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cDC1 prime and are licensed by CD4(+) T cells to induce anti-tumour immunity
Open accessAbstract
Conventional type 1 dendritic cells (cDC1)1 are thought to perform antigen cross-presentation, which is required to prime CD8+ T cells 2,3, whereas cDC2 are specialized for priming CD4+ T cells 4,5. CD4+ T cells are also considered to help CD8+ T cell responses through a variety of mechanisms 6-11, including a process whereby CD4+ T cells 'license' cDC1 for CD8+ T cell priming 12. However, this model has not been directly tested in vivo or in the setting of help-dependent tumour rejection. Here we generated an Xcr1 Cre mouse strain to evaluate the cellular interactions that mediate tumour rejection in a model requiring CD4+ and CD8+ T cells. As expected, tumour rejection required cDC1 and CD8+ T cell priming required the expression of major histocompatibility class I molecules by cDC1. Unexpectedly, early priming of CD4+ T cells against tumour-derived antigens also required cDC1, and this was not simply because they transport antigens to lymph nodes for processing by cDC2, as selective deletion of major histocompatibility class II molecules in cDC1 also prevented early CD4+ T cell priming. Furthermore, deletion of either major histocompatibility class II or CD40 in cDC1 impaired tumour rejection, consistent with a role for cognate CD4+ T cell interactions and CD40 signalling in cDC1 licensing. Finally, CD40 signalling in cDC1 was critical not only for CD8+ T cell priming, but also for initial CD4+ T cell activation. Thus, in the setting of tumour-derived antigens, cDC1 function as an autonomous platform capable of antigen processing and priming for both CD4+ and CD8+ T cells and of the direct orchestration of their cross-talk that is required for optimal anti-tumour immunity.
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“cDC1 are critical for antigen cross-presentation required to prime CD8+ T cells for optimal anti-tumor immunity and priming of CD4+ T cells at early stages, partly because cDC1 provides antigen transportation to lymph nodes for processing by cDC2 (36).”
From mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model (2022) · cites this paper as [36]
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“CD40 signaling in cDC1 is required for tumor rejection by playing a key role in augmenting the proliferation of antigen-specific CD8+ T cells (36).”
From mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model (2022) · cites this paper as [36]
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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
Ridge, J. P., Rosa, F. D., & Matzinger, P. (1998) · Nature · doi:10.1038/30989 · Cited by 2,360
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,091
Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008) · Science · doi:10.1126/science.1164206 · Cited by 2,081
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, É., Tussiwand, R., & Yona, S. (2014) · Nature reviews. Immunology · doi:10.1038/nri3712 · Cited by 1,923
CD4+ T cell help in cancer immunology and immunotherapy
Borst, J., Ahrends, T., Bąbała, N., Melief, C. J. M., & Kastenmüller, W. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0044-0 · Cited by 1,585
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H., Park, C. G., et al. (2007) · Science · doi:10.1126/science.1136080 · Cited by 1,454
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
Matsushita, H., Vesely, M. D., Koboldt, D. C., Rickert, C. G., Uppaluri, R., Magrini, V. J., Arthur, C. D., White, J. M., Chen, Y.-S., Shea, L. K., et al. (2012) · Nature · doi:10.1038/nature10755 · Cited by 1,285
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Sun, J. C., & Bevan, M. J. (2003) · Science · doi:10.1126/science.1083317 · Cited by 1,213
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Heras‐Murillo, I., Mañanes, D., Munné, P., Núñez, V., Herrera, J., Català-Montoro, M., Álvarez, M., del Pozo, M. Á., Melero, I., Wculek, S. K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58289-1 · Cited by 60
Gilardi, M., Saddawi‐Konefka, R., Wu, V. H., Lopez‐Ramirez, M. A., Wang, Z., Soto, F., Ramms, D. J., Proietto, M., Mikulski, Z., Miki, H., et al. (2022) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0234 · Cited by 47
Moreo, E., Jarit-Cabanillas, A., Robles‐Vera, I., Uranga, S., Guerrero, C., Gómez, A. B., Mata-Martínez, P., Minute, L., Araujo‐Voces, M., Felgueres, M. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41768-8 · Cited by 47
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Yang, B., Zhang, Z., Chen, X., Wang, X.-Y., Qin, S., Du, L., Yang, C., Zhu, L., Sun, W., Zhu, Y., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153454 · Cited by 49
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Chudnovskiy, A., Castro, T. B. R., Nakandakari-Higa, S., Cui, A., Lin, C., Sade-Feldman, M., Phillips, B. K., Pae, J., Mesin, L., Bortolatto, J., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adq8843 · Cited by 41
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Zhang, S., Audiger, C., Chopin, M., & Nutt, S. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1182553 · Cited by 41
Venzin, V., Beccaría, C. G., Perucchini, C., Delfino, P., Bono, E. B., Giustini, L., Moalli, F., Grillo, M., Fumagalli, V., Laura, C., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02199-3 · Cited by 41
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Zindl, C. L., Wilson, C. G., Chadha, A. S., Duck, L. W., Cai, B., Harbour, S. N., Nagaoka-Kamata, Y., Hatton, R. D., Gao, M., Figge, D. A., et al. (2024) · Nature · doi:10.1038/s41586-024-07288-1 · Cited by 38
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Bayerl, F., Bejarano, D. A., Bertacchi, G., Doffin, A., Gobbini, É., Hubert, M., Li, L., Meiser, P., Pedde, A., Posch, W., et al. (2023) · European Journal of Immunology · doi:10.1002/eji.202249923 · Cited by 36
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Salehi‐Rad, R., Lim, R. J., Du, Y., Tran, L. M., Li, R., Ong, S. L., Huang, Z. L., Dumitras, C., Zhang, T.-H., Park, S. J., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-006896 · Cited by 33
Calzada‐Fraile, D., Iborra, S., Ramírez‐Huesca, M., Jorge, I., Dotta, E., Hernández‐García, E., Martin-Cofreces, N. B., Nistal‐Villán, E., Veiga, E., Vázquez, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42480-3 · Cited by 33
Wang, S., Liu, L., Tian, L., Xu, P., Li, S., Hu, L., Xia, Y., Ding, Y., Wang, J., & Li, S. (2024) · Advanced Materials · doi:10.1002/adma.202403296 · Cited by 34
Shadbad, M. A., Hajiasgharzadeh, K., Derakhshani, A., Silvestris, N., Baghbanzadeh, A., Racanelli, V., & Baradaran, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623639 · Cited by 33
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory
Christian, D. A., Adams, T. A., Shallberg, L. A., Phan, A. T., Smith, T. E., Abraha, M., Perry, J. A., Ruthel, G. T., Clark, J. T., Pritchard, G. H., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abq7432 · Cited by 33
Paschen, A., Melero, I., & Ribas, A. (2021) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-070220-111016 · Cited by 32
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Parker, S., McDowall, C., Sanchez-Perez, L. A., Osorio, C., Duncker, P. C., Briley, A., Swartz, A. M., Herndon, J. E., Yu, Y.-R. A., McLendon, R. E., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abn5649 · Cited by 31
Gonzales, G. A., Huang, S., Wilkinson, L., Nguyen, J. A., Sikdar, S., Piot, C., Naumenko, V., Rajwani, J., Wood, C. M., Dinh, I., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adn2168 · Cited by 29
Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer
Hogg, G. D., Weinstein, A. G., Kingston, N. L., Liu, X., Dres, O. M., Kang, L., Lander, V. E., Kao, Y., Ahmad, F. F., Knolhoff, B. L., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adp3978 · Cited by 32
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Ghorbaninezhad, F., Asadzadeh, Z., Masoumi, J., Mokhtarzadeh, A., Kazemi, T., Maleki, L. A., Shotorbani, S. S., Shadbad, M. A., Baghbanzadeh, A., Hemmat, N., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120466 · Cited by 34
He, F., Wu, Z., Liu, C., Zhu, Y., Zhou, Y., Tian, E., Rosin‐Arbesfeld, R., Yang, D., Wang, M., & Zhu, D. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01838-9 · Cited by 31
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Fernandes, C. D. S., Novoszel, P., Gastaldi, T., Krauß, D., Lang, M., Rîca, R., Kutschat, A. P., Holcmann, M., Ellmeier, W., Seruggia, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114308 · Cited by 29
Reste, M., Ajazi, K., Sayi‐Yazgan, A., Janković, R., Bufan, B., Brandau, S., Bækkevold, E. S., Petitprez, F., Lindstedt, M., Adema, G. J., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1439413 · Cited by 32
Roerden, M., Castro, A., Cui, Y., Harake, N., Kim, B., Dye, J., Maiorino, L., White, F. M., Irvine, D. J., Litchfield, K., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010249 · Cited by 30
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Balan, S., Radford, K. J., & Bhardwaj, N. (2020) · Advances in immunology · doi:10.1016/bs.ai.2020.10.002 · Cited by 34
Tullett, K. M., Tan, P. S., Park, H., Schittenhelm, R. B., Michael, N., Li, R., Policheni, A. N., Gruber, E., Huang, C., Fulcher, A. J., et al. (2020) · eLife · doi:10.7554/elife.63452 · Cited by 30
McDaniel, M. M., Meibers, H. E., & Pasare, C. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.07.013 · Cited by 31
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Yang, B., Zhang, Z., Chen, X., Wang, X., Qin, S., Du, L., Yang, C., Zhu, L., Sun, W., Zhu, Y., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 30
Lau, D., Khare, S., Stein, M. M., Jain, P., Gao, Y., BenTaieb, A., Rand, T., Salahudeen, A. A., & Khan, A. A. (2022) · Nature Communications · doi:10.1038/s41467-022-31769-4 · Cited by 32
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Zhivaki, D., Gosselin, E. A., Sengupta, D., Concepcion, H. A., Arinze, C., Chow, J., Nikiforov, A., Komoroski, V., MacFarlane, C., Sullivan, C., et al. (2023) · mBio · doi:10.1128/mbio.02506-23 · Cited by 31
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Rudnitsky, A., Oh, H., Margolin, M., Dassa, B., Shteinberg, I., Stoler‐Barak, L., Shulman, Z., & Kedmi, R. (2025) · Nature · doi:10.1038/s41586-025-09173-x · Cited by 37
Zhang, H., Hong, L., Dong, Z., Shan, X., Lin, B., Cheng, J., Tian, W., Ли, Б., Wang, J., Liu, X., et al. (2025) · Cell Discovery · doi:10.1038/s41421-025-00811-2 · Cited by 37
Wu, Y., Chen, W., Deng, J., Zhou, X., Chen, J., Yang, Z., Cao, X., Liu, J., Tan, Q., Zhou, E., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113998 · Cited by 38
Opejin, A., Surnov, A., Misulovin, Z., Pherson, M., Gross, C. J., Iberg, C. A., Fallahee, I., Bourque, J., Dorsett, D., & Hawiger, D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108424 · Cited by 29
A potential novel cancer immunotherapy: Agonistic anti-CD40 antibodies
Jian, C.-Z., Li, L., Hsu, C., Chen, Y.-H., Hsu, C., Tan, C., & Ou, D. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.103893 · Cited by 28
Engineering dendritic cell biomimetic membrane as a delivery system for tumor targeted therapy
Liu, H., Lu, Y., Zong, J., Zhang, B., Li, X., Qi, H., Yu, T., & Li, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02913-7 · Cited by 34
Multi-disciplinary approaches paving the way for clinically effective peptide vaccines for cancer
Shah, B. A., Holden, J. A., Lenzo, J. C., Hadjigol, S., & O’brien-simpson, N. M. (2025) · npj Vaccines · doi:10.1038/s41541-025-01118-9 · Cited by 35
Pirillo, C., Al-Khalidi, S., Sims, A., Devlin, R., Zhao, H., Pinto, R. M., Jasim, S., Shearer, P. A., Shergold, A. L., Donnelly, H., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adg8249 · Cited by 29
Research Progress on Dendritic Cells in Hepatocellular Carcinoma Immune Microenvironments
Li, W., Chen, G., Peng, H., Zhang, Q., Nie, D., Guo, T., Zhu, Y., Zhang, Y. M., & Lin, M. (2024) · Biomolecules · doi:10.3390/biom14091161 · Cited by 27
Kanda, Y., Okazaki, T., & Katakai, T. (2021) · Cancers · doi:10.3390/cancers13184616 · Cited by 30
TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells
Iberg, C. A., Bourque, J., Fallahee, I., Son, S., & Hawiger, D. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110657 · Cited by 27
Ramamoorthi, G., Kodumudi, K. N., Snyder, C., Grover, P., Zhang, H., Greene, M. I., Basu, A. B., Gallen, C., Wiener, D. A., Costa, R. L. B., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004841 · Cited by 28
The multifaceted roles of CD4+ T cells and MHC class II in cancer surveillance
Bawden, E., & Gebhardt, T. (2023) · Current Opinion in Immunology · doi:10.1016/j.coi.2023.102345 · Cited by 27
A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs
English, K., Kwan, R. Y. Q., Holz, L. E., McGuffog, C., Krol, J. M. M., Kempe, D., Kaisho, T., Heath, W. R., Lisowski, L., Biro, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45612-5 · Cited by 27
Immune modulation in malignant pleural effusion: from microenvironment to therapeutic implications
Ge, S., Zhao, Y., Liang, J., He, Z., Li, K., Zhang, G., Hua, B., Zheng, H., Guo, Q., Qi, R., et al. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03211-w · Cited by 28
Li, X., Chen, T., Li, X., Zhang, H., Li, Y., Zhang, S., Luo, S., & Zheng, T. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00564-w · Cited by 28
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Wong, A., Hamidzada, H., & Epelman, S. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00701-0 · Cited by 26
Life and death of tolerogenic dendritic cells
Bourque, J., & Hawiger, D. (2023) · Trends in Immunology · doi:10.1016/j.it.2022.12.006 · Cited by 29
Unboxing dendritic cells: Tales of multi‐faceted biology and function
Giza, H., & Bozzacco, L. (2021) · Immunology · doi:10.1111/imm.13394 · Cited by 26
XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
Domenjo‐Vila, E., Casella, V., Iwabuchi, R., Fossum, E., Pedragosa, M., Castellví, Q., Rica, P. C., Kaisho, T., Terahara, K., Bocharov, G. A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112123 · Cited by 26
Purbey, P. K., Seo, J., Paul, M. K., Iwamoto, K. S., Daly, A. E., Feng, A., Champhekar, A. S., Langerman, J., Campbell, K. M., Schaue, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114289 · Cited by 27
Dendritic cells instruct T cell anti-tumor immunity and immunotherapy response
Xiao, Z., Wang, J., Yang, J., Guo, F., Zhang, L., & Zhang, L. (2025) · The Innovation Medicine · doi:10.59717/j.xinn-med.2025.100128 · Cited by 27
Xiao, Q., & Xia, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1140765 · Cited by 27
Nakazawa, T., Morimoto, T., Maeoka, R., Matsuda, R., Nakamura, M., Nishimura, F., Ouji, N., Yamada, S., Nakagawa, I., Park, Y.-S., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02770-6 · Cited by 27
Dendritic cells: the yin and yang in disease progression
Jiménez‐Cortegana, C., Palomares, F., Álba, G., Santa‐María, C., de la Cruz‐Merino, L., Sánchez‐Margalet, V., & López-Enríquez, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1321051 · Cited by 24
Phenotypic and spatial heterogeneity of CD8+ tumour infiltrating lymphocytes
Sun, Y., Yinwang, E., Wang, S., Wang, Z., Wang, F., Xue, Y., Zhang, W., Zhao, S., Mou, H., Chen, S., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02104-w · Cited by 29
Fu, J., Yu, A., Xiao, X., Tang, J., Zu, X., Chen, W., & He, B. (2020) · PubMed · Cited by 31
Piezo1 facilitates optimal T cell activation during tumor challenge
Abiff, M., Alshebremi, M., Bonner, M., Myers, J., Kim, B., Tomchuck, S. L., Santin, A., Kingsley, D., Choi, S. H., & Huang, A. Y.-C. (2023) · OncoImmunology · doi:10.1080/2162402x.2023.2281179 · Cited by 25
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Makker, S., Galley, C., & Bennett, C. L. (2023) · Immunotherapy Advances · doi:10.1093/immadv/ltad030 · Cited by 27
CD8+ T cells from experimental in situ breast carcinoma interfere with bone homeostasis
Monteiro, A. C., & Bonomo, A. C. (2021) · Bone · doi:10.1016/j.bone.2021.116014 · Cited by 26
Metadata
- Authors
- Ferris, S. T., Durai, V., Wu, R., Theisen, D. J., Ward, J. P., Bern, M. D., Davidson, J. T., Bagadia, P., Liu, T., Briseño, C. G., Li, L., Gillanders, W. E., Wu, G. F., Yokoyama, W. M., Murphy, T. L., Schreiber, R. D., & Murphy, K. M.
- Affiliations
- Washington University in St. Louis (US)
- University of California, San Francisco (US)
- Barnes-Jewish Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Murphy, Kenneth M.
- ORCID
- Venue
- Nature
- Published
- 2020-08-12
- Volume
- 584
- Issue
- 7822
- Pages
- 624-629
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7469755
- OpenAlex
- W3048641542
- Cited by
- 611
- References
- 50
- Citations by year
- 2026: 112 · 2025: 105 · 2024: 112 · 2023: 127 · 2022: 76 · 2021: 67 · 2020: 12
- FWCI
- 24.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR000448, UL1TR002345)
- National Cancer Institute (T32CA009573, R01CA190700, T32CA009621, R01CA248919, P30CA091842)
- National Institute of Allergy and Infectious Diseases (R01AI150297, R01AI129545, T32AI007163, R01AI162643)
- National Institute of Diabetes and Digestive and Kidney Diseases (F30DK108498, F30DK112466)
- National Institute of Neurological Disorders and Stroke (R01NS106289)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR073752)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- conventional type 1 dendritic cells, cDC1, CD4+ T cell priming, CD8+ T cell priming, MHC class II, MHC class I, cross-presentation, tumor rejection, antitumor immunity
- MeSH terms
- Animals, Histocompatibility Antigens Class II, Dendritic Cells, Female, Neoplasms, Signal Transduction, CD4-Positive T-Lymphocytes, Antigen Presentation, CD8-Positive T-Lymphocytes, CD40 Antigens, Cross-Priming, Mice
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