The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Proinflammatory IgG Fc structures in patients with severe COVID-19
Open accessPublished version of a preprint
Abstract
Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“On the other hand, antibodies promoting inflammatory responses may contribute to a cytokine storm resulting in severe disease32,33.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [32]
In the citing paper
“However, the potential role of IgG with reduced Fc fucosylation and enhanced binding to FcγRIII in the development of severe COVID-19 suggests that the quality of antibodies induced by vaccination may also be important in minimizing the risk of ADE32,33.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [32]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897
Presumed Asymptomatic Carrier Transmission of COVID-19
Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D., Chen, L., & Wang, M. (2020) · JAMA · doi:10.1001/jama.2020.2565 · Cited by 4,496
Epidemiology of COVID-19 Among Children in China
Dong, Y., Mo, X., Hu, Y., Qi, X., Jiang, F., Jiang, Z., & Tong, S. (2020) · PEDIATRICS · doi:10.1542/peds.2020-0702 · Cited by 4,240
Bi, Q., Wu, Y., Mei, S., Ye, C., Zou, X., Zhang, Z., Liu, X., Wei, L., Truelove, S., Zhang, T., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30287-5 · Cited by 1,960
A single-cell atlas of the peripheral immune response in patients with severe COVID-19
Wilk, A. J., Rustagi, A., Zhao, N. Q., Roque, J., Martínez-Colón, G. J., McKechnie, J. L., Ivison, G. T., Ranganath, T., Vergara, R., Hollis, T., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0944-y · Cited by 1,493
Self-citationA highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Yuan, M., Wu, N. C., Zhu, X., Lee, C.-C. D., So, R. T. Y., Lv, H., Mok, C. K. P., & Wilson, I. A. (2020) · Science · doi:10.1126/science.abb7269 · Cited by 1,429
Hu, Z., Song, C., Xu, C., Jin, G., Chen, Y., Xu, X., Ma, H., Chen, W., Lin, Y., Zheng, Y., et al. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1661-4 · Cited by 1,429
Xu, Y., Li, X., Zhu, B., Liang, H., Fang, C., Gong, Y., Guo, Q., Sun, X., Zhao, D., Shen, J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0817-4 · Cited by 1,415
Antibody-dependent enhancement of severe dengue disease in humans
Katzelnick, L. C., Gresh, L., Halloran, M. E., Mercado, J. C., Kuan, G. M., Gordon, A. L., Balmaseda, Á., & Harris, E. (2017) · Science · doi:10.1126/science.aan6836 · Cited by 1,202
Research works printed but not linked: 1
- Bournazos, S., Wang, T. T. & Ravetch, J. V. In Myeloid Cells in Health and Disease: A Synthesis (Ed. Gordon, S.) Ch. 22 (ASM Press, 2016).
Cited by
Sorted by citations
Items 201–300 of 320
Asymmetrically glycosylated IgG1 antibodies are universal and drive human disease
Azzam, T., Bournazos, S., Gunduz, H., Adams, T. M., Flowers, M. W., Niejadlik, E. G., Duong, V., Brown, T. J., Roberts, A. M., Sastre, D. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67070-3 · Cited by 7
Vanderven, H. A., & Kent, S. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1307398 · Cited by 6
Manh, T. V., Gouin, C., Wolf, J. D., Jouneau, L., Pascale, F., Bevilacqua, C., Gouilh, M. A., da Costa, B. R., Chevalier, C., Glorion, M., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05322-z · Cited by 6
Lovison, O. V. A., Volpato, F. C. Z., Weber, L. G., Barth, A. L., Coitinho, A. S., & Martins, A. F. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1531084 · Cited by 6
Overview of Memory NK Cells in Viral Infections: Possible Role in SARS-CoV-2 Infection
Sanctis, J. B. D., Garmendia, J. V., & Hajdúch, M. (2022) · Immuno · doi:10.3390/immuno2010005 · Cited by 6
Proteomics Investigation of Diverse Serological Patterns in COVID-19
Liang, X., Sun, R., Wang, J., Zhou, K., Li, J., Chen, S., Lyu, M., Li, S., Xue, Z., Shi, Y., et al. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100493 · Cited by 6
The sweet side of sex as a biological variable
Hunter, C. D., Morris, K. M., Derksen, T., & Willis, L. M. (2023) · Glycobiology · doi:10.1093/glycob/cwad030 · Cited by 6
Long, F., Xiao, C., Cui, H., Wang, W., Jiang, Z., Tang, M., Zhang, W., Liu, Y., Xiang, R., Zhang, L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1217444 · Cited by 6
Fernández‐Soto, D., Bueno, P., Garaigorta, U., Gastaminza, P., Bueno, J. L., Duarte, R. F., Jara‐Acevedo, R., Valés‐Gómez, M., & Reyburn, H. T. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae017 · Cited by 6
IgG1 glycosylation highlights premature aging in Down syndrome
Streng, B. M. M., Coillie, J. V., Wildenbeest, J., van Binnendijk, R. S., Smits, G. P., den Hartog, G., Wang, W., Nouta, J., Linty, F., Visser, R., et al. (2024) · Aging Cell · doi:10.1111/acel.14167 · Cited by 7
Gelderloos, A. T., Lakerveld, A. J., Schepp, R. M., Nicolaie, M. A., van Beek, J., Beckers, L., van Binnendijk, R. S., Rots, N. Y., & van Kasteren, P. B. (2024) · Clinical & Translational Immunology · doi:10.1002/cti2.1521 · Cited by 6
Johnson, M., Stockdale, L. K., de Haan, N., Wuhrer, M., Nouta, J., Koeleman, C. A. M., Clarke, J., Marinou, S., Shakya, M., Colin-Jones, R., et al. (2021) · Frontiers in Tropical Diseases · doi:10.3389/fitd.2021.742804 · Cited by 5
Fontes, J. L. M., Mesquita, B. R., Brito, R., Gomes, J. C. S., de Melo, C. V. B., & dos‐Santos, W. L. C. (2021) · Pathogens · doi:10.3390/pathogens10121635 · Cited by 5
Hansur, L., Louisa, M., Wuyung, P. E., & Fadilah, F. (2022) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2022.7961 · Cited by 5
Zhou, Y., Jönsson, A., Sticker, D., Zhou, G., Yuan, Z., Kutter, J. P., & Emmer, Å. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04498-2 · Cited by 5
Dhawan, M. K., Thakur, N., Sharma, M. K., & Rabaan, A. A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117936 · Cited by 5
Huang, R. Y., Lee, C. N., & Moochhala, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.709562 · Cited by 5
Jentzer, A., Dalliere, C. C., Lozano, C., Rivière, S., Darmon, O., Ayrignac, X., Labauge, P. M., & Vincent, T. (2022) · Journal of Neurology · doi:10.1007/s00415-022-10972-9 · Cited by 5
Wasiluk, T., Sredzinska, M., Rogowska, A., Zebrowska, A., Boczkowska‐Radziwon, B., Stasiak‐Barmuta, A., & Radziwon, P. (2022) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2022.103527 · Cited by 5
Whole Exome Sequencing in Vaccine‐Induced Thrombotic Thrombocytopenia (VITT)
Giusti, B., Sticchi, E., Capezzuoli, T., Orsi, R., Squillantini, L., Giannini, M., Suraci, S., Rogolino, A. A., Cesari, F., Berteotti, M., et al. (2024) · BioMed Research International · doi:10.1155/2024/2860547 · Cited by 4
Soye, B. J. D., Melani, R. D., Hollas, M. A. R., Duan, J., Patrie, S. M., Fisher, T. D., Mattamana, B. B., Daud, A., Pinelli, D. F., Ladner, D. P., et al. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00285 · Cited by 4
Immunoglobulin G N-Glycome as a biomarker of mortality risk in Escherichia coli induced sepsis
Wang, H., Li, H., Guo, Z., Hou, H., Hou, H., & Chen, B. Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1532145 · Cited by 4
Sun, S., Hao, J., Yu, C., Liu, H., Guan, Q., Wang, Y., Wang, J., Wang, X., Zhang, M., Zan, X., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07236-1 · Cited by 4
Zhang, J., Li, C., Wu, Y., Wang, L., Yu, J., Wang, A., Kong, W., Ning, M., Chen, J. M., & Chen, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1772257 · Cited by 4
Ravetch, J. V., & Bournazos, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95895-0.00005-2 · Cited by 4
Bermejo‐Jambrina, M., van der Donk, L. E. H., van Hamme, J. L., Wilflingseder, D., de Bree, G. J., Prins, M., de Jong, M. D., Nieuwkerk, P. T., van Gils, M. J., Kootstra, N. A., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00061-0 · Cited by 4
Longitudinal Analysis of Biologic Correlates of COVID-19 Resolution: Case Report
Bruiners, N., Guerrini, V., Ukey, R., Dikdan, R. J., Yang, J. H., Mishra, P. K., Onyuka, A., Handler, D., Vieth, J. A., Carayannopoulos, M. O., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.915367 · Cited by 4
Protective and pathogenic role of humoral responses in COVID-19
Park, U., & Cho, N. (2022) · The Journal of Microbiology · doi:10.1007/s12275-022-2037-8 · Cited by 4
Yang, K., Liu, J., Gong, Y., Li, Y., & Liu, Q. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1052850 · Cited by 4
Immunoglobulin G Glycosylation in Diseases
Pezer, M. (2021) · Experientia supplementum · doi:10.1007/978-3-030-76912-3_13 · Cited by 4
SARS-CoV-2-Specific Antibody Profiles Distinguish Patients with Moderate from Severe COVID-19Preprint
de Campos‐Mata, L., Piñero, J., Vaquero, S. T., Tachó‐Piñot, R., Kuksin, M., Arrieta‐Aldea, I., Melero, N. R., Carolis, C., Furlong, L. I., Cerutti, A., et al. (2020) · medRxiv · doi:10.1101/2020.12.18.20248461 · Cited by 4
Pan, N., Cao, P., Chen, B., Chen, L., Liao, X., & Ning, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13092133 · Cited by 3
Chen, Z., Xu, X., Song, M., & Lin, L. (2024) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2024.0176 · Cited by 3
Inflammasome-Driven Fatal Acute-on-Chronic Liver Failure Triggered by Mild COVID-19
Chen, V. C.-W., Joseph, C. R., Chan, W. O. Y., Sia, W. R., Su, Q., Sam, X. X., Tamilarasan, H., Mah, Y. Y., Ng, W. L., Yeong, J. P.-S., et al. (2024) · Viruses · doi:10.3390/v16101646 · Cited by 3
Clinical relevance of serum α-l-fucosidase activity in the SARS-CoV-2 infection
Liang, E., Li, G., Wang, W.-G., Qiu, X., Ke, P., He, M. Y., & Huang, X. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.03.031 · Cited by 3
de Graaf, E. L., Larsen, M. D., van der Bolt, N., Visser, R., Verhagen, O. J. H. M., Ederveen, A. L. H., Koeleman, C. A. M., van der Schoot, C. E., Wuhrer, M., & Vidarsson, G. (2023) · Immunology · doi:10.1111/imm.13737 · Cited by 3
Bharadwaj, P., & Ackerman, M. E. (2021) · Experientia supplementum · doi:10.1007/978-3-030-76912-3_18 · Cited by 3
Shull, T. L., Bhimalli, P. P., Welninski, S. J., Cho, B.-K., Mattamana, B. B., Arivalagan, J., Tarhoni, I., Goo, Y. A., Schneider, J. A., Agrawal, S., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.03.031 · Cited by 2
Fucosylation of hemocyanin is critical for antibacterial immunity in Penaeus vannamei
Jiang, M., Liu, Y., Aweya, J. J., Liang, S., Zhou, J., Tayyab, M., Zhao, Y., Liu, Q., Zhang, Y., & Zheng, Z. (2025) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2025.110406 · Cited by 3
Wang, Y., Liu, N., Zou, Y., Jie, J., Liu, Z., & Zou, X. (2025) · Talanta · doi:10.1016/j.talanta.2025.128326 · Cited by 2
Meyer, J., Klarmann‐Schulz, U., Nadal, J., Parčina, M., Debrah, L. B., Osei-Mensah, J., Mensah, D. A., Ahiadorme, M., Opoku, V. S., Obeng, M. A., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1633187 · Cited by 2
Quantitative Targeted Analysis of Antibody Fc Glycosylation by Glyco-MRM
Ma, Y., Song, Y., Luo, J., Wang, J., Tang, Y., & Zhou, D. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c00560 · Cited by 2
IgG/IgM-coated gut microbiota in schizophrenia: associations with inflammation disease activity
Xu, G., Luo, R., Wu, Z., Liu, C., Liao, H., Wu, J., Li, Z., Wang, Y., Chen, X., Li, Y., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1689069 · Cited by 2
Semenova, A., Poor, T. A., Müller, J., Prakki, S. R. S., Geyer, P. E., Mück-Häusl, M., Grant, R. A., Rasmussen, L., Holdt, L. M., Teupser, D., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.203056 · Cited by 3
Impaired mucosal IgA response in patients with severe COVID-19
Yaugel-Novoa, M., Noailly, B., Jospin, F., Pizzorno, A., Traversier, A., Pozzetto, B., Waeckel, L., Longet, S., Pillet, S., Botelho-Nevers, É., et al. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2401940 · Cited by 3
Goh, Y. S., Fong, S., Hor, P. X., Amrun, S. N., Lee, C. Y., Young, B. E., Chia, P. Y., Tambyah, P. A., Kalimuddin, S., Pada, S., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1043049 · Cited by 2
Wang, J., Mai, X., He, Y., Zhu, C., & Zhou, D. (2023) · Vaccines · doi:10.3390/vaccines11040827 · Cited by 2
Multifaceted roles of Fcγ receptors in COVID-19 and vaccine responses.
Bouayad, A. (2023) · PubMed Central · Cited by 2
Rubio‐Casillas, A., Redwan, E. M. M. M., & Uversky, V. N. (2025) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2025.02.001 · Cited by 1
Peng, X., Han, Y., Xue, S., Zhou, Y., Jiang, W., Xia, A., Wu, W., Gao, Y., Wu, F., & Wang, Q. (2025) · Vaccines · doi:10.3390/vaccines13040425 · Cited by 2
FcγRIIIa is a noncanonical costimulatory molecule for CD8 T cells
Kao, K. S., Pihlstrom, N. L., Niejadlik, E. G., Cantaert, T., Ahmed, R., Ravetch, J. V., & Bournazos, S. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2509016122 · Cited by 2
Recent SARS-CoV-2 Outlook and Implications in a COVID-19 Vaccination Era
Ehianeta, T. S., Mzee, S. A. S., Kehinde, A. M., & Ehianeta, O. (2021) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000072 · Cited by 2
Tamizuddin, S., Cham, J., Ghiasi, Y., Borroto, L. A., Cao, C., Orendain, N., Quigley, M. M., Nicholson, L. J., & Pandey, A. C. (2022) · Future Science OA · doi:10.2144/fsoa-2021-0126 · Cited by 2
Illuminating the Fc dependence of SARS-CoV-2 neutralization
González, J. C., & Wang, T. T. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.024 · Cited by 2
Self-citationSARS-CoV-2 Immunity: Review of Immune Response to Infection and Vaccination
Ahmad, R. (2021) · Bangladesh Journal of Medical Science · doi:10.3329/bjms.v20i5.55398 · Cited by 2
Desheva, Y. A., Lerner, A. A., Shvedova, T. N., Kopteva, O. S., Kudar, P. A., Koroleva, I. V., Leontieva, G., & Suvorov, A. N. (2023) · Antibodies · doi:10.3390/antib12010019 · Cited by 2
Graham, J. (2021) · medRxiv · doi:10.1101/2021.03.06.21253058 · Cited by 2
Nziza, N., Jung, W., Chen, T., Deng, Y., Franken, K. L. M. C., Ottenhoff, T. H. M., Kiguli, S., Lewinsohn, D. A., Boom, W. H., Mayanja‐Kizza, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.21.665984 · Cited by 2
Can human IgG subclasses distinguish between confirmed and unconfirmed SARS-CoV-2 infections?
Bahgat, M. M., Nasraa, M. H., Nadeem, R., Amer, K., Hassan, W. A., El-Raouf, A. A., & Abd‐Elshafy, D. N. (2024) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2024.100399 · Cited by 1
Sherman, J. D., Karmali, V., Kumar, B., Simon, T. W., Bechnak, S., Panjwani, A., Ciric, C. R., Wang, D., Huerta, C., Johnson, B. E., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae626 · Cited by 1
Relevance of Antibody-Dependent Enhancement in COVID-19
Rodríguez‐Pinto, D., & Mendoza-Ruiz, M. S. (2025) · Immuno · doi:10.3390/immuno5020020 · Cited by 1
Siddik, A. B., Faisal, A., Khan, A. K. A., Alam, M., Nayeem, J., Kulsum, U., Mukta, S. A., Kawser, Z., Hasan, I., Azad, K., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318959 · Cited by 1
Zhou, Y., Weiss, S. S., Tan, C., Bittner, P., Harrison, J. A., Tjernberg, L. O., Emmer, Å., & Zenobi, R. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c03703 · Cited by 2
Anti‐SARS‐CoV‐2 Spike IgA2 Induces Inflammation by Human Macrophages
Mes, L., Veth, J., Coillie, J. V., Keijser, J. B. D., Mantel, E., van der Mast, R., Rispens, T., Vidarsson, G., van Egmond, M., den Dunnen, J., et al. (2025) · European Journal of Immunology · doi:10.1002/eji.70068 · Cited by 1
IgG binding characteristics of ferret Fcγ receptors
Ge, X., Stoner, M. R., Weiner, J. A., Hernández, M. E. B., Taher, N. M., Khanwalkar, U. S., Carpenter, M. C., Lee, J., & Ackerman, M. E. (2025) · mAbs · doi:10.1080/19420862.2025.2590248 · Cited by 1
Pedreño-López, N., Tarrés-Freixas, F., Usai, C., Regué, D. R., Benet, S., Ainsua‐Enrich, E., Carabelli, J., Pradenas, E., Ávila‐Nieto, C., Roca, N., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09034-3 · Cited by 1
Lakerveld, A. J., Wang, W., Schepp, R. M., Nouta, J., Gijze, S., Gelderloos, A. T., Rots, N. Y., van Binnendijk, R. S., Vidarsson, G., Wuhrer, M., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-01262-2 · Cited by 1
Advances in MS-based glycomics for biomedical research
Solomon, J., Sanni, A., Purba, W. T., Oluokun, O., Sahioun, S., Fowowe, M., Oluokun, A., Hussein, A., & Mechref, Y. S. (2025) · Analytical Methods · doi:10.1039/d5ay01169h · Cited by 1
Dončević, L., Friganović, T., Grbčić, P., Filipović, M., Borosak, I., Habazin, S., Lauc, G., Müller, E., & Josić, D. (2026) · Journal of Chromatography B · doi:10.1016/j.jchromb.2026.125107 · Cited by 1
A rapid and high-throughput biotechnology quantifies major glycoforms of human IgG1 mAb drugs
Matsumoto, Y., Zhou, L., Ohno, S., Lu, W., Biel, T. G., Fratz‐Berilla, E. J., Ortega‐Rodriguez, U., Houchens, T., Dean, A. Q., Kim, S.-R., et al. (2026) · Trends in biotechnology · doi:10.1016/j.tibtech.2026.07.004 · Cited by 1
Vinicki, M., Vučković, F., Bodulić, K., Markotić, A., Barušić, Z., Laškaj, R., Kurolt, I.-C., Zember, S., Čivljak, R., Puljiz, I., et al. (2026) · Viruses · doi:10.3390/v18090960 · Cited by 1
Defining resistance and tolerance traits in Covid-19: towards a stratified medicine approach
Russell, C. D., & Clohisey, S. (2022) · QJM · doi:10.1093/qjmed/hcac143 · Cited by 1
Benabdessalem, C., Marzouki, S., Hamouda, W. B., Trabelsi, K., Boumaiza, M., Hamouda, S. B., Ouni, R., Bchiri, S., Chaaban, A., Gdoura, M., et al. (2022) · medRxiv · doi:10.1101/2022.03.01.22271696 · Cited by 1
Antibody Responses In Non-Severe SARS-CoV-2 Infections Are Driven By CD4+ T cells and AgePreprint
Murrell, A. E., Eyoh, E., Shaffer, J. G., Dietrich, M. L., Trinh, I. V., Yockachonis, T. J., Bai, S., Zheng, C. Y., Mayne, C. V., Cabrera, S. E., et al. (2022) · medRxiv · doi:10.1101/2022.04.22.22274032 · Cited by 1
Human parainfluenza virus infection remodels the host cell glycomePreprint
Das, P. K., Dirr, L., Bailly, B., Guillon, P., Everest‐Dass, A., & von Itzstein, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.15.659808 · Cited by 1
Antibodies: Friends, Foes, or Both? Lessons From COVID-19 for the Rheumatologist
Rodriguez, M. A., Fuentes-Silva, Y., & Vásquez, G. (2021) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000001733
Goh, Y. S., Fong, S., Amrun, S. N., Lee, C. Y., Hor, P. X., Young, B. E., Chia, P. Y., Tambyah, P. A., Kalimuddin, S., Pada, S., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-432867/v1
McKenzie, S. E. (2021) · Blood · doi:10.1182/blood.2021013359
Olagunju, A. S., Teibo, J. O., Ad, O. A., Akinfe, O. A., & Olagoke, O. D. (2022) · Journal of Pharmacology and Toxicology · doi:10.3923/jpt.2022.50.57
Dzananovic, B., Williamson, M., Nwaigwe, C. I., & Routray, C. (2022) · World Journal of Clinical Infectious Diseases · doi:10.5495/wjcid.v12.i2.50
AlGannas, N. S., Alghamdi, A., Hazazi, A., Alqahtani, N. S., Alshareef, M. N., Ahmed, M. H., Omer, A. A. M., & AlShehah, A. A. (2022) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_1369_22
The Rationale Behind the Effectiveness of COVID-19 Vaccines and Associated Immunological Mechanisms
Khatib, S. E. (2022) · Turkish Journal of Immunology · doi:10.4274/tji.galenos.2022.55264
Thurner, L., & Kessel, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18566-3.00031-1
The Passing Pandemic? Perspective and Projections for COVID-19
Nikhra, V. (2022) · Annals of Immunology & Immunotherapy · doi:10.23880/aii-16000164
Mabrouk, M., Jalali, F., Zaïd, N., Naya, A., Khyatti, M., Khalki, L., Guessous, F., & Zaid, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.14.549113
Costa, A. L. C. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2024.tde-11042024-103009
SARS-CoV-2 infection vs. vaccination during pregnancy: the placenta leads the way
Latorre, L. P., & Ramilo, O. (2024) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000001050
Chou, C.-Y., Cheng, C., Lee, C., Kuro‐o, M., Chen, T.-H., Wang, S., Chuang, Y., Yang, Y.-J., Lin, Y.-H., & Tsai, I. (2024) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2024.09.007
Cytokine response against coronavirus
Upreti, S., Samant, M., Sharma, N., & Mahara, K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15283-2.00008-7
Weiß, S., Lin, H.-M., Acosta, E., Komarova, N. L., Chen, P., Wodarz, D., Baine, I. L., Duerr, R., Wajnberg, A., Gervais, A., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci181136
Ashraf, U., Lee, A., Gao, Q., González, J. C., Scallan, C., Chinthrajah, R. S., Maecker, H. T., Davis, M. M., Nadeau, K. C., Chakraborty, S., et al. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127171
Self-citationMabrouk, M., Atifi, F., Wahnou, H., Allaoui, A., Zaïd, N., Naya, A., Agbani, E. O., Khalki, L., Khyatti, M., Tijani, Y., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26147002
IgG Fucosylation: An Emerging Key Player in the Treatment of Severe COVID-19
Zhao, C., Wang, J., Liu, Y., Shang, B., Lin, D., Xiao, Y., Ren, H., Li, Y., Wen, R., Zou, X., et al. (2025) · Engineering · doi:10.1016/j.eng.2025.08.004
Zhou, Y., Karlahag, F., Weiss, S. S., Jamshidi, S., Tjernberg, L. O., & Emmer, Å. (2025) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.5c00205
Latorre, L. P., Cohen, S. H., Sánchez, P. J., Antonio, R. D., Mertz, S. E., Ye, F., Pifer, T., Rodríguez-Molino, P., Kim, H., Eisner, M., et al. (2025) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000005032
Labied, S., Atifi, F., Wahnou, H., Mabrouk, M., Jeddoub, O., Allaoui, A., Jalali, F., & Zaid, Y. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119049
Antibody-Dependent Heterotypic Syncytia Drive COVID-19 Inflammation and Disease ProgressionPreprint
Yang, Y., Zhou, C., Zhang, T., Hu, W., Magazine, N., Carossino, M., Jia, N., Li, T., Wang, Y., Wang, C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.11.705426
Early Fc-effector antibody signatures impact COVID-19 disease trajectoryPreprint
Escalera, A., Gonzalez-Reiche, A. S., Aslam, S., Bernal, E., Alter, G., Rojo-Fernandez, A., Rombauts, A., Abelenda-Alonso, G., Amper, M. A. S., Nair, V. D., et al. (2026) · medRxiv · doi:10.64898/2026.02.18.26346542
Zamfir, M., Gerstner, D. G., Lahne, H., Fingerle, V., Redwitz, J., Schöber, W., Aschenbrenner, B., Graw, M., Nowak, D., Quartucci, C., et al. (2026) · Toxics · doi:10.3390/toxics14030192
Core fucose: Molecular targets and functions in inflammatory signaling pathways.
Ohkawa, Y., Abe, J., Kuribara, T., & Taniguchi, N. (2026) · Biochimica et Biophysica Acta - General Subjects · doi:10.1016/j.bbagen.2026.130934
Metadata
- Authors
- Chakraborty, S., Gonzalez, J., Edwards, K., Mallajosyula, V., Buzzanco, A. S., Sherwood, R., Buffone, C., Kathale, N., Providenza, S., Xie, M. M., Andrews, J. R., Blish, C. A., Singh, U., Dugan, H., Wilson, P. C., Pham, T. D., Boyd, S. D., Nadeau, K. C., Pinsky, B. A., Zhang, S., Memoli, M. J., Taubenberger, J. K., Morales, T., Schapiro, J. M., Tan, G. S., Jagannathan, P., & Wang, T. T.
- Affiliations
- Stanford Medicine (US)
- Stanford University (US)
- Cornell University (US)
- Chan Zuckerberg Biohub San Francisco (US)
- University of Chicago (US)
- Stanford Blood Center (US)
- National Institutes of Health (US)
- Kaiser Permanente Northern California (US)
- J. Craig Venter Institute (US)
- Corresponding author
- Wang, Taia T.
- ORCID
- Chakraborty, Saborni
- Edwards, Karlie
- Mallajosyula, Vamsee
- Buzzanco, Anthony S.
- Buffone, Cindy
- Xie, Markus M.
- Andrews, Jason R.
- Blish, Catherine A.
- Singh, Upinder
- Dugan, Haley
- Wilson, Patrick C.
- Pham, Tho D.
- Boyd, Scott D.
- Nadeau, Kari C.
- Pinsky, Benjamin A.
- Zhang, Sheng
- Memoli, Matthew J.
- Taubenberger, Jeffery K.
- Tan, Gene S.
- Jagannathan, Prasanna
- Wang, Taia T.
- Venue
- Nature Immunology
- Published
- 2020-11-09
- Volume
- 22
- Issue
- 1
- Pages
- 67-73
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC8130642
- OpenAlex
- W3105885548
- Cited by
- 326
- References
- 41
- Citations by year
- 2026: 25 · 2025: 35 · 2024: 32 · 2023: 41 · 2022: 98 · 2021: 83 · 2020: 12
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Immunology (publishedVersion)
- medRxiv (acceptedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (acceptedVersion, cc-by)
- PubMed Central (acceptedVersion)
- PubMed Central (submittedVersion)
- ImmPort
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (R01AI139119, U54CA260517, U19AI111825)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Keywords
- severe COVID-19, SARS-CoV-2, IgG1, Fc glycan, afucosylation, FcγRIIIa, Fcγ receptor binding, immune complexes, monocytes, interleukin-6, TNF-α, hyperinflammation, disease severity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
