A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease
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The second X chromosome confers resilience in a mouse model of Alzheimer’s disease potentially through the X-linked gene Kdm6a .
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Sex is an important factor that contributes to clinical and biological heterogeneity in Alzheimer's disease.
“Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer’s disease (AD)”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [9]
Men with AD have an increased risk for death.
“it has also been reported men with AD have an increased risk for death [9–11]”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [9]
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Sex differences in biological aging with a focus on human studies
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Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage
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- Authors
- Davis, E. J., Broestl, L., Abdulai-Saiku, S., Worden, K., Bonham, L. W., Miñones-Moyano, E., Moreno, A. J., Wang, D., Chang, K., Williams, G., Garay, B. I., Lobach, I., Devidze, N., Kim, D., Anderson-Bergman, C., Yu, G.-Q., White, C. C., Harris, J. A., Miller, B. L., Bennett, D. A., Arnold, A. P., De Jager, P. L., Palop, J. J., Panning, B., Yokoyama, J. S., Mucke, L., & Dubal, D. B.
- Affiliations
- University of California, San Francisco (US)
- Gladstone Institutes (US)
- Broad Institute (US)
- Allen Institute for Brain Science (US)
- Rush University Medical Center (US)
- University of California, Los Angeles (US)
- Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
- Corresponding author
- Davis, Emily J.
- Broestl, Lauren
- Dubal, Dena B.
- ORCID
- Davis, Emily J.
- Broestl, Lauren
- Abdulai-Saiku, Samira
- Worden, Kurtresha
- Bonham, Luke W.
- Miñones-Moyano, Elena
- Moreno, Arturo J.
- Wang, Dan
- Chang, Kevin
- Williams, Gina
- Garay, Bayardo I.
- Lobach, Iryna
- Kim, Daniel
- Anderson-Bergman, Cliff
- White, Charles C.
- Harris, Julie A.
- Miller, Bruce L.
- Bennett, David A.
- Arnold, Arthur P.
- De Jager, Phil L.
- Palop, Jorge J.
- Panning, Barbara
- Yokoyama, Jennifer S.
- Mucke, Lennart
- Dubal, Dena B.
- Venue
- Science Translational Medicine
- Published
- 2020-08-26
- Volume
- 12
- Issue
- 558
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8409261
- OpenAlex
- W3080470877
- Cited by
- 176
- References
- 141
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 28 · 2023: 26 · 2022: 44 · 2021: 21 · 2020: 6
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (1650113)
- National Institutes of Health (AG023501, NS043196, AG011385 and NS065780, P30AG10161, R01AG15819, and R01AG17917, U01AG46152 and U01AG61356, CTSI UL1 TR000004, AG049152, NS092918 and AG034531, R01AG36836)
- Larry L. Hillblom Foundation
- American Federation for Aging Research
- Glenn Foundation for Medical Research
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, X chromosome, sex chromosomes, resilience, cognitive decline, aging, preclinical Alzheimer's disease, mouse model, brain gene expression, disease susceptibility
- MeSH terms
- Alzheimer Disease, Animals, Female, Male, Sex Characteristics, Testis, X Chromosome, Y Chromosome, Mice
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