The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation
Open accessAbstract
The antimicrobial functions of neutrophils are facilitated by a defensive armamentarium of proteins stored in granules, and by the formation of neutrophil extracellular traps (NETs). However, the toxic nature of these structures poses a threat to highly vascularized tissues, such as the lungs. Here, we identified a cell-intrinsic program that modified the neutrophil proteome in the circulation and caused the progressive loss of granule content and reduction of the NET-forming capacity. This program was driven by the receptor CXCR2 and by regulators of circadian cycles. As a consequence, lungs were protected from inflammatory injury at times of day or in mouse mutants in which granule content was low. Changes in the proteome, granule content and NET formation also occurred in human neutrophils, and correlated with the incidence and severity of respiratory distress in pneumonia patients. Our findings unveil a ‘disarming’ strategy of neutrophils that depletes protein stores to reduce the magnitude of inflammation. Hidalgo and colleagues describe a cell-intrinsic program that induces changes in the proteome, granule content and NET-forming capacity of neutrophils and is driven by the chemokine receptor CXCR2 and regulators of the circadian clock.
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Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103
Thrombosis as an intravascular effector of innate immunity
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Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction
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IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
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Neutrophils, from Marrow to Microbes
Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,573
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
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Cited by
Targeting potential drivers of COVID-19: Neutrophil extracellular traps
Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J. M., Daßler-Plenker, J., Guerci, P., Huynh, C., Knight, J. S., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20200652 · Cited by 1,486
Self-citationNeutrophil profiling illuminates anti-tumor antigen-presenting potency
Wu, Y., Ma, J., Yang, X., Nan, F., Zhang, T., Ji, S., Rao, D., Feng, H., Gao, K., Gu, X., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.005 · Cited by 435
Neutrophil extracellular traps: from physiology to pathology
Hidalgo, A., Libby, P., Soehnlein, O., Aramburu, I. V., Papayannopoulos, V., & Silvestre-Roig, C. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvab329 · Cited by 401
Self-citationPatients with COVID-19: in the dark-NETs of neutrophils
Ackermann, M., Anders, H.-J., Bilyy, R., Bowlin, G. L., Daniel, C., De Lorenzo, R., Egeblad, M., Henneck, T., Hidalgo, A., Hoffmann, M., et al. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-021-00805-z · Cited by 304
Self-citationChronic stress increases metastasis via neutrophil-mediated changes to the microenvironment
He, X.-Y., Gao, Y., Ng, D., Michalopoulou, E., George, S., Adrover, J. M., Sun, L., Albrengues, J., Daßler-Plenker, J., Han, X., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.01.013 · Cited by 291
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Metadata
- Authors
- Adrover, J. M., Aroca-Crevillén, A., Crainiciuc, G., Ostos, F., Rojas-Vega, Y., Rubio-Ponce, A., Cilloniz, C., Bonzón-Kulichenko, E., Calvo, E., Rico, D., Moro, M. A., Weber, C., Lizasoaín, I., Torres, A., Ruiz-Cabello, J., Vázquez, J., & Hidalgo, A.
- Venue
- Nature Immunology
- Published
- 2020-01-13
- Volume
- 21
- Issue
- 2
- Pages
- 135-144
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2999714391
- Cited by
- 282
- References
- 52
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Adrover, J. M., Aroca-Crevillén, A., Crainiciuc, G., Ostos, F., Rojas-Vega, Y., Rubio-Ponce, A., Cilloniz, C., Bonzón-Kulichenko, E., Calvo, E., Rico, D., Moro, M. A., Weber, C., Lizasoaín, I., Torres, A., Ruiz-Cabello, J., Vázquez, J., & Hidalgo, A. (2020). Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation. Nature Immunology. https://doi.org/10.1038/s41590-019-0571-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
