The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Cellular anatomy of the mouse primary motor cortex
Open accessPublished version of a preprint
Abstract
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted 1 . Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input–output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fast unfolding of communities in large networks
Blondel, V. D., Guillaume, J.-L., Lambiotte, R., & Lefebvre, E. (2008) · Journal of Statistical Mechanics: Theory and Experiment · doi:10.1088/1742-5468/2008/10/p10008 · Cited by 21,424
Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,821
Solving Least Squares Problems
Lawson, C. L., & Hanson, R. J. (1995) · doi:10.1137/1.9781611971217 · Cited by 7,103
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Self-citationThe structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Self-citationA multi-modal parcellation of human cerebral cortex
Glasser, M. F., Coalson, T. S., Robinson, E. C., Hacker, C. D., Harwell, J., Yacoub, E., Ugurbil, K., Andersson, J., Beckmann, C. F., Jenkinson, M., et al. (2016) · Nature · doi:10.1038/nature18933 · Cited by 5,111
Elastix: a toolbox for intensity-based medical image registration
Klein, S., Staring, M., Murphy, K., Viergever, M. A., & Pluim, J. (2010) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2009.2035616 · Cited by 4,311
A mesoscale connectome of the mouse brain
Oh, S. W., Harris, J. A., Ng, L., Winslow, B., Cain, N., Mihalas, S., Wang, Q., Lau, C., Kuan, L., Henry, A. M., et al. (2014) · Nature · doi:10.1038/nature13186 · Cited by 2,612
Self-citationParvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606
Cited by
A multimodal cell census and atlas of the mammalian primary motor cortex
BRAIN Initiative Cell Census Network (BICCN), BRAIN Initiative Cell Census Network (BICCN) Corresponding authors, Callaway, E. M., Dong, H.-W., Ecker, J. R., Hawrylycz, M. J., Huang, Z. J., Lein, E. S., Ngai, J., Osten, P., et al. (2021) · Nature · doi:10.1038/s41586-021-03950-0 · Cited by 522
Self-citationSpatially resolved cell atlas of the mouse primary motor cortex by MERFISH
Zhang, M., Eichhorn, S. W., Zingg, B., Yao, Z., Cotter, K., Zeng, H., Dong, H., & Zhuang, X. (2021) · Nature · doi:10.1038/s41586-021-03705-x · Cited by 498
Self-citation
Metadata
- Authors
- Muñoz-Castañeda, R., Zingg, B., Matho, K. S., Chen, X., Wang, Q., Foster, N. N., Li, A., Narasimhan, A., Hirokawa, K. E., Huo, B., Bannerjee, S., Korobkova, L., Park, C. S., Park, Y.-G., Bienkowski, M. S., Chon, U., Wheeler, D. W., Li, X., Wang, Y., Naeemi, M., Xie, P., Liu, L., Kelly, K., An, X., Attili, S. M., Bowman, I., Bludova, A., Cetin, A., Ding, L., Drewes, R., D’Orazi, F., Elowsky, C., Fischer, S., Galbavy, W., Gao, L., Gillis, J., Groblewski, P. A., Gou, L., Hahn, J. D., Hatfield, J. T., Hintiryan, H., Huang, J. J., Kondo, H., Kuang, X., Lesnar, P., Li, X., Li, Y., Lin, M., Lo, D., Mizrachi, J., Mok, S., Nicovich, P. R., Palaniswamy, R., Palmer, J., Qi, X., Shen, E., Sun, Y.-C., Tao, H. W., Wakemen, W., Wang, Y., Yao, S., Yuan, J., Zhan, H., Zhu, M., Ng, L., Zhang, L. I., Lim, B. K., Hawrylycz, M., Gong, H., Gee, J. C., Kim, Y., Chung, K., Yang, X. W., Peng, H., Luo, Q., Mitra, P. P., Zador, A. M., Zeng, H., Ascoli, G. A., Josh Huang, Z., Osten, P., Harris, J. A., & Dong, H.-W.
- Venue
- Nature
- Published
- 2021-10-06
- Volume
- 598
- Issue
- 7879
- Pages
- 159-166
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3202762561
- Cited by
- 267
- References
- 134
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- creativecommons.org/licenses/by/4.0 (tdm)
- creativecommons.org/licenses/by/4.0 (vor)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cellular anatomy of the mouse primary motor cortex. https://app.cochat.ai/papers/10.1038/s41586-021-03970-w
- The paper
- Muñoz-Castañeda, R., Zingg, B., Matho, K. S., Chen, X., Wang, Q., Foster, N. N., Li, A., Narasimhan, A., Hirokawa, K. E., Huo, B., Bannerjee, S., Korobkova, L., Park, C. S., Park, Y.-G., Bienkowski, M. S., Chon, U., Wheeler, D. W., Li, X., Wang, Y., . . . Dong, H.-W. (2021). Cellular anatomy of the mouse primary motor cortex. Nature. https://doi.org/10.1038/s41586-021-03970-w
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
