Cited by 176Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

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Davis, Emily J., Broestl, Lauren, Abdulai-Saiku, Samira, Worden, Kurtresha, Bonham, Luke W., Miñones-Moyano, Elena, Moreno, Arturo J., Wang, Dan +19 more·2020·Science Translational Medicine

Abstract

The second X chromosome confers resilience in a mouse model of Alzheimer’s disease potentially through the X-linked gene Kdm6a .

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Authors
Davis, E. J., Broestl, L., Abdulai-Saiku, S., Worden, K., Bonham, L. W., Miñones-Moyano, E., Moreno, A. J., Wang, D., Chang, K., Williams, G., Garay, B. I., Lobach, I., Devidze, N., Kim, D., Anderson-Bergman, C., Yu, G.-Q., White, C. C., Harris, J. A., Miller, B. L., Bennett, D. A., Arnold, A. P., De Jager, P. L., Palop, J. J., Panning, B., Yokoyama, J. S., Mucke, L., & Dubal, D. B.
Affiliations
  • University of California, San Francisco (US)
  • Gladstone Institutes (US)
  • Broad Institute (US)
  • Allen Institute for Brain Science (US)
  • Rush University Medical Center (US)
  • University of California, Los Angeles (US)
  • Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
Corresponding author
  • Davis, Emily J.
  • Broestl, Lauren
  • Dubal, Dena B.
Venue
Science Translational Medicine
Published
2020-08-26
Volume
12
Issue
558
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3080470877
Cited by
176
References
141
Citations by year
2026: 19 · 2025: 32 · 2024: 28 · 2023: 26 · 2022: 44 · 2021: 21 · 2020: 6
FWCI
14.59
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Science Foundation (1650113)
  • National Institutes of Health (AG023501, NS043196, AG011385 and NS065780, P30AG10161, R01AG15819, and R01AG17917, U01AG46152 and U01AG61356, CTSI UL1 TR000004, AG049152, NS092918 and AG034531, R01AG36836)
  • Larry L. Hillblom Foundation
  • American Federation for Aging Research
  • Glenn Foundation for Medical Research
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, X chromosome, sex chromosomes, resilience, cognitive decline, aging, preclinical Alzheimer's disease, mouse model, brain gene expression, disease susceptibility
MeSH terms
Alzheimer Disease, Animals, Female, Male, Sex Characteristics, Testis, X Chromosome, Y Chromosome, Mice

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