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Cited by 281

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Identification of neural oscillations and epileptiform changes in human brain organoids

Open access
Samarasinghe, Ranmal A., Miranda, Osvaldo A., Buth, Jessie E., Mitchell, Simon, Ferando, Isabella, Watanabe, Momoko, Allison, Thomas F., Kurdian, Arinnae, Fotion, Namie N., Gandal, Michael J., Golshani, Peyman, Plath, Kathrin, Lowry, William E., Parent, Jack M., Mody, Istvan, Novitch, Bennett G.·2021·Nature Neuroscience
DOI 10.1038/s41593-021-00906-5
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Abstract

Brain organoids represent a powerful tool for studying human neurological diseases, particularly those that affect brain growth and structure. However, many diseases manifest with clear evidence of physiological and network abnormality in the absence of anatomical changes, raising the question of whether organoids possess sufficient neural network complexity to model these conditions. Here, we explore the network-level functions of brain organoids using calcium sensor imaging and extracellular recording approaches that together reveal the existence of complex network dynamics reminiscent of intact brain preparations. We demonstrate highly abnormal and epileptiform-like activity in organoids derived from induced pluripotent stem cells from individuals with Rett syndrome, accompanied by transcriptomic differences revealed by single-cell analyses. We also rescue key physiological activities with an unconventional neuroregulatory drug, pifithrin-α. Together, these findings provide an essential foundation for the utilization of brain organoids to study intact and disordered human brain network formation and illustrate their utility in therapeutic discovery. This paper explores neural network and cellular complexity within human cortical and subcortical fusion organoids. The platform is used to model network dysfunction associated with Rett syndrome and to identify new therapeutic candidates.

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Metadata

Authors
Samarasinghe, R. A., Miranda, O. A., Buth, J. E., Mitchell, S., Ferando, I., Watanabe, M., Allison, T. F., Kurdian, A., Fotion, N. N., Gandal, M. J., Golshani, P., Plath, K., Lowry, W. E., Parent, J. M., Mody, I., & Novitch, B. G.
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2021-08-23
Volume
24
Issue
10
Pages
1488-1500
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/s41593-021-00906-5
OpenAlex
W3193479663
Cited by
281
References
78
FWCI
20.37
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Identification of neural oscillations and epileptiform changes in human brain organoids. https://app.cochat.ai/papers/10.1038/s41593-021-00906-5
The paper
Samarasinghe, R. A., Miranda, O. A., Buth, J. E., Mitchell, S., Ferando, I., Watanabe, M., Allison, T. F., Kurdian, A., Fotion, N. N., Gandal, M. J., Golshani, P., Plath, K., Lowry, W. E., Parent, J. M., Mody, I., & Novitch, B. G. (2021). Identification of neural oscillations and epileptiform changes in human brain organoids. Nature Neuroscience. https://doi.org/10.1038/s41593-021-00906-5

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.