The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging
Open accessAbstract
Although current implementations of super-resolution microscopy are technically approaching true molecular-scale resolution, this has not translated to imaging of biological specimens, because of the large size of conventional affinity reagents. Here we introduce slow off-rate modified aptamers (SOMAmers) as small and specific labeling reagents for use with DNA points accumulation in nanoscale topography (DNA-PAINT). To demonstrate the achievable resolution, specificity, and multiplexing capability of SOMAmers, we labeled and imaged both transmembrane and intracellular targets in fixed and live cells. Slow off-rate modified aptamer (SOMAmer) reagents are small and versatile probes for DNA-PAINT super-resolution microscopy that enable multiplexed, quantitative, and high-resolution imaging in fixed and live cells.
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Cites
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
Gold, L., Ayers, D., Bertino, J., Bock, C., Bock, A., Brody, E. N., Carter, J., Dalby, A. B., Eaton, B. E., Fitzwater, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015004 · Cited by 1,754
Self-citationGupta, S., Hirota, M., Waugh, S. M., Murakami, I., Suzuki, T., Muraguchi, M., Shibamori, M., Ishikawa, Y., Jarvis, T. C., Carter, J. D., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.532580 · Cited by 151
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Single-molecule methods in structural DNA nanotechnology
Platnich, C. M., Rizzuto, F. J., Cosa, G., & Sleiman, H. F. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00776h · Cited by 52
Live‐cell super‐resolution imaging of actin using LifeAct ‐14 with a PAINT ‐based approach
Bhaskar, H., Kleinjan, D., Oi, C., Gidden, Z., Rosser, S. J., Horrocks, M. H., & Regan, L. (2023) · Protein Science · doi:10.1002/pro.4558 · Cited by 12
Metadata
- Authors
- Strauss, S., Nickels, P. C., Strauss, M. T., Jimenez Sabinina, V., Ellenberg, J., Carter, J. D., Gupta, S., Janjic, N., & Jungmann, R.
- Venue
- Nature Methods
- Published
- 2018-08-20
- Volume
- 15
- Issue
- 9
- Pages
- 685-688
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2885894609
- Cited by
- 203
- References
- 2
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Strauss, S., Nickels, P. C., Strauss, M. T., Jimenez Sabinina, V., Ellenberg, J., Carter, J. D., Gupta, S., Janjic, N., & Jungmann, R. (2018). Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging. Nature Methods. https://doi.org/10.1038/s41592-018-0105-0
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