The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
An integrated perfusion machine preserves injured human livers for 1 week
Open accessAbstract
The ability to preserve metabolically active livers ex vivo for 1 week or more could allow repair of poor-quality livers that would otherwise be declined for transplantation. Current approaches for normothermic perfusion can preserve human livers for only 24 h. Here we report a liver perfusion machine that integrates multiple core physiological functions, including automated management of glucose levels and oxygenation, waste-product removal and hematocrit control. We developed the machine in a stepwise fashion using pig livers. Study of multiple ex vivo parameters and early phase reperfusion in vivo demonstrated the viability of pig livers perfused for 1 week without the need for additional blood products or perfusate exchange. We tested the approach on ten injured human livers that had been declined for transplantation by all European centers. After a 7-d perfusion, six of the human livers showed preserved function as indicated by bile production, synthesis of coagulation factors, maintained cellular energy (ATP) and intact liver structure. Livers are stored long term in a sophisticated perfusion system.
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Schnitzbauer, A. A., Lang, S. A., Goessmann, H., Nadalin, S., Baumgart, J., Farkas, S. A., Fichtner-Feigl, S., Lorf, T., Goralcyk, A., Hörbelt, R., et al. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31824856f5 · Cited by 1,332
A randomized trial of normothermic preservation in liver transplantation
for the Consortium for Organ Preservation in Europe, Nasralla, D., Coussios, C. C., Mergental, H., Akhtar, M. Z., Butler, A. J., Ceresa, C. D. L., Chiocchia, V., Dutton, S. J., García-Valdecasas, J. C., et al. (2018) · Nature · doi:10.1038/s41586-018-0047-9 · Cited by 1,199
EASL Clinical Practice Guidelines: Liver transplantation
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.10.006 · Cited by 1,082
PRESERVATION AND REPERFUSION INJURIES IN LIVER ALLOGRAFTS
Clavien, P.-A., Harvey, P. R., & Strasberg, S. M. (1992) · Transplantation · doi:10.1097/00007890-199205000-00001 · Cited by 829
Self-citationA Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., & Murphy, M. P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.009 · Cited by 752
The promise of organ and tissue preservation to transform medicine
Giwa, S., Lewis, J. K., Alvarez, L., Langer, R., Roth, A. E., Church, G. M., Markmann, J. F., Sachs, D. H., Chandraker, A., Wertheim, J. A., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3889 · Cited by 539
Apoptosis: a mechanism of acute and chronic liver injury
Guicciardi, M. E., & Gores, G. J. (2005) · Gut · doi:10.1136/gut.2004.053850 · Cited by 514
Playing Play-Doh to Prevent Postoperative Liver Failure: The “ALPPS” approach
de Santibañes, E., & Clavien, P.-A. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e318248577d · Cited by 381
Self-citationObservations on the ex situ perfusion of livers for transplantation
Watson, C. J. E., Kosmoliaptsis, V., Pley, C., Randle, L., Fear, C., Crick, K., Gimson, A. E., Allison, M., Upponi, S., Brais, R., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.14687 · Cited by 355
Mechanisms of Ischemic Injury Are Different in the Steatotic and Normal Rat Liver
Selzner, M., RüDiger, H. A., Sindram, D., Madden, J., & Clavien, P.-A. (2000) · Hepatology · doi:10.1053/jhep.2000.20528 · Cited by 288
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Liver regeneration and inflammation: from fundamental science to clinical applications
Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00373-7 · Cited by 307
Willemse, J., van Tienderen, G., van Hengel, E., Schurink, I., van der Ven, D., Kan, Y., de Ruiter, P., Rosmark, O., Westergren-Thorsson G, G., Schneeberger, K., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121473 · Cited by 106
Metadata
- Authors
- Eshmuminov, D., Becker, D., Bautista Borrego, L., Hefti, M., Schuler, M. J., Hagedorn, C., Muller, X., Mueller, M., Onder, C., Graf, R., Weber, A., Dutkowski, P., Rudolf von Rohr, P., & Clavien, P.-A.
- Venue
- Nature Biotechnology
- Published
- 2020-01-13
- Volume
- 38
- Issue
- 2
- Pages
- 189-198
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W3000332038
- Cited by
- 389
- References
- 28
- FWCI
- 46.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Eshmuminov, D., Becker, D., Bautista Borrego, L., Hefti, M., Schuler, M. J., Hagedorn, C., Muller, X., Mueller, M., Onder, C., Graf, R., Weber, A., Dutkowski, P., Rudolf von Rohr, P., & Clavien, P.-A. (2020). An integrated perfusion machine preserves injured human livers for 1 week. Nature Biotechnology. https://doi.org/10.1038/s41587-019-0374-x
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