Macrophages in health and disease

Park, Matthew D.; Silvin, Aymeric; Ginhoux, Florent; Merad, Miriam

doi:10.1016/j.cell.2022.10.007

Cited by 644Immune cells in cancerPhagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Macrophages in health and disease

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Park, Matthew D., Silvin, Aymeric, Ginhoux, Florent, Merad, Miriam·2022·Cell

DOI 10.1016/j.cell.2022.10.007PMC PMC9908006

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Abstract

The heterogeneity of tissue macrophages, in health and in disease, has become increasingly transparent over the last decade. But with the plethora of data comes a natural need for organization and the design of a conceptual framework for how we can better understand the origins and functions of different macrophages. We propose that the ontogeny of a macrophage-beyond its fundamental derivation as either embryonically or bone marrow-derived, but rather inclusive of the course of its differentiation, amidst steady-state cues, disease-associated signals, and time-constitutes a critical piece of information about its contribution to homeostasis or the progression of disease.

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Monocytes and tissue-resident macrophages are predominant producers of SASP factors such as IL-1α, IL-1β, IL-6, TNF, and HMGB1.
“Studies have shown that immune cells, including monocytes and tissue-resident macrophages, are the predominant producers of SASP factors such as IL-1α, IL-1β, IL-6, TNF and HMGB1 (refs. 75–78).”
From SenNet recommendations for detecting senescent cells in different tissues (2024) · cites this paper as [76]
The section on decay of tissue-resident macrophage niches reports that inflammatory monocytes in IBD mucosa produce IL-6 and TNF-α. The section on disease-associated signals also lists activated immune cells among IL-6 producers, but it does not identify monocytes or tissue-resident macrophages as the predominant producers. Neither passage establishes that these cells predominantly produce SASP factors or supports the full list including IL-1α, IL-1β, and HMGB1. (LLM, conf=0.84)
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Macrophages consist of a heterogeneous population even in a healthy liver, comprising resident Kupffer cells and infiltrating monocyte-derived macrophages.
“Macrophages consist of a heterogeneous population even in a healthy liver, where they harbor a wide spectrum of expression profiles (19–22). They comprise resident Kupffer cells, which derive from erythromyeloid progenitors (23), and infiltrating monocyte-derived macrophages, which originate preferentially from the bone marrow but also from the peritoneal cavity or the spleen (21, 24).”
From Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy (2024) · cites this paper as [24]

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Willikens FLA, Werre JM, Kruijt JK, Roerdinkholder-Stoelwinder B, Groenen-Döpp YAM, van den Bos AG, Bosman GJCGM, and van Berkel TJC Blood 105, 2141– 2145. 15550489

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Authors: Park, M. D., Silvin, A., Ginhoux, F., & Merad, M.
Affiliations: Tisch Cancer Institute (US)
Inserm (FR)
Agency for Science, Technology and Research (SG)
Corresponding author: Ginhoux, Florent
ORCID: Park, Matthew D.
Silvin, Aymeric
Ginhoux, Florent
Merad, Miriam
Venue: Cell
Publisher: Elsevier BV
Published: 2022-11
Volume: 185
Issue: 23
Pages: 4259-4279
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2022.10.007
PMC: PMC9908006
OpenAlex: W4309080193
Cited by: 644
References: 254
Citations by year: 2026: 160 · 2025: 221 · 2024: 180 · 2023: 81 · 2022: 2
FWCI: 12.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 374 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Funders: National Cancer Institute (R01CA254104)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: tissue macrophages, macrophage heterogeneity, macrophage ontogeny, macrophage differentiation, embryonic macrophages, bone marrow-derived macrophages, macrophage function, homeostasis, disease progression, conceptual framework
MeSH terms: Bone Marrow, Cell Differentiation, Homeostasis, Macrophages

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