Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
Open accessAbstract
We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.
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In a study by Xu et al., rectal swabs were positive in 8 of 10 pediatric patients, even after the nasopharyngeal swabs became negative.
“In a study by Xu et al., rectal swabs were positive in 8 of 10 pediatric patients, even after the nasopharyngeal swabs became negative [14].”
From Acute mesenteric ischemia in COVID-19 patients (2021) · cites this paper as [14]
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- Authors
- Xu, Y., Li, X., Zhu, B., Liang, H., Fang, C., Gong, Y., Guo, Q., Sun, X., Zhao, D., Shen, J., Zhang, H., Liu, H., Xia, H., Tang, J., Zhang, K., & Gong, S.
- Affiliations
- Guangzhou Women and Children Medical Center (CN)
- Children's Hospital of Philadelphia (US)
- Macau University of Science and Technology (MO)
- Corresponding author
- Xia, Huimin
- Zhang, Kang
- Gong, Sitang
- ORCID
- Venue
- Nature Medicine
- Published
- 2020-03-13
- Volume
- 26
- Issue
- 4
- Pages
- 502-505
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC7095102
- OpenAlex
- W3012415734
- Cited by
- 1,415
- References
- 10
- Citations by year
- 2026: 9 · 2025: 26 · 2024: 53 · 2023: 107 · 2022: 189 · 2021: 388 · 2020: 643
- FWCI
- 43.50
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-10-29)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- SARS-CoV-2, pediatric COVID-19, fecal viral shedding, fecal-oral transmission, rectal swabs, nasopharyngeal swab, mild symptoms
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Testing, Child, Child, Preschool, Feces, Female, Humans, Infant, Male, Nasopharynx, Pneumonia, Viral, Rectum, Radiography, Thoracic, Virus Shedding, Coronavirus Infections, Clinical Laboratory Techniques, Pandemics, Real-Time Polymerase Chain Reaction
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