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The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus
Abstract
Early prenatal stress disrupts maternal-to-offspring microbiota transmission and has lasting effects on metabolism, physiology, cognition, and behavior in male mice. Here we show that transplantation of maternal vaginal microbiota from stressed dams into naive pups delivered by cesarean section had effects that partly resembled those seen in prenatally stressed males. However, transplantation of control maternal vaginal microbiota into prenatally stressed pups delivered by cesarean section did not rescue the prenatal-stress phenotype. Prenatal stress was associated with alterations in the fetal intestinal transcriptome and niche, as well as with changes in the adult gut that were altered by additional stress exposure in adulthood. Further, maternal vaginal transfer also partially mediated the effects of prenatal stress on hypothalamic gene expression, as observed after chronic stress in adulthood. These findings suggest that the maternal vaginal microbiota contribute to the lasting effects of prenatal stress on gut and hypothalamus in male mice.
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“Furthermore, the transfer of the maternal vaginal microbiota from stressed dams to non-stressed pups is sufficient to alter their response to stress in adulthood (Jasarevic et al., 2018).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Jasarevic et al., 2018
In the citing paper
“In a subsequent study, it was shown that FMT from stressed dams into stress-naïve germ-free mice was sufficient to instill the phenotype observed in stress-exposed offspring (344).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [344]
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Metadata
- Authors
- Jašarević, E., Howard, C. D., Morrison, K., Misic, A., Weinkopff, T., Scott, P., Hunter, C., Beiting, D., & Bale, T. L.
- Affiliations
- University of Maryland, Baltimore (US)
- University of Pennsylvania (US)
- Corresponding author
- Bale, Tracy L.
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2018-07-09
- Volume
- 21
- Issue
- 8
- Pages
- 1061-1071
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2840355095
- Cited by
- 189
- References
- 60
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 20 · 2023: 26 · 2022: 30 · 2021: 38 · 2020: 18 · 2019: 17 · 2018: 4
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (F32AI114080)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- prenatal stress, microbiota transfer, gut microbiota, hypothalamus, chronic stress, neurodevelopmental disorders, cesarean section, male offspring
- MeSH terms
- Animals, Body Weight, Cesarean Section, Female, Hypothalamo-Hypophyseal System, Hypothalamus, Intestinal Absorption, Male, Mice, Inbred C57BL, Paraventricular Hypothalamic Nucleus, Phenotype, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Vagina, Gene Expression, Gastrointestinal Tract, Mice, Transcriptome, Microbiota
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