The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Wearable materials with embedded synthetic biology sensors for biomolecule detection
Open accessAbstract
Integrating synthetic biology into wearables could expand opportunities for noninvasive monitoring of physiological status, disease states and exposure to pathogens or toxins. However, the operation of synthetic circuits generally requires the presence of living, engineered bacteria, which has limited their application in wearables. Here we report lightweight, flexible substrates and textiles functionalized with freeze-dried, cell-free synthetic circuits, including CRISPR-based tools, that detect metabolites, chemicals and pathogen nucleic acid signatures. The wearable devices are activated upon rehydration from aqueous exposure events and report the presence of specific molecular targets by colorimetric changes or via an optical fiber network that detects fluorescent and luminescent outputs. The detection limits for nucleic acids rival current laboratory methods such as quantitative PCR. We demonstrate the development of a face mask with a lyophilized CRISPR sensor for wearable, noninvasive detection of SARS-CoV-2 at room temperature within 90 min, requiring no user intervention other than the press of a button.
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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
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Nucleic acid detection with CRISPR-Cas13a/C2c2
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Self-citationCRISPR–Cas12-based detection of SARS-CoV-2
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Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
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Self-citationDNA Detection Using Recombination Proteins
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Aerodynamic Analysis of SARS-CoV-2 in Two Wuhan Hospitals
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Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate
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Cited by
End-to-end design of wearable sensors
Ates, H. C., Nguyen, P. Q., Gonzalez-Macia, L., Morales-Narváez, E., Güder, F., Collins, J. J., & Dincer, C. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00460-x · Cited by 1,306
Self-citationWearable chemical sensors for biomarker discovery in the omics era
Sempionatto, J. R., Lasalde-Ramírez, J. A., Mahato, K., Wang, J., & Gao, W. (2022) · Nature Reviews Chemistry · doi:10.1038/s41570-022-00439-w · Cited by 613
Applied body-fluid analysis by wearable devices
Brasier, N., Wang, J., Gao, W., Sempionatto, J. R., Dincer, C., Ates, H. C., Güder, F., Olenik, S., Schauwecker, I., Schaffarczyk, D., et al. (2024) · Nature · doi:10.1038/s41586-024-08249-4 · Cited by 298
Porous Conductive Textiles for Wearable Electronics
Ding, Y., Jiang, J., Wu, Y., Zhang, Y., Zhou, J., Zhang, Y., Huang, Q., & Zheng, Z. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00507 · Cited by 269
Artificial intelligence-powered electronic skin
Xu, C., Solomon, S. A., & Gao, W. (2023) · Nature Machine Intelligence · doi:10.1038/s42256-023-00760-z · Cited by 259
Metadata
- Authors
- Nguyen, P. Q., Soenksen, L. R., Donghia, N. M., Angenent-Mari, N. M., de Puig, H., Huang, A., Lee, R., Slomovic, S., Galbersanini, T., Lansberry, G., Sallum, H. M., Zhao, E. M., Niemi, J. B., & Collins, J. J.
- Venue
- Nature Biotechnology
- Published
- 2021-06-28
- Volume
- 39
- Issue
- 11
- Pages
- 1366-1374
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W3175119564
- Cited by
- 560
- References
- 48
- FWCI
- 26.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nguyen, P. Q., Soenksen, L. R., Donghia, N. M., Angenent-Mari, N. M., de Puig, H., Huang, A., Lee, R., Slomovic, S., Galbersanini, T., Lansberry, G., Sallum, H. M., Zhao, E. M., Niemi, J. B., & Collins, J. J. (2021). Wearable materials with embedded synthetic biology sensors for biomolecule detection. Nature Biotechnology. https://doi.org/10.1038/s41587-021-00950-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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