The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Brain capillary pericytes exert a substantial but slow influence on blood flow
Open accessAbstract
The majority of the brain’s vasculature is composed of intricate capillary networks lined by capillary pericytes. However, it remains unclear whether capillary pericytes influence blood flow. Using two-photon microscopy to observe and manipulate brain capillary pericytes in vivo, we find that their optogenetic stimulation decreases lumen diameter and blood flow, but with slower kinetics than similar stimulation of mural cells on upstream pial and precapillary arterioles. This slow vasoconstriction was inhibited by the clinically used vasodilator fasudil, a Rho-kinase inhibitor that blocks contractile machinery. Capillary pericytes were also slower to constrict back to baseline following hypercapnia-induced dilation, and slower to dilate towards baseline following optogenetically induced vasoconstriction. Optical ablation of single capillary pericytes led to sustained local dilation and a doubling of blood cell flux selectively in capillaries lacking pericyte contact. These data indicate that capillary pericytes contribute to basal blood flow resistance and slow modulation of blood flow throughout the brain. Vast networks of capillaries feed the brain. Hartmann et al. show that pericyte contractility is critical for maintenance of enduring capillary tone, which sets an optimized rate and distribution of blood flow through brain capillary networks.
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2 retracted
RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice
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RetractedA robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
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Capillary pericytes regulate cerebral blood flow in health and disease
Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., O’Farrell, F. M., Buchan, A. M., Lauritzen, M., & Attwell, D. (2014) · Nature · doi:10.1038/nature13165 · Cited by 1,870
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Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes
Nortley, R., Korte, N., Izquierdo, P., Hirunpattarasilp, C., Mishra, A., Jaunmuktane, Z., Kyrargyri, V., Pfeiffer, T., Khennouf, L., Madry, C., et al. (2019) · Science · doi:10.1126/science.aav9518 · Cited by 682
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Interplay between Brain Pericytes and Endothelial Cells in Dementia
Procter, T. V., Williams, A., & Montagne, A. (2021) · The American Journal of Pathology · doi:10.1016/j.ajpath.2021.07.003 · Cited by 106
Zhao, Q., Dai, W., Chen, H. Y., Jacobs, R. E., Zlokovic, B. V., Lund, B. T., Montagne, A., & Bonnin, A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113310119 · Cited by 52
Korte, N., James, G., You, H., Hirunpattarasilp, C., Christie, I., Sethi, H., & Attwell, D. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231152549 · Cited by 49
Metadata
- Authors
- Hartmann, D. A., Berthiaume, A.-A., Grant, R. I., Harrill, S. A., Koski, T., Tieu, T., McDowell, K. P., Faino, A. V., Kelly, A. L., & Shih, A. Y.
- Venue
- Nature Neuroscience
- Published
- 2021-02-18
- Volume
- 24
- Issue
- 5
- Pages
- 633-645
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W3130987271
- Cited by
- 396
- References
- 18
- FWCI
- 20.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Hartmann, D. A., Berthiaume, A.-A., Grant, R. I., Harrill, S. A., Koski, T., Tieu, T., McDowell, K. P., Faino, A. V., Kelly, A. L., & Shih, A. Y. (2021). Brain capillary pericytes exert a substantial but slow influence on blood flow. Nature Neuroscience. https://doi.org/10.1038/s41593-020-00793-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
