Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

ggplot2

Wickham, H. (2016) · Use R! · doi:10.1007/978-3-319-24277-4 · Cited by 34,873

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174

Fast, sensitive and accurate integration of single-cell data with Harmony

Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204

Dimensionality reduction for visualizing single-cell data using UMAP

Becht, E., McInnes, L., Healy, J., Dutertre, C.-A., Kwok, I. W. H., Ng, L. G., Ginhoux, F., & Newell, E. W. (2019) · Nature Biotechnology · doi:10.1038/nbt.4314 · Cited by 5,358

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

van de Wetering, M., Francies, H. E., Francis, J. M., Bounova, G., Iorio, F., Pronk, A., van Houdt, W., van Gorp, J., Taylor-Weiner, A., Kester, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.053 · Cited by 2,408

A single-cell survey of the small intestinal epithelium

Haber, A. L., Biton, M., Rogel, N., Herbst, R. H., Shekhar, K., Smillie, C., Burgin, G., Delorey, T. M., Howitt, M. R., Katz, Y., et al. (2017) · Nature · doi:10.1038/nature24489 · Cited by 1,750

Using Biosensors to Study Organoids, Spheroids and Organs-on-a-Chip: A Mechanobiology Perspective

Yousafzai, M. S., & Hammer, J. A. (2023) · Biosensors · doi:10.3390/bios13100905 · Cited by 30

Building gut from scratch — progress and update of intestinal tissue engineering

Tullie, L., Jones, B. C., De Coppi, P., & Li, V. S. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00586-x · Cited by 27

Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation

Hausmann, A., Steenholdt, C., Nielsen, O. H., & Jensen, K. B. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.01.001 · Cited by 31

Advances in gut–brain organ chips

Zhang, Y., Lu, S., Zhuang, J., & Liang, L. (2024) · Cell Proliferation · doi:10.1111/cpr.13724 · Cited by 31

The impact of emerging contaminants exposure on human health effects: A review of organoid assessment models

Yang, J., Zhang, X., Liu, Z., Yang, C., Li, S., Zhou, H., & Gao, Z. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155882 · Cited by 30

Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space

Karunasagara, S., Bayarkhangai, B., Shim, H.-W., Bae, H.-J., Lee, H., Taghizadeh, A., Ji, Y., Mandakhbayar, N., Kim, H. S., Hyun, J., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122854 · Cited by 28

Tissue geometry spatiotemporally drives bacterial infections.

Han, Y.-M., Liu, X., Qu, S., Duan, X.-C., Xiang, Y.-Q., Jiang, N., Yang, S.-Y., Fang, X., Xu, L., Wen, H., et al. (2025) · Cell · doi:10.1016/j.cell.2025.03.042 · Cited by 33

Organoids as models of immune-organ interaction

Harter, M. F., Recaldin, T., & Gjorevski, N. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116214 · Cited by 31

Deciphering Organoids: High-Dimensional Analysis of Biomimetic Cultures

Qin, X., & Tape, C. J. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.10.013 · Cited by 27

The Role of Organoids as a Novel Platform for Modeling of Inflammatory Bowel Disease

O’Connell, L., Winter, D. C., & Aherne, C. M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.624045 · Cited by 28

Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research

Chen, C., Ji, W., & Niu, Y. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2021.03.010 · Cited by 28

Exploiting unique features of the gut-brain interface to combat gastrointestinal cancer

Schledwitz, A., Xie, G., & Raufman, J. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143776 · Cited by 31

Challenges to, and prospects for, reverse engineering the gastrointestinal tract using organoids

Kakni, P., Truckenmüller, R. K., Habibović, P., & Giselbrecht, S. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.01.006 · Cited by 28

A Versatile Intestine‐on‐Chip System for Deciphering the Immunopathogenesis of Inflammatory Bowel Disease

Nguyen, O. T. P., Misun, P. M., Hierlemann, A. R., & Lohasz, C. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202302454 · Cited by 28

Image-based profiling and deep learning reveal morphological heterogeneity of colorectal cancer organoids

Huang, K., Li, M., Li, Q., Chen, Z., Zhang, Y., & Gu, Z. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108322 · Cited by 27

Go with the flow: modeling unique biological flows in engineered in vitro platforms

Wasson, E. M., Dubbin, K., & Moya, M. L. (2021) · Lab on a Chip · doi:10.1039/d1lc00014d · Cited by 27

In vitro and ex vivo modeling of enteric bacterial infections

Taebnia, N., Römling, U., & Lauschke, V. M. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2158034 · Cited by 29

Microfluidic intestinal organoid-on-a-chip uncovers therapeutic targets by recapitulating oxygen dynamics of intestinal IR injury

Huang, J., Xu, Z. Z., Jiao, J., Li, Z., Li, S., Liu, Y., Li, Z., Qu, G., Wu, J., Zhao, Y., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.07.001 · Cited by 27

Engineered Human Organoids for Biomedical Applications

Zhu, Y., Sun, L., Wu, X., Gu, Z., & Zhao, Y. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202310961 · Cited by 29

Microfluidic Platform for Generating and Releasing Patient‐Derived Cancer Organoids with Diverse Shapes: Insight into Shape‐Dependent Tumor Growth

Kheiri, S., Yakavets, I., Cruickshank, J., Ahmadi, F., Berman, H. K., Cescon, D. W., Young, E. W. K., & Kumacheva, E. (2024) · Advanced Materials · doi:10.1002/adma.202410547 · Cited by 26

Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection

Hofer, M., Correa, M. A. D., & Lütolf, M. P. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01313-4 · Cited by 28

Emulating the gut–liver axis: Dissecting the microbiome's effect on drug metabolism using multiorgan-on-chip models

Lucchetti, M., Kaminska, M., Aina, K. O., Mosig, A. S., & Wilmes, P. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.003 · Cited by 28

Macroscopic Supramolecular Assembly Strategy to Construct 3D Biocompatible Microenvironments with Site-Selective Cell Adhesion

Wang, C., Lin, C., Ming, R., Li, X., Jonkheijm, P., Cheng, M., & Shi, F. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c05181 · Cited by 26

Engineering the Cellular Microenvironment of Post-infarct Myocardium on a Chip

Khalil, N. N., & McCain, M. L. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.709871 · Cited by 27

Organoids as tools to investigate gastrointestinal nematode development and host interactions

White, R. F., Blow, F., Buck, A. H., & Correa, M. A. D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.976017 · Cited by 30

Surface tension of model tissues during malignant transformation and epithelial–mesenchymal transition

Nagle, I., Richert, A., Quinteros, M., Janel, S., Buysschaert, E., Luciani, N., Debost, H., Thevenet, V., Wilhelm, C., Prunier, C., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.926322 · Cited by 26

Advances in application and innovation of microfluidic platforms for pharmaceutical analysis

Ma, L., Li, N., Wang, J., Ma, C., Hu, X., Li, M., & Wu, Z. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.116951 · Cited by 27

Intestinal organoids: A versatile platform for modeling gastrointestinal diseases and monitoring epigenetic alterations

Ghorbaninejad, M., Asadzadeh‐Aghdaei, H., Baharvand, H., & Meyfour, A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121506 · Cited by 27

Listen to Your Gut: Key Concepts for Bioengineering Advanced Models of the Intestine

Cameron, O., Neves, J. F., & Gentleman, E. (2023) · Advanced Science · doi:10.1002/advs.202302165 · Cited by 26

Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies

Donkers, J. M., van der Vaart, J. I., & van de Steeg, E. (2023) · Biomimetics · doi:10.3390/biomimetics8020226 · Cited by 25

Towards single-cell bioprinting: micropatterning tools for organ-on-chip development

Bosmans, C., Rodriguez, N. G., Karperien, M., Malda, J., Teixeira, L. M., Levato, R., & Leijten, J. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2023.11.014 · Cited by 29

Technological advances and challenges in constructing complex gut organoid systems

Zheng, L., Zhan, Y., Wang, C., Fan, Q., Sun, D., Li, Y., & Xiong, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1432744 · Cited by 27

Challenges in validation of combination treatment strategies for CRC using patient-derived organoids

Benboubker, V., Ramzy, G. M., Jacobs, S., & Nowak-Sliwinska, P. M. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03173-x · Cited by 29

Mechanochemical bistability of intestinal organoids enables robust morphogenesis

Xue, S.-L., Yang, Q., Liberali, P., & Hannezo, É. (2025) · Nature Physics · doi:10.1038/s41567-025-02792-1 · Cited by 25

Artificial Intelligence for Organoids Multidimensional Assessment

Mo, Y., Wang, J., Yang, H., Bai, L., Xu, K., & Su, J. (2025) · SmartMat · doi:10.1002/smm2.70016 · Cited by 25

Stem Cells and Organoid Technology in Precision Medicine in Inflammation: Are We There Yet?

Tran, F., Klein, C., Arlt, A., Imm, S., Knappe, E., Simmons, A., Rosenstiel, P. C., & Seibler, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573562 · Cited by 25

Imaging therapeutic peptide transport across intestinal barriers

Larsen, J. B., Taebnia, N., Dolatshahi‐Pirouz, A., Eriksen, A. Z., Hjørringgaard, C. U., Kristensen, K., Larsen, N. W., Larsen, N. B., Marie, R., Mündler, A.-K., et al. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00024a · Cited by 26

The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis

Ojo, B. A., VanDussen, K. L., & Rosen, M. J. (2021) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izab161 · Cited by 24

Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates

Rajasekar, S., Lin, D. S. Y., Zhang, F., Sotra, A., Boshart, A., Clotet‐Freixas, S., Liu, A. W. K., Hirota, J. A., Ogawa, S., Konvalinka, A., et al. (2022) · Lab on a Chip · doi:10.1039/d1lc01141c · Cited by 25

Frequently expressed glypican‐3 as a promising novel therapeutic target for osteosarcomas

Nie, J., Yang, T., Li, H., Li, S., Li, T., Ye, H., Lu, M., Chu, X., Zhong, G., Zhou, J., et al. (2022) · Cancer Science · doi:10.1111/cas.15521 · Cited by 25

Development of lacrimal gland organoids from iPSC derived multizonal ocular cells

Asal, M., Koçak, G., Sarı, V., Reçber, T., Nemutlu, E., Utine, C. A., & Güven, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1058846 · Cited by 25

The Patient-Derived Cancer Organoids: Promises and Challenges as Platforms for Cancer Discovery

Bae, J., Choi, Y. S., Cho, G., & Jang, S. J. (2022) · Cancers · doi:10.3390/cancers14092144 · Cited by 27

Membrane-based microfluidic systems for medical and biological applications

Calzuola, S. T., Newman, G., Feaugas, T., Perrault, C. M., Blondé, J.-B., Roy, E., Porrini, C., Stojanović, G. M., & Vidić, J. (2024) · Lab on a Chip · doi:10.1039/d4lc00251b · Cited by 22

Collective behaviours in organoids

Yang, Q., & Liberali, P. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.06.006 · Cited by 24

Cell Aggregate Assembly through Microengineering for Functional Tissue Emergence

Eke, G., Vaysse, L., Yao, X., Escudero, M., Carrière, A., Trévisiol, E., Christophe Vieu, A., Dani, C., Casteilla, L., & Malaquin, L. (2022) · Cells · doi:10.3390/cells11091394 · Cited by 27

Role of in vitro two-dimensional (2D) and three-dimensional (3D) cell culture systems for ADME-Tox screening in drug discovery and development: a comprehensive review

Chunduri, V., & Maddi, S. (2022) · ADMET & DMPK · doi:10.5599/admet.1513 · Cited by 30

In vitro cultivation methods for coccidian parasite research

Feix, A. S., Bustos, T. C., Ruttkowski, B., & Joachim, A. (2022) · International Journal for Parasitology · doi:10.1016/j.ijpara.2022.10.002 · Cited by 26

Current gut-on-a-chip platforms for clarifying the interactions between diet, gut microbiota, and host health

Wu, J., Zhang, B., Liu, X., Peng, L., Liu, J., Hu, Y., Ji, X., Lv, H., & Wang, S. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.02.013 · Cited by 24

Measuring and modelling tumour heterogeneity across scales

Beeghly, G. F., Shimpi, A. A., Riter, R. N., & Fischbach, C. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00087-9 · Cited by 26

Tailoring biomaterials for biomimetic organs-on-chips

Sun, L., Bian, F., Xu, D., Luo, Y., Wang, Y., & Zhao, Y. (2023) · Materials Horizons · doi:10.1039/d3mh00755c · Cited by 25

Tuneable hydrogel patterns in pillarless microfluidic devices

Olaizola‐Rodrigo, C., Palma-Florez, S., Ranđelović, T., Bayona, C., Ashrafi, M., Samitier, J., Lagunas, A., Mir, M., Doblaré, M., Ochoa, I., et al. (2024) · Lab on a Chip · doi:10.1039/d3lc01082a · Cited by 24

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

Moskal, K., Khurana, N., Siegert, L., Lee, Y., Clevers, H. C., Elinav, E., & Puschhof, J. (2024) · International Journal of Cancer · doi:10.1002/ijc.35298 · Cited by 24

Biomimetic culture substrates for modelling homeostatic intestinal epithelium in vitro

Abdollahi, S., Zarin, B., Vatani, M., Vajhadin, F., Hassani, M., Jalali, P., Kim, K., & Sanati‐Nezhad, A. (2025) · Nature Communications · doi:10.1038/s41467-025-59459-x · Cited by 24

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Tzouanas, C. N., Shay, J. E. S., Sherman, M. S., Rubin, A. J., Mead, B. E., Dao, T. T., Tao, J., Lehrich, B. M., Eng, G. M., Patterson-Fortin, J., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.031 · Cited by 32

Evaluation of Hybrid Vesicles in an Intestinal Cell Model Based on Structured Paper Chips

Andres, P. D. D., Westensee, I. N., Brodszkij, E., Ramos‐Docampo, M. A., Gal, N., & Städler, B. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c00686 · Cited by 25

Translational organoid technology – the convergence of chemical, mechanical, and computational biology

Zhang, W., Li, J., Zhou, J., Rastogi, A., & Ma, S. (2022) · Trends in biotechnology · doi:10.1016/j.tibtech.2022.03.003 · Cited by 23

Creating a Microenvironment to Give Wings to Dental Pulp Regeneration—Bioactive Scaffolds

Hu, N., Li, W., Jiang, W., Wen, J., & Gu, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010158 · Cited by 23

Cell Shape and Forces in Elastic and Structured Environments: From Single Cells to Organoids

Link, R., Weißenbruch, K., Tanaka, M., Bastmeyer, M., & Schwarz, U. S. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202302145 · Cited by 25

Facile Photopatterning of Perfusable Microchannels in Synthetic Hydrogels to Recreate Microphysiological Environments

Mora‐Boza, A., Mulero‐Russe, A., Caprio, N. D., Burdick, J. A., Singh, A. K., & Garcı́a, A. J. (2023) · Advanced Materials · doi:10.1002/adma.202306765 · Cited by 23

Bioengineered Tubular Biliary Organoids

Elci, B. S., Nikolaev, M., Rezakhani, S., & Lütolf, M. P. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202302912 · Cited by 23

Differential Response to the Course of Cryptosporidium parvum Infection and Its Impact on Epithelial Integrity in Differentiated versus Undifferentiated Human Intestinal Enteroids

Lamisere, H., Bhalchandra, S., Kane, A. V., Zeng, X., Mo, D., Adams, W., Estes, M. K., & Ward, H. (2022) · Infection and Immunity · doi:10.1128/iai.00397-22 · Cited by 22

Human Organoids and Their Application in Tumor Models, Disease Modeling, and Tissue Engineering

Song, S., Liu, Z., Wang, Y., & Gong, B. (2025) · Medicine Bulletin · doi:10.1002/mdb2.70001 · Cited by 25

Organoids for tissue repair and regeneration

Yu, B., Zhou, D., Wang, F., Chen, X., Li, M., & Su, J. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102013 · Cited by 27

Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening

Ma, C., Seong, H., Li, X., Yu, X., Xu, S., & Li, Y. (2022) · Stem Cells International · doi:10.1155/2022/2150680 · Cited by 25

Developing 3D bioprinting for organs-on-chips

Wu, Z., Liu, R., Shao, N., & Zhao, Y. (2025) · Lab on a Chip · doi:10.1039/d4lc00769g · Cited by 24

Genetically modified organoids for tissue engineering and regenerative medicine

Zhang, Q., Jin, H., Zhu, D., Chen, Y., Fu, M., Lu, S., Qiu, Y., Zhou, G., Yang, G., & Jiang, Z. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103337 · Cited by 23

Intestinal organoid coculture systems: current approaches, challenges, and future directions

Al-Qadami, G. H., Raposo, A. E., Chien, C.-C., Ma, C., Priebe, I. K., Hor, M., & Fung, K. Y. C. (2024) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00203.2024 · Cited by 24

Organ-on-a-chip: Quo vademus? Applications and regulatory status

Mendes, M., Morais, A. S., Carlos, A., Sousa, J., Pais, A. A. C. C., Mihaila, S. M., & Vitorino, C. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114507 · Cited by 23

Organ-on-a-Chip: A Roadmap for Translational Research in Human and Veterinary Medicine

Surina, S., Chmielewska, A., Pratscher, B., Freund, P., Rodríguez-Rojas, A., & Burgener, I. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110753 · Cited by 23

The Truman Show for protozoan parasites: A review of in vitro cultivation platforms

Sutrave, S., & Richter, M. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009668 · Cited by 21

4D Materials with Photoadaptable Properties Instruct and Enhance Intestinal Organoid Development

Yavitt, F. M., Kirkpatrick, B. E., Blatchley, M. R., & Anseth, K. S. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c01450 · Cited by 21

Material Engineering in Gut Microbiome and Human Health

Yang, L., Hung, L. Y., Zhu, Y., Ding, S., Margolis, K. G., & Leong, K. W. (2022) · Research · doi:10.34133/2022/9804014 · Cited by 24

c-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs

González‐Loyola, A., Bernier‐Latmani, J., Roçi, I., Wyss, T., Langer, J., Durot, S., Muñoz, O., Prat-Luri, B., Delorenzi, M., Lütolf, M. P., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20212418 · Cited by 20

Microphysiological Constructs and Systems: Biofabrication Tactics, Biomimetic Evaluation Approaches, and Biomedical Applications

Zhang, S., Xu, G., Wu, J., Liu, X., Fan, Y. Z., Chen, J., Wallace, G. G., & Gu, Q. (2023) · Small Methods · doi:10.1002/smtd.202300685 · Cited by 26

Cellular agriculture for milk bioactive production

Yart, L., Wijaya, A. W., Lima, M. J., Haller, C., van der Beek, E. M., Carvalho, R. S., Kraus, M. R.-C., & Mashinchian, O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00112-x · Cited by 23

Progress of organoid platform in cardiovascular research

Du, X., Jia, H., Chang, Y., Zhao, Y., & Song, J. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.043 · Cited by 21

3D Interfacial and Spatiotemporal Regulation of Human Neuroepithelial Organoids

Tang, C., Wang, X., D’Urso, M., van der Putten, C., & Kurniawan, N. A. (2022) · Advanced Science · doi:10.1002/advs.202201106 · Cited by 20

Tumor organoid model of colorectal cancer (Review)

Yang, C., Xiao, W., Wang, R., Hu, Y., Yi, K., Sun, X., Wang, G., & Xu, X. (2023) · Oncology Letters · doi:10.3892/ol.2023.13914 · Cited by 24

Engineered epithelial curvature controls Paneth cell localization in intestinal organoids

Yavitt, F. M., Khang, A., Bera, K., McNally, D. L., Blatchley, M. R., Gallagher, A. P., Klein, O. D., Castillo‐Azofeifa, D., Dempsey, P. J., & Anseth, K. S. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100046 · Cited by 20

New developments and applications of human organoids

Andersson-Rolf, A., & Clevers, H. C. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-00974-0 · Cited by 25

Expanding the boundaries of synthetic development

Martyn, I., & Gartner, Z. J. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.01.017 · Cited by 19

Multi-cellular aggregates, a model for living matter

Ackermann, J., Amar, M. B., & Joanny, J. (2021) · Physics Reports · doi:10.1016/j.physrep.2021.05.001 · Cited by 24

Epithelial morphogenesis in organoids

Lee, B. H., Seijo-Barandiarán, I., & Grapin‐Botton, A. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2021.10.001 · Cited by 19

Endometriosis organoids: prospects and challenges

Esfandiari, F., Mansouri, N., Shahhoseini, M., Khoei, H. H., Mikaeeli, G., Vankelecom, H. E. J., & Baharvand, H. (2022) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2022.03.016 · Cited by 20

Microphysiological systems to study colorectal cancer: state-of-the-art

Ramos, P., Carvalho, M. R., Chen, W., Yan, L., Zhang, C., He, Y., Reis, R. L., & Oliveira, J. M. (2023) · Biofabrication · doi:10.1088/1758-5090/acc279 · Cited by 22

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Langer, J. (2025) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · doi:10.5075/epfl-thesis-10932

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