The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity
Open accessAbstract
Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in humans 1-3. Recently, ADCY3 (adenylyl cyclase 3) gene mutations have been implicated in obesity 4,5. ADCY3 localizes to the primary cilia of neurons 6 , organelles that function as hubs for select signaling pathways. Mutations that disrupt the functions of primary cilia cause ciliopathies, rare recessive pleiotropic diseases in which obesity is a cardinal manifestation 7 . We demonstrate that MC4R colocalizes with ADCY3 at the primary cilia of a subset of hypothalamic neurons, that obesity-associated MC4R mutations impair ciliary localization and that inhibition of adenylyl cyclase signaling at the primary cilia of these neurons increases body weight. These data suggest that impaired signaling from the primary cilia of MC4R neurons is a common pathway underlying genetic causes of obesity in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“NPY also has an important role in the central regulation of food intake and energy expenditure 181.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [181]
Experimental — accuracy not yet measuredIn the citing paper
“A specific ventromedial hypothalamus deletion resulted in the same effect (301), although a different subregion of the hypothalamus, the paraventricular nucleus, has also been implicated in the body weight regulation of AC3 (302).”
From Physiological roles of mammalian transmembrane adenylyl cyclase isoforms (2022) · cites this paper as [302]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824
Genes and molecular pathways underpinning ciliopathies
Reiter, J. F., & Leroux, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.60 · Cited by 1,588
Self-citationVertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
Self-citationHildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107
A frameshift mutation in human MC4R is associated with a dominant form of obesity
Vaisse, C., Clément, K., Guy-grand, B., & Froguel, P. (1998) · Nature Genetics · doi:10.1038/2407 · Cited by 1,091
Self-citationMelanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., & Froguel, P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9238 · Cited by 897
Self-citationNeurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
Davenport, J. R., Watts, A. J., Roper, V. C., Croyle, M. J., van Groen, T., Wyss, J. M., Nagy, T. R., Kesterson, R. A., & Yoder, B. K. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.034 · Cited by 482
Cited by
Sorted by citations
Items 101–200 of 250
MC4R in Central and Peripheral Systems
Wei, R., Li, D., Jia, S., Chen, Y., & Wang, J. (2023) · Advanced Biology · doi:10.1002/adbi.202300035 · Cited by 19
Medical semiology of patients with monogenic obesity: A systematic review
Renard, É., Thevenard-Berger, A., & Meyre, D. (2024) · Obesity Reviews · doi:10.1111/obr.13797 · Cited by 18
Salles, J., Eddiry, S., Lacassagne, E., Laurier, V., Molinas, C., Bieth, É., Franchitto, N., Salles, J.-P., & Tauber, M. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01143-0 · Cited by 17
Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity
Toumba, M., Fanis, P., Vlachakis, D., Neocleous, V., Phylactou, L. A., Skordis, N., Mantzoros, C. S., & Pantelidou, M. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5065 · Cited by 17
Primary cilia function as hubs for signal transduction
Li, B., He, Y., & Yang, Z. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01471-1 · Cited by 17
Szalanczy, A., Chuang, C., & Woods, L. C. S. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108928 · Cited by 19
Ciliary signaling proteins are mislocalized in the brains of Bardet-Biedl syndrome 1-null mice
Stubbs, T., Bingman, J. I., Besse, J., & Mykytyn, K. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1092161 · Cited by 17
Role of lipids in the control of autophagy and primary cilium signaling in neurons
Hernández‐Cáceres, M. P., Pinto-Núñez, D., Rivera, P., Burgos, P., Díaz‐Castro, F., Criollo, A., Yañez, M. J., & Morselli, E. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.377414 · Cited by 16
Exploring Coronary Artery Disease GWAs Targets With Functional Links to Immunometabolism
Hughes, M., Lenighan, Y. M., Godson, C., & Roche, H. M. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00148 · Cited by 16
PAM: diverse roles in neuroendocrine cells, cardiomyocytes, and green algae
Bäck, N., Mains, R. E., & Eipper, B. A. (2021) · FEBS Journal · doi:10.1111/febs.16049 · Cited by 15
The Multifaceted Melanocortin Receptors
Laiho, L., & Murray, J. F. (2022) · Endocrinology · doi:10.1210/endocr/bqac083 · Cited by 20
Ali, S., Baig, S., Wanninayake, S., Xavier, G. D. S., Dawson, C., Paisey, R., & Geberhiwot, T. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15398 · Cited by 16
Neuron‐specific cilia loss differentially alters locomotor responses to amphetamine in mice
Ramos-Galarza, C., Roberts, J. B., Jasso, K. R., Eyck, T. W. T., Everett, T. J., Pozo, P., Setlow, B., & McIntyre, J. C. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24755 · Cited by 14
Hoi, K. K., Xia, W., Wei, M. M., Ulloa-Navas, M. J., García‐Verdugo, J. M., Nachury, M. V., Reiter, J. F., & Fancy, S. P. J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113272 · Cited by 17
Self-citationBaldi, P., Alhassen, W., Chen, S., Nguyen, H. N., Khoudari, M., & Alachkar, A. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24919 · Cited by 12
Powell, D. R., Revelli, J., Doree, D. D., DaCosta, C. M., Desai, U., Shadoan, M. K., Rodriguez, L., Mullens, M., Yang, Q. M., Ding, Z., et al. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s322083 · Cited by 14
Iqbal, J., Jiang, H., Wu, H., Li, L., Zhou, Y., Hu, N., Xiao, F., Wang, T., Xu, S., & Zhou, H. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.03.016 · Cited by 15
Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
Nyamugenda, E., Griffin, H., Russell, S., Cooney, K. A., Kowalczyk, N. S., Islam, I., Phelan, K. D., & Baldini, G. (2020) · iScience · doi:10.1016/j.isci.2020.101114 · Cited by 14
Yang, D. J., Wu, X., Wang, W., Zhou, Y., & Wang, Z. (2021) · Advanced Science · doi:10.1002/advs.202102568 · Cited by 14
Adenylate cyclase 3: a potential genetic link between obesity and major depressive disorder
Fitzpatrick, M., & Woods, L. C. S. (2023) · Physiological Genomics · doi:10.1152/physiolgenomics.00056.2023 · Cited by 13
Bhushan, V., & Nita‐Lazar, A. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00839 · Cited by 15
Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia
Tian, X., Wang, H., Liu, S., Liu, W., Zhang, K., Gao, X., Li, Q., Zhao, H., Zhang, L., Liu, P., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002940 · Cited by 12
Self-citationSemi-supervised nonparametric Bayesian modelling of spatial proteomics
Crook, O. M., Lilley, K. S., Gatto, L., & Kirk, P. (2022) · The Annals of Applied Statistics · doi:10.1214/22-aoas1603 · Cited by 12
Primary cilia signalling at a glance
Wachten, D., & Christensen, S. T. (2025) · Journal of Cell Science · doi:10.1242/jcs.264187 · Cited by 12
The Hedgehog Signaling Pathway is Expressed in the Adult Mouse Hypothalamus and Modulated by Fasting
Antonellis, P. J., Engle, S. E., Brewer, K. M., & Berbari, N. F. (2021) · eNeuro · doi:10.1523/eneuro.0276-21.2021 · Cited by 13
Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors
Piper, N. B. C., Whitfield, E. A., Stewart, G. D., Xu, X., & Furness, S. G. B. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115115 · Cited by 11
The conserved ancestral signaling pathway from cilium to nucleus
Satir, P., & Satir, B. H. (2019) · Journal of Cell Science · doi:10.1242/jcs.230441 · Cited by 11
Analysis of ciliary status via G-protein-coupled receptors localized on primary cilia
Kobayashi, Y., Hamamoto, A., & Saito, Y. (2020) · Microscopy · doi:10.1093/jmicro/dfaa035 · Cited by 9
Primary ciliary protein kinase A activity in the prefrontal cortex modulates stress in mice
Yang, J., Dong, Y., Liu, J., Peng, Y., Wang, D., Li, L., Hu, X., Li, J., Wang, L., Chu, J., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.02.002 · Cited by 10
Zhang, Z., Li, W., Zhan, Q., Aillaud, M., Botey-Bataller, J., Zoodsma, M., ter Horst, R., Joosten, L. A. B., Bock, C., Schulte, L. N., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61192-4 · Cited by 11
Mulvey, B., Wang, Y., Divecha, H. R., Bach, S. V., Montgomery, K. D., Cinquemani, S., Chandra, A., Du, Y., Miller, R. A., Kleinman, J. E., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116877 · Cited by 10
Self-citationThe BBSome: a nexus controlling energy metabolism in the brain
Blaess, S., & Wachten, D. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148903 · Cited by 10
Meta-analysis of gene expression data in adipose tissue reveals new obesity associated genes
Goutzelas, Y., Kontou, P. I., Mamuris, Z., Bagos, P. G., & Sarafidou, T. (2022) · Gene · doi:10.1016/j.gene.2022.146223 · Cited by 11
Neuronal Cilia: Another Player in the Melanocortin System
Varela, L., & Horváth, T. L. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.02.004 · Cited by 10
Lunsky, I. O., & Meyre, D. (2018) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2018.10.002 · Cited by 11
NRF2 and Primary Cilia: An Emerging Partnership
Martín-Hurtado, A., Lastres‐Becker, I., Cuadrado, A., & García-Gonzalo, F. R. (2020) · Antioxidants · doi:10.3390/antiox9060475 · Cited by 11
Artificial Intelligence Approaches to Assessing Primary Cilia
Bansal, R., Engle, S. E., Kamba, T. K., Brewer, K. M., Lewis, W., & Berbari, N. F. (2021) · Journal of Visualized Experiments · doi:10.3791/62521 · Cited by 12
Trang, B. K., Pahl, M. C., Pippin, J. A., Su, C., Littleton, S. H., Sharma, P. K., Kulkarni, N. N., Ghanem, L. R., Terry, N. A., O’Brien, J. M., et al. (2024) · eLife · doi:10.7554/elife.95411.3 · Cited by 13
Obesity and Cardiometabolic Disease: Insights From Genetic Studies
Dash, S. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.01.034 · Cited by 10
Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption
Haddad, H. K., Mercado-Reyes, J. I., Mustafá, E. R., D’Souza, S. P., Chung, C., Nestor, R. R. M., Olinski, L. E., Damonte, V. M., Saskin, J., Vemaraju, S., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2403891122 · Cited by 9
Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice
Ding, W., Zhang, C., Wang, B., Zhou, X., Sun, L., Zhong, S., Liu, J., Zhang, J., Wang, X., & Wu, Q. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1767-5 · Cited by 12
Ni, Z., Wang, Y., Shi, C., Zhang, X., Gong, H., & Dong, Y. (2022) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-022-04089-y · Cited by 9
Self-citationCalta, J., Zadinová, K., Čítek, J., Kluzáková, E., Okrouhlá, M., Stupka, R., Tichý, L., Machová, K., Stratil, A., & VOSTRÝ, L. (2022) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12751 · Cited by 9
Mutation of FOP/FGFR1OP in mice recapitulates human short rib-polydactyly ciliopathy
Cabaud, O., Roubin, R., Comte, A., Bascunana, V., Sergé, A., Sedjaï, F., Birnbaum, D., Rosnet, O., & Acquaviva, C. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy246 · Cited by 8
Kinase-anchoring proteins in ciliary signal transduction
Gopalan, J., Wordeman, L. G., & Scott, J. D. (2021) · Biochemical Journal · doi:10.1042/bcj20200869 · Cited by 8
An N‐terminal fusion allele to study melanin concentrating hormone receptor 1
Jasso, K. R., Kamba, T. K., Zimmerman, A. D., Bansal, R., Engle, S. E., Everett, T. J., Wu, C., Kulaga, H. M., Reed, R. R., Berbari, N. F., et al. (2021) · genesis · doi:10.1002/dvg.23438 · Cited by 8
Competition between stochastic neuropeptide signals calibrates the rate of satiation
Zhang, S. X., Kim, A., Madara, J. C., Zhu, P. K., Christenson, L. F., Lutas, A., Kalugin, P. N., Jin, Y., Pal, A., Tian, L., et al. (2023) · doi:10.1101/2023.07.11.548551 · Cited by 56
Self-citationAdopting GPR75 in treating obesity: unraveling the knowns and unknowns of this orphan GPCR
Jiang, Y., & Zhang, Z. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.12.006 · Cited by 8
Mifsud, F., Chalopin, S., Guillon, E., Faucher, P., Muller, J., Beyec, J. L., Clément, K., & Poitou, C. (2025) · Obesity · doi:10.1002/oby.70002 · Cited by 8
The prevalence of obesity and metabolic abnormalities in eastern China: a cross-sectional study
Fan, J., Li, H. H., Liu, X., & Huang, S. (2019) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-019-00725-2 · Cited by 7
RABL2 promotes the outward transition zone passage of signaling proteins in cilia via ARL3
Zhang, R., Sun, W.-Y., Liu, Y., Zhang, E. Y., & Fan, Z. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302603120 · Cited by 7
Li, Z., Ye, C.-Y., Wang, L., Li, J., & Yang, L. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17145217 · Cited by 7
Bi, W., Zhou, W., Zhang, P., Sun, Y., Yue, W., & Lee, S. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.03.010 · Cited by 8
Jeziorny, K., Pietrowska, K., Siemińska, J., Zmysłowska-Polakowska, E., Kretowski, A. J., Ciborowski, M., & Zmysłowska, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1251905 · Cited by 7
Ciliary localization of GPR75 promotes fat accumulation in mice
Chávez, M., Asthana, A., & Jackson, P. K. (2024) · Journal of Clinical Investigation · doi:10.1172/jci185059 · Cited by 6
Unraveling the Genetic Architecture of Obesity: A Path to Personalized Medicine
Kunnathodi, F., Arafat, A. A., Alhazzani, W. A., Mustafa, M., Azmi, S., Ahmad, I., Selan, J. S., Riyasdeen, A., & Alotaibi, H. F. (2025) · Diagnostics · doi:10.3390/diagnostics15121482 · Cited by 7
Genetic Control of Body Weight by the Human Brain Proteome
Gagnon, É., Girard, A., Gobeil, J. B. É., Bourgault, J., Couture, C., Mitchell, P. L., Bouchard, C., Tremblay, A., Mathieu, P., Michaud, A., et al. (2022) · iScience · doi:10.1016/j.atherosclerosis.2022.06.163 · Cited by 4
Everett, T. J., Eyck, T. W. T., Wu, C., Shelowitz, A. L., Stansbury, S. M., Firek, A., Setlow, B., & McIntyre, J. C. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231219058 · Cited by 6
Ciliary localization of a light-activated neuronal GPCR shapes behavior
Winans, A., Friedmann, D., Stanley, C., Xiao, T., Liu, T., Chang, C. J., & Isacoff, E. Y. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311131120 · Cited by 6
Fitzpatrick, M. K., Szalanczy, A., Beeson, A., Vora, A., Scott, C., Grzybowski, M. N., Klotz, J., Der, N., Chen, R., Geurts, A. M., et al. (2024) · Obesity · doi:10.1002/oby.24178 · Cited by 5
Primary cilia regulate GLP-1 signaling in pancreatic β cells
Melena, I., Jo, J. H., Townsend, S. E., DiGruccio, S. A., Dong, X., Zhu, L., Campbell, J., & Hughes, J. W. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102357 · Cited by 4
BBSome: An essential component of hypothalamic regulation of energy homeostasis
Guo, D., Zhao, Y., Laule, C. F., & Rahmouni, K. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09979-0 · Cited by 5
Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins
Lan, Q., Li, J., Zhang, H., Zhou, Z., Fang, Y., & Yang, B. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02446-4 · Cited by 4
Siddiqui, J., Kinney, C. E., & Han, J. C. (2024) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2024.06.001 · Cited by 6
Functional Evaluation of a Novel Homozygous ADCY3 Variant Causing Childhood Obesity
Mohammed, I., Selvaraj, S., Ahmed, W. S., Al-Barazenji, T., Dauleh, H., Love, D. R., Saraiva, L. R., & Hussain, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111815 · Cited by 4
Electroacupuncture altered expression of microRNAs in Stat 5 knockout obese mice
Hong, H., Xu, H., Meng, J.-Z., & Zhu, B. (2021) · Acupuncture in Medicine · doi:10.1177/09645284211056345 · Cited by 4
Nanobody-directed targeting of optogenetic tools to study signaling in the primary ciliumPreprint
Hansen, J. N., Kaiser, F., Klausen, C., Stüven, B., Chong, R., Bönigk, W., Mick, D. U., Möglich, A., Jurisch‐Yaksi, N., Schmidt, F. I., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.04.933440 · Cited by 4
Inferring differential subcellular localisation in comparative spatial proteomics using BANDLEPreprint
Crook, O. M., Davies, C. T. R., Breckels, L. M., Christopher, J. A., Gatto, L., Kirk, P., & Lilley, K. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.04.425239 · Cited by 4
Ciliary ARL13B is essential for body weight regulation in micePreprint
Terry, T. T., Gigante, E. D., Alexandre, C. M., Brewer, K. M., Yue, X., Berbari, N. F., Vaisse, C., & Caspary, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.02.551695 · Cited by 4
Self-citationKreis, N., Friemel, A., Ritter, A., Hentrich, A. E., Siebelitz, E., Louwen, F., & Yuan, J. (2025) · Communications Biology · doi:10.1038/s42003-025-08986-w · Cited by 5
A new era in childhood obesity
Martos‐Moreno, G. Á., Guijo, B., Tena‐Sempere, M., Chowen, J. A., & Argente, J. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.03.006 · Cited by 5
Methods to Assess Neuronal Primary Cilia Electrochemical Signaling
DeCaen, P. G., & Kimura, L. F. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.70034 · Cited by 3
Wu, X., Yang, D. J., Zhou, Y., Li, S., & Wang, Z. (2022) · iScience · doi:10.1016/j.isci.2022.104534 · Cited by 3
Griffin, H., Hanson, J., Phelan, K. D., & Baldini, G. (2024) · Cells · doi:10.3390/cells13151235 · Cited by 4
Kobayashi, Y. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113474 · Cited by 3
Bernard, A., Naharros, I. O., Bourgain‐Guglielmetti, F., Ciprin, J., Yue, X., Zhang, S., McDaid, E., Nachury, M. V., Reiter, J. F., & Vaisse, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.13.382325 · Cited by 3
Self-citationThe primary cilium is required for MC4R control of food intake and body weightPreprint
Wang, Y., Bernard, A., Comblain, F., Yue, X., Paillart, C., Zhang, S., Reiter, J. F., & Vaisse, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.13.382234 · Cited by 3
Self-citationInferring differential subcellular localisation in comparative spatial proteomics using BANDLEPreprint
Crook, O. M., Davies, C. T. R., Gatto, L., Kirk, P., & Lilley, K. S. (2021) · Research Square · doi:10.21203/rs.3.rs-145772/v1 · Cited by 3
Zhang, R., Liu, Y., Sun, W.-Y., Bao, D.-X., Jia, R.-Q., Zhang, C., & Fan, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.13.480273 · Cited by 3
Artificial Intelligence Approaches to Assessing Primary Cilia
Bansal, R., Engle, S. E., Kamba, T. K., Brewer, K. M., Lewis, W., & Berbari, N. F. (2021) · Journal of Visualized Experiments · doi:10.3791/62521-v · Cited by 2
Fitzpatrick, M. K., Dyson, C., Beeson, A., Adrian, L., Marrs, G. S., Grzybowski, M. N., Klotz, J., Geurts, A. M., Chen, R., Weiner, J. L., et al. (2025) · Genes Brain & Behavior · doi:10.1111/gbb.70028 · Cited by 2
IMPROVE 2023: The 2nd International Meeting on Pathway‐Related Obesity: Vision & Evidence
Clément, K., van den Akker, E. V. D., Argente, J., Beales, P., Cetiner, M., Dubern, B., Farooqi, S., Gouronc, A., Kühnen, P., Beyec, J. L., et al. (2025) · Clinical Obesity · doi:10.1111/cob.70029 · Cited by 2
Self-citationCharacterization of astrocytic primary cilia in the adult mouse cortex and hippocampus
Lahaie, S. C., Fok, A. H. K., Nicholls, J. M., Lee, H., Syed, T. A., Chierzi, S., Hatada, S., Egawa, N., Schober, A. L., Wong, T. L. H., et al. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e44010 · Cited by 2
Primary cilia in the hypothalamic AgRP neurons mediate metabolic effects of butyrate
Rijal, S., Yang, D. J., Doan, K. V., Lyoo, S. H., Lee, A., Choi, Y.-H., Shin, D. M., & Kim, K. W. (2026) · Nature Communications · doi:10.1038/s41467-026-71745-w · Cited by 2
Evaluation of ciliary-GPCR dynamics using a validated organotypic brain slice culture method
Kobayashi, Y., & Saito, Y. (2023) · Methods in cell biology · doi:10.1016/bs.mcb.2022.09.007 · Cited by 3
Obesity-Related Ciliopathies: Focus on Advances of Biomarkers
Zhang, Q., Huang, Y., Gao, S., Ding, Y., Zhang, H., Chang, G., & Wang, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158484 · Cited by 2
Circadian cilia transcriptome in mouse brain across physiological and pathological states
Chen, K., Ashtiani, K. C., Monfared, R. V., Baldi, P., & Alachkar, A. (2024) · Molecular Brain · doi:10.1186/s13041-024-01143-0 · Cited by 2
Baron, M., Froguel, P., & Bonnefond, A. (2020) · médecine/sciences · doi:10.1051/medsci/2020156 · Cited by 7
An Update on Mendelian Forms of Obesity and their Personalized Treatments
Chen, S., & Meyre, D. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_16 · Cited by 2
Knoll, J., Altintas, B., Gahl, W. A., Parisi, M. A., & Gunay‐Aygun, M. (2021) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62593 · Cited by 2
Smoothened inhibition of PKA at cilia transduces Hedgehog signalsPreprint
Nguyen, T. D., Konjikusic, M. J., Castillo, L. M. D., & Reiter, J. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.01.646243 · Cited by 2
Self-citationPrimary cilium disappearance in podocytes during vertebrate phylogeny revealed by array tomography
Miyaki, T., Xu, J., Sugiura, M., Kaneda, H., Trejo, J. A. O., Kawasaki, Y., Omotehara, T., Negishi‐Koga, T., Ishijima, M., Yamaguchi, J., et al. (2025) · Cell and Tissue Research · doi:10.1007/s00441-025-04002-z · Cited by 1
The NME7 Gene Is Involved in the Kinetics of Glucose Processing
Vejražková, D., Včelák, J., Vaňková, M., Lukášová, P., Dušková, M., Grimmichová, T., Kvasničková, H., Tura, A., Šedová, L., Šeda, O., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199821 · Cited by 1
Semi-supervised Bayesian integration of multiple spatial proteomics datasets
Coleman, S. D., Breckels, L. M., Waller, R. F., Lilley, K. S., Wallace, C., Crook, O. M., & Kirk, P. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013799 · Cited by 1
Farooqi, I. S., & O’Rahilly, S. (2026) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-026-10050-9 · Cited by 2
Nguyen, T. D., Konjikusic, M. J., Castillo, L. M. D., Irannejad, R., & Reiter, J. F. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003841 · Cited by 4
Self-citationKondou, A., Siolos, P., Sotiriou, G., Agakidis, C., Dotis, J., Christoforidis, A., & Printza, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177740 · Cited by 1
Central Channelopathies in Obesity
Li, A. H., Kuo, Y., Yang, S., & Chen, P. (2024) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-23-00029 · Cited by 1
Awasthi, M., Ranjan, P., Kelterborn, S., Hegemann, P., & Snell, W. J. (2022) · Journal of Cell Science · doi:10.1242/jcs.259814 · Cited by 1
Reviewed and updated Algorithm for Genetic Characterization of Syndromic Obesity Phenotypes
Rodríguez‐López, R., Gimeno-Ferrer, F., do Santos, D. A., Ferrer‐Bolufer, I., Luján, C. G., Alcalá, O. Z., Banacloy, A. G., Cogollos, V. B., & Juan, C. S. (2022) · Current Genomics · doi:10.2174/1389202923666220426093436 · Cited by 1
Metadata
- Authors
- Siljee, J. E., Wang, Y., Bernard, A. A., Ersoy, B. A., Zhang, S., Marley, A., Von Zastrow, M., Reiter, J. F., & Vaisse, C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Vaisse, Christian
- Venue
- Nature Genetics
- Published
- 2018-01-08
- Volume
- 50
- Issue
- 2
- Pages
- 180-185
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC5805646
- OpenAlex
- W2781875842
- Cited by
- 247
- References
- 30
- Citations by year
- 2026: 24 · 2025: 30 · 2024: 27 · 2023: 22 · 2022: 25 · 2021: 40 · 2020: 33 · 2019: 22 · 2018: 24
- FWCI
- 18.21
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Drug Abuse (P01DA010154, R01DA010711, R01DA012864)
- National Institute of General Medical Sciences (R01GM095941)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK098722, R01DK060540, P30DK063720, R01DK106404)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR054396)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- melanocortin-4 receptor, ADCY3, primary cilia, obesity, leptin-melanocortin pathway, hypothalamic neurons, ciliopathies, adenylyl cyclase signaling, genetic predisposition to obesity, body weight, receptor subcellular localization
- MeSH terms
- Adenylyl Cyclases, Animals, Cells, Cultured, Cilia, Female, Humans, Male, Mice, Transgenic, Mutation, Neurons, Obesity, Signal Transduction, Genetic Predisposition to Disease, NIH 3T3 Cells, Intracellular Space, Receptor, Melanocortin, Type 4, Mice, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
