Vaccine-induced CD8+ T cells are key to protection from SARS-CoV-2

Dictionary learning for integrative, multimodal and scalable single-cell analysis

Hao, Y., Stuart, T., Kowalski, M. H., Choudhary, S., Hoffman, P., Hartman, A., Srivastava, A., Molla, G., Madad, S., Fernandez-Granda, C., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-023-01767-y · Cited by 5,631 · see citing works

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., Dejnirattisai, W., Rostron, T., Supasa, P., Liu, C., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0782-6 · Cited by 1,179 · see citing works

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

Poon, M. M. L., Rybkina, K., Kato, Y., Kubota, M., Matsumoto, R., Bloom, N. I., Zhang, Z., Hastie, K. M., Grifoni, A., Weiskopf, D., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abl9105 · Cited by 214 · see citing works

SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells

Minervina, A. A., Pogorelyy, M. V., Kirk, A. M., Crawford, J. C., Allen, E. K., Chou, C., Mettelman, R. C., Allison, K., Lin, C.-Y., Brice, D. C., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01184-4 · Cited by 210 · see citing works

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01627-6 · Cited by 202 · see citing works

An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Peng, Y., Felce, S. L., Dong, D., Penkava, F., Mentzer, A. J., Yao, X., Liu, G., Yin, Z., Chen, J., Lu, Y., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01084-z · Cited by 164 · see citing works

Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

Painter, M. M., Johnston, T. S., Lundgreen, K. A., Santos, J. J. S., Qin, J. S., Goel, R. R., Apostolidis, S. A., Mathew, D., Fulmer, B., Williams, J. C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01613-y · Cited by 106 · see citing works

High levels of virus-specific CD4+ T cells predict severe pandemic influenza A virus infection.

Zhao, Y., Zhang, Y.-H., Denney, L., Young, D., Powell, T., Peng, Y.-C., Li, N., Yan, H.-P., Wang, D.-Y., Shu, Y., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201207-1245oc · Cited by 70 · see citing works

Multimodal single-cell datasets characterize antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection

Zhang, B., Upadhyay, R., Hao, Y., Samanovic, M. I., Herati, R. S., Blair, J. D., Axelrad, J. E., Mulligan, M. J., Littman, D. R., & Satija, R. (2023) · Nature Immunology · doi:10.1038/s41590-023-01608-9 · Cited by 61 · see citing works

Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2

Diniz, M. O., Mitsi, E., Swadling, L., Rylance, J., Johnson, M., Goldblatt, D., Ferreira, D. M., & Maini, M. K. (2022) · Nature Immunology · doi:10.1038/s41590-022-01292-1 · Cited by 55 · see citing works

Cross-reactivity of SARS-CoV-2– and influenza A–specific T cells in individuals exposed to SARS-CoV-2

Chaisawangwong, W., Wang, H., Kouo, T. S., Salathe, S. F., Isser, A., Bieler, J. G., Zhang, M. L., Livingston, N. K., Li, S., Horowitz, J. J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158308 · Cited by 31 · see citing works

Landscape of T‐cell repertoires with public COVID‐19‐associated T‐cell receptors in pre‐pandemic risk cohorts

Simnica, D., Schultheiß, C., Mohme, M., Paschold, L., Willscher, E., Fitzek, A., Püschel, K., Matschke, J., Ciesek, S., Sedding, D., et al. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1340 · Cited by 21 · see citing works

3-year outcomes of discharged survivors of COVID-19 following the SARS-CoV-2 omicron (B.1.1.529) wave in 2022 in China: a longitudinal cohort study

Zhang, H., Huang, C., Gu, X., Wang, Y., Li, X., Liu, M., Wang, Q., Xu, J., Wang, Y., Dai, H., et al. (2023) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(23)00387-9 · Cited by 118 · see citing works

An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial

Saraf, A., Gurjar, R., Kaviraj, S., Kulkarni, A., Kumar, D., Kulkarni, R., Virkar, R., Krishnan, J., Yadav, A., Baranwal, E., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02955-2 · Cited by 66 · see citing works

Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial

Jeyanathan, M., Afkhami, S., D’Agostino, M. R., Satia, I., Fritz, D. K., Miyasaki, K., Ang, J. C., Zganiacz, A., Howie, K. J., Swinton, M. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60726-0 · Cited by 20 · see citing works

Developing CAR-immune cell therapy against SARS-CoV-2: Current status, challenges and prospects

Chen, Y., Liu, C., Fang, Y., Chen, W., Qiu, J., Zhu, M., Wei, W., & Tu, J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116066 · Cited by 8 · see citing works

Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA.1 infection of K18-hACE2 mice

Carolin, A., Yan, K., Bishop, C., Tang, B., Nguyen, W., Rawle, D. J., & Suhrbier, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302344 · Cited by 7 · see citing works

Mucosal vaccines with STING-agonist liposomal formulations inhibit RSV (respiratory syncytial virus) replication in cotton rats

Sefat, K. M. S. R., Kulkarni, R. S., Trinh, J., Leekha, A., Kumar, M., Wu, H., McBride, T., Aideyan, L. O., Avadhanula, V., Piedra, P. A., et al. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127183 · Cited by 6 · see citing works

A next-generation inhalable dry powder COVID vaccine

Xing, Z., & Jeyanathan, M. (2023) · Nature · doi:10.1038/d41586-023-03557-7 · Cited by 6 · see citing works

Immunity Induced by Inactivated SARS-CoV-2 Vaccine: Breadth, Durability, Potency, and Specificity in a Healthcare Worker Cohort

Chen, Y., Hu, C., Wang, Z., Su, J., Wang, S., Li, B., Liu, X., Yuan, Z., Li, D., Wang, H., et al. (2023) · Pathogens · doi:10.3390/pathogens12101254 · Cited by 4 · see citing works

Humoral and cellular immune response to AZD1222 /Covishield and BV152/Covaxin COVID-19 vaccines among adults in India

Tripathy, A. S., Singh, D., Trimbake, D., Salwe, S., Tripathy, S. P., Kakrani, A. L., Jali, P., Chavan, H., Yadav, P. D., Sahay, R. R., et al. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2410579 · Cited by 5 · see citing works

Immunotherapeutic Blockade of CD47 Increases Virus Neutralization Antibodies

Cham, L. B., Hamdan, T. A., Bhat, H., Sirajo, B., Ali, M., Tabbara, K. S., Farid, E., Barbouche, M., & Adomati, T. (2025) · Vaccines · doi:10.3390/vaccines13060602 · Cited by 4 · see citing works

Persistent differences in the immunogenicity of the two COVID-19 primary vaccines series, modulated by booster mRNA vaccination and breakthrough infection

Lee, K. Y., Song, K., Lee, K. H., Baek, J. Y., Kim, E. S., Song, Y. G., Kim, Y. C., Park, Y. S., Ahn, J. Y., Choi, J. Y., et al. (2024) · Vaccine · doi:10.1016/j.vaccine.2024.05.003 · Cited by 4 · see citing works

AeroVax: study protocol for a randomised, double-blind, placebo-controlled phase 2 trial to evaluate safety and immunogenicity of a next-generation COVID-19 vaccine delivered by inhaled aerosol to humans

Komorowski, A. S., Mbuagbaw, L. C. E., Jeyanathan, M., Afkhami, S., Swinton, M. E., D’Agostino, M. R., Howie, K. J., Medina, M. F. C., Gauvreau, G. M., Brister, D. L., et al. (2025) · ERJ Open Research · doi:10.1183/23120541.00758-2024 · Cited by 1 · see citing works

Severe Acute Respiratory Syndrome Coronavirus 2 Immunology and Coronavirus Disease 2019 Clinical Outcomes

Alrubayyi, A., Huang, H., & Gaiha, G. D. (2025) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2025.02.001

A conserved region T-cell vaccine for SarbecovirusesPreprint

Escarra‐Senmarti, M., Brockhurst, J., Maxwell, A. R., Godwin, T., Zhang, T., Chen, Y., Um, P. K., Danilova, L., Hsu, W.-C., Lin, C. T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.20.654373

Enhanced Spike-specific, but attenuated Nucleocapsid-specific T cell responses upon SARS-CoV-2 breakthrough versus non-breakthrough infections

Ahmed, M. I. M., Diepers, P., Janke, C., Plank, M., Eser, T. M., Rubio‐Acero, R., Fuchs, A., Baranov, O., Castelletti, N., Kroidl, I., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026473 · Cited by 13 · see citing works

SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses

Koutsakos, M., Reynaldi, A., Lee, W. S., Nguyen, J. T., Amarasena, T. H., Taiaroa, G., Kinsella, P. M., Liew, K. C., Tran, T., Kent, H. E., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.02.017 · Cited by 106 · see citing works

Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine

Oberhardt, V., Luxenburger, H., Kemming, J., Schulien, I., Ciminski, K., Giese, S., Csernalabics, B., Lang-Meli, J., Janowska, I., Staniek, J., et al. (2021) · Nature · doi:10.1038/s41586-021-03841-4 · Cited by 391 · see citing works

Role of antiviral CD8+ T cell immunity to SARS-CoV-2 infection and vaccination

Karl, V., Hofmann, M., & Thimme, R. (2025) · Journal of Virology · doi:10.1128/jvi.01350-24 · Cited by 34 · see citing works

Breakthrough SARS-COV-2 infection induces broad anti-viral T cell immunity

Lineburg, K. E., Crooks, P., Raju, J., Texier, L. L., Khaledi, P., Berry, K., Swaminathan, S., Panikkar, A., Rehan, S., Guppy-Coles, K., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108474 · Cited by 9 · see citing works