The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway
Open accessAbstract
Reactive oxygen species (ROS) are generated by virus-infected cells; however, the physiological importance of ROS generated under these conditions is unclear. Here we found that the inflammation and cell death induced by exposure of mice or cells to sources of ROS were not altered in the absence of canonical ROS-sensing pathways or known cell-death pathways. ROS-induced cell-death signaling involved interactions among the cellular ROS sensor and antioxidant factor KEAP1, the phosphatase PGAM5 and the proapoptotic factor AIFM1. Pgam5–/– mice showed exacerbated lung inflammation and proinflammatory cytokines in an ozone-exposure model. Similarly, challenge with influenza A virus led to increased infiltration of the virus, lymphocytic bronchiolitis and reduced survival of Pgam5–/– mice. This pathway, which we have called ‘oxeiptosis’, was a ROS-sensitive, caspase independent, non-inflammatory cell-death pathway and was important for protection against inflammation induced by ROS or ROS-generating agents such as viral pathogens. Reactive oxygen species (ROS) are generated by cells during viral infection. Pichlmair and colleagues demonstrate a ROS-dependent form of cell death, ‘oxeiptosis’, that resembles apoptosis but uses a pathway distinct from all previously described death pathways.
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Metadata
- Authors
- Holze, C., Michaudel, C., Mackowiak, C., Haas, D. A., Benda, C., Hubel, P., Pennemann, F. L., Schnepf, D., Wettmarshausen, J., Braun, M., Leung, D. W., Amarasinghe, G. K., Perocchi, F., Staeheli, P., Ryffel, B., & Pichlmair, A.
- Venue
- Nature Immunology
- Published
- 2017-12-18
- Volume
- 19
- Issue
- 2
- Pages
- 130-140
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2775328130
- Cited by
- 452
- References
- 57
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Holze, C., Michaudel, C., Mackowiak, C., Haas, D. A., Benda, C., Hubel, P., Pennemann, F. L., Schnepf, D., Wettmarshausen, J., Braun, M., Leung, D. W., Amarasinghe, G. K., Perocchi, F., Staeheli, P., Ryffel, B., & Pichlmair, A. (2018). Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nature Immunology. https://doi.org/10.1038/s41590-017-0013-y
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