Loeffler, Markus

Intensive insulin therapy and pentastarch resuscitation in severe sepsis

Brunkhorst, F. M., Engel, C., Bloos, F., Meier-Hellmann, A., Ragaller, M., Weiler, N., Moerer, O., Gruendling, M., Oppert, M., Grond, S., et al. (2008) · New England Journal of Medicine

Hyperglycemia and glycemic control in critically ill and hospitalized patientsSepsis Diagnosis and Treatment

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Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Kasela, S., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., et al. (2021) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 2,607

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Chapuy, B., Stewart, C., Dunford, A. J., Kim, J., Kamburov, A., Redd, R. A., Lawrence, M. S., Roemer, M. G. M., Li, A. J., Ziepert, M., et al. (2018) · Nature Medicine

Lymphoma Diagnosis and TreatmentCNS Lymphoma Diagnosis and Treatment

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The power of genetic diversity in genome-wide association studies of lipids

Graham, S. E., Clarke, S. L., Wu, K.-H. H., Kanoni, S., Zajac, G. J. M., Ramdas, S., Surakka, I., Ntalla, I., Vedantam, S., Winkler, T. W., et al. (2021) · Nature

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 972

A saturated map of common genetic variants associated with human height

Yengo, L., Vedantam, S., Marouli, E., Sidorenko, J., Bartell, E., Sakaue, S., Graff, M., Eliasen, A. U., Jiang, Y., Raghavan, S., et al. (2022) · Nature

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 825

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Rodriguez-Martin, B., Alvarez, E. G., Baez-Ortega, A., Zamora, J., Supek, F., Demeulemeester, J., Santamarina, M., Ju, Y. S., Temes, J., Garcia-Souto, D., et al. (2020) · Nature Genetics

Genomic variations and chromosomal abnormalitiesCancer Genomics and Diagnostics

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Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

Qi, T., Wu, Y., Zeng, J., Zhang, F., Xue, A., Jiang, L., Zhu, Z., Kemper, K., Yengo, L., Zheng, Z., et al. (2018) · Nature Communications

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 427

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits.

Porcu, E., Rüeger, S., Lepik, K., eQTLGen Consortium, Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., et al. (2019) · Nature Communications

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 322

Contralateral Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Graeser, M. K., Engel, C., Rhiem, K., Gadzicki, D., Bick, U., Kast, K., Froster, U. G., Schlehe, B., Bechtold, A., Arnold, N., et al. (2009) · Journal of Clinical Oncology

BRCA gene mutations in cancerMultiple and Secondary Primary Cancers

Cited by 314

Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial

Bloos, F., Trips, E., Nierhaus, A., Briegel, J., Heyland, D. K., Jaschinski, U., Moerer, O., Weyland, A., Marx, G., Gründling, M., et al. (2016) · JAMA Internal Medicine

Sepsis Diagnosis and TreatmentVitamin C and Antioxidants Research

Cited by 268

Evaluating selection bias in a population-based cohort study with low baseline participation: the LIFE-Adult-Study

Enzenbach, C., Wicklein, B., Wirkner, K., & Loeffler, M. (2019) · BMC Medical Research Methodology

Survey Methodology and NonresponseStatistical Methods in Epidemiology

Cited by 186

Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial)

Verry, C., Dufort, S., Villa, J., Gavard, M., Iriart, C., Grand, S., Charles, J., Chovelon, B., Cracowski, J.-L., Quesada, J.-L., et al. (2021) · Radiotherapy and Oncology

Brain Metastases and TreatmentRadiation Therapy and Dosimetry

Cited by 173

Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives

Bae, Y. J., Zeidler, R., Baber, R., Vogel, M., Wirkner, K., Loeffler, M., Ceglarek, U., Kiess, W., Körner, A., Thiery, J., et al. (2019) · The Journal of Steroid Biochemistry and Molecular Biology

Clinical Laboratory Practices and Quality ControlAdrenal Hormones and Disorders

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Phase I/II study testing the combination of AGuIX nanoparticles with radiochemotherapy and concomitant temozolomide in patients with newly diagnosed glioblastoma (NANO-GBM trial protocol)

Thivat, E., Casile, M., Moreau, J., Molnar, I., Dufort, S., Seddik, K., Le Duc, G., De Beaumont, O., Loeffler, M., Durando, X., et al. (2023) · BMC Cancer

Glioma Diagnosis and TreatmentRadiation Therapy and Dosimetry

Cited by 76

Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer

Kloth, M., Ruesseler, V., Engel, C., Koenig, K., Peifer, M., Mariotti, E., Kuenstlinger, H., Florin, A., Rommerscheidt-Fuss, U., Koitzsch, U., et al. (2016) · Gut

Genetic factors in colorectal cancerColorectal Cancer Treatments and Studies

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The age-dependent relationship between resting heart rate variability and functional brain connectivity

Kumral, D., Schaare, H. L., Beyer, F., Reinelt, J., Uhlig, M., Liem, F., Lampe, L., Babayan, A., Reiter, A., Erbey, M., et al. (2019) · NeuroImage

Heart Rate Variability and Autonomic ControlFunctional Brain Connectivity Studies

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Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

Vojinovic, D., Adams, H. H., Jian, X., Yang, Q., Smith, A. V., Bis, J. C., Teumer, A., Scholz, M., Armstrong, N. J., Hofer, E., et al. (2018) · Nature Communications

Genetic Associations and EpidemiologyCerebrospinal fluid and hydrocephalus

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The association between an anxiety disorder and cancer in medical history

Zeynalova, N., Schimpf, S., Setter, C., Yahiaoui-Doktor, M., Zeynalova, S., Lordick, F., Loeffler, M., & Hinz, A. (2019) · Journal of Affective Disorders

Cancer survivorship and careAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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