The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Evolution of buffering in a genetic circuit controlling plant stem cell proliferation
Open accessAbstract
Precise control of plant stem cell proliferation is necessary for the continuous and reproducible development of plant organs1,2. The peptide ligand CLAVATA3 (CLV3) and its receptor protein kinase CLAVATA1 (CLV1) maintain stem cell homeostasis within a deeply conserved negative feedback circuit1,2. In Arabidopsis, CLV1 paralogs also contribute to homeostasis, by compensating for the loss of CLV1 through transcriptional upregulation3. Here, we show that compensation4,5 operates in diverse lineages for both ligands and receptors, but while the core CLV signaling module is conserved, compensation mechanisms have diversified. Transcriptional compensation between ligand paralogs operates in tomato, facilitated by an ancient gene duplication that impacted the domestication of fruit size. In contrast, we found little evidence for transcriptional compensation between ligands in Arabidopsis and maize, and receptor compensation differs between tomato and Arabidopsis. Our findings show that compensation among ligand and receptor paralogs is critical for stem cell homeostasis, but that diverse genetic mechanisms buffer conserved developmental programs. A study of a stem cell receptor–ligand signaling module across tomato, maize and Arabidopsis identifies different genetic mechanisms of compensation that contribute to homeostasis.
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Cites
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Katoh, K., & Standley, D. M. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst010 · Cited by 46,209
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Genetic compensation: A phenomenon in search of mechanisms
El-Brolosy, M. A., & Stainier, D. Y. R. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006780 · Cited by 829
Cited by
Enhancing grain-yield-related traits by CRISPR–Cas9 promoter editing of maize CLE genes
Liu, L., Gallagher, J., Arevalo, E. D., Chen, R., Skopelitis, T., Wu, Q., Bartlett, M., & Jackson, D. (2021) · Nature Plants · doi:10.1038/s41477-021-00858-5 · Cited by 437
Self-citationXu, X., Crow, M., Rice, B. R., Li, F., Harris, B., Liu, L., Demesa-Arevalo, E., Lu, Z., Wang, L., Fox, N., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2020.12.015 · Cited by 264
Self-citationDifferential expansion and retention patterns of LRR‐RLK genes across plant evolution
Kileeg, Z., Haldar, A., Khan, H., Qamar, A., & Mott, G. A. (2023) · Plant Direct · doi:10.1002/pld3.556 · Cited by 13
Metadata
- Authors
- Rodriguez-Leal, D., Xu, C., Kwon, C.-T., Soyars, C., Demesa-Arevalo, E., Man, J., Liu, L., Lemmon, Z. H., Jones, D. S., Van Eck, J., Jackson, D. P., Bartlett, M. E., Nimchuk, Z. L., & Lippman, Z. B.
- Venue
- Nature Genetics
- Published
- 2019-04-15
- Volume
- 51
- Issue
- 5
- Pages
- 786-792
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2938511997
- Cited by
- 183
- References
- 4
- FWCI
- 14.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Rodriguez-Leal, D., Xu, C., Kwon, C.-T., Soyars, C., Demesa-Arevalo, E., Man, J., Liu, L., Lemmon, Z. H., Jones, D. S., Van Eck, J., Jackson, D. P., Bartlett, M. E., Nimchuk, Z. L., & Lippman, Z. B. (2019). Evolution of buffering in a genetic circuit controlling plant stem cell proliferation. Nature Genetics. https://doi.org/10.1038/s41588-019-0389-8
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