The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Adipose tissue retains an epigenetic memory of obesity after weight loss
Open accessAbstract
Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity 1,2. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes 3,4. Overcoming this barrier for long-term treatment success is difficult because the molecular mechanisms underpinning this phenomenon remain largely unknown. Here, by using single-nucleus RNA sequencing, we show that both human and mouse adipose tissues retain cellular transcriptional changes after appreciable weight loss. Furthermore, we find persistent obesity-induced alterations in the epigenome of mouse adipocytes that negatively affect their function and response to metabolic stimuli. Mice carrying this obesogenic memory show accelerated rebound weight gain, and the epigenetic memory can explain future transcriptional deregulation in adipocytes in response to further high-fat diet feeding. In summary, our findings indicate the existence of an obesogenic memory, largely on the basis of stable epigenetic changes, in mouse adipocytes and probably other cell types. These changes seem to prime cells for pathological responses in an obesogenic environment, contributing to the problematic ‘yo-yo’ effect often seen with dieting. Targeting these changes in the future could improve long-term weight management and health outcomes.
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Cited by
Weight cycling and its effects on muscle mass, sarcopenia and sarcopenic obesity
Zamboni, M., Giani, A., Fantin, F., Rossi, A. P., Mazzali, G., & Zoico, E. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09963-8 · Cited by 24
Pugliese, N. R., Paneni, F., Tricò, D., Bacca, A. V., De Biase, N., Dalpiaz, H., Mengozzi, A., Virdis, A., Ghiadoni, L., Taddei, S., et al. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02778-6 · Cited by 16
Metadata
- Authors
- Hinte, L. C., Castellano-Castillo, D., Ghosh, A., Melrose, K., Gasser, E., Noé, F., Massier, L., Dong, H., Sun, W., Hoffmann, A., Wolfrum, C., Rydén, M., Mejhert, N., Blüher, M., & von Meyenn, F.
- Venue
- Nature
- Published
- 2024-11-18
- Volume
- 636
- Issue
- 8042
- Pages
- 457-465
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W4404467861
- Cited by
- 269
- References
- 98
- FWCI
- 70.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hinte, L. C., Castellano-Castillo, D., Ghosh, A., Melrose, K., Gasser, E., Noé, F., Massier, L., Dong, H., Sun, W., Hoffmann, A., Wolfrum, C., Rydén, M., Mejhert, N., Blüher, M., & von Meyenn, F. (2024). Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature. https://doi.org/10.1038/s41586-024-08165-7
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