & Liu, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.759376 · Cited by 24

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells

Bellio, C., Emperador, M., Castellano‐Escuder, P., Gris‐Oliver, A., Canals, F., Sánchez‐Pla, Á., Zamora, E., Arribas, J., Saura, C., Serra, V., et al. (2022) · Cancers · doi:10.3390/cancers14102562 · Cited by 25

Anticancer Potential of Bioactive Molecule Luteolin and Its Analogs: An Update

Basha, N. J., & Basavarajaiah, S. M. (2022) · Polycyclic aromatic compounds · doi:10.1080/10406638.2022.2080728 · Cited by 24

Emerging role of lncRNAs in drug resistance mechanisms in head and neck squamous cell carcinoma

Peña-Flores, J. A., Bermúdez, M., Ramos‐Payán, R., Villegas‐Mercado, C. E., Soto‐Barreras, U., Muela‐Campos, D., Álvarez-Ramírez, A., Perez‐Aguirre, B., Larrinúa-Pacheco, A. D., López‐Camarillo, C., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.965628 · Cited by 25

Enzymatic Nanosphere‐to‐Nanofiber Transition and Autophagy Inducer Release Promote Tumor Chemotherapy

Cheng, X., Xia, T., Zhan, W., Xu, H., Jiang, J., Liu, X., Sun, X., Wu, F., & Liang, G. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201916 · Cited by 24

Drug Resistance in Cancers: A Free Pass for Bullying

Li, J., Li, X., & Guo, Q. (2022) · Cells · doi:10.3390/cells11213383 · Cited by 24

Norbornene and Related Structures as Scaffolds in the Search for New Cancer Treatments

Calvo-Martín, G., Plano, D., Martínez‐Sáez, N., Aydillo, C., Moreno, E., Espuelas, S., & Sanmartín, C. (2022) · Pharmaceuticals · doi:10.3390/ph15121465 · Cited by 26

Rational Design in Photopharmacology with Molecular Photoswitches

Kobauri, P., Dekker, F. J., Szymański, W., & Feringa, B. L. (2023) · Angewandte Chemie · doi:10.1002/ange.202300681 · Cited by 23

Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin

Vojtek, M., Martins, C. B., Ramos, R., Duarte, S. G., Ferreira, I. M. P. L. V. O., de Carvalho, A. L. M. B., Marques, M. P. M., & Diniz, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041205 · Cited by 24

Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells

Li, L., & Jensen, R. A. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0230 · Cited by 24

How Can the Microbiome Induce Carcinogenesis and Modulate Drug Resistance in Cancer Therapy?

Mendes, I., & Vale, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411855 · Cited by 24

Intracellular metabolic profiling of drug resistant cells by surface enhanced Raman scattering

Liu, F., Wu, T., Tian, A., He, C., Bi, X., Lu, Y., Yang, K., Xia, W., & Ye, J. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341809 · Cited by 24

The mechanisms of multidrug resistance of breast cancer and research progress on related reversal agents

Yu, S., Zheng, J., Zhang, Y., Meng, D., Wang, Y., Xu, X., Xu, X., Shabiti, S., Zhang, X., Wang, Z., et al. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117486 · Cited by 27

A second life for MAO inhibitors? From CNS diseases to anticancer therapy

Sblano, S., Boccarelli, A., Mesiti, F., Purgatorio, R., de Candia, M., Catto, M., & Altomare, C. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116180 · Cited by 24

Benefits and Pitfalls of a Glycosylation Inhibitor Tunicamycin in the Therapeutic Implication of Cancers

Banerjee, S., Ansari, A. A., Upadhyay, S. P., Mettman, D. J., Hibdon, J. R., Quadir, M., Ghosh, P., Kambhampati, A., & Banerjee, S. K. (2024) · Cells · doi:10.3390/cells13050395 · Cited by 24

Unraveling the secrets: Evolution of resistance mediated by membrane proteins

Yang, X., Li, M., Jia, Z., Liu, Y., Wu, S., Chen, M., Hao, G., & Yang, Q. K. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101140 · Cited by 24

Understanding the role of miRNAs in cervical cancer pathogenesis and therapeutic responses

Chauhan, P. K., Pramodh, S., Hussain, A., Elsori, D. H., Lakhanpal, S., Kumar, R., Alsaweed, M., Iqbal, D., Pandey, P., Othaim, A. A., et al. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1397945 · Cited by 24

Noninvasive assessment and therapeutic monitoring of drug-resistant colorectal cancer by MR molecular imaging of extradomain-B fibronectin

Vaidya, A. M., Ayat, N. R., Buford, M., Wang, H., Shankardass, A., Zhao, Y., Gilmore, H. L., Wang, Z., & Lu, Z. (2020) · Theranostics · doi:10.7150/thno.47448 · Cited by 25

Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)

Shao, L., Li, Z., Wang, M., Ning, Y., Chen, F.-Q., Gao, X.-Q., Yang, C.-T., Wang, H., & Liu, X. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5272 · Cited by 23

Metabolic challengers selecting tumor-persistent cells

Mancini, C., Lori, G., Pranzini, E., & Taddei, M. L. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.11.005 · Cited by 25

Ferroptosis: a novel strategy to overcome chemoresistance in gynecological malignancies

Xu, J., Zheng, B., Wang, W., & Zhou, S. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1417750 · Cited by 26

Synergistic chemo-photothermal treatment via MXene-encapsulated nanoparticles for targeted melanoma therapy

Lee, S. B., Park, J. M., Park, R., Choi, H. E., Hong, S. W., & Kim, K. S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113729 · Cited by 23

Activating Mutation of SHP2 Establishes a Tumorigenic Phonotype Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms

Dong, L., Han, D. W., Meng, X., Xu, M., Zheng, C., & Qin, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.630712 · Cited by 23

Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting

Subbarao, S. A. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00796-w · Cited by 24

Surface Hydrophobicity Modulates the Key Characteristics of Cancer Spheroids through the Interaction with the Adsorbed Proteins

Lee, M.-S., Kim, Y., Yu, S. J., Lee, S. Y., Son, J. G., Lee, T. G., Cho, Y., Shin, J. H., Lee, E., & Im, S. G. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100775 · Cited by 23

Nanoparticle enhanced blue light therapy

Akasov, R., Khaydukov, E. V., Yamada, M., Zvyagin, A. V., Leelahavanichkul, A., Leanse, L. G., Dai, T., & Prow, T. W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114198 · Cited by 26

In vitro and In silico anticancer activities of Mn( ii ), Co( ii ), and Ni( ii ) complexes: synthesis, characterization, crystal structures, and DFT studies

Gond, M. K., Pandey, S. K., Singh, R. K., Bharty, M. K., Manna, P. P., Singh, V. K., Maiti, B., Prasad, L. B., & Butcher, R. J. (2022) · New Journal of Chemistry · doi:10.1039/d2nj00264g · Cited by 23

NASMDR: a framework for miRNA-drug resistance prediction using efficient neural architecture search and graph isomorphism networks

Zheng, K., Zhao, H., Zhao, Q., Wang, B., Gao, X., & Wang, J. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac338 · Cited by 23

Type XXII Collagen Complements Fibrillar Collagens in the Serological Assessment of Tumor Fibrosis and the Outcome in Pancreatic Cancer

Madsen, E. A., Thorlacius‐Ussing, J., Nissen, N. I., Jensen, C., Chen, I. M., Johansen, J. S., Diab, H. M. H., Jørgensen, L. N., Hansen, C. P., Karsdal, M. A., et al. (2022) · Cells · doi:10.3390/cells11233763 · Cited by 23

ENO1 contributes to 5-fluorouracil resistance in colorectal cancer cells via EMT pathway

Gu, J., Zhong, K., Wang, L., Ni, H., Zhao, Y., Wang, X., Yao, Y., Jiang, L., Wang, B., & Zhu, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1013035 · Cited by 25

Lactic acid fermentation: A maladaptive mechanism and an evolutionary throwback boosting cancer drug resistance

Gnocchi, D., Sabbà, C., & Mazzocca, A. (2023) · Biochimie · doi:10.1016/j.biochi.2023.01.005 · Cited by 23

Supramolecular nanoprodrug based on a chloride channel blocker and glycosylated pillar[5]arenes for targeted chemoresistance cancer therapy

Yang, K., Ma, K., Yang, M., Lv, Y., Pei, Y., & Pei, Z. (2023) · Chemical Communications · doi:10.1039/d3cc00233k · Cited by 23

The prognostic and immune significance of C15orf48 in pan-cancer and its relationship with proliferation and apoptosis of thyroid carcinoma

Li, C., Tang, Y., Li, Q., Liu, H., Ma, X., Liu, H., & Shi, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1131870 · Cited by 23

An orthogonally activatable CRISPR-Cas13d nanoprodrug to reverse chemoresistance for enhanced chemo-photodynamic therapy

Liu, Z., Feng, Z., Chen, M., Zhan, J., WU, R. T., Shi, Y., Xue, Y., Liu, R., Zhu, J., & Zhang, J. (2023) · Chemical Science · doi:10.1039/d3sc00020f · Cited by 23

Anticancer Activity of Region B Capsaicin Analogs

Brown, K. C., Modi, K. J., Light, R. S., Cox, A. J., Long, T. E., Gadepalli, R. S., Rimoldi, J. M., Miles, S. L., Rankin, G. O., Valentovic, M. A., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01594 · Cited by 28

Flavonostilbenes natural hybrids from Rhamnoneuron balansae as potential antitumors targeting ALDH1A1: molecular docking, ADMET, MM-GBSA calculations and molecular dynamics studies

Elsaman, T., Ahmad, I., Eltayib, E. M., Mohamed, M. S., Yusuf, O., Saeed, M. E. M., Patel, H., & Mohamed, M. A. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2218936 · Cited by 23

High-content microscopy reveals a morphological signature of bortezomib resistance

Kelley, M. E., Berman, A. Y., Stirling, D. R., Cimini, B. A., Han, Y., Singh, S., Carpenter, A. E., Kapoor, T. M., & Way, G. P. (2023) · eLife · doi:10.7554/elife.91362 · Cited by 22

Exosomes in lung cancer metastasis, diagnosis, and immunologically relevant advances

Zhao, J., Li, X., Liu, L., Zhu, Z., & He, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1326667 · Cited by 26

The functional roles of chemokines and chemokine receptors in colorectal cancer progression

Yue, M., Chen, M., Zhang, B., Wang, Y., Li, P., & Zhao, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116040 · Cited by 25

LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma

Zhao, K., Wang, X., Jin, Y., Zhu, X., Zhou, T. Y., Yu, Y., Ji, X., Chang, Y., Luo, J., Ni, X., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06394-8 · Cited by 23

Enhanced LRP8 expression induced by Helicobacter pylori drives gastric cancer progression by facilitating β-Catenin nuclear translocation

Liu, B., Bukhari, I., Li, F., Ren, F., Xue, X., Hu, B., Liu, H., Meyer, T. F., Marshall, B. J., Tay, C. Y., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.002 · Cited by 24

Mutually reinforced cancer treatment based on phototherapy combined with ferroptosis

Chen, G., Gan, L., Tian, L.-Y., Huang, B.-X., Xiao, Q., Zhang, Y., Xiao, M., Zheng, B.-D., & Ye, J. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152397 · Cited by 23

In situ synthesis of multifunctional tellurium nanorods stabilized by polypeptide-engineered for photothermal-sonodynamic combination therapy of tumors

Li, C.-Q., Zhao, D., Hou, X. L., Zhang, B., Song, L.-B., Jin, R., Zhao, Y., & Liu, B. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127989 · Cited by 23

Recent Progress of Novel Nanotechnology Challenging the Multidrug Resistance of Cancer

Zhang, C., Zhou, X., Zhang, H., Han, X., Li, B., Yang, R., & Zhou, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.776895 · Cited by 23

Editorial: Novel Small-Molecule Agents in Overcoming Multidrug Resistance in Cancers

Cui, Q., Wang, C., Zeng, L., Zhou, Q., & Fan, Y. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.921985 · Cited by 23

The Relationship between Trop-2, Chemotherapeutic Drugs, and Chemoresistance

Koltai, T., & Fliegel, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010087 · Cited by 22

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies

Yuan, W., Zhang, R., Lyu, H., Xiao, S., Guo, D., Zhang, Q., Ali, D. W., Michalak, M., Chen, X., Zhou, C., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02097-x · Cited by 26

A Ruthenium(II) Complex Inhibits BRD4 for Synergistic Seno‐ and Chemo‐Immunotherapy in Cisplatin‐Resistant Tumor Cells

Yang, J., Wang, F., Huang, S., Feng, T., Xiong, K., Chen, Y., & Chao, H. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202505689 · Cited by 21

Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers

Chen, R., Liu, Y., Jiang, Y., Sun, M., Fan, Z., & Du, J. (2025) · Polymer science & technology. · doi:10.1021/polymscitech.5c00014 · Cited by 23

Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches

Wang, J., Guo, D., Jiang, S., Wu, W., & Gao, X. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00416-5 · Cited by 27

Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance

Yan, Y., Zang, X., Jamieson, C. S., Lin, H., Houk, K. N., Zhou, J., & Tang, Y. (2020) · Chemical Science · doi:10.1039/d0sc03805a · Cited by 22

Mathematical model predicts response to chemotherapy in advanced non-resectable non-small cell lung cancer patients treated with platinum-based doublet

Kozłowska, E., Suwiński, R., Giglok, M., Świerniak, A., & Kimmel, M. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008234 · Cited by 22

A Perspective on Therapeutic Pan-Resistance in Metastatic Cancer

Korentzelos, D. K., Clark, A. M., & Wells, A. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197304 · Cited by 21

Translational Modeling of Anticancer Efficacy to Predict Clinical Outcomes in a First-in-Human Phase 1 Study of MDM2 Inhibitor HDM201

Guerreiro, N., Jullion, A., Ferretti, S., Fabre, C., & Meille, C. (2021) · The AAPS Journal · doi:10.1208/s12248-020-00551-z · Cited by 22

E3 Ubiquitin Ligase in Anticancer Drugdsla Resistance: Recent Advances and Future Potential

Liu, Y., Duan, C., & Zhang, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.645864 · Cited by 22

Association of SMAD4 loss with drug resistance in clinical cancer patients: A systematic meta-analysis

Xu, W., Lee, S. H., Qiu, F., Zhou, L. Q., Wang, X., Ye, T., & Hu, X. (2021) · PLoS ONE · doi:10.1371/journal.pone.0250634 · Cited by 22

RNA editing restricts hyperactive ciliary kinases

Li, D., Liu, Y., Yi, P., Zhu, Z., Li, W., Zhang, Q. C., Li, J. B., & Ou, G. (2021) · Science · doi:10.1126/science.abd8971 · Cited by 19

Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET –rearranged thyroid cancer

Raman, R., Villefranc, J. A., Ullmann, T. M., Thiesmeyer, J. W., Anelli, V., Yao, J., Hurley, J. R., Pauli, C., Bareja, R., Eng, K., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20210390 · Cited by 22

Preclinical studies of the antitumor effect of curcumin‐loaded polymeric nanocapsules: A systematic review and meta‐analysis

de Oliveira, T. V., Stein, R., de Andrade, D. F., & Beck, R. C. R. (2022) · Phytotherapy Research · doi:10.1002/ptr.7538 · Cited by 22

Spatiotemporal heterogeneity and clinical challenge of pancreatic neuroendocrine tumors

Lou, X., Qin, Y., Xu, X., Yu, X., & Ji, S. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188782 · Cited by 23

P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma

Arnaud-Sampaio, V. F., Bento, C. A., Glaser, T., Adinolfi, E., Ulrich, H., & Lameu, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.966404 · Cited by 23

Engineering near-infrared laser-activated gold nanorod vesicles with upper critical solution temperature for photothermal therapy and chemotherapy

Xing, W., Tang, Y., Ji, Y., Cheng, D., Wang, B., Fu, Y. Z., Xu, Y. F., Qian, X. H., & Zhu, W. P. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.02.049 · Cited by 22

Improving the response to oxaliplatin by targeting chemotherapy-induced CLDN1 in resistant metastatic colorectal cancer cells

Cherradi, S., Garambois, V., Marines, J., Andrade, A. F., Fauvre, A., Morand, O., Fargal, M., Mancouri, F., Ayrolles-Torro, A., Vié, N., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01015-5 · Cited by 23

p53-Dependent Cytoprotective Mechanisms behind Resistance to Chemo-Radiotherapeutic Agents Used in Cancer Treatment

Krishnaraj, J., Yamamoto, T., & Ohki, R. (2023) · Cancers · doi:10.3390/cancers15133399 · Cited by 22

Mitochondrial Artificial K+ Channel Construction Using MPTPP@5F8 Nanoparticles for Overcoming Cancer Drug Resistance via Disrupting Cellular Ion Homeostasis

Ma, P., Luo, Z., Li, Z., Lin, Y., Li, Z., Wu, Z., Ren, C., & Wu, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302012 · Cited by 22

Research progress in MCM family: Focus on the tumor treatment resistance

Tian, Y., Zhou, Y., Chen, F., Qian, S., Hu, X., Zhang, B., & Liu, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116408 · Cited by 22

Wnt signaling and tumors (Review)

Wang, H., Zhang, L., Hu, C., Li, H., & Jiang, M. (2024) · Molecular and Clinical Oncology · doi:10.3892/mco.2024.2743 · Cited by 24

The Hidden Link of Exosomes to Head and Neck Cancer

Teng, Y., Gao, L., Loveless, R., Rodrigo, J. P., Strojan, P., Willems, S. M., Nathan, C. O., Mäkitie, A. A., Saba, N. F., & Ferlito, A. (2021) · Cancers · doi:10.3390/cancers13225802 · Cited by 25

Therapeutic Options in Neuro-Oncology

Afonso, M. G., & Brito, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105351 · Cited by 22

Liquid biopsy: circulating tumor DNA monitors neoadjuvant chemotherapy response and prognosis in stage II / III gastric cancer

Zhang, M., Yang, H., Fu, T., Meng, M., Feng, Y., Qu, C., Li, Z., Xing, X., Li, W., Ye, M., et al. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13481 · Cited by 21

A novel intra-tumoral drug delivery carrier for treatment of oral squamous cell carcinoma

Elsaady, S. A., Aboushelib, M. N., Al-Wakeel, E., & Badawi, M. F. (2023) · Scientific Reports · doi:10.1038/s41598-023-38230-6 · Cited by 21

Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells

Yang, L., Pi, P., Zhang, M., Jiang, Y., Wu, T., Qing, L., Wang, H., Ma, M., Zhang, Z., Yang, H., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.08.066 · Cited by 24

Identification of gene signatures and potential therapeutic targets for acquired chemotherapy resistance in gastric cancer patients

Sun, J., Zhao, J., Yang, Z., Zhou, Z., & Lu, P. (2021) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-21-81 · Cited by 21

Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids

Casagrande, N., Borghese, C., Gabbatore, L., Morbiato, L., Zotti, M. D., & Aldinucci, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168362 · Cited by 21

Omics and Computational Modeling Approaches for the Effective Treatment of Drug-Resistant Cancer Cells

Jung, H. D., Sung, Y. J., & Kim, H. U. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.742902 · Cited by 22

LACTB suppresses carcinogenesis in lung cancer and regulates the EMT pathway

Xu, Y., Shi, H., Wang, M., Huang, P. C., Xu, M., Han, S., Li, H., & Wang, Y. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11172 · Cited by 21

Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells

Pang, K., Lee, J., Kim, J., Park, J., Park, Y., Hong, E., An, H., Ooshima, A., Son, M., Park, K., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04619-w · Cited by 21

PGC-1α participates in tumor chemoresistance by regulating glucose metabolism and mitochondrial function

Li, Y., Hei, H., Zhang, S., Gong, W., Liu, Y., & Qin, J. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04477-2 · Cited by 21

Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo

Basu, R., Qian, Y., Mathes, S. C., Terry, J., Arnett, N., Riddell, T., Stevens, A., Funk, K. R., Bell, S. R. C., Bokal, Z., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.936145 · Cited by 21

Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance

Choe, Y.-J., Min, J. Y., Lee, H., Lee, S.-Y., Kwon, J. S., Kim, H., Lee, J., Kim, H. M., Park, H. S., Cho, M. Y., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105017 · Cited by 21

Mass Spectrometry-Based Chemical Proteomics for Drug Target Discoveries

Fedorov, I. I., Lineva, V. I., Tarasova, I. A., & Gorshkov, M. V. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922090103 · Cited by 21

CD8+ T cell–Dependent Remodeling of the Tumor Microenvironment Overcomes Chemoresistance

Lao, L., Zeng, W., Huang, P., Chen, H., Jia, Z., Wang, P., Huang, D., Chen, J.-N., Nie, Y., Yang, L., et al. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0356 · Cited by 21

Response and resistance to BRAFV600E inhibition in gliomas: Roadblocks ahead?

Capogiri, M., Micheli, A. J. D., Lassaletta, Á., Muñoz, D. P., Coppé, J., Mueller, S., & Stücklin, A. G. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1074726 · Cited by 21

Clinical and exploratory biomarker findings from the MODUL trial (Cohorts 1, 3 and 4) of biomarker-driven maintenance therapy for metastatic colorectal cancer

Ducreux, M. P., Tabernero, J. M., Grothey, A. F., Arnold, D., O'Dwyer, P. J., Gilberg, F., Abbas, A. R., Thakur, M. D., Prizant, H., Irahara, N., et al. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.01.023 · Cited by 20

mRNA Vaccine - A New Cancer Treatment Strategy

Tan, T., Deng, S., Wu, B.-H., Yang, Q., Wu, M., Wu, H., Cao, C., & Xu, C. S. (2023) · Current Cancer Drug Targets · doi:10.2174/1568009623666230222124424 · Cited by 22

Inhibition of JNK/c-Jun-ATF2 Overcomes Cisplatin Resistance in Liver Cancer through down-Regulating Galectin-1

Yang, F., Li, M., Xu, D., Jiang, Z., Jiang, H., Xiao, Y., Mei, C., Yang, M., Chen, C., Zhou, B., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.79163 · Cited by 21

Polyvinyl Alcohol (PVA)-Based Nanoniosome for Enhanced in vitro Delivery and Anticancer Activity of Thymol

Abdihaji, M., Chegeni, M. M., Hadizadeh, A., Farrokhzad, N., Kheradmand, Z., Fakhrfatemi, P., Faress, F., Moeinabadi‐Bidgoli, K., Noorbazargan, H., & Mostafavi, E. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s401725 · Cited by 21

The role of mesenchymal stem cells derived exosomes as a novel nanobiotechnology target in the diagnosis and treatment of cancer

Zhou, Y. L., Dong, Y., Zhang, A., Wu, J., & Sun, Q. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1214190 · Cited by 21

Spiky Silver–Iron Oxide Nanohybrid for Effective Dual-Imaging and Synergistic Thermo-Chemotherapy

Moonshi, S. S., Vazquez‐Prada, K. X., Tang, J., van Holthe, N. J. W., Cowin, G., Wu, Y., Nguyen, D. H. T., Mckinnon, R., Bulmer, A. C., & Ta, H. T. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c04696 · Cited by 21

Application of hyaluronic acid-based nanoparticles for cancer combination therapy

Yang, M., Zhang, Y., Hu, Z., Xie, H., Tian, W., & Liu, Z. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123459 · Cited by 21

Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer

Macaya, I., Román, M., Welch, C., Entrialgo‐Cadierno, R., Salmón, M., Santos, A., Feliu, I., Kovalski, J. R., López, I., Rodríguez‐Remírez, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41828-z · Cited by 22

Exploring Therapeutic Avenues in Lung Cancer: The Epigenetic Perspective

Munteanu, R. A., Tomuleasa, C., Iuga, C. A., Gulei, D., & Ciuleanu, T. (2023) · Cancers · doi:10.3390/cancers15225394 · Cited by 23

TRAIL-Sensitizing Effects of Flavonoids in Cancer

Luiz-Ferreira, Â., Pacifico, T., Cruz, Á. C., Laudisi, F., Monteleone, G., & Stolfi, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316596 · Cited by 25

Synthesis, characterization and discovery of multiple anticancer mechanisms of dibutyltin complexes based on salen-like ligands

Tian, W., Zhong, W., Yang, Z., Chen, L., Lin, S., Li, Y., Wang, Y., Yang, P., & Long, X. (2023) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2023.112434 · Cited by 20

Design, synthesis, and molecular docking of novel 1,3, 4-triaryl pyrazole derivatives bearing methylsulfonyl moiety with anticancer activity through dual targeting CDK2 and COX-2 enzymes

Shaker, A. M. M., Shahin, M. I., AboulMagd, A. M., Abdel-Rahman, H. M., & Ella, D. A. A. E. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.137323 · Cited by 21

Roles of PPAR activation in cancer therapeutic resistance: Implications for combination therapy and drug development

Zhang, Y., Xiao, B., Liu, Y., Wu, S., Xiang, Q., Xiao, Y., Zhao, J., Yuan, R., Xie, K., & Li, L. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176304 · Cited by 23

Recent updates on innovative approaches to overcome drug resistance for better outcomes in cancer

Sharma, M., Bakshi, A. K., Mittapelly, N., Gautam, S., Marwaha, D., Rai, N., Singh, N., Tiwari, P., Agarwal, N., Kumar, A., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.04.007 · Cited by 84

Drug resistance in cancer

Fatima, Z., Irfan, T., Shabbir, M., & Badshah, Y. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-34671-2.00006-2

Editorial: Uncovering Drug Resistance During Cancer Therapy

Wang, H., Wang, R.-H., Zhou, J., Hou, W., & Wong, A. H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.945842 · Cited by 2

Understanding Drug Sensitivity and Tackling Resistance in Cancer

Tyner, J. W., Haderk, F., Kumaraswamy, A., Baughn, L. B., Ness, B. V., Liu, S., Marathe, H., Alumkal, J. J., Bivona, T. G., Chan, K. S., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3695 · Cited by 81

Mechanisms and insights into drug resistance in cancer

Zahreddine, H. A., & Borden, K. L. B. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00028 · Cited by 680