The road not taken: host genetics in shaping intergenerational microbiomes
Abstract
The early-life gut microbiome is linked to human phenotypes as an imbalanced microbiome of this period is implicated in diseases throughout life. Several determinants of early-life gut microbiome are explored, however, mechanisms of acquisition, colonization, and stability of early-life gut microbiome and their interindividual variability remain elusive. Host genetics play a vital role to shape the gut microbiome and interact with it to modulate individual phenotypes in human studies and animal models. Given the microbial linkage between host generations, we discuss the current state of roles of host genetics in forming intergenerational microbiomes associated with mothers, offspring, and those vertically transmitted, providing a basis for taking into account host genetics in future early-life microbiome research. We further expand our discussion to the bidirectional interactions between host gene expression and microbiome in human health.
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Caesarean section delivery alters the initial microbial composition.
“Caesarean section delivery alters the initial microbial composition (82).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [82]
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Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
- Authors
- Zeng, S., Wang, S., Ross, R. P., & Stanton, C.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Corresponding author
- Wang, Shaopu
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2022-11
- Volume
- 38
- Issue
- 11
- Pages
- 1180-1192
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W4283576136
- Cited by
- 9
- References
- 119
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland (12/RC/2273_P2)
- National Natural Science Foundation of China (82100590)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- host genetics, gut microbiota, early-life microbiota, vertical transmission, maternal microbiome, host-microbiome interactions, gene expression, interindividual variability
- MeSH terms
- Gastrointestinal Microbiome, Animals, Humans, Microbiota
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