Cited by 128Neurotransmitter Receptor Influence on BehaviorNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Development, wiring and function of dopamine neuron subtypes

Open access
Garritsen, Oxana, van Battum, Eljo Y., Grossouw, Laurens M., Pasterkamp, R. Jeroen·2023·Nature reviews. Neuroscience

Abstract

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.

Integrity signals

Registry

Crossref · 10.1038/s41583-022-00669-3

Cites

290 of 290 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Ventral midbrain dopamine neurons are diverse, project to different regions, and can release neurotransmitters besides dopamine.

    “Dopamine neurons of the ventral midbrain (DANs) comprise a diverse population of neurons targeting different regions and capable of releasing multiple neurotransmitters in addition to dopamine.31,103,104”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Garritsen, O., van Battum, E. Y., Grossouw, L. M., & Pasterkamp, R. J.
Affiliations
Utrecht University (NL)
Corresponding author
Pasterkamp, R. Jeroen
Venue
Nature reviews. Neuroscience
Published
2023-01-18
Volume
24
Issue
3
Pages
134-152
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W4317234536
Cited by
128
References
289
Citations by year
2026: 32 · 2025: 40 · 2024: 41 · 2023: 15
FWCI
4.93
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Funders
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (865.14.004)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
midbrain dopaminergic neurons, neuronal development, neuronal migration, axon guidance, molecular identity, treatment options
MeSH terms
Brain, Brain Diseases, Dopamine, Humans, Mesencephalon, Dopaminergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review