CoChat
Sign Up
Cited by 124

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys

Tao, Yunlong, Vermilyea, Scott C., Zammit, Matthew, Lu, Jianfeng, Olsen, Miles, Metzger, Jeanette M., Yao, Lin, Chen, Yuejun, Phillips, Sean, Holden, James E., Bondarenko, Viktoriya, Block, Walter F., Barnhart, Todd E., Schultz-Darken, Nancy, Brunner, Kevin, Simmons, Heather, Christian, Bradley T., Emborg, Marina E., Zhang, Su-Chun·2021·Nature Medicine
DOI 10.1038/s41591-021-01257-1PMC PMC8198752
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41591-021-01257-1

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 6 references

Research works printed but not linked: 34

  1. Bjorklund, A. & Lindvall, O. Replacing dopamine neurons in Parkinson’s disease: how did it happen? J. Parkinsons Dis. 7, S21–S31 (2017). · DOI
  2. Barker, R. A., Barrett, J., Mason, S. L. & Bjorklund, A. Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson’s disease. Lancet Neurol. 12, 84–91 (2013). · DOI
  3. Kriks, S. et al. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature 480, 547–551 (2011). · DOI
  4. Barker, R. A., Parmar, M., Studer, L. & Takahashi, J. Human trials of stem cell-derived dopamine neurons for Parkinson’s disease: dawn of a new era. Cell Stem Cell 21, 569–573 (2017). · DOI · Paper page
  5. Emborg, M. E. et al. Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain. Cell Rep. 3, 646–650 (2013). · DOI
  6. Hallett, P. J. et al. Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson’s disease. Cell Stem Cell 16, 269–274 (2015). · DOI
  7. Xi, J. et al. Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells 30, 1655–1663 (2012). · DOI
  8. Reeve, A., Simcox, E. & Turnbull, D. Ageing and Parkinson’s disease: why is advancing age the biggest risk factor? Ageing Res. Rev. 14, 19–30 (2014). · DOI
  9. Takagi, Y. et al. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J. Clin. Invest. 115, 102–109 (2005). · DOI
  10. Daadi, M. M., Grueter, B. A., Malenka, R. C., Redmond, D. E. Jr. & Steinberg, G. K. Dopaminergic neurons from midbrain-specified human embryonic stem cell-derived neural stem cells engrafted in a monkey model of Parkinson’s disease. PLoS ONE 7, e41120 (2012). · DOI
  11. Wakeman, D. R. et al. Survival and integration of neurons derived from human embryonic stem cells in MPTP-lesioned primates. Cell Transplant. 23, 981–994 (2014). · DOI
  12. Gonzalez, C., Bonilla, S., Flores, A. I., Cano, E. & Liste, I. An update on human stem cell-based therapy in Parkinson’s disease. Curr. Stem Cell Res. Ther. 11, 561–568 (2016). · DOI
  13. Kikuchi, T. et al. Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson’s disease. J. Parkinsons Dis. 1, 395–412 (2011). · DOI
  14. Wang, Y. K. et al. Human clinical-grade parthenogenetic ESC-derived dopaminergic neurons recover locomotive defects of nonhuman primate models of Parkinson’s disease. Stem Cell Rep. 11, 171–182 (2018). · DOI
  15. Wang, S. et al. Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model. Cell Disco. 1, 15012 (2015). · DOI
  16. Emborg-Knott, M. E. & Domino, E. F. MPTP-Induced hemiparkinsonism in nonhuman primates 6-8 years after a single unilateral intracarotid dose. Exp. Neurol. 152, 214–220 (1998). · DOI
  17. Gash, D. M. et al. An automated movement assessment panel for upper limb motor functions in rhesus monkeys and humans. J. Neurosci. Methods 89, 111–117 (1999). · DOI
  18. Vermilyea, S. C. et al. Real-time intraoperative MRI intracerebral delivery of induced pluripotent stem cell-derived neurons. Cell Transplant. 26, 613–624 (2017). · DOI
  19. Ahlskog, J. E., Maraganore, D. M., Uitti, R. J. & Uhl, G. R. Brain imaging to assess the effects of dopamine agonists on progression of Parkinson disease. JAMA 288, 311 (2002).
  20. Hsiao, I. T. et al. Correlation of Parkinson disease severity and 18F-DTBZ positron emission tomography. JAMA Neurol. 71, 758–766 (2014). · DOI
  21. Tiklova, K. et al. Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease. Nat. Commun. 11, 2434 (2020). · DOI
  22. Morizane, A. et al. MHC matching improves engraftment of iPSC-derived neurons in non-human primates. Nat. Commun. 8, 385 (2017). · DOI · Paper page
  23. Mendez, I. et al. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson’s disease. Brain 128, 1498–1510 (2005). · DOI
  24. Hallett, P. J. et al. Long-term health of dopaminergic neuron transplants in Parkinson’s disease patients. Cell Rep. 7, 1755–1761 (2014). · DOI
  25. Yin, D. et al. Striatal volume differences between non-human and human primates. J. Neurosci. Methods 176, 200–205 (2009). · DOI
  26. Kordower, J. H. et al. Functional fetal nigral grafts in a patient with Parkinson’s disease: chemoanatomic, ultrastructural, and metabolic studies. J. Comp. Neurol. 370, 203–230 (1996). · DOI
  27. Li, W. et al. Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain. Proc. Natl Acad. Sci. USA 113, 6544–6549 (2016). · DOI · Paper page
  28. Wu, J. et al. An alternative pluripotent state confers interspecies chimaeric competency. Nature 521, 316–321 (2015). · DOI
  29. Jewett, D. M., Kilbourn, M. R. & Lee, L. C. A simple synthesis of [11C]dihydrotetrabenazine (DTBZ). Nucl. Med. Biol. 24, 197–199 (1997). · DOI
  30. Innis, R. B. et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J. Cereb. Blood Flow Metab. 27, 1533–1539 (2007). · DOI · Paper page
  31. Lammertsma, A. A. & Hume, S. P. Simplified reference tissue model for PET receptor studies. Neuroimage 4, 153–158 (1996). · DOI
  32. Ichise, M. et al. Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J. Cereb. Blood Flow Metab. 23, 1096–1112 (2003). · DOI
  33. Tao, Y. et al. PAX6D instructs neural retinal specification from human embryonic stem cell-derived neuroectoderm. EMBO Rep. https://doi.org/10.15252/embr.202050000 (2020). · DOI
  34. Ohshima-Hosoyama, S. et al. A monoclonal antibody-GDNF fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys. PLoS ONE 7, e39036 (2012). · DOI

Cited by

See all 124

Metadata

Authors
Tao, Y., Vermilyea, S. C., Zammit, M., Lu, J., Olsen, M., Metzger, J. M., Yao, L., Chen, Y., Phillips, S., Holden, J. E., Bondarenko, V., Block, W. F., Barnhart, T. E., Schultz-Darken, N., Brunner, K., Simmons, H., Christian, B. T., Emborg, M. E., & Zhang, S.-C.
ORCID
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2021-03-01
Volume
27
Issue
4
Pages
632-639
ISSN
  • 1078-8956
  • 1546-170X
DOI
10.1038/s41591-021-01257-1
PMC
PMC8198752
Cited by
124
References
6
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. https://app.cochat.ai/papers/10.1038/s41591-021-01257-1
The paper
Tao, Y., Vermilyea, S. C., Zammit, M., Lu, J., Olsen, M., Metzger, J. M., Yao, L., Chen, Y., Phillips, S., Holden, J. E., Bondarenko, V., Block, W. F., Barnhart, T. E., Schultz-Darken, N., Brunner, K., Simmons, H., Christian, B. T., Emborg, M. E., & Zhang, S.-C. (2021). Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nature Medicine. https://doi.org/10.1038/s41591-021-01257-1