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MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency
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Cites
Crystal structure of the β2 adrenergic receptor–Gs protein complex
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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
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Self-citationEffects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998
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Self-citationProopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist
Kühnen, P., Clément, K., Wiegand, S., Blankenstein, O., Gottesdiener, K., Martini, L. L., Mai, K., Blume-Peytavi, U., Grüters, A., & Krude, H. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1512693 · Cited by 485
Self-citationEvaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
Collet, T.-H., Dubern, B., Mokrosinski, J., Connors, H., Keogh, J. M., Mendes de Oliveira, E., Henning, E., Poitou-Bernert, C., Oppert, J.-M., Tounian, P., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.015 · Cited by 302
Self-citationOxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design
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Perdomo, C. M., Cohen, R. V., Sumithran, P., Clément, K., & Frühbeck, G. (2023) · The Lancet · doi:10.1016/s0140-6736(22)02403-5 · Cited by 738
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Self-citationAron-Wisnewsky, J., Warmbrunn, M. V., Nieuwdorp, M., & Clément, K. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.057 · Cited by 452
Self-citationGenetics and epigenetics in obesity
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Human gain-of-function MC4R variants show signaling bias and protect against obesity
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Zeng, Q., Li, N., Pan, X.-F., Chen, L., & Pan, A. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00047-4 · Cited by 269
Pharmacotherapy of obesity: available medications and drugs under investigation.
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“Nonetheless, the five patients who met the study objective each achieved 15% or more weight loss, and two achieved 20% or more weight loss.(7) These results are also shown in Fig.”
BackgroundMethodResultInfluentialKleinendorst, L., Abawi, O., van der Voorn, B., Jongejan, M. H. T. M., Brandsma, A. E., Visser, J. A., van Rossum, E. F. C., van der Zwaag, B., Alders, M., Boon, E. M. J., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0232990 · Cited by 62
Metzger, P. J., Zhang, A., Carlson, B. A., Sun, H., Cui, Z., Li, Y., Jahnke, M. T., Layton, D. R., Gupta, M. B., Liu, N., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci165418 · Cited by 42
Liu, T., Ji, R.-L., & Tao, Y.-X. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108044 · Cited by 34
Recent progress in the pharmacotherapy for obesity
Lu, J., Liu, P., Cai, M., Lv, T., Zhang, M., Yin, K., Cheng, J., & Zhang, G. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177850 · Cited by 17
Metadata
- Authors
- Clément, K., Biebermann, H., Farooqi, I. S., Van der Ploeg, L., Wolters, B., Poitou, C., Puder, L., Fiedorek, F., Gottesdiener, K., Kleinau, G., Heyder, N., Scheerer, P., Blume-Peytavi, U., Jahnke, I., Sharma, S., Mokrosinski, J., Wiegand, S., Müller, A., Weiß, K., Mai, K., Spranger, J., Grüters, A., Blankenstein, O., Krude, H., & Kühnen, P.
- Venue
- Nature Medicine
- Published
- 2018-05
- Volume
- 24
- Issue
- 5
- Pages
- 551-555
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2802308993
- Cited by
- 309
- References
- 7
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
