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Reduced reproductive success is associated with selective constraint on human genes
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“Third, although aggregating data from both sexes increased statistical power, the current lack of sex-stratified data prevents us from uncovering sex-specific associations and gene–sex interactions63,77,78.”
From Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans (2026) · cites this paper as [78]
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Stefansson, H., Meyer-Lindenberg, A., Steinberg, S., Magnusdottir, B., Morgen, K., Arnarsdottir, S., Bjornsdottir, G., Walters, G. B., Jonsdottir, G. A., Doyle, O. M., et al. (2014) · Nature · doi:10.1038/nature12818 · Cited by 699
Mouse Genome Database (MGD) 2019
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Phenotypic Heterogeneity of Genomic Disorders and Rare Copy-Number Variants
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Education, Gender, and Cohort Fertility in the Nordic Countries
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Samocha, K. E., Kosmicki, J. A., Karczewski, K. J., O’Donnell-Luria, A. H., Pierce-Hoffman, E., MacArthur, D. G., Neale, B. M., & Daly, M. J. (2017) · doi:10.1101/148353 · Cited by 351
Self-citationKendall, K. M., Rees, E., Escott-Price, V., Einon, M., Thomas, R., Hewitt, J., O’Donovan, M. C., Owen, M. J., Walters, J. T. R., & Kirov, G. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.014 · Cited by 226
Self-citationGenetic predictors of participation in optional components of UK Biobank
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Brigos-Barril, E., Vasallo, C., Farré, X., Morcillo-Suárez, C., Polo-Alonso, S., Rodríguez-Fernández, B., Valenzuela, A., Sarabia, C., Bosch, E., Laayouni, H., et al. (2026) · Nature Ecology & Evolution · doi:10.1038/s41559-026-03140-z · Cited by 6
Metadata
- Authors
- Gardner, E. J., Neville, M. D. C., Samocha, K. E., Barclay, K., Kolk, M., Niemi, M. E. K., Kirov, G., Martin, H. C., & Hurles, M. E.
- ORCID
- Venue
- Nature
- Published
- 2022-03-23
- Volume
- 603
- Issue
- 7903
- Pages
- 858-863
- ISSN
- 0028-0836
- 1476-4687
- Cited by
- 72
- References
- 12
- Language
- en
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