Cited by 110Animal Behavior and ReproductionNeurotransmitter Receptor Influence on BehaviorPersonality Traits and Psychology

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Identity domains capture individual differences from across the behavioral repertoire

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Forkosh, Oren, Karamihalev, Stoyo, Roeh, Simone, Alon, Uri, Anpilov, Sergey, Touma, Chadi, Nussbaumer, Markus, Flachskamm, Cornelia, Kaplick, Paul M., Shemesh, Yair, Chen, Alon·2019·Nature Neuroscience

DOI 10.1038/s41593-019-0516-y

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Abstract

Personality traits can offer considerable insight into the biological basis of individual differences. However, existing approaches toward understanding personality across species rely on subjective criteria and limited sets of behavioral readouts, which result in noisy and often inconsistent outcomes. Here we introduce a mathematical framework for describing individual differences along dimensions with maximum consistency and discriminative power. We validate this framework in mice, using data from a system for high-throughput longitudinal monitoring of group-housed male mice that yields a variety of readouts from across the behavioral repertoire of individual animals. We demonstrate a set of stable traits that capture variability in behavior and gene expression in the brain, allowing for better-informed mechanistic investigations into the biology of individual differences.

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Authors: Forkosh, O., Karamihalev, S., Roeh, S., Alon, U., Anpilov, S., Touma, C., Nussbaumer, M., Flachskamm, C., Kaplick, P. M., Shemesh, Y., & Chen, A.
Affiliations: Max Planck Institute of Psychiatry (DE)
Weizmann Institute of Science (IL)
Osnabrück University (DE)
Corresponding author: Chen, Alon
ORCID: Forkosh, Oren
Karamihalev, Stoyo
Roeh, Simone
Alon, Uri
Anpilov, Sergey
Kaplick, Paul M.
Shemesh, Yair
Chen, Alon
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2019-11-04
Volume: 22
Issue: 12
Pages: 2023-2028
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/s41593-019-0516-y
OpenAlex: W2986988144
Cited by: 110
References: 23
Citations by year: 2026: 13 · 2025: 17 · 2024: 17 · 2023: 14 · 2022: 18 · 2021: 13 · 2020: 15 · 2019: 2
FWCI: 9.40
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Pratt Foundation
Perlman Family Foundation
International Max Planck Research School for Environmental, Cellular and Molecular Microbiology
Weizmann Institute of Science
Bundesministerium für Bildung und Forschung (01KU1501A)
Israel Science Foundation (1565/15, 1916/12)
Max-Planck-Gesellschaft
Ministry of Health, State of Israel
International Max Planck Research School for Advanced Methods in Process and Systems Engineering
Israeli Centers for Research Excellence (1916/12)
Planning and Budgeting Committee of the Council for Higher Education of Israel
FP7 Ideas: European Research Council (260463)
Topics: Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
Keywords: individual differences, personality traits, identity domains, behavioral repertoire, mathematical framework, group-housed mice, gene expression, brain
MeSH terms: Animals, Behavior, Animal, Hierarchy, Social, Individuality, Male, Models, Theoretical, Personality, Social Behavior, Mice

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