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Thalamic subnetworks as units of function
Open accessAbstract
The thalamus engages in various functions including sensory processing, attention, decision making and memory. Classically, this diversity of function has been attributed to the nuclear organization of the thalamus, with each nucleus performing a well-defined function. Here, we highlight recent studies that used state-of-the-art expression profiling, which have revealed gene expression gradients at the single-cell level within and across thalamic nuclei. These gradients, combined with anatomical tracing and physiological analyses, point to previously unappreciated heterogeneity and redefine thalamic units of function on the basis of unique input-output connectivity patterns and gene expression. We propose that thalamic subnetworks, defined by the intersection of genetics, connectivity and computation, provide a more appropriate level of functional description; this notion is supported by behavioral phenotypes resulting from appropriately tailored perturbations. We provide several examples of thalamic subnetworks and suggest how this new perspective may both propel progress in basic neuroscience and reveal unique targets with therapeutic potential.
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“subtype 4 specifically targets the thalamus (Fig. 2C), likely participating in the transmission and processing of sensory information to regulate attention, consciousness, and sensory perception [32,33].”
From The Insular Cortex: An Interface Between Sensation, Emotion and Cognition (2024) · cites this paper as [33]
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Cited by
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Roy, D. S., Park, Y.-G., Kim, M. E., Zhang, Y., Ogawa, S. K., DiNapoli, N., Gu, X., Cho, J. H., Choi, H., Kamentsky, L. D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29384-4 · Cited by 253
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Metadata
- Authors
- Roy, D. S., Zhang, Y., Halassa, M. M., & Feng, G.
- Affiliations
- Broad Institute (US)
- McGovern Institute for Brain Research (US)
- Corresponding author
- Roy, Dheeraj S.
- Feng, Guoping
- Venue
- Nature Neuroscience
- Published
- 2022-01-31
- Volume
- 25
- Issue
- 2
- Pages
- 140-153
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC9400132
- OpenAlex
- W4221072568
- Cited by
- 177
- References
- 129
- Citations by year
- 2026: 35 · 2025: 54 · 2024: 47 · 2023: 27 · 2022: 14
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institute of Mental Health (U01MH114819)
- National Institute of Neurological Disorders and Stroke (R01NS113245)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- thalamus, thalamic nuclei, behavioral phenotypes, therapeutic target
- MeSH terms
- Attention, Neural Pathways, Thalamic Nuclei, Thalamus
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