Single-molecule methods in structural DNA nanotechnology
Abstract
In this tutorial review, we explore the suite of single-molecule techniques currently available to probe DNA nanostructures and highlight the relationship between single-molecule method development and DNA nanotechology.
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Atomic force microscopy (AFM) was used to read out images formed by DNA origami and remains a key technique for the study of DNA-based nanomaterials.
“Atomic force microscopy (AFM) was used to “read-out” images formed by DNA origami, and this remains a key technique for the study of DNA-based nanomaterials.126”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [126]
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- Authors
- Platnich, C. M., Rizzuto, F. J., Cosa, G., & Sleiman, H. F.
- Affiliations
- McGill University (CA)
- Corresponding author
- Cosa, Gonzalo
- Sleiman, Hanadi F.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 49
- Issue
- 13
- Pages
- 4220-4233
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W3034772251
- Cited by
- 52
- References
- 51
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 4
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation for Innovation
- Fonds de Recherche du Québec - Nature et Technologies
- Canadian Institutes of Health Research
- Canada Research Chairs
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Force Microscopy Techniques and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanopore and Nanochannel Transport Studies
- Keywords
- DNA nanotechnology, DNA nanostructures, fluorescence microscopy, electron microscopy, force spectroscopy, structural heterogeneity, DNA-based materials, DNA nanomaterials
- MeSH terms
- Single Molecule Imaging, DNA, Microscopy, Electron, Microscopy, Fluorescence, Nucleic Acid Conformation, Biosensing Techniques, Microscopy, Atomic Force, Nanostructures
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