Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
Abstract
An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.
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VT/fP is proportional to binding potential, which is proportional to receptor number at equilibrium, given no change in affinity and no difference in nondisplaceable uptake between subjects or comparison groups.
“VT/fP is proportional to the binding potential (BP, mL/g=Bmax/KD), which is proportional to the receptor number (Bmax) at equilibrium, given the assumptions that there is no change in affinity (KD) and that nondisplaceable (nonspecific and free) uptake does not differ between subjects or comparison groups.”
From β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco Smoking (2009) · cites this paper as [52]
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Self-citationMaternal dopamine encodes affective signals of human infants
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Increased binding of 5-HT1A receptors in a dissociative amnesic patient after the recovery process
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Dopamine Type 2/3 Receptor Availability in the Striatum and Social Status in Human Volunteers
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- Authors
- Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Houle, S., Huang, S.-C., Ichise, M., Iida, H., Ito, H., Kimura, Y., Koeppe, R. A., Knudsen, G. M., Knuuti, J., Lammertsma, A. A., Laruelle, M., Logan, J., Maguire, R. P., Mintun, M. A., Morris, E. D., Parsey, R., Price, J. C., Slifstein, M., Sossi, V., Suhara, T., Votaw, J. R., Wong, D. F., & Carson, R. E.
- Affiliations
- National Institute of Mental Health (US)
- GlaxoSmithKline (United Kingdom) (GB)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Aarhus University (DK)
- University of Wisconsin–Madison (US)
- Centre for Addiction and Mental Health (CA)
- University of California, Los Angeles (US)
- Columbia University (US)
- National Cerebral and Cardiovascular Center (JP)
- National Institute of Radiological Sciences (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- University of Michigan (US)
- Copenhagen University Hospital (DK)
- University of Turku (FI)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Brookhaven National Laboratory (US)
- Pfizer (United States) (US)
- Washington University in St. Louis (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Pittsburgh (US)
- University of British Columbia (CA)
- Emory University (US)
- Johns Hopkins University (US)
- Yale University (US)
- Corresponding author
- Innis, Robert B
- ORCID
- Innis, Robert B
- Fujita, Masahiro
- Gjedde, Albert
- Gunn, Roger N
- Houle, Sylvain
- Ichise, Masanori
- Iida, Hidehiro
- Ito, Hiroshi
- Kimura, Yuichi
- Koeppe, Robert A
- Knudsen, Gitte M
- Knuuti, Juhani
- Lammertsma, Adriaan A
- Logan, Jean
- Maguire, Ralph Paul
- Morris, Evan D
- Parsey, Ramin
- Price, Julie C
- Slifstein, Mark
- Sossi, Vesna
- Suhara, Tetsuya
- Wong, Dean F
- Carson, Richard E
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2007-09
- Volume
- 27
- Issue
- 9
- Pages
- 1533-1539
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2112278807
- Cited by
- 1,955
- References
- 0
- Citations by year
- 2026: 40 · 2025: 63 · 2024: 70 · 2023: 59 · 2022: 86 · 2021: 85 · 2020: 106 · 2019: 93 · 2018: 97 · 2017: 114 · 2016: 122 · 2015: 148 · 2014: 167 · 2013: 138 · 2012: 151
- FWCI
- 73.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiology practices and education
- Keywords
- in vivo molecular imaging, pharmacokinetic modeling, radiotracer binding
- MeSH terms
- Diagnostic Imaging, Terminology as Topic, Radioligand Assay, Tomography, Emission-Computed, Single-Photon, Radiopharmaceuticals, Consensus, Positron-Emission Tomography
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