Targeting potential drivers of COVID-19: Neutrophil extracellular traps
Open accessAbstract
Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10–15% of patients progresses to acute respiratory distress syndrome (ARDS) triggered by a cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis that a little known yet powerful function of neutrophils—the ability to form neutrophil extracellular traps (NETs)—may contribute to organ damage and mortality in COVID-19. We show lung infiltration of neutrophils in an autopsy specimen from a patient who succumbed to COVID-19. We discuss prior reports linking aberrant NET formation to pulmonary diseases, thrombosis, mucous secretions in the airways, and cytokine production. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19.
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Excessive NETosis has been implicated in the development of cytokine storms and thrombosis.
“Excessive NETosis has been implicated in the development of cytokine storms and thrombosis.259”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [259]
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Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884 · see citing works
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263 · see citing works
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415 · see citing works
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148 · see citing works
La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
Martínez González, M. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,463 · see citing works
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works
COVID-19: consider cytokine storm syndromes and immunosuppression
Mehta, P., McAuley, D. F., Brown, M., Sanchez, E., Tattersall, R. S., & Manson, J. J. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30628-0 · Cited by 9,664 · see citing works
Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., Huang, H., Zhang, L., Zhou, X., Du, C., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.0994 · Cited by 8,249 · see citing works
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works
Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992 · see citing works
Ruan, Q., Yang, K., Wang, W., Jiang, L., & Song, J. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05991-x · Cited by 4,898 · see citing works
Clinical and immunological features of severe and moderate coronavirus disease 2019
Chen, G., Wu, D., Guo, W., Cao, Y., Huang, D., Wang, H., Wang, T., Zhang, X., Chen, H., Yu, H., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137244 · Cited by 4,750 · see citing works
Neutrophil extracellular traps in immunity and disease
Papayannopoulos, V. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.105 · Cited by 3,428 · see citing works
Effective treatment of severe COVID-19 patients with tocilizumab
Xu, X., Han, M., Li, T., Sun, W., Wang, D., Fu, B., Zhou, Y., Zheng, X., Yang, Y., Li, X., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005615117 · Cited by 2,636 · see citing works
Channappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0629-x · Cited by 2,524 · see citing works
Extracellular DNA traps promote thrombosis
Fuchs, T. A., Brill, A. G., Duerschmied, D., Schatzberg, D., Monestier, M., Myers, D. D., Wrobleski, S. K., Wakefield, T. W., Hartwig, J. H., & Wagner, D. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005743107 · Cited by 2,517 · see citing works
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309 · see citing works
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103 · see citing works
von Brühl, M.-L., Stark, K., Steinhart, A., Chandraratne, S., Konrad, I., Lorenz, M., Khandoga, A. G., Tirniceriu, A., Coletti, R., Köllnberger, M., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112322 · Cited by 1,827 · see citing works
Functional exhaustion of antiviral lymphocytes in COVID-19 patients
Zheng, M., Gao, Y., Wang, G., Song, G., Liu, S., Sun, D., Xu, Y., & Tian, Z. (2020) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-0402-2 · Cited by 1,768 · see citing works
Netting neutrophils in autoimmune small-vessel vasculitis
Kessenbrock, K., Krumbholz, M., Schönermarck, U., Back, W. E., Gross, W. L., Werb, Z., Gröne, H., Brinkmann, V., & Jenne, D. E. (2009) · Nature Medicine · doi:10.1038/nm.1959 · Cited by 1,650 · see citing works
Extracellular histones are major mediators of death in sepsis
Xu, J., Zhang, X., Pelayo, R., Monestier, M., Ammollo, C. T., Semeraro, F., Taylor, F. B., Esmon, N. L., Lupu, F., & Esmon, C. T. (2009) · Nature Medicine · doi:10.1038/nm.2053 · Cited by 1,547 · see citing works
Fox, S., Akmatbekov, A., Harbert, J. L., Li, G., Brown, J. Q., & Heide, R. S. V. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30243-5 · Cited by 1,524 · see citing works
Cytokine storm and sepsis disease pathogenesis
Chousterman, B. G., Świrski, F. K., & Weber, G. F. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0639-8 · Cited by 1,340 · see citing works
Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis
Warnatsch, A., Ιωάννου, Μ., Wang, Q., & Papayannopoulos, V. (2015) · Science · doi:10.1126/science.aaa8064 · Cited by 1,280 · see citing works
Zhang, W., Zhao, Y., Zhang, F., Wang, Q., Li, T., Liu, Z., Wang, J., Qin, Y., Zhang, X., Yan, X., et al. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108393 · Cited by 1,266 · see citing works
An emerging role for neutrophil extracellular traps in noninfectious disease
Jorch, S. K., & Kubes, P. (2017) · Nature Medicine · doi:10.1038/nm.4294 · Cited by 1,244 · see citing works
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases
Maßberg, S., Grahl, L., von Bruehl, M., Manukyan, D., Pfeiler, S., Goosmann, C., Brinkmann, V., Lorenz, M., Bidzhekov, K., Khandagale, A. B., et al. (2010) · Nature Medicine · doi:10.1038/nm.2184 · Cited by 1,212 · see citing works
Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity
Kaplan, M. J., & Radic, M. Z. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201719 · Cited by 1,168 · see citing works
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Hu, J. J., Liu, X., Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0669-6 · Cited by 1,145 · see citing works
Liu, J., Liu, Y., Xiang, P., Pu, L., Xiong, H., Li, C., Zhang, M., Tan, J., Xu, Y., Song, R., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02374-0 · Cited by 1,081 · see citing works
Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury
Caudrillier, A., Kessenbrock, K., Gilliss, B. M., Nguyen, J. X., Marques, M. B., Monestier, M., Toy, P. T. C. Y., Werb, Z., & Looney, M. R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61303 · Cited by 1,047 · see citing works
Self-citationCancer cells induce metastasis-supporting neutrophil extracellular DNA traps
Park, J., Wysocki, R. W., Amoozgar, Z., Maiorino, L., Fein, M. R., Jorns, J., Schott, A. F., Kinugasa-Katayama, Y., Lee, Y., Won, N. H., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1711 · Cited by 984 · see citing works
Self-citation[A pathological report of three COVID-19 cases by minimal invasive autopsies].
Yao, X. H., Li, T. Y., He, Z. C., Ping, Y. F., Liu, H. W., Yu, S. C., Mou, H. M., Wang, L. H., Zhang, H. R., Fu, W. J., et al. (2020) · PubMed · doi:10.3760/cma.j.cn112151-20200312-00193 · Cited by 963 · see citing works
Narasaraju, T., Yang, E., Samy, R. P., Ng, H. H., Poh, W. P., Liew, A.-A., Phoon, M. C., van Rooijen, N., & Chow, V. T. K. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.013 · Cited by 893 · see citing works
Thrombosis: tangled up in NETs
Martinod, K., & Wagner, D. D. (2013) · Blood · doi:10.1182/blood-2013-10-463646 · Cited by 875 · see citing works
Semeraro, F., Ammollo, C. T., Morrissey, J. H., Dale, G. L., Friese, P., Esmon, N. L., & Esmon, C. T. (2011) · Blood · doi:10.1182/blood-2011-03-343061 · Cited by 870 · see citing works
TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib
Wu, D., & Yang, X. O. (2020) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2020.03.005 · Cited by 783 · see citing works
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps
Sollberger, G., Choidas, A., Burn, G. L., Habenberger, P., Lucrezia, R. D., Kordes, S., Menninger, S., Eickhoff, J., Nußbaumer, P., Klebl, B., et al. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar6689 · Cited by 761 · see citing works
Neutrophils scan for activated platelets to initiate inflammation
Sreeramkumar, V., Adrover, J. M., Ballesteros, I., Cuartero, M. I., Rossaint, J., Bilbao, I., Nácher, M., Pitaval, C., Radovanovic, I., Fukui, Y., et al. (2014) · Science · doi:10.1126/science.1256478 · Cited by 651 · see citing works
Self-citationNoncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
Chen, K. W., Monteleone, M. M., Boucher, D., Sollberger, G., Ramnath, D., Condon, N. D., von Pein, J. B., Brož, P., Sweet, M. J., & Schroder, K. (2018) · Science Immunology · doi:10.1126/sciimmunol.aar6676 · Cited by 640 · see citing works
Host DNases prevent vascular occlusion by neutrophil extracellular traps
Jiménez-Alcázar, M., Rangaswamy, C., Panda, R., Bitterling, J., Simsek, Y., Long, A. T., Bilyy, R. O., Krenn, V., Renné, C., Renné, T., et al. (2017) · Science · doi:10.1126/science.aam8897 · Cited by 597 · see citing works
Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality
Bonow, R. O., Fonarow, G. C., O’Gara, P. T., & Yancy, C. W. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.1105 · Cited by 593 · see citing works
Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis
Fuchs, T. A., Brill, A. G., & Wagner, D. D. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.242859 · Cited by 587 · see citing works
Kahlenberg, J. M., Carmona‐Rivera, C., Smith, C. K., & Kaplan, M. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202388 · Cited by 511 · see citing works
Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury
Lefrançais, E., Mallavia, B., Zhuo, H., Calfee, C. S., & Looney, M. R. (2018) · JCI Insight · doi:10.1172/jci.insight.98178 · Cited by 472 · see citing works
Self-citationBorissoff, J. I., Joosen, I. A., Versteylen, M. O., Brill, A. G., Fuchs, T. A., Savchenko, A. S., Gallant, M., Martinod, K., Cate, H. T., Hofstra, L., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301627 · Cited by 448 · see citing works
Pulmonary and Cardiac Pathology in Covid-19: The First Autopsy Series from New OrleansPreprint
Fox, S., Akmatbekov, A., Harbert, J. L., et al. (2020) · medRxiv · doi:10.1101/2020.04.06.20050575 · Cited by 410 · see citing works
Activation of PAD4 in NET formation
Rohrbach, A. S., Slade, D. J., Thompson, P. R., & Mowen, K. A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00360 · Cited by 404 · see citing works
Nakazawa, D., Kumar, S. V. R., Marschner, J. A., Desai, J., Holderied, A., Rath, L., Kraft, F., Lei, Y., Fukasawa, Y., Moeckel, G. W., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016080925 · Cited by 362 · see citing works
IL-6 biology: implications for clinical targeting in rheumatic disease
Calabrese, L., & Rose-John, S. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.127 · Cited by 329 · see citing works
Liu, J., Liu, Y., Xiang, P., et al. (2020) · medRxiv · doi:10.1101/2020.02.10.20021584 · Cited by 327 · see citing works
Ferreira, R. C., Freitag, D. F., Cutler, A. J., Howson, J. M. M., Rainbow, D. B., Smyth, D. J., Kaptoge, S., Clarke, P., Boreham, C., Coulson, R. M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003444 · Cited by 316 · see citing works
Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice
Thomas, G. M., Carbó, C., Curtis, B. R., Martinod, K., Mazo, I. B., Schatzberg, D., Cifuni, S. M., Fuchs, T. A., von Andrian, U. H., Hartwig, J. H., et al. (2012) · Blood · doi:10.1182/blood-2012-01-405183 · Cited by 307 · see citing works
Neutrophil Extracellular Traps in Arterial and Venous Thrombosis
Laridan, E., Martinod, K., & Meyer, S. F. D. (2019) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0038-1677040 · Cited by 293 · see citing works
Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation
Adrover, J. M., Aroca-Crevillén, A., Crainiciuc, G., Ostos, F., Rojas-Vega, Y., Rubio-Ponce, A., Cillóniz, C., Bonzón‐Kulichenko, E., Calvo, E., Rico, D., et al. (2020) · Nature Immunology · doi:10.1038/s41590-019-0571-2 · Cited by 284 · see citing works
Self-citationNeutrophil Extracellular Traps Go Viral
Schönrich, G., & Raftery, M. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00366 · Cited by 277 · see citing works
Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma
Lachowicz-Scroggins, M. E., Dunican, E. M., Charbit, A. R., Raymond, W. W., Looney, M. R., Peters, M. C., Gordon, E. D., Woodruff, P. G., Lefrançais, E., Phillips, B. R., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-1869oc · Cited by 275 · see citing works
Self-citationLiu, S., Su, X., Pan, P., Zhang, L., Hu, Y., Tan, H., Wu, D., Liu, B., Li, H., Li, H., et al. (2016) · Scientific Reports · doi:10.1038/srep37252 · Cited by 254 · see citing works
Meher, A. K., Spinosa, M. D., Davis, J. P., Pope, N. H., Laubach, V. E., Su, G., Serbulea, V., Leitinger, N., Ailawadi, G., & Upchurch, G. R. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309897 · Cited by 254 · see citing works
Papayannopoulos, V., Staab, D., & Zychlinsky, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028526 · Cited by 252 · see citing works
Cedervall, J., Zhang, Y., Huang, H., Zhang, L., Femel, J., Dimberg, A., & Olsson, A. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3299 · Cited by 229 · see citing works
Clinical and immunologic features in severe and moderate forms of Coronavirus Disease 2019Preprint
Chen, G., Wu, D., Guo, W., et al. (2020) · medRxiv · doi:10.1101/2020.02.16.20023903 · Cited by 209 · see citing works
Extracellular DNA Is Required for Root Tip Resistance to Fungal Infection
Wen, F., White, G. J., VanEtten, H. D., Xiong, Z., & Hawes, M. C. (2009) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.142067 · Cited by 204 · see citing works
Activation of the Human Contact System on Neutrophil Extracellular Traps
Oehmcke-Hecht, S., Mörgelin, M., & Herwald, H. (2009) · Journal of Innate Immunity · doi:10.1159/000203700 · Cited by 202 · see citing works
Raup‐Konsavage, W. M., Wang, Y., Wang, W. W., Féliers, D., Ruan, H., & Reeves, W. B. (2017) · Kidney International · doi:10.1016/j.kint.2017.08.014 · Cited by 201 · see citing works
Manzenreiter, R., Kienberger, F., Marcos, V., Schilcher, K., Krautgartner, W. D., Obermayer, A., Huml, M., Stoiber, W., Hector, A., Griese, M., et al. (2011) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2011.09.008 · Cited by 200 · see citing works
Jansen, M. P. B., Emal, D., Teske, G. J. D., Dessing, M. C., Florquin, S., & Roelofs, J. J. T. H. (2016) · Kidney International · doi:10.1016/j.kint.2016.08.006 · Cited by 179 · see citing works
Mikacenic, C. R., Moore, R., Dmyterko, V., West, T. E., Altemeier, W. A., Liles, W. C., & Lood, C. (2018) · Critical Care · doi:10.1186/s13054-018-2290-8 · Cited by 153 · see citing works
Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation
Yost, C. C., Schwertz, H., Cody, M. J., Wallace, J. A., Campbell, R. A., Vieira‐de‐Abreu, A., de Araujo, C. V., Schubert, S., Harris, E. S., Rowley, J. W., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83873 · Cited by 151 · see citing works
Self-citationEbrahimi, F., Giaglis, S., Hahn, S., Blum, C. A., Baumgartner, C., Kutz, A., van Breda, S. V., Müeller, B., Schüetz, P., Christ‐Crain, M., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01389-2017 · Cited by 113 · see citing works
Tagami, T., Tosa, R., Omura, M., Fukushima, H., Kaneko, T., Endo, T., Rinka, H., Murai, A., Yamaguchi, J., Yoshikawa, K., et al. (2014) · Journal of Intensive Care · doi:10.1186/s40560-014-0067-y · Cited by 104 · see citing works
Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation
Sil, P., Wicklum, H., Surell, C., & Rada, B. (2016) · Inflammation Research · doi:10.1007/s00011-016-1008-0 · Cited by 103 · see citing works
The IL6R variation Asp358Ala is a potential modifier of lung function in subjects with asthma
Hawkins, G. A., Robinson, M., Hastie, A. T., Li, X., Li, H., Moore, W. C., Howard, T. D., Busse, W. W., ERZURUM, S. C., Wenzel, S. E., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.03.018 · Cited by 98 · see citing works
Understanding the Entanglement: Neutrophil Extracellular Traps (NETs) in Cystic Fibrosis
Martínez-Alemán, S. R., Campos-García, L., Palma‐Nicolás, J. P., Hernández‐Bello, R., González, G. M., & Sánchez-González, A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00104 · Cited by 94 · see citing works
Bendib, I., de Chaisemartin, L., Granger, V., Schlemmer, F., Maître, B., Hüe, S., Surénaud, M., Beldi‐Ferchiou, A., Carteaux, G., Razazi, K., et al. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002619 · Cited by 89 · see citing works
Sepsis: the dark side of histones
Chaput, C., & Zychlinsky, A. (2009) · Nature Medicine · doi:10.1038/nm1109-1245 · Cited by 83 · see citing works
Lv, X., Wen, T., Song, J., Xie, D., Wu, L., Jiang, X., Jiang, P., & Wen, Z. (2017) · Respiratory Research · doi:10.1186/s12931-017-0651-5 · Cited by 78 · see citing works
Sepsis and ARDS: The Dark Side of Histones
Xu, Z., Huang, Y., Mao, P., Zhang, J., & Li, Y. (2015) · Mediators of Inflammation · doi:10.1155/2015/205054 · Cited by 77 · see citing works
How Should Aerosols Be Delivered During Invasive Mechanical Ventilation?
Dhand, R. (2017) · Respiratory Care · doi:10.4187/respcare.05803 · Cited by 70 · see citing works
Molecular quantitation of thymic output in mice and the effect of IL-7
Pido-Lopez, J., Imami, N., Andrew, D., & Aspinall, R. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(2002010)32:10 · Cited by 56 · see citing works
Zou, Y., Chen, X., Xiao, J., Zhou, D. B., Lu, X. X., Li, W., Xie, B., Kuang, X., & Chen, Q. (2018) · Oncotarget · doi:10.18632/oncotarget.24022 · Cited by 56 · see citing works
Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury
Wygrecka, M., Kosanovic, D., Wujak, L. A., Reppe, K., Henneke, I., Frey, H., Didiášová, M., Kwapiszewska, G., Marsh, L. M., Baal, N., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201604-0712oc · Cited by 48 · see citing works
Mao, Y., Lin, W., Wen, J., & Chen, G. (2020) · medRxiv · doi:10.1101/2020.02.20.20025601 · Cited by 39 · see citing works
Zhao, Z., Xie, J., Yin, M., Yang, Y., He, H., Jin, T., Li, W., Zhu, X., Xu, J., Zhao, C., et al. (2020) · medRxiv · doi:10.1101/2020.03.01.20029785 · Cited by 37 · see citing works
Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin DPreprint
Hu, J., Liu, X., Zhao, J.-X., Xia, S., Ruan, J., Luo, X., Kim, J., Lieberman, J., & Wu, H. (2018) · bioRxiv · doi:10.1101/365908 · Cited by 34 · see citing works
Dinarello, C. A. (2009) · Mayo Clinic Proceedings · doi:10.4065/84.2.105 · Cited by 23 · see citing works
Lefrançais, E., & Looney, M. R. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0095ed · Cited by 20 · see citing works
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Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Schulte-Schrepping, J., Reusch, N., Paclik, D., Baßler, K., Schlickeiser, S., Zhang, B., Krämer, B., Krammer, T., Brumhard, S., Bonaguro, L., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.001 · Cited by 1,461 · see citing works
Immunology of COVID-19: Current State of the Science
Vabret, N., Britton, G. J., Gruber, C., Hegde, S., Kim, J., Kuksin, M., Levantovsky, R., Malle, L., Moreira, A., Park, M. D., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.002 · Cited by 1,623 · see citing works
Neutrophil extracellular traps in COVID-19
Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J. A., Blair, C., Weber, A. G., Barnes, B. J., Egeblad, M., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138999 · Cited by 1,602 · see citing works
Self-citationMiddleton, E. A., He, X., Denorme, F., Campbell, R. A., Ng, D. C., Salvatore, S., Mostyka, M., Baxter-Stoltzfus, A., Borczuk, A., Loda, M. F., et al. (2020) · Blood · doi:10.1182/blood.2020007008 · Cited by 1,482 · see citing works
Self-citationSex differences in immune responses that underlie COVID-19 disease outcomes
Takahashi, T., Ellingson, M. K., Wong, P., Israelow, B., Lucas, C., Klein, J., Silva, J., Mao, T., Oh, J. E., Tokuyama, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2700-3 · Cited by 1,459 · see citing works
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
Bonaventura, A., Vecchié, A., Dagna, L., Martinod, K., Dixon, D. L., Tassell, B. W. V., Dentali, F., Montecucco, F., Maßberg, S., Levi, M. M., et al. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00536-9 · Cited by 1,010 · see citing works
COVID-19 is, in the end, an endothelial disease
Libby, P., & Lüscher, T. F. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa623 · Cited by 960 · see citing works
A dynamic COVID-19 immune signature includes associations with poor prognosis
Laing, A. G., Lorenc, A., del Molino del Barrio, I., Das, A., Fish, M., Monin, L., Muñoz-Ruiz, M., McKenzie, D. R., Hayday, T. S., Francos-Quijorna, I., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1038-6 · Cited by 946 · see citing works
Ferroptosis in infection, inflammation, and immunity
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 828 · see citing works
Skendros, P., Mitsios, A., Chrysanthopoulou, A., Mastellos, D. C., Metallidis, S., Rafailidis, P., Ntinopoulou, M., Sertaridou, E., Tsironidou, V., Tsigalou, C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci141374 · Cited by 786 · see citing works
Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment
Soy, M., Keser, G., Atagündüz, P., Tabak, F., Atagündüz, I., & Kayhan, S. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05190-5 · Cited by 821 · see citing works
Wang, J., Jiang, M., Chen, X., & Montaner, L. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3covr0520-272r · Cited by 730 · see citing works
The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management
Abou-Ismail, M. Y., Diamond, A., Kapoor, S., Arafah, Y., & Nayak, L. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.06.029 · Cited by 694 · see citing works
COVID-19 update: Covid-19-associated coagulopathy
Becker, R. C. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02134-3 · Cited by 698 · see citing works
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19
Zuo, Y., Estes, S. K., Ali, R. A., Gandhi, A. A., Yalavarthi, S., Shi, H., Sule, G. J., Gockman, K., Madison, J. A., Zuo, M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abd3876 · Cited by 658 · see citing works
Self-citationLarge-Scale Multi-omic Analysis of COVID-19 Severity
Overmyer, K. A., Shishkova, E., Miller, I. J., Balnis, J., Bernstein, M. N., Peters-Clarke, T. M., Meyer, J. G., Quan, Q., Muehlbauer, L. K., Trujillo, E. A., et al. (2020) · Cell Systems · doi:10.1016/j.cels.2020.10.003 · Cited by 584 · see citing works
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
Perico, L., Benigni, A., Casiraghi, F., Ng, L. F. P., Rénia, L., & Remuzzi, G. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00357-4 · Cited by 603 · see citing works
Tissue damage from neutrophil-induced oxidative stress in COVID-19
Laforge, M., Elbim, C., Frère, C., Hémadi, M., Massaad, C., Nuss, P., Benoliel, J. J., & Becker, C. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0407-1 · Cited by 587 · see citing works
NETosis: Molecular Mechanisms, Role in Physiology and Pathology
Vorobjeva, N. V., & Chernyak, B. V. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920100065 · Cited by 559 · see citing works
Neutrophil extracellular traps in homeostasis and disease
Wang, H., Kim, S. J., Yu, L., Wang, S., Wang, H., Huang, H., Zhang, H., & Tsung, A. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01933-x · Cited by 579 · see citing works
Coagulopathy of Coronavirus Disease 2019
Iba, T., Levy, J. H., Levi, M. M., Connors, J. M., & Thachil, J. V. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004458 · Cited by 537 · see citing works
Immunopathology of Hyperinflammation in COVID-19
Gustine, J. N., & Jones, D. (2021) · The American Journal of Pathology · doi:10.1016/j.ajpath.2020.08.009 · Cited by 516 · see citing works
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
Osuchowski, M., Winkler, M., Skirecki, T., Cajander, S., Shankar-Hari, M., Lachmann, G., Monneret, G., Venet, F., Bauer, M., Brunkhorst, F., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00218-6 · Cited by 396 · see citing works
Montopoli, M., Zumerle, S., Vettor, R., Rugge, M., Zorzi, M., Catapano, C. V., Carbone, G. M., Cavalli, A., Pagano, F. C., Ragazzi, E., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.04.479 · Cited by 516 · see citing works
Schurink, B., Roos, E., Radonic, T. R., Barbé, E., Bouman, C. S. C., de Boer, H. H., de Bree, G. J., Bulle, E., Aronica, E., Florquin, S., et al. (2020) · The Lancet Microbe · doi:10.1016/s2666-5247(20)30144-0 · Cited by 505 · see citing works
Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19
Zaid, Y., Puhm, F., Allaeys, I., Naya, A., Oudghiri, M., Khalki, L., Limami, Y., Zaïd, N., Sadki, K., Haj, R. B. E., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317703 · Cited by 499 · see citing works
The SARS-CoV-2 as an instrumental trigger of autoimmunity
Dotan, A., Muller, S., Kanduc, D., David, P., Halpert, G., & Shoenfeld, Y. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102792 · Cited by 503 · see citing works
New-onset IgG autoantibodies in hospitalized patients with COVID-19
Chang, S. E., Feng, A., Meng, W., Apostolidis, S. A., Mack, E., Artandi, M. K., Barman, L., Bennett, K., Chakraborty, S., Chang, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25509-3 · Cited by 488 · see citing works
COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
Borczuk, A. C., Salvatore, S. P., Seshan, S. V., Patel, S. S., Bussel, J. B., Mostyka, M., Elsoukkary, S., He, B., Del Vecchio, C., Fortarezza, F., et al. (2020) · Modern Pathology · doi:10.1038/s41379-020-00661-1 · Cited by 452 · see citing works
Self-citationZhang, Y., Chandra, V., Riquelme, E. M., Dutta, P., Quesada, P. R., Rakoski, A. I., Zoltan, M. A., Arora, N., Baydogan, S., Horne, W. T., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190354 · Cited by 446 · see citing works
Self-citationSpecialized pro-resolving mediator network: an update on production and actions
Chiang, N., & Serhan, C. N. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200018 · Cited by 441 · see citing works
Neutrophil extracellular traps: from physiology to pathology
Hidalgo, A., Libby, P., Soehnlein, O., Aramburu, I. V., Papayannopoulos, V., & Silvestre-Roig, C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab329 · Cited by 404 · see citing works
COVID-19: A Multidisciplinary Review
Chams, N., Chams, S., Badran, R., Shams, A., Araji, A., Raad, M., Mukhopadhyay, S., Stroberg, E., Duval, E. J., Barton, L. M., et al. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00383 · Cited by 401 · see citing works
The complement system in COVID-19: friend and foe?
Java, A., Apicelli, A. J., Liszewski, M. K., Coler-Reilly, A. L. G., Atkinson, J. P., Kim, A. H. J., & Kulkarni, H. S. (2020) · JCI Insight · doi:10.1172/jci.insight.140711 · Cited by 387 · see citing works
scCODA is a Bayesian model for compositional single-cell data analysis
Büttner, M., Ostner, J., Müller, C. L., Theis, F. J., & Schubert, B. (2021) · Nature Communications · doi:10.1038/s41467-021-27150-6 · Cited by 388 · see citing works
Radermecker, C., Detrembleur, N., Guiot, J., Cavalier, E., Henket, M. A., D'Emal, C., Vanwinge, C., Cataldo, D. D., Oury, C., Delvenne, P., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201012 · Cited by 343 · see citing works
Wauters, E., Mol, P. V., Garg, A. D., Jansen, S., Herck, Y. V., Vanderbeke, L., Bassez, A., Boeckx, B., Malengier‐Devlies, B., Timmerman, A., et al. (2021) · Cell Research · doi:10.1038/s41422-020-00455-9 · Cited by 339 · see citing works
IL-6: Relevance for immunopathology of SARS-CoV-2
Gubernatorova, E. O., Gorshkova, E. A., Polinova, A. I., & Drutskaya, M. S. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.05.009 · Cited by 340 · see citing works
Neutrophil phenotypes and functions in cancer: A consensus statement
Quail, D. F., Amulic, B., Aziz, M., Barnes, B. J., Eruslanov, E. B., Fridlender, Z. G., Goodridge, H. S., Granot, Z., Hidalgo, A., Anna Huttenlocher, A., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20220011 · Cited by 336 · see citing works
Self-citationAdrover, J. M., McDowell, S. A. C., He, X., Quail, D. F., & Egeblad, M. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.001 · Cited by 349 · see citing works
Self-citationZhang, H., Liu, J., Zhou, Y., Qu, M., Wang, Y., Guo, K., Shen, R., Sun, Z., Cata, J. P., Yang, S., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.69141 · Cited by 340 · see citing works
Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians
Batah, S. S., & Fabro, A. T. (2021) · Respiratory Medicine · doi:10.1016/j.rmed.2020.106239 · Cited by 319 · see citing works
Calabrese, F., Pezzuto, F., Fortarezza, F., Hofman, P. M., Kern, I., Panizo, Á., von der Thüsen, J. H., Timofeev, S., Gorkiewicz, G., & Lunardi, F. (2020) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-020-02886-6 · Cited by 304 · see citing works
Patients with COVID-19: in the dark-NETs of neutrophils
Ackermann, M., Anders, H., Bilyy, R. O., Bowlin, G. L., Daniel, C., LORENZO, R. D., Egeblad, M., Henneck, T., Hidalgo, A., Hoffmann, M. H., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00805-z · Cited by 307 · see citing works
Self-citationThe state of complement in COVID-19
Afzali, B., Noris, M., Lambrecht, B. N., & Kemper, C. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00665-1 · Cited by 290 · see citing works
Gorog, D. A., Storey, R. F., Gurbel, P. A., Tantry, U. S., Berger, J. S., Chan, M. Y., Duerschmied, D., Smyth, S. S., Parker, W. A., Ajjan, R., et al. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00665-7 · Cited by 286 · see citing works
Hoepel, W., Chen, H., Geyer, C. E., Allahverdiyeva, S., Manz, X. D., de Taeye, S. W., Aman, J., Mes, L., Steenhuis, M., Griffith, G. R., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf8654 · Cited by 276 · see citing works
COVID–19-associated coagulopathy: An exploration of mechanisms
Colling, M. E., & Kanthi, Y. M. (2020) · Vascular Medicine · doi:10.1177/1358863x20932640 · Cited by 276 · see citing works
Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19
Wang, J., Li, Q., Yin, Y., Zhang, Y., Cao, Y., Lin, X., Huang, L., Hoffmann, D. E., Lu, M., & Qiu, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02063 · Cited by 273 · see citing works
The immune system and COVID-19: Friend or foe?
Yazdanpanah, F., Hamblin, M. R., & Rezaei, N. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117900 · Cited by 272 · see citing works
Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease
Berretta, A. A., Silveira, M. A. D., Capcha, J. M. C., & JONG, D. D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110622 · Cited by 281 · see citing works
Neutrophil extracellular traps and thrombosis in COVID-19
Zuo, Y., Zuo, M., Yalavarthi, S., Gockman, K., Madison, J. A., Shi, H., Woodard, W., Lezak, S. P., Lugogo, N. L., Knight, J. S., et al. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02324-z · Cited by 268 · see citing works
Self-citationNeutrophils and Neutrophil Extracellular Traps Drive Necroinflammation in COVID-19
Tomar, B., Anders, H., Desai, J., & Mulay, S. R. (2020) · Cells · doi:10.3390/cells9061383 · Cited by 263 · see citing works
Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression
Bohn, M. K., Hall, A., Sepiashvili, L., Jung, B., Steele, S., & Adeli, K. (2020) · Physiology · doi:10.1152/physiol.00019.2020 · Cited by 259 · see citing works
Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation
Mandel, J., Casari, M., Stepanyan, M. G., Martyanov, A. A., & Deppermann, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073868 · Cited by 267 · see citing works
Neutrophil diversity and function in health and disease
Zhang, F., Xia, Y., Su, J., Quan, F., Zhou, H., Li, Q., Feng, Q., Lin, C., Wang, D., & Jiang, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02049-y · Cited by 283 · see citing works
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19
Sinha, S., Rosin, N. L., Arora, R., Labit, E., Jaffer, A., Cao, L., Farias, R., Nguyen, A., de Almeida, L. G. N., Dufour, A., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01576-3 · Cited by 247 · see citing works
The Roles of Neutrophil-Derived Myeloperoxidase (MPO) in Diseases: The New Progress
Lin, W. C., Chen, H., Chen, X., & Guo, C. (2024) · Antioxidants · doi:10.3390/antiox13010132 · Cited by 254 · see citing works
Systematic investigation of cytokine signaling activity at the tissue and single-cell levels
Jiang, P., Zhang, Y., Ru, B., Yang, Y.-A., Vu, T., Paul, R., Mirza, A. M., Altan-Bonnet, G. Y., Liu, L., Ruppin, E., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01274-5 · Cited by 243 · see citing works
Reusch, N., Domenico, E. D., Bonaguro, L., Schulte-Schrepping, J., Bassler, K. E., Schultze, J. L., & Aschenbrenner, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.652470 · Cited by 251 · see citing works
Borges, L., Pithon-Curi, T. C., Curi, R., & Hatanaka, E. (2020) · Mediators of Inflammation · doi:10.1155/2020/8829674 · Cited by 235 · see citing works
Vanderbeke, L., Van Mol, P., Van Herck, Y., De Smet, F., Humblet-Baron, S., Martinod, K., Antoranz, A., Arijs, I., Boeckx, B., Bosisio, F. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24360-w · Cited by 247 · see citing works
Facchetti, F., Bugatti, M., Drera, E., Tripodo, C., Sartori, E., Cancila, V., Papaccio, M., Castellani, R., Casola, S. S., Boniotti, M. B., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102951 · Cited by 247 · see citing works
Neutrophil extracellular traps in cancer
Cristinziano, L., Modestino, L., Antonelli, A., Marone, G., Simon, H., Varricchi, G., & Galdiero, M. R. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.011 · Cited by 247 · see citing works
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
Mann, E. R., Menon, M., Knight, S., Konkel, J. E., Jagger, C. P., Shaw, T. N., Krishnan, S., Rattray, M., Ustianowski, A., Bakerly, N. D., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abd6197 · Cited by 242 · see citing works
Arcanjo, A. F., Logullo, J., Menezes, C. C. B., Giangiarulo, T. C. D. S. C., dos Reis, M. C., de Castro, G. M. M., Fontes, Y. D. S., Todeschini, A. R., Freire‐de‐Lima, L., Decotè-Ricardo, D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76781-0 · Cited by 241 · see citing works
Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease
Klopf, J., Brostjan, C., Eilenberg, W. H., & Neumayer, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020559 · Cited by 237 · see citing works
Zuo, Y., Warnock, M., Harbaugh, A., Yalavarthi, S., Gockman, K., Zuo, M., Madison, J. A., Knight, J. S., Kanthi, Y. M., & Lawrence, D. A. (2021) · Scientific Reports · doi:10.1038/s41598-020-80010-z · Cited by 234 · see citing works
Self-citationGM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches
Lang, F. M., Lee, M.-C., Teijaro, J. R., Becher, B., & Hamilton, J. A. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0357-7 · Cited by 232 · see citing works
Understanding the role of neutrophils in acute respiratory distress syndrome
Yang, S.-C., Tsai, Y.-F., Pan, Y.-L., & Hwang, T. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.09.001 · Cited by 234 · see citing works
Drury, B., Hardisty, G. R., Gray, R. D., & Ho, G. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.03.002 · Cited by 222 · see citing works
The role of neutrophil extracellular traps in acute lung injury
Scozzi, D., Liao, F., Krupnick, A. S., Kreisel, D., & Gelman, A. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953195 · Cited by 220 · see citing works
Schönrich, G., Raftery, M. J., & Samstag, Y. (2020) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100741 · Cited by 221 · see citing works
Wilk, A. J., Lee, M. J., Wei, B., Parks, B. E., Pi, R., Martínez-Colón, G. J., Ranganath, T., Zhao, N. Q., Taylor, S., Becker, W. R., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210582 · Cited by 208 · see citing works
Phenotypes and personalized medicine in the acute respiratory distress syndrome
Matthay, M. A., Arabi, Y. M., Siegel, E. R., Ware, L. B., Bos, L. D. J., Sinha, P., Beitler, J. R., Wick, K. D., Curley, M. A. Q., Constantin, J., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06296-9 · Cited by 216 · see citing works
The immune response to SARS-CoV-2 and COVID-19 immunopathology – Current perspectives
Boechat, J. L., Chora, I., Morais, A., & Delgado, L. (2021) · Pulmonology · doi:10.1016/j.pulmoe.2021.03.008 · Cited by 214 · see citing works
Golden, J. W., Cline, C. R., Zeng, X., Garrison, A. R., Carey, B. D., Mucker, E. M., White, L. E., Shamblin, J. D., Brocato, R. L., Liu, J., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.142032 · Cited by 195 · see citing works
Polidoro, R. B., Hagan, R. S., Santiago, R. R. D. S., & Schmidt, N. W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01626 · Cited by 202 · see citing works
Platelets contribute to disease severity in COVID‐19
Barrett, T. J., Bilaloglu, S., Cornwell, M., Burgess, H. M., Virginio, V. W., Drenkova, K., Ibrahim, H., Yuriditsky, E., Aphinyanaphongs, Y., Lifshitz, M. S., et al. (2021) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15534 · Cited by 203 · see citing works
Deep insight into cytokine storm: from pathogenesis to treatment
Nie, J., Zhou, L., Tian, W., Liu, X., Yang, L., Yang, X., Zhang, Y., Wei, S., Wang, D. W., & Wei, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02178-y · Cited by 224 · see citing works
Wong, L.-Y. R., & Perlman, S. M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00656-2 · Cited by 196 · see citing works
Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality
Al-Kuraishy, H. M., Al-Gareeb, A. I., Al-Hussaniy, H. A., Al-Harcan, N. A. H., Alexiou, A. T., & Batiha, G. E. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108516 · Cited by 189 · see citing works
Mackman, N., Antoniak, S., Wolberg, A. S., Kasthuri, R. S., & Key, N. S. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314514 · Cited by 186 · see citing works
Carissimo, G., Xu, W., Kwok, I., Abdad, M. Y., Chan, Y., Fong, S., Puan, K. J., Lee, C. Y., Yeo, N. K., Amrun, S. N., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19080-6 · Cited by 178 · see citing works
I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People
Pietrobon, A. J., Teixeira, F. M. E., & Sato, M. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579220 · Cited by 185 · see citing works
Thrombosis and COVID-19 pneumonia: the clot thickens!
Price, L., McCabe, C., Garfield, B., & Wort, S. J. (2020) · European Respiratory Journal · doi:10.1183/13993003.01608-2020 · Cited by 183 · see citing works
Mohanty, S. K., Satapathy, A., Naidu, M. M., Mukhopadhyay, S., Sharma, S., Barton, L. M., Stroberg, E., Duval, E. J., Pradhan, D., Tzankov, A., et al. (2020) · Diagnostic Pathology · doi:10.1186/s13000-020-01017-8 · Cited by 184 · see citing works
Roles of neutrophil granule proteins in orchestrating inflammation and immunity
Othman, A., Sekheri, M., & Filep, J. G. (2021) · FEBS Journal · doi:10.1111/febs.15803 · Cited by 184 · see citing works
COVID-19 and Respiratory System Disorders
Brosnahan, S. B., Jonkman, A. H., Kugler, M. C., Munger, J. S., & Kaufman, D. A. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314515 · Cited by 179 · see citing works
Ortega‐Paz, L., Capodanno, D., Montalescot, G., & Angiolillo, D. J. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.019650 · Cited by 177 · see citing works
Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology
Cleary, S. J., Pitchford, S. C., Amison, R. T., Carrington, R., Cabrera, C. L. R., Magnen, M., Looney, M. R., Gray, E., & Page, C. P. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15143 · Cited by 169 · see citing works
Self-citationLu, L., Zhong, W., Bian, Z., Li, Z., Zhang, K., Liang, B., Zhong, Y., Hu, M., Lin, L., Liu, J., et al. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.07.002 · Cited by 171 · see citing works
NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond
Zhu, Y., Chen, X., & Liu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.838011 · Cited by 173 · see citing works
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Lopes‐Pacheco, M., Silva, P. L., Cruz, F. F., Battaglini, D., Robba, C., Pelosi, P. P., Morales, M. M., Neves, C. C., & Rocco, P. R. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.593223 · Cited by 171 · see citing works
Sokołowska, M., Łukasik, Z. M., Agache, I. O., Akdiş, C. A., Akdiş, D., Akdiş, M., Barcik, W., Brough, H. A., Eiwegger, T., Eljaszewicz, A., et al. (2020) · Allergy · doi:10.1111/all.14462 · Cited by 169 · see citing works
Treatment of Acute Ischemic Stroke due to Large Vessel Occlusion With COVID-19
Escalard, S., Maïer, B., Redjem, H., Delvoye, F., Hébert, S., Smajda, S., Cicciò, G., Désilles, J., Mazighi, M., Blanc, R., et al. (2020) · Stroke · doi:10.1161/strokeaha.120.030574 · Cited by 168 · see citing works
Platelets Promote Thromboinflammation in SARS-CoV-2 Pneumonia
Taus, F., Salvagno, G. L., Canè, S., Fava, C., Mazzaferri, F., Carrara, E., Petrova, V., Barouni, R. M., Dima, F., Dalbeni, A., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315175 · Cited by 167 · see citing works
Neutrophils and COVID-19: The road so far
Silva, L. H. A. C., Carvalho, D. C. M., Lima, É. D. A., Galvão, J. G. F. M., da Silva, J. S. D. F., de Sales-Neto, J. M., & Rodrigues‐Mascarenhas, S. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107233 · Cited by 166 · see citing works
Cesta, M. C., Zippoli, M., Marsiglia, C., Gavioli, E. M., Mantelli, F., Allegretti, M., & BALK, R. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.808797 · Cited by 167 · see citing works
- Authors
- Barnes, B. J., Adrover, J. M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J. M., Daßler-Plenker, J., Guerci, P., Huynh, C., Knight, J. S., Loda, M., Looney, M. R., McAllister, F., Rayes, R., Renaud, S., Rousseau, S., Salvatore, S., Schwartz, R. E., Spicer, J. D., Yost, C. C., Weber, A., Zuo, Y., & Egeblad, M.
- Affiliations
- Feinstein Institute for Medical Research (US)
- Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 2
- Weill Cornell Medicine (US)
- Division of Thoracic and Upper GI Surgery, Department of Surgery, Montreal, Canada 4
- Hofstra University (US)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- McGill University (CA)
- University of Michigan (US)
- University of California, San Francisco (US)
- The University of Texas MD Anderson Cancer Center (US)
- Centre Hospitalier Universitaire de Nancy, Nancy, France 6
- Research Institute of the McGill University Health Centre (CA)
- University of Utah (US)
- Northwell Health (US)
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Barnes, Betsy J.
- Egeblad, Mikala
- ORCID
- Barnes, Betsy J.
- Baxter-Stoltzfus, Amelia
- Borczuk, Alain
- Crawford, James M.
- Guerci, Philippe
- Huynh, Caroline
- Knight, Jason S.
- Loda, Massimo
- Looney, Mark R.
- McAllister, Florencia
- Rayes, Roni
- Rousseau, Simon
- Salvatore, Steven
- Schwartz, Robert E.
- Spicer, Jonathan D.
- Yost, Christian C.
- Weber, Andrew
- Zuo, Yu
- Egeblad, Mikala
- Venue
- Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2020-04-16
- Volume
- 217
- Issue
- 6
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC7161085
- OpenAlex
- W3016393661
- Cited by
- 1,486
- References
- 84
- Citations by year
- 2026: 34 · 2025: 70 · 2024: 124 · 2023: 150 · 2022: 288 · 2021: 438 · 2020: 378 · 2014: 1 · 2012: 1
- FWCI
- 110.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Experimental Medicine (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- eScholarship@McGill (McGill) (submittedVersion)
- Funders
- National Institutes of Health (5p30ca045508-35)
- National Heart, Lung, and Blood Institute (R01HL130324, R01HL134846)
- National Cancer Institute (P30-CA045508)
- National Institute of Allergy and Infectious Diseases (R01AI125445)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK121072)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR076242)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD093826)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- COVID-19 pandemic, neutrophil extracellular traps, neutrophils, acute respiratory distress syndrome, cytokine storm, lung infiltration, organ damage, thrombosis, airway mucus secretion, targeted drug delivery, autopsy findings
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Humans, Lung Diseases, Neutrophils, Pneumonia, Viral, Cytokines, Coronavirus Infections, Pandemics, Extracellular Traps
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