The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Proinflammatory IgG Fc structures in patients with severe COVID-19
Open accessPublished version of a preprint
Abstract
Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life-threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature, including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that patients with severe COVID-19 produced a unique serologic signature, including an increased likelihood of IgG1 with afucosylated Fc glycans. This Fc modification on severe acute respiratory syndrome coronavirus 2 IgGs enhanced interactions with the activating Fcγ receptor FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including interleukin-6 and tumor necrosis factor. These results show that disease severity in COVID-19 correlates with the presence of proinflammatory IgG Fc structures, including afucosylated IgG1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“On the other hand, antibodies promoting inflammatory responses may contribute to a cytokine storm resulting in severe disease32,33.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [32]
In the citing paper
“However, the potential role of IgG with reduced Fc fucosylation and enhanced binding to FcγRIII in the development of severe COVID-19 suggests that the quality of antibodies induced by vaccination may also be important in minimizing the risk of ADE32,33.”
From Immunological mechanisms of vaccine-induced protection against COVID-19 in humans (2021) · cites this paper as [32]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897
Presumed Asymptomatic Carrier Transmission of COVID-19
Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D., Chen, L., & Wang, M. (2020) · JAMA · doi:10.1001/jama.2020.2565 · Cited by 4,496
Epidemiology of COVID-19 Among Children in China
Dong, Y., Mo, X., Hu, Y., Qi, X., Jiang, F., Jiang, Z., & Tong, S. (2020) · PEDIATRICS · doi:10.1542/peds.2020-0702 · Cited by 4,240
Bi, Q., Wu, Y., Mei, S., Ye, C., Zou, X., Zhang, Z., Liu, X., Wei, L., Truelove, S., Zhang, T., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30287-5 · Cited by 1,960
A single-cell atlas of the peripheral immune response in patients with severe COVID-19
Wilk, A. J., Rustagi, A., Zhao, N. Q., Roque, J., Martínez-Colón, G. J., McKechnie, J. L., Ivison, G. T., Ranganath, T., Vergara, R., Hollis, T., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0944-y · Cited by 1,493
Self-citationA highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Yuan, M., Wu, N. C., Zhu, X., Lee, C.-C. D., So, R. T. Y., Lv, H., Mok, C. K. P., & Wilson, I. A. (2020) · Science · doi:10.1126/science.abb7269 · Cited by 1,429
Hu, Z., Song, C., Xu, C., Jin, G., Chen, Y., Xu, X., Ma, H., Chen, W., Lin, Y., Zheng, Y., et al. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1661-4 · Cited by 1,429
Xu, Y., Li, X., Zhu, B., Liang, H., Fang, C., Gong, Y., Guo, Q., Sun, X., Zhao, D., Shen, J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0817-4 · Cited by 1,415
Antibody-dependent enhancement of severe dengue disease in humans
Katzelnick, L. C., Gresh, L., Halloran, M. E., Mercado, J. C., Kuan, G. M., Gordon, A. L., Balmaseda, Á., & Harris, E. (2017) · Science · doi:10.1126/science.aan6836 · Cited by 1,202
Research works printed but not linked: 1
- Bournazos, S., Wang, T. T. & Ravetch, J. V. In Myeloid Cells in Health and Disease: A Synthesis (Ed. Gordon, S.) Ch. 22 (ASM Press, 2016).
Cited by
Sorted by citations
Items 101–200 of 320
Antibody glycosylation in COVID-19
Pongrácz, T., Vidarsson, G., & Wuhrer, M. (2022) · Glycoconjugate Journal · doi:10.1007/s10719-022-10044-0 · Cited by 27
Bulk IgG Glycosylation Predicts COVID-19 Severity and Vaccine Antibody Response
Ash, M. K., Bhimalli, P. P., Cho, B.-K., Mattamana, B. B., Gambut, S., Tarhoni, I., Fhied, C. L., Reyes, A. F., Welninski, S. J., Arivalagan, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111799 · Cited by 30
Edgar, J. E., & Bournazos, S. (2024) · Immunological Reviews · doi:10.1111/imr.13393 · Cited by 32
Mazzitelli, I. G., Bleichmar, L., Ludueña, G., Pisarevsky, A. A., Labato, M. I., Chiaradia, V., Finocchietto, P. V., Paulín, F., Hormanstorfer, M., Baretto, M. C., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab174 · Cited by 26
Gunn, B. M., & Bai, S. (2021) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2021.1976580 · Cited by 28
Bharadwaj, P., Shrestha, S., Pongrácz, T., Catalano, C., Sharma, S., Moine, A. L., de Haan, N., Murakami, N., Riella, L. V., Holovská, V., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100818 · Cited by 26
Robertson, S. J., Bedard, O., McNally, K. L., Shaia, C., Clancy, C. S., Lewis, M. C., Broeckel, R. M., Chiramel, A. I., Shannon, J. G., Sturdevant, G. L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40076-5 · Cited by 28
IgG Glycosylation: Biomarker, Functional Modulator, and Structural Component
Radovani, B., & Nimmerjahn, F. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2400447 · Cited by 25
Torchia, J. A., Tavares, A. H., Carstensen, L. S., Chen, D. W., Huang, J., Xiao, T., Mukherjee, S., Reeves, P. M., Tu, H., Sluder, A. E., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq6527 · Cited by 25
Antibody and B Cell Responses to SARS-CoV-2 Infection and Vaccination: The End of the Beginning
Röltgen, K., & Boyd, S. D. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-042754 · Cited by 25
Self-citationRoles of core fucosylation modification in immune system and diseases
Pan, Q., & Zhang, X. (2024) · Cell Insight · doi:10.1016/j.cellin.2024.100211 · Cited by 24
Pediatric COVID-19: Immunopathogenesis, Transmission and Prevention
Rohner, G. B., Didierlaurent, A. M., Tilmanne, A., Smeesters, P. R., & Marchant, A. (2021) · Vaccines · doi:10.3390/vaccines9091002 · Cited by 28
Rieke, G. J., van Bremen, K., Bischoff, J., ToVinh, M., Monin, M. B., Schlabe, S., Raabe, J., Kaiser, K. M., Finnemann, C., Odainic, A., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac060 · Cited by 25
Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients
Sasson, J. M., Campo, J. J., Carpenter, R. M., Young, M. K., Randall, A. Z., Trappl, K., Oberai, A., Hung, C., Edgar, J. M., Teng, A., et al. (2021) · mBio · doi:10.1128/mbio.01229-21 · Cited by 26
Bandeira, C. C. S., Madureira, K. C. R., Rossi, M. B., Gallo, J. F., da Silva, A. P. M. A., Torres, V. L., de Lima, V. A., Kesper, N., Almeida, J. D., Zerbinati, R. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-08156-6 · Cited by 24
Matsui, Y., Li, L., Prahl, M. K., Cassidy, A. G., Özarslan, N., Golan, Y., Gonzalez, V. J., Lin, C. Y., Jigmeddagva, U., Chidboy, M. A., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.157354 · Cited by 23
Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19
Gregory, D. J., Vannier, A., Duey, A. H., Roady, T. J., Dzeng, R. K., Pavlovic, M., Chapin, M. H., Mukherjee, S., Wilmot, H., Chronos, N., et al. (2022) · Virulence · doi:10.1080/21505594.2022.2073025 · Cited by 23
Heterogeneity in IgG‐CD16 signaling in infectious disease outcomes*
González, J. C., Chakraborty, S., Thulin, N. K., & Wang, T. T. (2022) · Immunological Reviews · doi:10.1111/imr.13109 · Cited by 24
Self-citationCoillie, J. V., Pongrácz, T., Šuštić, T., Wang, W., Nouta, J., Gars, M. L., Keijzer, S., Linty, F., Cristianawati, O., Keijser, J. B. D., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107619 · Cited by 27
Goudsmit, J., van den Biggelaar, A. H. J., Koudstaal, W., Albert Hofman, D., Koff, W. C., Schenkelberg, T., Alter, G., Mina, M. J., & Wu, J. W. (2021) · European Journal of Epidemiology · doi:10.1007/s10654-021-00767-z · Cited by 22
Immune interventions in COVID-19: a matter of time?
Plaçais, L., Richier, Q., Noël, N., Lacombe, K., Mariette, X., & Hermine, O. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00464-w · Cited by 22
α2,6-Sialylation Is Upregulated in Severe COVID-19, Implicating the Complement Cascade
Qin, R., Kurz, E., Chen, S., Zeck, B., Chiribogas, L., Jackson, D., Herchen, A., Attia, T., Carlock, M. A., Rapkiewicz, A., et al. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00421 · Cited by 21
Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes
Lasso, G., Khan, S. M., Allen, S. A., Mariano, M. C., Florez, C., Orner, E. P., Quiroz, J. A., Quevedo, G., Massimi, A. B., Hegde, A., et al. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009778 · Cited by 21
Forgacs, D., Silva‐Moraes, V., Sautto, G. A., Hanley, H. B., Gattiker, J. L., Jefferson, A. M., Kolhe, R. B., & Ross, T. M. (2022) · Vaccines · doi:10.3390/vaccines10050696 · Cited by 21
Immune complexes as culprits of immunopathology in severe COVID-19
Kolb, P., Giese, S., Voll, R. E., Hengel, H., & Falcone, V. (2022) · Medical Microbiology and Immunology · doi:10.1007/s00430-022-00743-8 · Cited by 21
Chen, J., Fries, C. N., Berendam, S. J., Rodgers, N. S., Roe, E. F., Wu, Y., Li, S. H., Jain, R., Watts, B. E., Eudailey, J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq0273 · Cited by 21
The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity
Siekman, S. L., Pongrácz, T., Wang, W., Nouta, J., Kremsner, P. G., Silva-Neto, P. V. D., Esen, M., Kreidenweiss, A., Held, J., Trapé, Á. A., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.993354 · Cited by 22
Composition of the immunoglobulin G glycome associates with the severity of COVID-19Preprint
Petrović, T., Alves, I., Bugada, D., Pascual, J., Vučković, F., Skelin, A., Gaifem, J., Villar-García, J., Vicente, M. M., Fernandes, Â., et al. (2020) · medRxiv · doi:10.1101/2020.10.17.20214205 · Cited by 20
COVID-19: Imbalanced Immune Responses and Potential Immunotherapies
Xie, B., Zhang, J., Li, Y., Yuan, S., & Shang, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.607583 · Cited by 19
Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody
Gupta, A., Kao, K. S., Yamin, R., Oren, D. A., Goldgur, Y., Du, J. J., Lollar, P., Sundberg, E. J., & Ravetch, J. V. (2023) · Nature Communications · doi:10.1038/s41467-023-38453-1 · Cited by 19
Non-neutralizing functions in anti-SARS-CoV-2 IgG antibodies
Reinig, S., & Shih, S. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100666 · Cited by 22
The host glycomic response to pathogens
Qin, R., & Mahal, L. K. (2021) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2020.12.011 · Cited by 19
Seddiki, N., & French, M. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.649567 · Cited by 20
Coronavirus persistence in human respiratory tract and cell culture: An overview
Gaspar-Rodríguez, A., Padilla-González, A., & Rivera-Toledo, E. (2021) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2021.101632 · Cited by 19
Peddireddy, S. P., Rahman, S. A., Cillo, A. R., Vijay, G. K. M., Somasundaram, A., Workman, C. J., Bain, W., McVerry, B. J., Methé, B. A., Lee, J. S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111020 · Cited by 19
Nimmerjahn, F., & Ravetch, J. V. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201753 · Cited by 18
Liu, P., Wang, X., Dun, A., Li, Y., Li, H., Wang, L., Zhang, Y., Li, C., Zhang, J., Zhang, X., et al. (2023) · Engineering · doi:10.1016/j.eng.2023.02.008 · Cited by 18
McMillen, C. M., Chapman, N. S., Hoehl, R. M., Skvarca, L. B., Schwarz, M. M., Handal, L. S., Crowe, J. E., & Hartman, A. L. (2023) · Nature Communications · doi:10.1038/s41467-023-40187-z · Cited by 18
Vo, H. T. M., Maestri, A., Auerswald, H., Sorn, S., Lay, S., Seng, H., Sann, S., Ya, N., Pean, P., Dussart, P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.817905 · Cited by 19
New-Onset and Relapsed Membranous Nephropathy post SARS-CoV-2 and COVID-19 Vaccination
Ma, Q., Li, X., & Xu, G. (2022) · Viruses · doi:10.3390/v14102143 · Cited by 18
Decay of Fc-dependent antibody functions after mild to moderate COVID-19
Lee, W. S., Selva, K. J., Davis, S. K., Wines, B. D., Reynaldi, A., Esterbauer, R., Kelly, H. G., Haycroft, E. R., Tan, H.-X., Juno, J. A., et al. (2020) · doi:10.1101/2020.12.13.20248143 · Cited by 80
COVID-19 and earlier pandemics, sepsis, and vaccines: A historical perspective
Cavaillon, J.-M., & Osuchowski, M. F. (2021) · Journal of Intensive Medicine · doi:10.1016/j.jointm.2021.04.003 · Cited by 17
Structure, function, and implications of fucosyltransferases in health and disease
Ghirardello, M., Yruela, I., Merino, P., Sackstein, R., Sanz‐Martínez, I., & Hurtado‐Guerrero, R. (2025) · Nature Communications · doi:10.1038/s41467-025-66871-w · Cited by 17
Synthetic nanobodies as tools to distinguish IgG Fc glycoforms
Kao, K. S., Gupta, A., Zong, G., Li, C., Kerschbaumer, I., Borghi, S., Achkar, J. M., Bournazos, S., Wang, L., & Ravetch, J. V. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212658119 · Cited by 17
Zhang, Z., Wang, H., Lian, T., Zhou, Y., Xu, X., Guo, F., Wei, Y., Li, J., Sun, K., Liu, C., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21408 · Cited by 17
Kanto, N., Ohkawa, Y., Kitano, M., Maeda, K., Shiida, M., Ono, T., Ota, F., Kizuka, Y., Kunimasa, K., Nishino, K., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105365 · Cited by 17
Ruiz, M. J., Siracusano, G., Cottignies-Calamarte, A., Tudor, D., Real, F., Zhu, A., Pastori, C., Capron, C., Rosenberg, A. R., Temperton, N. J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.842468 · Cited by 21
van der Straten, K., van Gils, M. J., de Taeye, S. W., & de Bree, G. J. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.867982 · Cited by 17
Park, Y.-J., Acosta, D. I., Vassell, R. A., Tang, J., Khurana, S., Weiss, C. D., Golding, H., & Zaitseva, M. B. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010468 · Cited by 16
Wieczorek, L., Zemil, M., Merbah, M., Dussupt, V., Kavusak, E., Molnar, S., Heller, J., Beckman, B., Wollen-Roberts, S. E., Peachman, K. K., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.901217 · Cited by 16
Harnessing IgG Fc glycosylation for clinical benefit
Archer, E. J., González, J. C., Ghosh, D., Mellins, E., & Wang, T. T. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102231 · Cited by 15
Self-citationPolyfunctional antibodies: a path towards precision vaccines for vulnerable populations
Purcell, R. A., Theisen, R. M., Arnold, K. B., Chung, A. W., & Selva, K. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1183727 · Cited by 16
Antibody‐mediated control mechanisms of viral infections
Mackin, S., Sariol, A., & Diamond, M. (2024) · Immunological Reviews · doi:10.1111/imr.13383 · Cited by 15
Kavur, M. M., Lauc, G., & Pezer, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819475-1.00086-9 · Cited by 15
The Importance of Glycosylation in COVID-19 Infection
Pribić, T., Lauc, G., & Trbojević‐Akmačić, I. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-70115-4_12 · Cited by 15
Yu, P., Liu, Z., Zhu, Z., Yang, J., Deng, M., Chen, M., Lai, C., Kong, W., Xiong, S., Wan, L., et al. (2023) · Virologica Sinica · doi:10.1016/j.virs.2022.12.008 · Cited by 14
Immunology of SARS-CoV-2 infections and vaccines
Schenten, D., & Bhattacharya, D. (2021) · Advances in immunology · doi:10.1016/bs.ai.2021.08.002 · Cited by 14
Shin, J. J., Par‐Young, J., Ünlü, S., McNamara, A., Park, H., Shin, M. S., Gee, R. J., Doyle, H. A., Afinogenova, Y., Zidan, E., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01296-4 · Cited by 14
Glyco engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues
Kallolimath, S., Palt, R., Föderl-Höbenreich, E., Sun, L., Chen, Q., Pruckner, F., Eidenberger, L., Strasser, R., Zatloukal, K., & Steinkellner, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1147960 · Cited by 14
Adhikari, E. H., Lu, P., Kang, Y. J., McDonald, A. R., Pruszynski, J. E., Bates, T. A., McBride, S. K., Trank-Greene, M., Tafesse, F., & Lu, L. L. (2023) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiad421 · Cited by 15
Antibodies as key mediators of protection against Mycobacterium tuberculosis
Wang, Q., Nag, D., Baldwin, S. L., Coler, R. N., & McNamara, R. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1430955 · Cited by 13
Kealy, L. C., & Good‐Jacobson, K. L. (2021) · Oxford Open Immunology · doi:10.1093/oxfimm/iqab018 · Cited by 14
Mitochondrial regulation of acute extrafollicular B‐cell responses to COVID‐19 severity
Cao, T., Liu, L., To, K. K., Lim, C., Zhou, R., Ming, Y., Kwan, K., Yu, S., Chan, C., Zhou, B., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1025 · Cited by 13
Abdulla, Z. A., Al-Bashir, S. M., Alzoubi, H., Al-Salih, N. S., Aldamen, A. A., & Abdulazeez, A. Z. (2023) · Pathogens · doi:10.3390/pathogens12020329 · Cited by 13
Bowman, K. A., Wiggins, C. D., DeRiso, E. A., Paul, S. B., Strle, K., Branda, J. A., Steere, A. C., Lauffenburger, D. A., & Alter, G. (2024) · iScience · doi:10.1016/j.isci.2024.108804 · Cited by 12
Tokgoz, G., Kırboğa, K. K., Özel, F., Yücepur, S., Ardahanlı, İ., & Gurbanov, R. (2024) · Talanta · doi:10.1016/j.talanta.2024.126652 · Cited by 12
Neutrophil Heterogeneity in Airway Inflammatory Diseases
Guo, D.-Y., Liu, Z., Xu, X.-C., Yu, J.-K., Zhou, J.-S., Li, Z., Lv, B., Xu, T., & Chen, Z. (2025) · Inflammation · doi:10.1007/s10753-025-02351-z · Cited by 13
Modalities and Mechanisms of Treatment for Coronavirus Disease 2019
Zuo, Z., Wu, T., Pan, L., Zuo, C., Hu, Y., Luo, X., Jiang, L., Xia, Z., Xiao, X., Liu, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.583914 · Cited by 14
Volkan, E. (2021) · Molecular Biotechnology · doi:10.1007/s12033-021-00353-4 · Cited by 12
Iles, J. K., Zmuidinaite, R., Sadée, C., Gardiner, A. E., Lacey, J., Harding, S. J., Wallis, G. L. F., Patel, R., Roblett, D., Heeney, J. L., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116050 · Cited by 12
Garrido, J. L. V., Medina, M. A., Bravo, F., McGee, S., Fuentes‐Villalobos, F., Calvo, M. A., Pinos, Y., Bowman, J. W., Bahl, C. D., Barría, M. I., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110904 · Cited by 13
Frush, K. S., Lee, G. M., Wald, S. H., Hawn, M. T., Krna, C. D., Holubar, M. K., Beatty, D. E., Chawla, A., Pinsky, B. A., Schilling, L. M., et al. (2020) · NEJM Catalyst · doi:10.1056/cat.20.0378 · Cited by 11
Self-citationSevere Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced Disease
Hussman, J. P. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.637642 · Cited by 11
Douxfils, J., Gillot, C., Gottal, É. D., Vandervinne, S., Bayart, J., Dogné, J., & Favresse, J. (2021) · Vaccines · doi:10.3390/vaccines9080907 · Cited by 11
Importance and Monitoring of Therapeutic Immunoglobulin G Glycosylation
Mimura, Y., Saldova, R., Mimura‐Kimura, Y., Rudd, P. M., & Jefferis, R. (2021) · Experientia supplementum · doi:10.1007/978-3-030-76912-3_15 · Cited by 11
Differential Peripheral Blood Glycoprotein Profiles in Symptomatic and Asymptomatic COVID-19
Pickering, C., Zhou, B., Xu, G., Rice, R. A., Ramachandran, P., Huang, H. H., Pham, T. D., Schapiro, J. M., Xin, C., Chakraborty, S., et al. (2022) · Viruses · doi:10.3390/v14030553 · Cited by 11
Self-citationCirculating multimeric immune complexes drive immunopathology in COVID-19Preprint
Ankerhold, J., Giese, S., Kolb, P., Maul-Pavicic, A., Voll, R. E., Göppert, N., Ciminski, K., Kreutz, C., Lother, A., Salzer, U., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.25.449893 · Cited by 13
Infection and the Glycome─New Insights into Host Response
Mohideen, F. I., & Mahal, L. K. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00315 · Cited by 11
Crowley, A. R., Osei‐Owusu, N. Y., Dekkers, G., Gao, W., Wuhrer, M., Magnani, D. M., Reimann, K. A., Pincus, S. H., Vidarsson, G., & Ackerman, M. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.754710 · Cited by 11
A functional spleen contributes to afucosylated IgG in humans
Wójcik, I., Schmidt, D. E., de Neef, L. A., Rab, M. A. E., Meek, B., de Weerdt, O., Wuhrer, M., van der Schoot, C. E., Zwaginga, J. J., de Haas, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-03196-w · Cited by 10
Geyer, C. E., Chen, H., Bye, A. P., Manz, X. D., Guerra, D., Caniels, T. G., Bijl, T. P. L., Griffith, G. R., Hoepel, W., de Taeye, S. W., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202302106 · Cited by 10
Serum immunoglobulin and the threshold of Fc receptor-mediated immune activation
Bauer-Smith, H., Sudol, A. S. L., Beers, S. A., & Crispin, M. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130448 · Cited by 10
Wu, Y., Wang, Y., Qiu, Y., Lv, C., Zhu, Y., Wang, L., Xu, L., You, H., Wang, F., & Tan, W. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03921-y · Cited by 9
Antibody glycosylation directs innate and adaptive immune collaboration
Polmear, J., & Good‐Jacobson, K. L. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.12.002 · Cited by 9
Does SARS-CoV-2 Induce IgG4 Synthesis to Evade the Immune System?
Rubio‐Casillas, A., Redwan, E. M. M. M., & Uversky, V. N. (2023) · Biomolecules · doi:10.3390/biom13091338 · Cited by 9
Zhuang, Z., Qi, Y., Yao, Y., & Yu, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1286380 · Cited by 9
Toraldo, D. M., Satriano, F., Rollo, R., Verdastro, G., Imbriani, G., Rizzo, E., Argentiero, A., Falco, A., Ambrosino, P., Miani, A., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262911 · Cited by 9
Ashraf, U., Chakraborty, S., Scallan, C., Lo, N. C., Alera, M. T., Farmer, A. R., Chua, M. N., Michael, N. L., Rothman, A. L., & Wang, T. T. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adx7231 · Cited by 8
Self-citationHowell, M., Green, R. J., McGill, A. R., Kahlil, R. M., Dutta, R., Mohapatra, S. S., & Mohapatra, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.700705 · Cited by 8
Ayass, M. A., Cao, W., Zhang, J., Dai, J., Zhu, K., Tripathi, T., Griko, N., Pashkov, V., & Abi-Mosleh, L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274228 · Cited by 8
Capuano, C., Federicis, D. D., Ciuti, D., Turriziani, O., Angeloni, A., Anastasi, E., Giannini, G., Belardinilli, F., Molfetta, R., Alvaro, D., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1285203 · Cited by 8
Zhang, T., Feng, H., Zou, X., & Peng, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1054445 · Cited by 8
Poolchanuan, P., Matsee, W., Sengyee, S., Siripoon, T., Dulsuk, A., Phunpang, R., Pisutsan, P., Piyaphanee, W., Luvira, V., & Chantratita, N. (2023) · mSphere · doi:10.1128/msphere.00465-22 · Cited by 8
The Functional Roles of MDSCs in Severe COVID-19 Pathogenesis
Chan, K. R., Len, J. S., & Koh, C. W. (2023) · Viruses · doi:10.3390/v16010027 · Cited by 8
Total plasma N-glycomic signature of SARS-CoV-2 infection
Bladergroen, M. R., Pongrácz, T., Wang, W., Nicolardi, S., Arbous, M. S., Roukens, A. H. E., & Wuhrer, M. (2024) · iScience · doi:10.1016/j.isci.2024.110374 · Cited by 7
Yang, Q., Zhang, S., Wu, S., Yao, B., Wang, L., Li, Y., Peng, H., Huang, M., Bi, Q., Xiong, P., et al. (2022) · Immunologic Research · doi:10.1007/s12026-022-09266-z · Cited by 7
Self-citationSchwedler, C., Grzeski, M., Kappert, K., Rust, J., Heymann, G. A., Hoppe, B., & Blanchard, V. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.775186 · Cited by 8
López‐Martínez, R., Albaiceta, G. M., Amado‐Rodríguez, L., Gómez, J., Cuesta‐Llavona, E., Clemente, M. M. G., Hermida-Valverde, T., Enríquez-Rodríguez, A. I., Hernández-González, C., Martı́nez-Borra, J., et al. (2022) · Genes and Immunity · doi:10.1038/s41435-022-00179-3 · Cited by 7
Stefanini, L., Ruberto, F., Curreli, M., Chistolini, A., Schiera, E., Marrapodi, R., Visentini, M., Ceccarelli, G., d’Ettorre, G., Santoro, C., et al. (2022) · Thrombosis and Haemostasis · doi:10.1055/a-1962-5447 · Cited by 7
Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages
Pickering, S., Wilson, H., Bravo, E., Perera, M. R., Seow, J., Graham, C., Almeida, N., Fotopoulos, L., Williams, T., Moitra, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54458-w · Cited by 6
Metadata
- Authors
- Chakraborty, S., Gonzalez, J., Edwards, K., Mallajosyula, V., Buzzanco, A. S., Sherwood, R., Buffone, C., Kathale, N., Providenza, S., Xie, M. M., Andrews, J. R., Blish, C. A., Singh, U., Dugan, H., Wilson, P. C., Pham, T. D., Boyd, S. D., Nadeau, K. C., Pinsky, B. A., Zhang, S., Memoli, M. J., Taubenberger, J. K., Morales, T., Schapiro, J. M., Tan, G. S., Jagannathan, P., & Wang, T. T.
- Affiliations
- Stanford Medicine (US)
- Stanford University (US)
- Cornell University (US)
- Chan Zuckerberg Biohub San Francisco (US)
- University of Chicago (US)
- Stanford Blood Center (US)
- National Institutes of Health (US)
- Kaiser Permanente Northern California (US)
- J. Craig Venter Institute (US)
- Corresponding author
- Wang, Taia T.
- ORCID
- Chakraborty, Saborni
- Edwards, Karlie
- Mallajosyula, Vamsee
- Buzzanco, Anthony S.
- Buffone, Cindy
- Xie, Markus M.
- Andrews, Jason R.
- Blish, Catherine A.
- Singh, Upinder
- Dugan, Haley
- Wilson, Patrick C.
- Pham, Tho D.
- Boyd, Scott D.
- Nadeau, Kari C.
- Pinsky, Benjamin A.
- Zhang, Sheng
- Memoli, Matthew J.
- Taubenberger, Jeffery K.
- Tan, Gene S.
- Jagannathan, Prasanna
- Wang, Taia T.
- Venue
- Nature Immunology
- Published
- 2020-11-09
- Volume
- 22
- Issue
- 1
- Pages
- 67-73
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC8130642
- OpenAlex
- W3105885548
- Cited by
- 326
- References
- 41
- Citations by year
- 2026: 25 · 2025: 35 · 2024: 32 · 2023: 41 · 2022: 98 · 2021: 83 · 2020: 12
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature Immunology (publishedVersion)
- medRxiv (acceptedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (acceptedVersion, cc-by)
- PubMed Central (acceptedVersion)
- PubMed Central (submittedVersion)
- ImmPort
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (R01AI139119, U54CA260517, U19AI111825)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Keywords
- severe COVID-19, SARS-CoV-2, IgG1, Fc glycan, afucosylation, FcγRIIIa, Fcγ receptor binding, immune complexes, monocytes, interleukin-6, TNF-α, hyperinflammation, disease severity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review