Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Giladi, Amir; Wagner, Lisa Katharina; Li, Hanjie; Dörr, Dorothea; Medaglia, Chiara; Paul, Franziska; Shemer, Anat; Jung, Steffen; Yona, Simon; Mack, Matthias; Leutz, Achim; Amit, Ido; Mildner, Alexander

doi:10.1038/s41590-020-0661-1

Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Multiple sclerosis (MS) is characterized by pathological inflammation that results from the recruitment of lymphoid and myeloid immune cells from the blood into the brain. Due to subset heterogeneity, defining the functional roles of the various cell subsets in acute and chronic stages of MS has …