Cited by 189Gut microbiota and healthMaternal Mental Health During Pregnancy and PostpartumStress Responses and Cortisol

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The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

Jašarević, Eldin, Howard, Christopher D., Morrison, Kathleen, Misic, Ana, Weinkopff, Tiffany, Scott, Phillip, Hunter, Christopher, Beiting, Daniel, Bale, Tracy L.·2018·Nature Neuroscience

DOI 10.1038/s41593-018-0182-5

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Abstract

Early prenatal stress disrupts maternal-to-offspring microbiota transmission and has lasting effects on metabolism, physiology, cognition, and behavior in male mice. Here we show that transplantation of maternal vaginal microbiota from stressed dams into naive pups delivered by cesarean section had effects that partly resembled those seen in prenatally stressed males. However, transplantation of control maternal vaginal microbiota into prenatally stressed pups delivered by cesarean section did not rescue the prenatal-stress phenotype. Prenatal stress was associated with alterations in the fetal intestinal transcriptome and niche, as well as with changes in the adult gut that were altered by additional stress exposure in adulthood. Further, maternal vaginal transfer also partially mediated the effects of prenatal stress on hypothalamic gene expression, as observed after chronic stress in adulthood. These findings suggest that the maternal vaginal microbiota contribute to the lasting effects of prenatal stress on gut and hypothalamus in male mice.

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Authors: Jašarević, E., Howard, C. D., Morrison, K., Misic, A., Weinkopff, T., Scott, P., Hunter, C., Beiting, D., & Bale, T. L.
Affiliations: University of Maryland, Baltimore (US)
University of Pennsylvania (US)
Corresponding author: Bale, Tracy L.
ORCID: Jašarević, Eldin
Howard, Christopher D.
Morrison, Kathleen
Misic, Ana
Weinkopff, Tiffany
Scott, Phillip
Hunter, Christopher
Beiting, Daniel
Bale, Tracy L.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-07-09
Volume: 21
Issue: 8
Pages: 1061-1071
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/s41593-018-0182-5
OpenAlex: W2840355095
Cited by: 189
References: 60
Citations by year: 2026: 12 · 2025: 24 · 2024: 20 · 2023: 26 · 2022: 30 · 2021: 38 · 2020: 18 · 2019: 17 · 2018: 4
FWCI: 6.85
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (F32AI114080)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: prenatal stress, microbiota transfer, gut microbiota, hypothalamus, chronic stress, neurodevelopmental disorders, cesarean section, male offspring
MeSH terms: Animals, Body Weight, Cesarean Section, Female, Hypothalamo-Hypophyseal System, Hypothalamus, Intestinal Absorption, Male, Mice, Inbred C57BL, Paraventricular Hypothalamic Nucleus, Phenotype, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Vagina, Gene Expression, Gastrointestinal Tract, Mice, Transcriptome, Microbiota

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The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus

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