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Diagnosing COVID-19: The Disease and Tools for Detection

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NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

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Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

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De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

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RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

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Algorithm discovery by protein folding game players

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Structure-based Design of Prefusion-stabilized SARS-CoV-2 SpikesPreprint

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Synthesis of Protein-Oligonucleotide Conjugates

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Multiplexed bioluminescence imaging with a substrate unmixing platform

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An Experimental Framework for Developing Point-of-Need Biosensors: Connecting Bio-Layer Interferometry and Electrochemical Impedance Spectroscopy

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A Connected World: System-Level Support Through Biosensors

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Empowering single-molecule analysis with self-assembled DNA nanostructures

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Engineering Escherichia coli biofilm to increase contact surface for shikimate and L-malate production

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Recent advances in immunoassay technologies for the detection of human coronavirus infections

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Research progress on nanomaterial-empowered electrochemical biosensors for the detection of cardiac troponin I

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Unravelling the Structure of the Tetrahedral Metal-Binding Site in METP3 through an Experimental and Computational Approach

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DNA-Mediated Peptide Assembly into Protein Mimics

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Reshaping de Novo Protein Switches into Bioresponsive Materials for Biomarker, Toxin, and Viral Detection

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Predictive Molecular Models for Charged Materials Systems: From Energy Materials to Biomacromolecules

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Unlocking the Potential of Field Effect Transistor (FET) Biosensors: A Perspective on Methodological Advances in Computational and Molecular Biology

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Advances in ligand-specific biosensing for structurally similar molecules

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Genetically encoded biosensors for spatiotemporal monitoring of plant proteins in growth and stress responses

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Significance of Cardiac Troponins as an Identification Tool in COVID-19 Patients Using Biosensors: An Update

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Road testing new CAR design strategies in multiple myeloma

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Phase transition of GvpU regulates gas vesicle clustering in bacteria

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Probing and imaging phospholipid dynamics in live cells

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Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance

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Conformational Entropy as a Potential Liability of Computationally Designed Antibodies

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Robust de novo design of protein binding proteins from target structural information alonePreprint

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Artificial intelligence-driven approaches for the rational design of peptides with predictable aggregation propensity

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mRNA Display Pipeline for Protein Biosensor Construction

Cui, Z., Ayva, C. E., Liew, Y. J., Guo, Z., Mutschler, R., Dreier, B., Fiorito, M. M., Walden, P. M., Howard, C. B., Ely, F., et al. (2024) · ACS Sensors · doi:10.1021/acssensors.3c02471 · Cited by 11

Bioconvergence: advancing biosensors with nanotechnology for real-time health monitoring

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Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensors

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What Can De Novo Protein Design Bring to the Treatment of Hematological Disorders?

Lu, H. J., Cheng, Z., Hu, Y., & Tang, L. V. (2023) · Biology · doi:10.3390/biology12020166 · Cited by 10

De novo design of membrane transport proteins

Zhou, C. X., & Lu, P. (2022) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26336 · Cited by 8

Advances in the Computational Design of Small-Molecule-Controlled Protein-Based Circuits for Synthetic Biology

Kretschmer, S., & Kortemme, T. (2022) · Proceedings of the IEEE · doi:10.1109/jproc.2022.3157898 · Cited by 10

Diversifying Design of Nucleic Acid Aptamers Using Unsupervised Machine Learning

Moussa, S., Kilgour, M., Jans, C., Hernández-García, Á., Čuperlović‐Culf, M., Bengio, Y., & Simine, L. (2022) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.2c05660 · Cited by 10

A Bioluminescent Sensor for Rapid Detection of PPEP-1, a Clostridioides difficile Biomarker

Ng, K. K., Reinert, Z. E., Corver, J., Resurreccion, D., Hensbergen, P. J., & Prescher, J. A. (2021) · Sensors · doi:10.3390/s21227485 · Cited by 10

Towards hybrid one-pot/one-electrode Pd-NPs-based nanoreactors for modular biocatalysis

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Computational design of a sensitive, selective phase-changing sensor protein for the VX nerve agent

McCann, J. J., Pike, D. H., Brown, M. C., Crouse, D. T., Nanda, V., & Koder, R. L. (2022) · Science Advances · doi:10.1126/sciadv.abh3421 · Cited by 9

Fe3+ ion quantification with reusable bioinspired nanopores

Wang, Y., Hou, Y., Huo, F., & Hou, X. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110428 · Cited by 9

Multi-input biocomputer gene circuits for therapeutic application

Jaekel, J. J., Schweingruber, D., Cheras, V., Doshi, J., & Benenson, Y. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.100371 · Cited by 9

Recent Application of Metal-Organic Frameworks in an Electrochemical Immunosensor

Dai, C., Zhao, Y., Chen, P., Liu, J., Wang, C., Jiang, L., Huang, Y., Feng, M., Ouyang, R., Miao, Y., et al. (2022) · International Journal of Electrochemical Science · doi:10.20964/2022.05.28 · Cited by 9

Engineering protein activity into off-the-shelf DNA devices

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Tailored structured peptide design with a key-cutting machine approach

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Smart genetically-encoded biosensors for the chemical monitoring of living systems

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From De Novo Design to Redesign: Harnessing Computational Protein Design for Understanding SARS-CoV-2 Molecular Mechanisms and Developing Therapeutics

Padhi, A. K., Kalita, P., Maurya, S., Poluri, K. M., & Tripathi, T. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.3c04542 · Cited by 9

Expanding the versatility of natural and de novo designed coiled coils and helical bundles

ElGamacy, M., & Alvarez, B. H. (2021) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2021.03.011 · Cited by 8

Protein sensors combining both on-and-off model for antibody homogeneous assay

Li, J., Wang, J., Zhang, W., Tu, Z., Cai, X.-F., Wang, Y., Gan, C.-Y., Deng, H., Cui, J., Shu, Z., et al. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114226 · Cited by 8

Synthetic Biology for Designing Allostery and Its Potential Biomedical Applications

Plaper, T., Štibler, U., & Jerala, R. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169225 · Cited by 7

High-performance nanobiosensing technologies for future diagnostic needs

Martínez-Banderas, A. I., Malki, A., Fröhlich, T., & Petrich, W. H. (2025) · Trends in biotechnology · doi:10.1016/j.tibtech.2025.05.014 · Cited by 7

The Next Frontier for Designing Switchable Proteins: Rational Enhancement of Kinetics

Bogetti, A. T., Presti, M. F., Loh, S. N., & Chong, L. T. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.1c04082 · Cited by 7

Small-Molecule Modulated Affinity-Tunable Semisynthetic Protein Switches

Wu, C., Shao-jie, H., Fu, T.-Y., Lin, F.-L., Wang, X.-Y., & Tan, K. (2022) · ACS Sensors · doi:10.1021/acssensors.2c01211 · Cited by 7

Introduction to Biosensing

Korotcenkov, G. S., Ahmad, R. G., Guleria, P., & Kumar, V. (2023) · Springer eBooks · doi:10.1007/978-3-031-24000-3_17 · Cited by 7

Corrole–protein interactions in H-NOX and HasA

Lemon, C. M., Nissley, A. J., Latorraca, N. R., Wittenborn, E. C., & Marletta, M. A. (2022) · RSC Chemical Biology · doi:10.1039/d2cb00004k · Cited by 7

Emerging strategies to develop novel genetically encoded biosensors

Chang, L., Wang, J., Wang, M., & Zhang, Y. (2025) · Trends in biotechnology · doi:10.1016/j.tibtech.2025.04.014 · Cited by 6

On-site detection of airborne foodborne pathogens using a field-deployable recombinase polymerase amplification and CRISPR/Cas12a cleavage activity assay

Jeong, Y., Lee, J., Choi, S., Shin, D., Jang, S., Son, S. U., Kang, T., Jung, J., Hwang, J., & Lim, E. (2026) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2026.118571 · Cited by 6

Accelerating functional protein discovery with GPT models: Antimicrobials and enzymes

Zeng, Z., Xu, R.-F., Guo, J., Jin, J., He, H., & Luo, X. (2025) · The Innovation Life · doi:10.59717/j.xinn-life.2025.100133 · Cited by 7

Click it or stick it: Covalent and non-covalent methods for protein-self assembly

Lange, O. J., & Polizzi, K. M. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.100374 · Cited by 6

BAGEL: Protein engineering via exploration of an energy landscape

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And… cut! – how conformational regulation of CRISPR-Cas effectors directs nuclease activity

Calvert, R. W., & Knott, G. J. (2025) · Biochemical Journal · doi:10.1042/bcj20240481 · Cited by 6

Automated and modular protein binder design with BinderFlow

González-Rodríguez, N., González-Rodríguez, N., Llorca, Ó., & Fernández-Leiro, R. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013747 · Cited by 6

ProBID-Net: a deep learning model for protein–protein binding interface design

Chen, Z., Ji, M., Qian, J., Zhang, Z., Zhang, X., Gao, H., Wang, H., Wang, R., & Qi, Y. (2024) · Chemical Science · doi:10.1039/d4sc02233e · Cited by 8

LuxSit Pro and sPro: Next-Generation Designed Luciferases for Bioluminescent Reporting and Complementation-Based DetectionPreprint

Vergara, R., Wagner, J., Kamalian, P., Harman, J. L., Lara, N., Fischer, E. S., Bernardes, G. J. L., Quijano‐Rubio, A., & Silva, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.21.665742 · Cited by 5

Protein Design Meets Single-Molecule Detection: Towards Programmable Nanopore Sensors

Liu, X., & Xu, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110561 · Cited by 4

Luciferase complementation for cellular assays beyond protein–protein interactions

Kawamura, G., & Ozawa, T. (2025) · Analytical Sciences · doi:10.1007/s44211-025-00730-y · Cited by 5

Comprehensive review on emerging nanotechnologies for combating COVID-19 and future pandemic preparedness

Liang, Z., Shan, G., Shan, S., Ding, Z., Zhang, J., & Chu, B. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125970 · Cited by 5

Economical and Versatile Subunit Design Principles for Self-Assembled DNA Origami Structures

Wei, W.-S., Videbæk, T. E., Hayakawa, D., Saha, R., Pombo, J., Arya, G., Rogers, W. B., & Fraden, S. (2025) · ACS Nano · doi:10.1021/acsnano.5c06681 · Cited by 6

Impact of solvent forces and broken symmetry on the assembly of designed proteins at a liquid-solid interface

Schmid, S. Y., Helfrecht, B. A., Stegmann, A. E., Legg, B. A., Pyles, H., Chen, J., Edison, J. R., Ziatdinov, M. A., Preisler, Z., Dollar, O., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69170-0 · Cited by 4

Guiding protein design choices by per-residue energy breakdown analysis with an interactive web application

Engelberger, F., Zakary, J. D., & Künze, G. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1178035 · Cited by 5

Hard–soft chemistry guides the adaptable charge transport in lysine-doped heptapeptide junctions

Li, Y., Li, X., Qi, P., & Guo, C. (2022) · Chemical Communications · doi:10.1039/d2cc00752e · Cited by 4

Cell-free biosensors: where have we been and where do we need to go?

Arce, A., Brown, D. M., Demissie, H. A., Feng, S., Naji, M., & Lucks, J. B. (2026) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2026.103451 · Cited by 3

Deep learning revolutionizes protein research: Advances in structure prediction, functional annotation, and engineered design

Zhang, J., Wang, S., Gao, L., & Li, Q. (2026) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2026.03.012 · Cited by 4

Synthetic biology-engineered immunotherapies: Precision control of immune responses

Wang, Z., Fu, W., Ding, Y.-F., Gao, C.-C., Qin, H.-Y., & Zhao, J.-L. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.108871 · Cited by 3

High-throughput Optical Analysis to Inform Design of Electrochemical Biosensors

Ricks, N. J., Pence, M. A., Brachi, M., & Minteer, S. D. (2026) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.6c00018 · Cited by 3

Measurement of Dilational Modulus of an Adsorbed BSA Film Using Pendant Bubble Tensiometry: From a Clean Interface to Saturation

Hussain, S., Rivas, J. E. M., Tseng, W., Tsay, R.-Y., Noskov, B. A., Loglio, G., & Lin, S. (2023) · Colloids and Interfaces · doi:10.3390/colloids8010004 · Cited by 3

De novo design of cavity-containing proteins with a backbone-centered neural network energy function

Xu, Y., Hu, X., Wang, C., Liu, Y., Chen, Q., & Liu, H. (2024) · Structure · doi:10.1016/j.str.2024.01.006 · Cited by 3

Advances in Bioinspired Artificial System Enabling Biomarker‐Driven Therapy

Wang, M., Zhong, H., Li, Y., Li, J., Zhang, X., He, F., Wei, P., Wang, H., & Nie, Z. (2024) · Chemistry - A European Journal · doi:10.1002/chem.202401593 · Cited by 3

From “stars” to nano: Porous poly(ethylene glycol) hydrogel films and nanosheets as a versatile platform for sensing and nanofabrication

Zharnikov, M. (2024) · Nano Research · doi:10.1007/s12274-024-6881-1 · Cited by 3

Walking by design: how to build artificial molecular motors made of proteins

Nilsson, P. F., Zink, A., Laprévote, O. M. C., Korosec, C. S., Gustafsson, N., Robertson, N. O., Forde, N. R., Eichhorn, R., Höcker, B., Curmi, P. M. G., et al. (2024) · Nano Futures · doi:10.1088/2399-1984/ad7d7e · Cited by 2

Recent Progresses of Peptide Fluorescent Probes for Protein Analysis in Living Cells

Wu, X., Zhang, H., Li, M., Xia, F., & Lou, X. (2025) · ACS Materials Letters · doi:10.1021/acsmaterialslett.4c02671 · Cited by 3

Exploiting a rational β-strand insertion strategy and disulfide locking to mechanically manipulate domain-swapped protein structures

Ghanbarpour, A., Kenaya, N., Bingham, C., Turke, M. J., Pinger, C. W., Kemp, C., Studzinski, E., Vasileiou, C., Borhan, B., & Geiger, J. H. (2025) · Structure · doi:10.1016/j.str.2025.06.012 · Cited by 3

Creating a Thermostable β-Glucuronidase Switch for Homogeneous Immunoassay by Disruption of Conserved Salt Bridges at Diagonal Interfaces

Zhu, B., Qian, C., Tang, H., Kitaguchi, T., & Ueda, H. (2022) · Biochemistry · doi:10.1021/acs.biochem.2c00165 · Cited by 3

Tailoring the whole-cell sensing spectrum with cyborgian redox machinery

Yang, K., Lu, Z., Zhu, T., Wang, J., Yang, F.-Q., Abbas, S. Z., Zhou, J. W., Yang, Z., Mi, J., Ravi, S. K., et al. (2023) · Analytica Chimica Acta · doi:10.1016/j.aca.2023.341046 · Cited by 3

Protein circuit design using de novo proteins

Chen, Z. (2023) · Trends in biotechnology · doi:10.1016/j.tibtech.2023.02.011 · Cited by 3

Graphene-based Nanocomposites for DNA Sensing

Pourmadadi, M., Ostovar, S., Eshaghi, M. M., & Shamsabadipour, A. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837671847-00394 · Cited by 3

Engineering of a Fluorescent Protein for a Sensing of an Intrinsically Disordered Protein through Transition in the Chromophore State

Yu, T.-G., Lee, J., Yoon, J., Choi, J. M., Kim, D., Heo, W. D., Song, J., & Kim, H. (2023) · JACS Au · doi:10.1021/jacsau.3c00445 · Cited by 3

Programming interchangeable and reversible heterooligomeric protein self-assembly using a bifunctional ligand

Son, S.-Y., & Song, W. J. (2024) · Chemical Science · doi:10.1039/d3sc05448a · Cited by 3

Dynamics design of a non-natural transcription factor responding to androst-4-ene-3,17-dione

Zhao, M., Hu, M., Han, R., Ye, C., Li, X., Wang, T., Liu, Y., Xue, Z., & Liu, K. (2024) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2024.04.001 · Cited by 3

Dissolution-enhanced emission of 1,3,6,8-tetrakis( p -benzoic acid)pyrene for selectively detecting protamine and “on-to-on” heparin detection in water

Li, H., Zhang, Y., Huang, Y., Cao, D., & Wang, S. (2021) · New Journal of Chemistry · doi:10.1039/d1nj03946f · Cited by 3

Exploration of novel αβ-protein folds through de novo designPreprint

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Interferometric measurement of an axi-symmetric density field

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