The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Observations on the ex situ perfusion of livers for transplantation
Open accessAbstract
Normothermic ex situ liver perfusion might allow viability assessment of livers before transplantation. Perfusion characteristics were studied in 47 liver perfusions, of which 22 resulted in transplants. Hepatocellular damage was reflected in the perfusate transaminase concentrations, which correlated with posttransplant peak transaminase levels. Lactate clearance occurred within 3 hours in 46 of 47 perfusions, and glucose rose initially during perfusion in 44. Three livers required higher levels of bicarbonate support to maintain physiological pH, including one developing primary nonfunction. Bile production did not correlate with viability or cholangiopathy, but bile pH, measured in 16 of the 22 transplanted livers, identified three livers that developed cholangiopathy (peak pH < 7.4) from those that did not (pH > 7.5). In the 11 research livers where it could be studied, bile pH > 7.5 discriminated between the 6 livers exhibiting >50% circumferential stromal necrosis of septal bile ducts and 4 without necrosis; one liver with 25-50% necrosis had a maximum pH 7.46. Liver viability during normothermic perfusion can be assessed using a combination of transaminase release, glucose metabolism, lactate clearance, and maintenance of acid-base balance. Evaluation of bile pH may offer a valuable insight into bile duct integrity and risk of posttransplant ischemic cholangiopathy.
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A comparison of three methods of glycogen measurement in tissues
Passonneau, J. V., & Lauderdale, V. R. (1974) · Analytical Biochemistry · doi:10.1016/0003-2697(74)90248-6 · Cited by 739
Glycogen and its metabolism: some new developments and old themes
Roach, P. J., Depaoli-Roach, A. A., Hurley, T. D., & Tagliabracci, V. S. (2012) · Biochemical Journal · doi:10.1042/bj20111416 · Cited by 709
Ravikumar, R., Jassem, W., Mergental, H., Heaton, N., Mirza, D., Perera, M. T. P. R., Quaglia, A., Holroyd, D., Vogel, T., Coussios, C. C., et al. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13708 · Cited by 496
The protein family of glucose transport facilitators: It's not only about glucose after all
Augustin, R. (2010) · IUBMB Life · doi:10.1002/iub.315 · Cited by 398
Dutkowski, P., Polak, W. G., Muiesan, P., Schlegel, A., Verhoeven, C. J., Scalera, I., DeOliveira, M. L., Kron, P., & Clavien, P.-A. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001473 · Cited by 377
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Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation
Mergental, H., Perera, M. T. P. R., Laing, R. W., Muiesan, P., Isaac, J., Smith, A. J., Stephenson, B. T. F., Cilliers, H., Neil, D., Hübscher, S. G., et al. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13875 · Cited by 328
Protective mechanisms of end-ischemic cold machine perfusion in DCD liver grafts
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Watson, C. J. E., Kosmoliaptsis, V., Randle, L. V., Gimson, A. E., Brais, R., Klinck, J. R., Hamed, M., Tsyben, A., & Butler, A. J. (2017) · Transplantation · doi:10.1097/tp.0000000000001661 · Cited by 216
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Cited by
Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Sampaziotis, F., Muraro, D., Tysoe, O. C., Sawiak, S., Beach, T. E., Godfrey, E. M., Upponi, S. S., Brevini, T., Wesley, B. T., Garcia-Bernardo, J., et al. (2021) · Science · doi:10.1126/science.aaz6964 · Cited by 394
Self-citationAn integrated perfusion machine preserves injured human livers for 1 week
Eshmuminov, D., Becker, D., Bautista Borrego, L., Hefti, M., Schuler, M. J., Hagedorn, C., Muller, X., Mueller, M., Onder, C., Graf, R., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0374-x · Cited by 389
Messner, F., Guo, Y., Etra, J. W., & Brandacher, G. (2019) · Transplant International · doi:10.1111/tri.13432 · Cited by 29
Metadata
- Authors
- Watson, C. J. E., Kosmoliaptsis, V., Pley, C., Randle, L., Fear, C., Crick, K., Gimson, A. E., Allison, M., Upponi, S., Brais, R., Jochmans, I., & Butler, A. J.
- Venue
- American Journal of Transplantation
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 18
- Issue
- 8
- Pages
- 2005-2020
- ISSN
- 1600-6135 (ISSN-L)
- OpenAlex
- W2794134218
- Cited by
- 355
- References
- 22
- FWCI
- 40.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Watson, C. J. E., Kosmoliaptsis, V., Pley, C., Randle, L., Fear, C., Crick, K., Gimson, A. E., Allison, M., Upponi, S., Brais, R., Jochmans, I., & Butler, A. J. (2018). Observations on the ex situ perfusion of livers for transplantation. American Journal of Transplantation. https://doi.org/10.1111/ajt.14687
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