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Versatility of gasdermin D beyond pyroptosis

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Gold nanoparticles modulate macrophage polarization to promote skeletal muscle regeneration

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Application of Fluorescence- and Bioluminescence-Based Biosensors in Cancer Drug Discovery

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Targeting NINJ1-mediated cell rupture to treat inflammatory diseases

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Hepatic ischemia–reperfusion injury: Underlying mechanisms and concepts in liver surgery and liver transplantation

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The roles of the nerve-immune axis in modulating bone regeneration

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Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation

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Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis

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Macrophages and Tissue Homeostasis: From Physiological Functions to Disease Onset

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Interplay between aging and metabolic diseases: from molecular mechanisms to therapeutic horizons

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Complosome as a new intracellular regulatory network in both normal and malignant hematopoiesis

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From mechanism to application: programmed cell death pathways in nanomedicine-driven cancer therapies

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DPSCs modulate synovial macrophage polarization and efferocytosis via PINK1/Parkin-dependent mitophagy

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Neutrophils and neutrophil extracellular traps: double-edged swords in cancer pathophysiology and therapy resistance

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Gasdermin D regulates the activation of EGFR in colorectal cancer

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BBB breakdown caused by plasma membrane pore formation

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Targeted soluble epoxide hydrolase inhibits M1 macrophage polarization to improve cartilage injury in temporomandibular joint osteoarthritis

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The NLRP3 Inflammasome Transmits Sterile Inflammation Signals to Sustain Proper Mitochondrial Electron Transport Chain Function and Influences Cellular Metabolism

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Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells

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Exploring mesenchymal stem cell niches for regeneration

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Metabolic symphony coordinates the muscle regeneration niche

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Janus Hydrogel Microparticles with Tea Polyphenol/Melanin Nanoparticles Integration from Microfluidics for Wound Healing

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Chiral gold nanoparticle synergizes immunometabolic crosstalk and metabolism remodeling for diabetic wound healing

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Dynamic Covalent Dual Prodrug Assemblies for Endometritis Therapy via Inflammation Alleviation, Tissue Repair, and Reproductive Function Restoration

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Mechanisms of action and clinical research progress of photobiomodulation

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Ferroptosis in adipose tissue: A promising pathway for treating obesity?

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GSDME–IL-18 pyroptotic axis prevents myosteatosis by expanding tissue-resident macrophages to promote muscle regeneration

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Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

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An updated overview of lipid-regulated immunobiology in macrophages

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Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

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A Novel Bioluminescent Biosensor Quantifying Intramolecular Interaction and Levels of Pyroptosis Effector GSDMD

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LC-MS/MS based metabolomics reveals the mechanism of skeletal muscle regeneration

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Hepatocyte‐Specific GSDMD Deficiency Aggravates Sepsis by Disrupting Non‐Canonical Secretion of Anti‐Inflammatory Factors

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Integrin-mediated SPP1 signaling from macrophages orchestrates extracellular matrix remodeling and chondrogenesis in heterotopic ossification

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Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation

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Advances in immune cell-based therapeutic agents for the treatment of inflammation-related diseases

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Cell Death in Skeletal Muscle Diseases: Diverse Roles and Pathological Processes

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Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis

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The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke

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The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after strokePreprint

Li, T., Yang, L., Tu, J., Hao, Y., Zhu, Z., Xiong, Y., Gao, Q., Zhou, L., Xie, G., Zhang, D., et al. (2025) · eLife · doi:10.7554/elife.105593 · Cited by 3

Unveiling the dynamic drivers: phase separation’s pivotal role in stem cell biology and therapeutic potential

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Exosomes derived from bone marrow-derived mesenchymal stem cells of exercise-trained mice improve wound healing by inhibiting macrophage M1 polarization

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Porcine decellularized splenic matrix hydrogel-based vesicle sustained-release System: A dual-regulatory biomaterial for accelerated wound healing via angiogenesis and immune remodeling

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TPPU alleviates hepatic ischemia–reperfusion injury by regulating macrophage polarization

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Oxidized Dextran/Carboxymethyl Chitosan Dynamic Schiff-Base Hydrogel for Sustained Hydrogen Sulfide Delivery and Burn Wound Microenvironment Remodeling

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Post-translational modifications of gasdermin D: implications for pyroptosis and autoimmune diseases

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Gasdermin D unlocks metabolic pathways to enhance tissue regeneration

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Pan-immune-inflammatory value and systemic immune-inflammatory index in relation to osteoradionecrosis of the jaws: a single institutional experience over 15 years

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Deciphering Periodontitis: Host Mechanisms, Predictive Biomarkers, and Systemic Drivers for Precision PreventionPreprint

Zong, C., Zong, C., Li, T., Nguyen, A., Ginsberg, S., Feng, M., Wang, M., & Lee, C. K. (2025) · Research Square · doi:10.21203/rs.3.rs-7715539/v1 · Cited by 2

Macrophage duality in liver diseases: heterogeneity, plasticity, and the quest for precision therapeutics

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Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulation

Ma, C., Jia, Z., Jiang, T., Cai, Q., Yang, J., Gan, L., Qian, K., Pan, Z., Ye, Q., Dai, M., et al. (2025) · eLife · doi:10.7554/elife.107938.3 · Cited by 1

Immune and metabolic mechanisms underlying fishmeal replacement with Tenebrio molitor in enhancing Pseudobagrus ussuriensis resistance to Aeromonas veronii

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Atomic‐Precision NiCo Dual‐Atom Nanozybiotic for Drug‐Resistant Infections and Tissue Repair

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Targeting methionine-induced pyroptosis enhances anti-tumor immunity

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The eicosanoid-cell death axis: A mechanistic review of crosstalk in health and disease

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Triggering Receptor Expressed on Myeloid Cells 2+ Macrophages Promote Pancreatic Regeneration Through Cholesterol–Metabolism Reprogramming and Hedgehog Signaling Activation Following Acute Pancreatitis

Song, P., Qi, P., Jin, X., Li, B., Wang, R., Jiang, J., Shen, J., Ni, J., Chen, C., Ge, X., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101819 · Cited by 1

Regulated cell death programs shaping cancer therapy

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Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling

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Zinc accumulation in macrophages exacerbates metabolic dysfunction-associated steatotic liver disease progression

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Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation

Jiang, K., He, Q., Wang, C., Yang, W., Zhou, C., Li, J., Li, J., Cui, Y., Shi, J., Wei, Z., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12112526 · Cited by 1

The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after strokePreprint

Li, T., Yang, L., Tu, J., Hao, Y., Zhu, Z., Xiong, Y., Gao, Q., Zhou, L., Xie, G., Zhang, D., et al. (2025) · eLife · doi:10.7554/elife.105593.1

The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after strokePreprint

Li, T., Yang, L., Tu, J., Hao, Y., Zhu, Z., Xiong, Y., Gao, Q., Zhou, L., Xie, G., Zhang, D., et al. (2025) · eLife · doi:10.7554/elife.105593.2

Advances in gasdermin activation, regulation, and targeted drug development

Luo, T., & Guo, Y. R. (2025) · Acta Materia Medica · doi:10.15212/amm-2025-0014

Toward Pan-Age Sepsis Detection: Leveraging Pediatric Transcriptome Data to Enhance Diagnostic Model Generalizability in Heterogeneous Populations

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Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulationPreprint

Ma, C., Jia, Z., Jiang, T., Cai, Q., Yang, J., Gan, L., Qian, K., Pan, Z., Ye, Q., Dai, M., et al. (2025) · eLife · doi:10.7554/elife.107938.1

Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulationPreprint

Ma, C., Jia, Z., Jiang, T., Cai, Q., Yang, J., Gan, L., Qian, K., Pan, Z., Ye, Q., Dai, M., et al. (2025) · eLife · doi:10.7554/elife.107938.2

Advancing tumor immunotherapy through rationally engineered inorganic nanomaterials

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O-GlcNAcylation-regulated classical programmed cell death in diseases: molecular crosstalk and therapeutic opportunities

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Liquid-liquid phase separation in physiological and pathophysiological bone turnover

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Wetting-mediated extracellular phase separation drives long-range cell adhesionPreprint

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Comprehensive Analysis of Immune-Related Mitochondrial Genes in Ischemic Stroke Through Integrated Bioinformatics and Validation

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