Cited by 918Genetic Associations and EpidemiologyProstate Cancer Treatment and ResearchProstate Cancer Diagnosis and Treatment

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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

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The Profile Study, Schumacher, Fredrick R., Australian Prostate Cancer BioResource (APCB), The IMPACT Study, Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium (BPC3), The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Cancer of the Prostate in Sweden (CAPS), Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, Al Olama, Ali Amin, Berndt, Sonja I., Benlloch, Sara, Ahmed, Mahbubl, Saunders, Edward J., Dadaev, Tokhir, Leongamornlert, Daniel, Anokian, Ezequiel, Cieza-Borrella, Clara, Goh, Chee, Brook, Mark N., Sheng, Xin, Fachal, Laura, Dennis, Joe, Tyrer, Jonathan, Muir, Kenneth, Lophatananon, Artitaya, Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Tangen, Catherine M., Goodman, Phyllis J., Thompson, Ian M., Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Håkansson, Niclas, West, Catharine M. L., Dunning, Alison M., Burnet, Neil, Mucci, Lorelei A., Giovannucci, Edward, Andriole, Gerald L., Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Beane Freeman, Laura E., Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Travis, Ruth C., Key, Tim J., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C., Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., FitzGerald, Liesel M., Kibel, Adam S., Drake, Bettina F., Vega, Ana, Gómez-Caamaño, Antonio, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L., Stampfer, Meir, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Stanford, Janet L., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Ostrander, Elaine A., Geybels, Milan S., Nordestgaard, Børge G., Nielsen, Sune F., Weischer, Maren, Bisbjerg, Rasmus, Røder, Martin Andreas, Iversen, Peter, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Maier, Christiane, Luedeke, Manuel, Schnoeller, Thomas, Kim, Jeri, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Paulo, Paula, Cardoso, Marta, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Lin, Daniel W., Newcomb, Lisa F., Lessel, Davor, Gamulin, Marija, Kulis, Tomislav, Kaneva, Radka, Usmani, Nawaid, Singhal, Sandeep, Slavov, Chavdar, Mitev, Vanio, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, Xu, Jianfeng, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Michael, Agnieszka, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Lindstrom, Sara, Turman, Constance, Ma, Jing, Hunter, David J., Riboli, Elio, Siddiq, Afshan, Canzian, Federico, Kolonel, Laurence N., Le Marchand, Loic, Hoover, Robert N., Machiela, Mitchell J., Cui, Zuxi, Kraft, Peter, Amos, Christopher I., Conti, David V., Easton, Douglas F., Wiklund, Fredrik, Chanock, Stephen J., Henderson, Brian E., Kote-Jarai, Zsofia, Haiman, Christopher A., Eeles, Rosalind A.·2018·Nature Genetics

DOI 10.1038/s41588-018-0142-8PMC PMC6568012

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Abstract

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa 1.

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Chen, P., Xiong, Z., Luo, T., Lai, Y., Peng, S., Zhuang, R., Li, K., & Huang, H. W. (2023) · Research Square · doi:10.21203/rs.3.rs-3224738/v1
Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onsetPreprint
Maksimova, E. S., Ojavee, S. E., Läll, K., Sadler, M. C., Mägi, R., Kutalik, Z., & Robinson, M. R. (2023) · doi:10.7554/elife.89882
Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onsetPreprint
Maksimova, E. S., Ojavee, S. E., Läll, K., Sadler, M. C., Mägi, R., Kutalik, Z., & Robinson, M. R. (2023) · doi:10.7554/elife.89882.1
Causal associations between plasma ADAMTS-5 protein level and cancer risk: a bi-directional mendelian randomization analysisPreprint
Huang, R., Lu, T., Qin, J., Fang, X., Liang, C., Li, S., & Li, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3397054/v1
Mendelian randomization revealing the protective effect of sodium-glucose cotransporter 2 inhibition on prostate cancer with verified evidence from electronic healthcare and biological dataPreprint
Zheng, J., Lu, J., Qi, J., Yang, Q., Zhao, H., Liu, H., Ye, Y., Xu, M., Xu, Y., Wang, T., et al. (2023) · medRxiv · doi:10.1101/2023.10.10.23296790
“A set of Mendelian randomization In the main MR analyses, the effects of genetically proxied SGLT2 inhibition (using seven primary instruments) were estimated on total prostate cancer, its subtypes and PSA levels in the general male population (PRACTICAL and GAME-ON/ELLIPSE) 25 .”
BackgroundMethodInfluentialSelf-citation
Vitamin D and prostate cancer
Nonn, L., Krieger, K. D., Yates, C. C., & Campbell, M. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91338-6.00041-0
Reassessment of casual association between body mass index and site-specific solid cancers: A comprehensive Mendelian randomization studyPreprint
Lai, J., Xu, Y., & Li, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3552788/v1
Large-scale alternative polyadenylation (APA)-wide association studies to identify putative susceptibility genes in human common cancersPreprint
Guo, X., Ping, J., Yang, Y., Su, X., Shu, X., Wen, W., Chen, Z., Zhang, Y., Tao, R., Jia, G., et al. (2023) · medRxiv · doi:10.1101/2023.11.05.23298125
Self-citation
Withdraw or Deposit?
Mian, O. Y., & Tendulkar, R. D. (2023) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2023.10.042
Causal relationships between prostate cancer and six psychiatri c disorders: A two-sample Mendelian randomization studyPreprint
wu, X., Zhang, W., Chen, H., & Weng, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3667280/v1
Contribution of Bone Scintigraphy in the Metastatic Extension Assessment of Prostate Cancer: A Study of 288 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital, Dakar
Bathily, E. H. A. L., Diop, O., Djigo, M. S., Thiaw, G., Gueye, K., Chekhma, M., Fachinan, O. H., Ndong, B., Ndoye, O., & Mbodj, M. (2024) · Open Journal of Biophysics · doi:10.4236/ojbiphy.2024.142005
Causal relationship between prostate cancer and cardiovascular diseases: Univariable and multivariable Mendelian randomizationPreprint
wu, X., Zhang, W., Chen, H., & Weng, J. (2024) · Research Square · doi:10.21203/rs.3.rs-3757050/v1
Genetically predicted body mass index and prostate cancer riskPreprint
Minjun, X., Wen, X., Weng, X.-T., & tao, X. (2024) · Research Square · doi:10.21203/rs.3.rs-3960069/v1
Genetic Susceptibility to Prostate Cancer
Simic, T. P., Matic, M. G., & Jerotić, D. (2024) · Springer eBooks · doi:10.1007/978-3-031-51712-9_2
Additional file 1 of Causal associations between gut microbiota and urological tumors: a two-sample mendelian randomization study
Mingdong, W., Gao, X., Yongjun, Q., Mingshuai, W., & Hao, P. (2023) · Figshare · doi:10.6084/m9.figshare.24123719
Additional file 2 of GATA2 co-opts TGFβ1/SMAD4 oncogenic signaling and inherited variants at 6q22 to modulate prostate cancer progression
Yang, X., Zhang, Q., Li, S., Devarajan, R., Luo, B., Tan, Z., Wang, Z., Giannareas, N., Wenta, T., Ma, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23902905
Additional file 2 of Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis
Bouras, E., Karhunen, V., Gill, D., Huang, J. V., Haycock, P., Gunter, M. J., Johansson, M., Brennan, P., Key, T. J., Lewis, S. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.18132334
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Additional file 2 of An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses
Kim, J. Y., Song, M., Kim, M. S., Natarajan, P., Do, R., Myung, W., & Won, H. (2023) · Figshare · doi:10.6084/m9.figshare.24002939
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Additional file 2 of Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Fu, Y., Xu, F., Jiang, L., Miao, Z., Liang, X., Yang, J., Larsson, S. C., & Zheng, J. (2021) · Figshare · doi:10.6084/m9.figshare.15079687
The relationship between metabolic syndrome components and prostate cancer risk : a Mendelian randomization studyPreprint
Shen, C., Zhu, Z., Zhang, X., Fang, M., Chen, J., Shao, F., Sun, F., & Tang, G. (2024) · Research Square · doi:10.21203/rs.3.rs-4205784/v1
Identification of multi-cancer risk genes
Rivera, S. (2024) · Queensland University of Technology · doi:10.5204/thesis.eprints.248736
Hierarchical joint analysis of marginal summary statistics—Part II: High‐dimensional instrumental analysis of omics data
Jiang, L., Shen, J., Darst, B. F., Haiman, C. A., Mancuso, N., & Conti, D. V. (2024) · Genetic Epidemiology · doi:10.1002/gepi.22577
“The corresponding prostate cancer summary data for these variants were obtained from the same prostate cancer GWAS as in the first data example (Schumacher et al., 2018).”
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Multi-Omics Association Study Identifies New Potential Prostate Cancer- Causing GenePreprint
Wang, X., Jiang, A., Shen, J., Wang, L., & liu, Z. (2024) · Research Square · doi:10.21203/rs.3.rs-4663599/v1
Causal association of dietary factors with five common cancers: univariate and multivariate Mendelian randomization studies
Yang, L., Wang, L., Bao, E., Wang, J., & Zhu, P.-Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1428844
“Cancer genetic information was extracted from the GWAS statistical data for prostate cancer, involving 79,148 diagnosed cases and 61,106 healthy controls (24).”
Method
Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis
Wan, Z., & Liu, G. (2024) · Cellular and Molecular Biology · doi:10.14715/cmb/2024.70.7.12
“Recently, reports have shown that CDCA7 is aberrantly upregulated in PCa, proposing the potentiality of being a novel marker for PCa diagnosis and prognosis [17, 18].”
Background
Mapping Epigenetic Gene Variant Dynamics: Comparative Analysis of Frequency, Functional Impact and Trait Associations in African and European PopulationsPreprint
Sinkala, M., Retshabile, G., Mpangase, P. T., Bamba, S., Goita, M. K., Nembaware, V., Elsheikh, S. S. M., Heckmann, J. M., Esoh, K. K., Matshaba, M., et al. (2024) · medRxiv · doi:10.1101/2024.08.11.24311816
GeneDB4PCa: Developing and Curating a Comprehensive Gene Database for Prostate Cancer Single Nucleotide Polymorphisms
Osamor, V. C., & Adebola, P. (2024) · International Conference on Science, Engineering and Business for Driving Sustainable Development Goals (SEB4SDG) · doi:10.1109/seb4sdg60871.2024.10629960
Potential drug targets for prostate cancer ： A mendelian randomization study and application for target-derived drug designPreprint
Cheng, L., Gan, S., Huang, P., Zhang, Q., Kang, S., Han, L., Zhang, P., Zhan, M., Wu, X., Huang, X., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4954410/v1
Association between prostate cancer and susceptibility, hospitalization, and severity of COVID-19: Based on a Mendelian randomization study
Liu, J., Wan, L., Zhu, J., & Pan, R. (2024) · Medicine · doi:10.1097/md.0000000000039430
“[15] To each GWAS, the analysis was adjusted for both specific principal components and relevant covariates, while the overall meta-analysis accounted for principal components.”
Multi-Cancer PRS Constellation Model for Cancer Risk PredictionPreprint
Moragas, N., Díez-Villanueva, A., Moratalla-Navarro, F., Fernández‐Navarro, P., Pérez‐Gómez, B., Morales‐Suárez‐Varela, M., Molina‐Barceló, A., Castaño‐Vinyals, G., Rius‐Sansalvador, B., Riobó‐Mayo, L., et al. (2024) · medRxiv · doi:10.1101/2024.10.17.24315686
“Infinium Oncoarray-500k was used for CRC cases an controls that were included in the CORECT(15) project and PC cases and controls included in the PRACTICAL(16), both part of the GAME-ON project(17), and Illumina Global Screening Array-24 v3.”
MethodSelf-citation
CCAFE: Estimating case and control allele frequencies from GWAS summary statistics
Stoneman, H. R., Gomez, H. L., Price, A., Gignoux, C. R., & Hendricks, A. E. (2026) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2026.100616
Mendelian Randomization Analyses Identified Bioavailable Testosterone Mediates the Effect of Fat Intake on Prostate Cancer
Du, Q., Wang, X., Yang, H., Luo, Z., & Xu, Y. J. (2024) · Journal of Contemporary Medical Practice · doi:10.53469/jcmp.2024.06(10).02
“Genetic data for PCa were sourced from a genome-wide association analysis (GWAS) conducted by the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) [20].”
Method
Genetic regulation of TERT splicing contributes to reduced or elevated cancer risk by altering cellular longevity and replicative potentialPreprint
Flórez-Vargas, O., Ho, M., Hogshead, M. H., Lee, C.-H., Papenberg, B. W., Forsythe, K., Jones, K. M., Luo, W., Teshome, K., Blauwendraat, C., et al. (2024) · medRxiv · doi:10.1101/2024.11.04.24316722
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Implementing genomics research in developing countries: Common challenges, and emerging solutions
Reynolds, A. W., Lea, A. J., & Nieves-Colón, M. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18546-5.00004-8
Prostate Cancer: Disease Burden
Pethe, S. K., & Gupta, N. P. (2024) · Springer eBooks · doi:10.1007/978-981-97-5357-4_1
Genetic variations related to the prostate cancer risk: A field synopsis and revaluation by Bayesian approaches of genome-wide association studies
Monteiro, A. V. O., dos Santos, N. N. D. C., da Silva, J. P. R., Brasileiro, S. A., Botelho, J. C., Sobreira, L. E. R., Leal, A. L. A. B., Pereira, A. L., de Oliveira, A. C. A., Monteiro, J. R. S., et al. (2024) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2024.10.023
GWAS and Post-GWAS: Single-Nucleotide Polymorphism Mapping and Analyses
Azimi, A., Batra, J., & Srinivasan, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95502-7.00258-x
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Insights of prostate diseases risk among patients with male pattern baldness: a mendelian randomized study
Wang, Z., Bao, Z., Cao, X., Jing, Z., Yan, X., Zhao, W., Tian, J., Zhang, H., Zhao, X., & Zhou, Y. (2025) · Archives of Dermatological Research · doi:10.1007/s00403-024-03738-y
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Prospective and genetic analyses implicate lower immunosurveillance in the aetiology of prostate cancerPreprint
Smith-Byrne, K., Parsaeian, M., Chan, W. C., Atkins, J., Papier, K., Desai, T. A., Huang, Z., Conti, D. V., Bogumil, D. D., Shen, J., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5684986/v1
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Serum Matrix Metalloproteinases and Risk of Urologic Cancers: A Bidirectional Mendelian Randomization Study
Yang, B. S., Zeng, X., Wang, H., Feng, J., & Hou, S. (2025) · American Journal of Men s Health · doi:10.1177/15579883241311229
“(Schumacher et al., 2018).”
Causal effects of depression on prostatitis: a two‐step Mendelian randomisation study with immune cell mediation
Liu, F., Han, L., Wang, J., Song, Y., Wu, F., Wu, H., Lyu, J., & Ning, H. (2025) · Psychogeriatrics · doi:10.1111/psyg.70023
“…outcomes were derived from a large-scale meta-analysis research, comprising 79 148 PCa patients and 61 106 control participants, covering a total of 19 733 911 SNPs. 20 All participants were of European ancestry, and the case diagnosis was based on clinically con ﬁ rmed prostate cancer diagnoses.”

Authors: Study, T. P., Schumacher, F. R., (APCB), A. P. C. B., Study, T. I., Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium (BPC3), The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, (CAPS), C. O. T. P. I. S., Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), The Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, Al Olama, A. A., Berndt, S. I., Benlloch, S., Ahmed, M., Saunders, E. J., Dadaev, T., Leongamornlert, D., Anokian, E., Cieza-Borrella, C., Goh, C., Brook, M. N., Sheng, X., Fachal, L., Dennis, J., Tyrer, J., Muir, K., Lophatananon, A., Stevens, V. L., Gapstur, S. M., Carter, B. D., Tangen, C. M., Goodman, P. J., Thompson, I. M., Batra, J., Chambers, S., Moya, L., Clements, J., Horvath, L., Tilley, W., Risbridger, G. P., Gronberg, H., Aly, M., Nordström, T., Pharoah, P., Pashayan, N., Schleutker, J., Tammela, T. L. J., Sipeky, C., Auvinen, A., Albanes, D., Weinstein, S., Wolk, A., Håkansson, N., West, C. M. L., Dunning, A. M., Burnet, N., Mucci, L. A., Giovannucci, E., Andriole, G. L., Cussenot, O., Cancel-Tassin, G., Koutros, S., Beane Freeman, L. E., Sorensen, K. D., Orntoft, T. F., Borre, M., Maehle, L., Grindedal, E. M., Neal, D. E., Donovan, J. L., Hamdy, F. C., Martin, R. M., Travis, R. C., Key, T. J., Hamilton, R. J., Fleshner, N. E., Finelli, A., Ingles, S. A., Stern, M. C., Rosenstein, B. S., Kerns, S. L., Ostrer, H., Lu, Y.-J., Zhang, H.-W., Feng, N., Mao, X., Guo, X., Wang, G., Sun, Z., Giles, G. G., Southey, M. C., MacInnis, R. J., FitzGerald, L. M., Kibel, A. S., Drake, B. F., Vega, A., Gómez-Caamaño, A., Szulkin, R., Eklund, M., Kogevinas, M., Llorca, J., Castaño-Vinyals, G., Penney, K. L., Stampfer, M., Park, J. Y., Sellers, T. A., Lin, H.-Y., Stanford, J. L., Cybulski, C., Wokolorczyk, D., Lubinski, J., Ostrander, E. A., Geybels, M. S., Nordestgaard, B. G., Nielsen, S. F., Weischer, M., Bisbjerg, R., Røder, M. A., Iversen, P., Brenner, H., Cuk, K., Holleczek, B., Maier, C., Luedeke, M., Schnoeller, T., Kim, J., Logothetis, C. J., John, E. M., Teixeira, M. R., Paulo, P., Cardoso, M., Neuhausen, S. L., Steele, L., Ding, Y. C., De Ruyck, K., De Meerleer, G., Ost, P., Razack, A., Lim, J., Teo, S.-H., Lin, D. W., Newcomb, L. F., Lessel, D., Gamulin, M., Kulis, T., Kaneva, R., Usmani, N., Singhal, S., Slavov, C., Mitev, V., Parliament, M., Claessens, F., Joniau, S., Van den Broeck, T., Larkin, S., Townsend, P. A., Aukim-Hastie, C., Gago-Dominguez, M., Castelao, J. E., Martinez, M. E., Roobol, M. J., Jenster, G., van Schaik, R. H. N., Menegaux, F., Truong, T., Koudou, Y. A., Xu, J., Khaw, K.-T., Cannon-Albright, L., Pandha, H., Michael, A., Thibodeau, S. N., McDonnell, S. K., Schaid, D. J., Lindstrom, S., Turman, C., Ma, J., Hunter, D. J., Riboli, E., Siddiq, A., Canzian, F., Kolonel, L. N., Le Marchand, L., Hoover, R. N., Machiela, M. J., Cui, Z., Kraft, P., Amos, C. I., Conti, D. V., Easton, D. F., Wiklund, F., Chanock, S. J., Henderson, B. E., Kote-Jarai, Z., Haiman, C. A., & Eeles, R. A.
Affiliations: Case Western Reserve University (US)
University of Cambridge (GB)
Division of Cancer Epidemiology and Genetics (US)
Institute of Cancer Research (GB)
University of Manchester (GB)
American Cancer Society (US)
Griffith University (AU)
Translational Research Institute (AU)
Garvan Institute of Medical Research (AU)
Karolinska University Hospital (SE)
University of Turku (FI)
Tampere University (FI)
Karolinska Institutet (SE)
Uppsala University (SE)
Harvard University (US)
Washington University in St. Louis (US)
Aarhus University Hospital (DK)
Oslo University Hospital (NO)
Aarhus University (DK)
Princess Margaret Cancer Centre (CA)
University of Oxford (GB)
Albert Einstein College of Medicine (US)
Queen Mary University of London (GB)
Second Military Medical University (CN)
Nanjing Medical University (CN)
Shanghai Medical College of Fudan University (CN)
Cancer Council Victoria (AU)
Brigham and Women's Hospital (US)
The University of Melbourne (AU)
Monash Health (AU)
University of Tasmania (AU)
Universitat Pompeu Fabra (ES)
Fundación Pública Galega de Medicina Xenómica (ES)
Universidad de Cantabria (ES)
Moffitt Cancer Center (US)
National Institutes of Health (US)
University of Washington (US)
University of Copenhagen (DK)
Copenhagen University Hospital (DK)
German Cancer Research Center (DE)
Herlev Hospital (DK)
The University of Texas MD Anderson Cancer Center (US)
Cancer Prevention Institute of California (US)
Universidade do Porto (PT)
Instituto Português de Oncologia Francisco Gentil (PT)
Ghent University (BE)
Ghent University Hospital (BE)
University of Malaya (MY)
University Hospital Centre Zagreb (HR)
University of Alberta (CA)
Alexandrovska Hospital (BG)
Southampton General Hospital (GB)
University of Surrey (GB)
Universitair Ziekenhuis Leuven (BE)
Manchester Academic Health Science Centre (GB)
Inserm (FR)
Endeavor Health (US)
Mayo Clinic (US)
USC Norris Comprehensive Cancer Center (US)
Dartmouth College (US)
Royal Marsden NHS Foundation Trust (GB)
Corresponding author: Schumacher, Fredrick R.
Eeles, Rosalind A.
ORCID: Schumacher, Fredrick R.
Berndt, Sonja I.
Ahmed, Mahbubl
Saunders, Edward J.
Dadaev, Tokhir
Leongamornlert, Daniel
Anokian, Ezequiel
Cieza-Borrella, Clara
Goh, Chee
Brook, Mark N.
Sheng, Xin
Fachal, Laura
Dennis, Joe
Tyrer, Jonathan
Muir, Kenneth
Lophatananon, Artitaya
Stevens, Victoria L.
Gapstur, Susan M.
Carter, Brian D.
Tangen, Catherine M.
Goodman, Phyllis J.
Thompson, Ian M.
Batra, Jyotsna
Chambers, Suzanne
Moya, Leire
Clements, Judith
Horvath, Lisa
Tilley, Wayne
Risbridger, Gail P.
Aly, Markus
Nordström, Tobias
Pharoah, Paul
Pashayan, Nora
Schleutker, Johanna
Tammela, Teuvo L. J.
Sipeky, Csilla
Auvinen, Anssi
Albanes, Demetrius
Weinstein, Stephanie
Wolk, Alicja
Håkansson, Niclas
West, Catharine M. L.
Dunning, Alison M.
Burnet, Neil
Mucci, Lorelei A.
Giovannucci, Edward
Andriole, Gerald L.
Cussenot, Olivier
Koutros, Stella
Borre, Michael
Grindedal, Eli Marie
Neal, David E.
Donovan, Jenny L.
Hamdy, Freddie C.
Martin, Richard M.
Travis, Ruth C.
Hamilton, Robert J.
Fleshner, Neil E.
Finelli, Antonio
Ingles, Sue Ann
Stern, Mariana C.
Rosenstein, Barry S.
Kerns, Sarah L.
Lu, Yong-Jie
Zhang, Hong-Wei
Feng, Ninghan
Mao, Xueying
Wang, Guomin
Giles, Graham G.
Southey, Melissa C.
MacInnis, Robert J.
FitzGerald, Liesel M.
Kibel, Adam S.
Drake, Bettina F.
Vega, Ana
Szulkin, Robert
Eklund, Martin
Kogevinas, Manolis
Llorca, Javier
Penney, Kathryn L.
Stampfer, Meir
Park, Jong Y.
Sellers, Thomas A.
Lin, Hui-Yi
Stanford, Janet L.
Cybulski, Cezary
Ostrander, Elaine A.
Nordestgaard, Børge G.
Nielsen, Sune F.
Weischer, Maren
Bisbjerg, Rasmus
Røder, Martin Andreas
Iversen, Peter
Brenner, Hermann
Holleczek, Bernd
Kim, Jeri
Logothetis, Christopher J.
John, Esther M.
Teixeira, Manuel R.
Paulo, Paula
Cardoso, Marta
Neuhausen, Susan L.
Steele, Linda
Ding, Yuan Chun
Ost, Piet
Razack, Azad
Lim, Jasmine
Teo, Soo-Hwang
Lin, Daniel W.
Lessel, Davor
Gamulin, Marija
Kaneva, Radka
Usmani, Nawaid
Singhal, Sandeep
Slavov, Chavdar
Mitev, Vanio
Parliament, Matthew
Claessens, Frank
Joniau, Steven
Townsend, Paul A.
Castelao, Jose Esteban
Roobol, Monique J.
Jenster, Guido
van Schaik, Ron H. N.
Truong, Thérèse
Xu, Jianfeng
Khaw, Kay-Tee
Pandha, Hardev
Michael, Agnieszka
Thibodeau, Stephen N.
McDonnell, Shannon K.
Schaid, Daniel J.
Turman, Constance
Ma, Jing
Siddiq, Afshan
Canzian, Federico
Kolonel, Laurence N.
Hoover, Robert N.
Machiela, Mitchell J.
Cui, Zuxi
Kraft, Peter
Amos, Christopher I.
Conti, David V.
Easton, Douglas F.
Wiklund, Fredrik
Chanock, Stephen J.
Haiman, Christopher A.
Eeles, Rosalind A.
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2018-06-11
Volume: 50
Issue: 7
Pages: 928-936
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/s41588-018-0142-8
PMC: PMC6568012
OpenAlex: W2806504012
Cited by: 902
References: 65
Citations by year: 2026: 53 · 2025: 96 · 2024: 133 · 2023: 123 · 2022: 151 · 2021: 132 · 2020: 104 · 2019: 79 · 2018: 30
FWCI: 52.93
Type: journal article
Language: en
Update notices: correction (2019-01-08)
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
PubMed (publishedVersion)
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Apollo
Funders: U.S. Department of Defense (C5047/A10692, C1287/A10118, C5047/A7357, W81XWH, C1287/A16563, C8197/A16565, C1281/A12014, C5047/A8384, C12292/A11174, C5047/A15007, CA128978, W81XWH1010341, 223175)
Cancer Research Institute
Prostate Cancer Foundation
Breast Cancer Research Foundation (C5047/A10692, C5047/A15007, C1287/A10118, CA128978, 209057, C1287/A16563, W81XWH-10-1-0341, C8197/A16565, C5047/A8384, C1281/A12014, 396414, C12292/A11174, HEALTH-F2-2009-223175)
Ovarian Cancer Research Fund (W81XWH-10-1-0341, C1281/A12014, C1287/A10118, C8197/A16565, C12292/A11174, CA128978, C5047/A10692, C5047/A15007, C1287/A16563, C5047/A8384, HEALTH-F2-2009-223175)
University of Southern California (C1281/A12014, C5047/A10692, C8197/A16565, C1287/A10118, C12292/A11174, C5047/A8384, W81XWH-10-1-0341, C5047/A15007, CA128978, C1287/A16563, HEALTH-F2-2009-223175)
Aarhus Universitet
Aarhus Universitetshospital
Case Western Reserve University
Harvard T.H. Chan School of Public Health
Institut for Klinisk Medicin, Aarhus Universitet
National Cancer Research Institute
Royal Marsden NHS Foundation Trust
Australian Prostate Cancer Research
Cancer Research UK (C8197/A16565’, 223175, C1281/A12014, 10119, C5047/A7357, C5047/A15007’, C1287‐A10118, 12014, HEALTHF2-2009-223175, C5047/A3354, 21332, 16561, 16565, C12292/A11174, ‘C5047/A10692, 15007, C1287, C5047/A8384, 10118, 14136, 16563, 18504, 16491, 17528, C16913-A6135, CA128978, A16563, 19169, C1287-A10710, W81XWH-10-1-0341, C1287‐A16563, C1281)
National Institute for Health and Care Research (C5047/A15007, W81XWH-10-1-0341, NF-SI-0510-10096, C8197/A16565, HEALTH-F2-2009-223175, NF-SI-0509-10242, CA128978, C1287/A10118, C1281/A12014, NF-SI-0512-10114, C5047/A10692, NF-SI-0513-10121, C1287/A16563, C12292/A11174, C5047/A8384)
University of Cambridge
University of Warwick
University College London
University of Oxford
European Commission (C1287/A10118, W81XWH-10-1-0341, C1281/A12014, C1287/A16563, C5047/A10692, C5047/A8384, C12292/A11174, C5047/A15007, C8197/A16565, CA128978, 223175)
University of Bristol
Prostate Cancer Foundation of Australia
Monash University
Griffith University
Queensland University of Technology
Cambridge University Hospitals
Karolinska Institutet (W81XWH-10-1-0341, C1281/A12014, C1287/A10118, HEALTH-F2-2009-223175, C1287/A16563, CA128978, C5047/A8384, C5047/A10692, C12292/A11174, C8197/A16565, C5047/A15007)
Peter MacCallum Cancer Centre
Tampereen Yliopisto
Turun Yliopisto
Uppsala Universitet
Tays
Turun Yliopistollinen Keskussairaala
National Institutes of Health (C1281/A12014, 223175, W81XWH-10-1-0341, C8197/A16565, C5047/A7357, C12292/A11174, C1287/A16563, W81XWH, C1287/A10118, HHSN268201200008I, C5047/A10692, HEALTH-F2-2009-223175, C5047/A15007, C5047/A8384, X01HG007492)
Canadian Institutes of Health Research (C5047/A8384, C5047/A15007, C5047/A10692, C1287/A10118, C1287/A16563, CA128978, C8197/A16565, C1281/A12014, C12292/A11174, W81XWH-10-1-0341, HEALTH-F2-2009-223175, 223175)
Medical Research Council (C12292/A11174, C1281/A12014, CA128978, C5047/A8384, HEALTH-F2-2009-223175, C8197/A16565, W81XWH-10-1-0341, C1287/A16563, C5047/A10692, MR/N003284/1, C1287/A10118, C5047/A15007)
National Health and Medical Research Council (623204, 504702, 126402, 614296, 251533, 504700, 504715)
Cancer Council Victoria (C1287/A16563, C1287/A10118, C8197/A16565, HEALTH-F2-2009-223175, C1281/A12014, C5047/A15007, C12292/A11174, W81XWH-10-1-0341, CA128978, C5047/A10692, C5047/A8384)
Cancer Council Queensland
Warwick Medical School
Servicio Gallego de Salud
Monash Biomedicine Discovery Institute, Monash University
National Heart, Lung, and Blood Institute (HHSN268201200008I, HHSN268201200008C)
National Cancer Institute (R01CA128978, U01CA188392, C5047/A15007, C5047/A10692, C5047/A8384, U19CA148065, HEALTH-F2-2009-223175, W81XWH-10-1-0341, UM1CA182883, UG1CA189974, U01CA098710, U19CA148537, K05CA175147, CA148065, U01CA098216, C1281/A12014, C12292/A11174, U01CA098758, U19CA148112, (CA128978, C1287/A16563, K07CA187546, C1287/A10118, C8197/A16565, U01CA098233, U10CA037429)
Division of Cancer Epidemiology and Genetics, National Cancer Institute
DOD Prostate Cancer Research Program
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Urology › Prostate Cancer Diagnosis and Treatment
Keywords: prostate cancer, cancer susceptibility loci, genetic association, early-onset prostate cancer, polygenic risk score, ATM, p27, European ancestry, risk prediction, fine mapping
MeSH terms: Genotype, Humans, Male, Prostatic Neoplasms, Risk, Case-Control Studies, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci

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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

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