The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Axicabtagene ciloleucel as first-line therapy in high-risk large B-cell lymphoma: the phase 2 ZUMA-12 trial
Open accessAbstract
High-risk large B-cell lymphoma (LBCL) has poor outcomes with standard first-line chemoimmunotherapy. In the phase 2, multicenter, single-arm ZUMA-12 study (ClinicalTrials.gov NCT03761056) we evaluated axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, as part of first-line treatment in 40 patients with high-risk LBCL. This trial has completed accrual. The primary outcome was complete response rate (CRR). Secondary outcomes were objective response rate (ORR), duration of response (DOR), event-free survival (EFS), progression-free survival (PFS), overall survival (OS), assessment of safety, central nervous system (CNS) relapse and blood levels of CAR T cells and cytokines. The primary endpoint in efficacy-evaluable patients (n = 37) was met, with 78% CRR (95% confidence interval (CI), 62–90) and 89% ORR (95% CI, 75–97). As of 17 May 2021 (median follow-up, 15.9 months), 73% of patients remained in objective response; median DOR, EFS and PFS were not reached. Grade ≥3 cytokine release syndrome (CRS) and neurologic events occurred in three patients (8%) and nine patients (23%), respectively. There were no treatment-related grade 5 events. Robust CAR T-cell expansion occurred in all patients with a median time to peak of 8 days. We conclude that axi-cel is highly effective as part of first-line therapy for high-risk LBCL, with a manageable safety profile.
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Cites
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Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
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Self-citationKTE-X19 CAR T cell therapy in relapsed or refractory mantle-cell lymphoma
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Long-term outcomes following CAR T cell therapy: what we know so far
Cappell, K. M., & Kochenderfer, J. N. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00754-1 · Cited by 1,382
Kelkar, A. H., Cliff, E. R. S., Jacobson, C. A., Abel, G. A., Dijk, S. W., Krijkamp, E. M., Redd, R., Zurko, J. C., Hamadani, M., Hunink, M. G. M., et al. (2023) · Annals of Internal Medicine · doi:10.7326/m22-2276 · Cited by 31
Ma, J., Sarén, T., Jin, C., Kim, H. S., Contreras Pineda, P. D., de Bernard, M., Amini, R.-M., Rondahl, V., Enblad, G., Yu, D., et al. (2025) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-025-04112-1 · Cited by 1
Metadata
- Authors
- Neelapu, S. S., Dickinson, M., Munoz, J., Ulrickson, M. L., Thieblemont, C., Oluwole, O. O., Herrera, A. F., Ujjani, C. S., Lin, Y., Riedell, P. A., Kekre, N., de Vos, S., Lui, C., Milletti, F., Dong, J., Xu, H., & Chavez, J. C.
- Venue
- Nature Medicine
- Published
- 2022-03-21
- Volume
- 28
- Issue
- 4
- Pages
- 735-742
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W4221044986
- Cited by
- 291
- References
- 34
- FWCI
- 23.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Neelapu, S. S., Dickinson, M., Munoz, J., Ulrickson, M. L., Thieblemont, C., Oluwole, O. O., Herrera, A. F., Ujjani, C. S., Lin, Y., Riedell, P. A., Kekre, N., de Vos, S., Lui, C., Milletti, F., Dong, J., Xu, H., & Chavez, J. C. (2022). Axicabtagene ciloleucel as first-line therapy in high-risk large B-cell lymphoma: the phase 2 ZUMA-12 trial. Nature Medicine. https://doi.org/10.1038/s41591-022-01731-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
