The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Distinction of lymphoid and myeloid clonal hematopoiesis
Open accessAbstract
Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. Somatic gene mutations associated with hematologic malignancies detected in hematopoietic cells of healthy individuals, referred to as CH of indeterminate potential (CHIP), have been associated with myeloid malignancies, while mosaic chromosomal alterations (mCAs) have been associated with lymphoid malignancies. Here, we analyzed CHIP in 55,383 individuals and autosomal mCAs in 420,969 individuals with no history of hematologic malignancies in the UK Biobank and Mass General Brigham Biobank. We distinguished myeloid and lymphoid somatic gene mutations, as well as myeloid and lymphoid mCAs, and found both to be associated with risk of lineage-specific hematologic malignancies. Further, we performed an integrated analysis of somatic alterations with peripheral blood count parameters to stratify the risk of incident myeloid and lymphoid malignancies. These genetic alterations can be readily detected in clinical sequencing panels and used with blood count parameters to identify individuals at high risk of developing hematologic malignancies. Genomic analyses in the UK Biobank show that clonal hematopoiesis of indeterminate potential in the lymphoid lineage is associated with a higher risk of developing lymphoid malignancies
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The UK Biobank resource with deep phenotyping and genomic data
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Age-related clonal hematopoiesis associated with adverse outcomes
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Self-citationRobust relationship inference in genome-wide association studies
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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
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Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
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Age-related mutations associated with clonal hematopoietic expansion and malignancies
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Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
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Cited by
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Kar, S. P., Quiros, P. M., Gu, M., Jiang, T., Mitchell, J., Langdon, R., Iyer, V., Barcena, C., Vijayabaskar, M. S., Fabre, M. A., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01121-z · Cited by 377
Common and rare variant associations with clonal haematopoiesis phenotypes
Kessler, M. D., Damask, A., O’Keeffe, S., Banerjee, N., Li, D., Watanabe, K., Marketta, A., Van Meter, M., Semrau, S., Horowitz, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05448-9 · Cited by 313
Causes and consequences of clonal hematopoiesis
Weeks, L. D., & Ebert, B. L. (2023) · Blood · doi:10.1182/blood.2023022222 · Cited by 169
Self-citationClonal haematopoiesis and dysregulation of the immune system
Belizaire, R., Wong, W. J., Robinette, M. L., & Ebert, B. L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00843-3 · Cited by 161
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Metadata
- Authors
- Niroula, A., Sekar, A., Murakami, M. A., Trinder, M., Agrawal, M., Wong, W. J., Bick, A. G., Uddin, M. M., Gibson, C. J., Griffin, G. K., Honigberg, M. C., Zekavat, S. M., Paruchuri, K., Natarajan, P., & Ebert, B. L.
- Venue
- Nature Medicine
- Published
- 2021-10-18
- Volume
- 27
- Issue
- 11
- Pages
- 1921-1927
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3206778834
- Cited by
- 307
- References
- 15
- FWCI
- 26.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Niroula, A., Sekar, A., Murakami, M. A., Trinder, M., Agrawal, M., Wong, W. J., Bick, A. G., Uddin, M. M., Gibson, C. J., Griffin, G. K., Honigberg, M. C., Zekavat, S. M., Paruchuri, K., Natarajan, P., & Ebert, B. L. (2021). Distinction of lymphoid and myeloid clonal hematopoiesis. Nature Medicine. https://doi.org/10.1038/s41591-021-01521-4
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