Cited by 386RNA modifications and cancerRNA regulation and diseaseEpigenetics and DNA Methylation

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Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI

Liu, Cong, Sun, Hanxiao, Yi, Yunpeng, Shen, Weiguo, Li, Kai, Xiao, Ye, Li, Fei, Li, Yuchen, Hou, Yongkang, Lu, Bo, Liu, Wenqing, Meng, Haowei, Peng, Jinying, Yi, Chengqi, Wang, Jing·2023·Nature Biotechnology

DOI 10.1038/s41587-022-01487-9

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Abstract

N 6 -methyladenosine (m 6 A) is the most abundant RNA modification in mammalian cells and the best-studied epitranscriptomic mark. Despite the development of various tools to map m 6 A, a transcriptome-wide method that enables absolute quantification of m 6 A at single-base resolution is lacking. Here we use glyoxal and nitrite-mediated deamination of unmethylated adenosines (GLORI) to develop an absolute m 6 A quantification method that is conceptually similar to bisulfite-sequencing-based quantification of DNA 5-methylcytosine. We apply GLORI to quantify the m 6 A methylomes of mouse and human cells and reveal clustered m 6 A modifications with differential distribution and stoichiometry. In addition, we characterize m 6 A dynamics under stress and examine the quantitative landscape of m 6 A modification in gene expression regulation. GLORI is an unbiased, convenient method for the absolute quantification of the m 6 A methylome.

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Authors: Liu, C., Sun, H., Yi, Y., Shen, W., Li, K., Xiao, Y., Li, F., Li, Y., Hou, Y., Lu, B., Liu, W., Meng, H., Peng, J., Yi, C., & Wang, J.
Affiliations: Peking University (CN)
Center for Life Sciences (CN)
Corresponding author: Yi, Chengqi
Wang, Jing
ORCID: Liu, Cong
Sun, Hanxiao
Yi, Yunpeng
Li, Kai
Xiao, Ye
Li, Fei
Li, Yuchen
Hou, Yongkang
Lu, Bo
Meng, Haowei
Peng, Jinying
Yi, Chengqi
Wang, Jing
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2022-10-27
Volume: 41
Issue: 3
Pages: 355-366
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/s41587-022-01487-9
OpenAlex: W4307500724
Cited by: 386
References: 67
Citations by year: 2026: 100 · 2025: 125 · 2024: 103 · 2023: 53 · 2022: 4
FWCI: 23.26
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (22077006, 91940304)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: N6-methyladenosine, m6A RNA methylation, epitranscriptomics, absolute quantification, single-base resolution, m6A methylome, stress response, gene expression regulation, mouse cells, human cells
MeSH terms: Animals, DNA, Gene Expression Regulation, Humans, Mammals, Methylation, DNA Methylation, Transcriptome

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Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI

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