The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity
Open accessAbstract
White adipose tissue (WAT) is an essential regulator of energy storage and systemic metabolic homeostasis. Regulatory networks consisting of immune and structural cells are necessary to maintain WAT metabolism, which can become impaired during obesity in mammals. Using single-cell transcriptomics and flow cytometry, we unveil a large-scale comprehensive cellular census of the stromal vascular fraction of healthy lean and obese human WAT. We report new subsets and developmental trajectories of adipose-resident innate lymphoid cells, dendritic cells and monocyte-derived macrophage populations that accumulate in obese WAT. Analysis of cell–cell ligand–receptor interactions and obesity-enriched signaling pathways revealed a switch from immunoregulatory mechanisms in lean WAT to inflammatory networks in obese WAT. These results provide a detailed and unbiased cellular landscape of homeostatic and inflammatory circuits in healthy human WAT. Immune cells exert important effects on white adipose tissue (WAT) in metabolic diseases. O’Sullivan and colleagues generate a comprehensive single-cell atlas of WAT cells in both health and disease to identify new cellular networks and differentiation trajectories.
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Cites
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Massier, L., Jalkanen, J., Elmastas, M., Zhong, J., Wang, T., Nono Nankam, P. A., Frendo-Cumbo, S., Bäckdahl, J., Subramanian, N., Sekine, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36983-2 · Cited by 195
Immunopathogenic mechanisms and immunoregulatory therapies in MASLD
He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01307-5 · Cited by 81
“Investigating cell ‒ cell ligand ‒ receptor interactions and obesity-enriched signaling pathways in white adipose tissue (WAT) [154] highlighted a dramatic shift from immunoregulatory mechanisms in lean WAT to the establishment of in fl ammatory networks in obese WAT.”
Adipose tissue aging is regulated by an altered immune system
Zhang, Y.-X., Ou, M.-Y., Yang, Z.-H., Sun, Y., Li, Q.-F., & Zhou, S.-B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125395 · Cited by 62
Metadata
- Authors
- Hildreth, A. D., Ma, F., Wong, Y. Y., Sun, R., Pellegrini, M., & O’Sullivan, T. E.
- Venue
- Nature Immunology
- Published
- 2021-04-27
- Volume
- 22
- Issue
- 5
- Pages
- 639-653
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W3157583546
- Cited by
- 359
- References
- 59
- FWCI
- 35.85
- Type
- journal article
- Language
- en
- Open access
- green
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