Development, wiring and function of dopamine neuron subtypes
Open accessAbstract
The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.
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Ventral midbrain dopamine neurons are diverse, project to different regions, and can release neurotransmitters besides dopamine.
“Dopamine neurons of the ventral midbrain (DANs) comprise a diverse population of neurons targeting different regions and capable of releasing multiple neurotransmitters in addition to dopamine.31,103,104”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [103]
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- Authors
- Garritsen, O., van Battum, E. Y., Grossouw, L. M., & Pasterkamp, R. J.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Pasterkamp, R. Jeroen
- Venue
- Nature reviews. Neuroscience
- Published
- 2023-01-18
- Volume
- 24
- Issue
- 3
- Pages
- 134-152
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W4317234536
- Cited by
- 128
- References
- 289
- Citations by year
- 2026: 32 · 2025: 40 · 2024: 41 · 2023: 15
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (865.14.004)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- midbrain dopaminergic neurons, neuronal development, neuronal migration, axon guidance, molecular identity, treatment options
- MeSH terms
- Brain, Brain Diseases, Dopamine, Humans, Mesencephalon, Dopaminergic Neurons
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