Microglial microRNAs mediate sex-specific responses to tau pathology
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RNA-seq sample size was determined to match or exceed those of similar studies, such that comparisons between age groups were 12 vs 12 (matched for sex), and between tissue types were 36 vs 36 (correcting for animal, age and sex).
“RNA-seq sample size was determined to match or exceed those of similar studies34,35, such that comparisons between age groups were 12 vs 12 (matched for sex), and between tissue types were 36 vs 36 (correcting for animal, age and sex).”
From Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system (2023) · cites this paper as [35]
Previous reports indicate sexual dimorphism in microglial genetics.
“based on previous reports of sexual dimorphism in microglial genetics34–36”
From Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system (2023) · cites this paper as [35]
Transcriptomics studies have defined subsets of mRNAs and miRNAs that are differentially expressed between male and female microglia, in steady state and particularly following immune challenge in adult mice.
“Transcriptomics studies have defined subsets of mRNAs and miRNAs that are differentially expressed between male and female microglia, in steady state and particularly following immune challenge in adult mice34,35,68–70.”
From Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system (2023) · cites this paper as [35]
Mouse cohorts in this study were balanced for sex.
“Mouse cohorts in this study were balanced for sex based on previous reports of sexual dimorphism in microglial genetics34–36.”
From Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system (2023) · cites this paper as [35]
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Cites
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- Authors
- Kodama, L., Guzman, E., Etchegaray, J. I., Li, Y., Sayed, F. A., Zhou, L., Zhou, Y., Zhan, L., Le, D., Udeochu, J. C., Clelland, C. D., Cheng, Z., Yu, G., Li, Q., Kosik, K. S., & Gan, L.
- Venue
- Nature Neuroscience
- Published
- 2019-12-23
- Volume
- 23
- Issue
- 2
- Pages
- 167-171
- ISSN
- 1097-6256
- 1546-1726
- PMC
- PMC7394069
- Cited by
- 109
- References
- 13
- Language
- en
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