Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine

QIIME allows analysis of high-throughput community sequencing data

Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887

WGCNA: an R package for weighted correlation network analysis

Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

Afgan, E., Baker, D., Batut, B., van den Beek, M., Bouvier, D., Čech, M., Chilton, J., Clements, D., Coraor, N., Grüning, B. A., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky379 · Cited by 3,662

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update

Afgan, E., Baker, D., van den Beek, M., Blankenberg, D. J., Bouvier, D., Čech, M., Chilton, J. M., Clements, D., Coraor, N., Eberhard, C., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw343 · Cited by 2,150

HIF-1α is essential for myeloid cell-mediated inflammation

Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00154-5 · Cited by 2,046

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755

Neuroimmunology of healthy brain aging

Fonken, L. K., & Gaudet, A. D. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102649 · Cited by 17

Lactobacillus amylovorus extracellular vesicles mitigate mammary gland ferroptosis via the gut-mammary gland axis

Zhang, Q., Chen, D., Ding, H., Li, Q., Yuan, S., Li, H., Guan, W., & Zhang, S. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00752-4 · Cited by 13

c-Jun N-terminal kinase signaling in aging

Li, Y., You, L., Nepovimová, E., Adam, V., Heger, Z., Jomová, K., Valko, M., Wu, Q., & Kuča, K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1453710 · Cited by 13

MicroRNAs in the biology and hallmarks of neurodegenerative diseases

Dhuppar, S., Poller, W. C., & Murugaiyan, G. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.03.006 · Cited by 16

Metabolome informs about the chemical exposome and links to brain health

Orešič, M., Karu, N., Zhao, H. N., Moseley, M. A., Hankemeier, T., Wishart, D. S., Dorrestein, P. C., Fiehn, O., Hyötyläinen, T., & Kaddurah‐Daouk, R. (2025) · Environment International · doi:10.1016/j.envint.2025.109741 · Cited by 15

Implications of Gut Microbiota-Derived Metabolites in Neurological Disorders

Dalal, N., Jaiswal, J., Kushwaha, M., Verma, H., Rana, P., Gupta, S., Panwar, R., Janmeda, P., Jain, P., Singh, A. K., et al. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00414 · Cited by 12

Microglia in the crosstalk between peripheral and central nervous systems in Parkinson’s disease

Li, T., Qiu, T., Jiang, F., Cai, H., & Le, W. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00531-3 · Cited by 15

The possible role of gut microbiota dysbiosis in the pathophysiology of delirium in older persons

Ticinesi, A., Parise, A., Nouvenne, A., Cerundolo, N., Prati, B., & Meschi, T. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.15 · Cited by 12

From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging

Peinado, P. J., & Urbach, A. (2023) · Cells · doi:10.3390/cells12162086 · Cited by 13

Does the liver facilitate aging‐related cognitive impairment: Conversation between liver and brain during exercise?

Wei, C., Li, X., Yu, J. Z., Zhang, Y., & Yuan, Q. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31287 · Cited by 13

Clostridium butyricum enhances cognitive function in APP/PS1 mice by modulating neuropathology and regulating acetic acid levels in the gut microbiota

Ye, S., Xinjie, L., Xiaotong, Z., Chen, J., Jia-hai, L., Xiaodong, C., Lou, Y., & Li, X. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.00178-25 · Cited by 12

Gut-based manipulations spur hippocampal mitochondrial bioenergetics in a model of pediatric epilepsy

Mu, C., Tompkins, T. A., Rho, J. M., Scantlebury, M. H., & Shearer, J. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166446 · Cited by 12

SERS Tracking Oxidative Stress on a Metalloporphyrin Framework by Vitamin C.

Xie, Q., Liu, H., Wen, S.-S., Wang, X., Bing, W., Ji, W., Zhao, B.-G., Ozaki, Y., & Song, W. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02935 · Cited by 10

Melatonin-mediated mitophagy protects against long-term impairments after repeated neonatal sevoflurane exposures

Zhang, H., Niu, Y., Qiu, L., Yang, J., Sun, J., & Xia, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111210 · Cited by 11

Psychobiotic potential of Lactiplantibacillus plantarum: Current perspective in neurodegeneration and geriatric therapies

Gupta, N., Agarwal, A. K., Al-Dossari, M., & El-Gawaad, N. S. A. (2023) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2023.100038 · Cited by 11

Biomineralized ZIF‐8 Encapsulating SOD from Hydrogenobacter Thermophilus: Maintaining Activity in the Intestine and Alleviating Intestinal Oxidative Stress

Li, Y., Chen, W., Yin, J., Xia, S., Jiang, Y., Ge, Q., Liu, J., Wang, M., Hou, Z., Bai, Y., et al. (2024) · Small · doi:10.1002/smll.202402812 · Cited by 12

An "inside-out"-guided genetically engineered hydrogel for augmenting aged bone regeneration

Zhu, Y., Sun, L., Hou, M., Yu, J., Yu, C., Zhang, Z., Yang, H., Liu, C., Huang, L., Jiang, D., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.05.003 · Cited by 11

Impaired gut barrier affects microglia health

Bostick, J. W., & Mazmanian, S. K. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01028-2 · Cited by 12

Analysis of 16S rRNA Gene Sequence of Nasopharyngeal Exudate Reveals Changes in Key Microbial Communities Associated with Aging

Candel, S., Pérez-Sánz, F., Tyrkalska, S. D., Moreno‐Docón, A., Esteban, Á., Cayuela, M. L., & Mulero, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044127 · Cited by 11

Advanced Glycation End Products (AGEs) in Diet and Skin in Relation to Stool Microbiota: The Rotterdam Study

Chen, J., Radjabzadeh, D., Medina‐Gómez, C., Voortman, T., van Meurs, J. B. J., Ikram, M. A., Uitterlinden, A. G., Kraaij, R., & Zillikens, M. C. (2023) · Nutrients · doi:10.3390/nu15112567 · Cited by 11

Circulatory proteins shape microglia state and boost phagocytosisPreprint

Lu, N., Losada, P. M., Hahn, O., Saksena, A., Tapp, E., Chadarevian, J. P., Dong, W., Shi, S. M., Shuken, S. R., Guldner, I. H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.30.615861 · Cited by 12

Microglia and myeloperoxidase in neuroinflammatory and neurodegenerative diseases

Moro, L. D., Brunetta, E., Gershwin, M. E., & Selmi, C. F. (2025) · Current Opinion in Immunology · doi:10.1016/j.coi.2025.102660 · Cited by 10

The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms

Olejnik, P., Golenia, A., & Małyszko, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041590 · Cited by 10

Neuroglia and the microbiota-gut-brain axis

Blair, H., Morales, L., Cryan, J. F., & Aburto, M. R. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00001-2 · Cited by 12

Dysbiosis and fecal microbiota transplant: Contemplating progress in health, neurodegeneration and longevity

Ahmadi, S., Hasani, A., Khabbaz, A., Poortahmasebi, V., Hosseini, S., Yasdchi, M., Mehdizadehfar, E., Mousavi, Z. B., Hasani, R., Nabizadeh, E., et al. (2024) · Biogerontology · doi:10.1007/s10522-024-10136-4 · Cited by 9

Inhibitory effect of tea flower polysaccharides on oxidative stress and microglial oxidative damage in aging mice by regulating gut microbiota

Cai, Y., Liu, S., Ge, X., Cheng, L., & Zhang, X. (2024) · Food & Function · doi:10.1039/d4fo03484h · Cited by 9

Improved early postoperative cognition in elderly gastrointestinal patients: a randomized controlled trial on the role of ultrasound-guided stellate ganglion block

Xue, R., Li, Y., Zhan, M., Yang, L., & Sun, D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1503314 · Cited by 9

The Metabolomic Mind: Microbial Metabolite Programming of Microglia

Verosky, B. G., Bailey, M. T., & Gur, T. (2025) · NeuroImmunoModulation · doi:10.1159/000545484 · Cited by 9

The role of gut dysbiosis and mitochondrial dysfunction in type 2 diabetes: Insights on pathogenesis, intervention and future perspective

Yu, X., Li, M., & Li, H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118846 · Cited by 13

Akkermansia muciniphila vesicles attenuate smoking-induced cognitive decline via ILA-mediated AhR-dependent microglial reprogramming

Zhu, B., Huang, J., Zhang, H., Lin, H., Chen, T., Min, L., Yang, Y., Liu, Y., & Guo, S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04044-7 · Cited by 9

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

Bertoni, G., Ristori, S., & Monti, D. (2026) · Cells · doi:10.3390/cells15080657 · Cited by 10

Germ-Free Animals

Lynch, C. M. K., Nagpal, J. K., Luczynski, P., Neufeld, K. M., Dinan, T. G., Clarke, G. A., & Cryan, J. F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00012-6 · Cited by 9

Oral Supplementation with the Short-Chain Fatty Acid Acetate Ameliorates Age-Related Arterial Dysfunction in Mice

Brunt, V. E., Longtine, A. G., Greenberg, N., Gonzalez, A., Lindquist, A., VanDongen, N. S., Mahoney, S. A., Rahman, G., Clayton, Z. S., Ziemba, B. P., et al. (2024) · doi:10.59368/agingbio.20240033 · Cited by 8

Reactivity-based metabolomics reveal cysteine has glyoxalase 1-like and glyoxalase 2-like activities

Opfermann, M. D., Søndergård, M. B., Bech, L. V., Nielsen, C. B., Mahía, A., Holt, C. B., Wang, T., Olesen, S. B., Frisch, K., Østergaard, J. A., et al. (2025) · Nature Chemical Biology · doi:10.1038/s41589-025-01909-0 · Cited by 8

Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases

Wang, A., Guan, B., Zhang, H., & Xu, H. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106983 · Cited by 9

The inhibitory effects of endophytic metabolites on glycated proteins under non-communicable disease conditions: A review

Nawaz, M., Afridi, M. N., Ullah, I., Khan, I. A., Ishaq, M. S., Su, Y., Rizwan, H. M., Cheng, K., Zhou, Q., & Wang, M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131869 · Cited by 8

Long-term exposure to third-hand smoke could accelerate biological aging via mitochondrial dysfunction: Evidence from population and animal studies

Jiang, W., Liu, X., Lei, Q., Xiao, M., Li, M., Ma, Y., Hu, C., Kong, X., Qi, L., Wu, H., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136061 · Cited by 7

Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis

Zheng, Z.-L., Zheng, Q.-F., Wang, L., & Liu, Y. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i2.100589 · Cited by 9

Gut microbiome, a potential modulator of neuroepigenome

Yang, R., Xu, Y., Zhu, F., Ma, X., Fan, T., & Wang, H.-L. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109961 · Cited by 7

The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model

Morais, L. H., Stiles, L., Freeman, M., Oguienko, A. D., Hoang, J. D., Ji, J., Jones, J. J., Quan, B., Devine, J., Bois, J. S., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01142-5 · Cited by 9

Mitochondria and the reactive species interactome: shaping the future of mitoredox medicine

Châtre, L. (2024) · Journal of Mitochondria Plastids and Endosymbiosis · doi:10.1080/28347056.2024.2304348 · Cited by 7

Supplementation of coated sodium butyrate relieved weaning stress and reshaped microbial flora in weaned lambs

Zhao, F., He, W., Wu, T., Elmhadi, M., Jiang, N., Zhang, A., & Guan, P. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1423920 · Cited by 7

Dietary Natural Melanin Nanozymes Delay Aging and Ameliorate Neurodegeneration via Improving Gut Microbiota and Redox Homeostasis

Xiao, Y., Zhang, S., Zhuo, H., Zhang, X., Zhu, K., Chen, W., You, G., Chen, H., Luo, Q., Zhou, H. M., et al. (2025) · ACS Omega · doi:10.1021/acsomega.4c08419 · Cited by 6

From bench to bedside: translational insights into aging research

Pandey, K. B. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1492099 · Cited by 7

The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson’s disease

Yue, M., Chen, T., Chen, W., Wei, J., Liao, B., Zhang, J., Li, F., Hong, D., & Fang, X. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00702 · Cited by 9

The gut as a central hub for multi-organ crosstalk in aging

Zhang, X., Li, R., Gao, Y., Zhang, W., Ni, T., & Liu, Y. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06129-w · Cited by 7

Impact of gut microbiota on cardiac aging

Yin, Z., Fu, L., Wang, Y., & Tai, S. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105639 · Cited by 6

The gut microbiota regulates diabetic retinopathy in adult rats

Hou, J., Lv, Z., Wang, Y., & Chen, D. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1479792 · Cited by 7

An emerging role for the gut microbiome in tauopathy

Zhu, Y., Self, W. K., & Holtzman, D. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00423 · Cited by 6

The prospective therapeutic benefits of sesamol: neuroprotection in neurological diseases

Guo, Y., Wang, Y., Xu, B., & Li, Y. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2457051 · Cited by 5

Unlocking the therapeutic potential of gut microbiota for preventing and treating aging-related neurological disorders

Garg, G., Trisal, A., & Singh, A. K. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.020 · Cited by 6

Dietary Management and Nutritional Strategies for Preventing Age-Related Diseases

Ahn, B. Y., Wu, X., & Kim, Y. (2025) · Nutrients · doi:10.3390/nu17091450 · Cited by 5

Biomarkers for diabetic peripheral neuropathy: A narrative review of advanced glycation end products

Srivastava, S., Bisen, A. C., Srivastava, D., & Awasthi, H. (2025) · NeuroMarkers. · doi:10.1016/j.neumar.2025.100149 · Cited by 6

Gut microbiota and aging: current understanding and future perspectives

Lan, M., Ding, H., Cao, Y., Liu, J., Tu, L., Fu, S., & Guo, W. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00499-0 · Cited by 6

Probiotics: A potential strategy for improving diabetes mellitus complicated with cognitive impairment

Shen, X., Zhao, F., Zhao, Z., Yu, J. Z., & Sun, Z. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127960 · Cited by 5

Mammalian hydroxylation of microbiome-derived obesogen, delta-valerobetaine, to homocarnitine, a 5-carbon carnitine analog

Weinberg, J., Liu, K., Lee, C., Crandall, W. J., Cuevas, A. R., Druzak, S., Morgan, E. T., Jarrell, Z. R., Ortlund, E. A., Martin, G. S., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.108074 · Cited by 5

The connection between epigenetics and gut microbiota‐current perspective

Yuan, X., Tan, Y., Bajinka, O., Jammeh, M. L., Dukureh, A., Obiegbusi, C. N., Abdelhalim, K. A., & Mohanad, M. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3941 · Cited by 5

Gut microbiota and myelination: Crosstalk across the lifespan and microbiota-based modulation strategies

Li, Q., Wang, G., Zhao, J., Chen, W., & Tian, P. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128286 · Cited by 6

Rumen microbiota modulates metabolic stress in high-yield dairy cows: insights from early to peak lactation

Li, M., Zhu, S., Sun, H., Huo, Y., Cao, Q., Deng, Z., Li, K., He, Y., Lu, X., Gao, J., et al. (2026) · Microbiome · doi:10.1186/s40168-025-02318-0 · Cited by 4

Microbiome-Glia Crosstalk: Bridging the Communication Divide in the Central Nervous System

Tabatabaee, M. S. (2024) · Neuroglia · doi:10.3390/neuroglia5020007 · Cited by 4

The microbiota-microglia axis: A novel clue for diet and brain health

Song, Z., Song, R., Liu, Y., Zhu, Y., & Zhang, X. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.104942 · Cited by 4

Multifactorial glial responses and their contributions to Alzheimer's disease continuum

Hijioka, M., Manabe, T., & Saito, T. (2023) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12745 · Cited by 4

The mechanism of disease progression by aging and age-related gut dysbiosis in multiple sclerosis

Yadav, S. K., Chen, C., Dhib-Jalbut, S. S., & Ito, K. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106956 · Cited by 4

Natural killer cell-based senotherapy: a promising strategy for healthy aging

中澤務, Yamanishi, R., Morimoto, T., & Matusda, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1737572 · Cited by 3

Environmental cadmium drives placental senescence and fetal growth restriction via activating CLPP-dependent mitochondrial stress

Pan, R., Zhang, J., Wu, L., Sun, C.-F., Zhang, X., Wu, Y.-X., Yin, X.-A., Luo, Y., LIU, S.-T., Bao, Z.-J., et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.142400 · Cited by 3

Influence of CTG repeats from the human DM1 locus on murine gut microbiota

Mahdavi, M., Taeyeon, K., Prévost, K., Balthazar, P., Gagné‐Ouellet, V., Hus, I. F.-P., Duchesne, É., Harvey, S., Gagnon, C., Laforest‐Lapointe, I., et al. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.02.016 · Cited by 3

Identification and evaluation of active fractions from Radix Hedysari polysaccharides: Their regulatory impacts on intestinal flora and metabolism in mice

Dong, J., Yao, W., Zhang, W., Han, J., Yang, M., Hua, Y., & Wei, Y. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142260 · Cited by 3

Gut microbes of the cecum versus the colon drive more severe lethality and multi-organ damage

Xu, K., Tan, J., Lin, D., Jiang, H., Chu, Y., Zhou, L., Zhang, J., & Lu, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114029 · Cited by 3

Role of the Intestinal Microbiota in the Molecular Pathogenesis of Atypical Parkinsonian Syndromes

Przewodowska, D., Alster, P., & Madetko‐Alster, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093928 · Cited by 4

Metagenomics reveals an increased proportion of an Escherichia coli-dominated enterotype in elderly Chinese people

Li, J., Gui, Q., Yang, Y., Chen, L., Huang, S., Zhang, X., 蒋婧瑾, Peng, C., Wu, Y., Chen, L., et al. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400341 · Cited by 4

Comprehensive characterization of multi-omic landscapes between gut-microbiota metabolites and the G-protein-coupled receptors in Alzheimer’s diseasePreprint

Qiu, Y., Hou, Y., Zhou, Y., Xu, J., Bykova, M., Leverenz, J. B., Pieper, A. A., Nussinov, R., Caldwell, J., Brown, J. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.20.508759 · Cited by 3

Progress in the mechanism of functional dyspepsia: roles of mitochondrial autophagy in duodenal abnormalities

Zhong, K., Du, X., Niu, Y., Li, Z., Tao, Y., Wu, Y., Zhang, R., Guo, L., Bi, Y., Tang, L., et al. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1491009 · Cited by 2

Antiepileptic Effects of Acorus tatarinowii Schott in a Rat Model of Epilepsy: Regulation of Metabolic Axes and Gut Microbiota

Chen, L., Li, J., Zhang, W., & Wang, J. (2025) · Biology · doi:10.3390/biology14050488 · Cited by 2

Threshold of phenylacetylglutamine changes: exponential growth between age and gut microbiota in stroke patients

Liu, Y., Chu, M. K., Wang, D., Li, Q., Lin, J., & Zhao, J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1576777 · Cited by 2

Crocin drives intestinal microbiota variation in a rat model of Alzheimer’s disease by reducing DKK3 expression

Yang, X., Jiang, M., Wu, M., Jin, X., Wang, X., Lv, L., & Liu, L. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149734 · Cited by 2

The Causal Role of the Gut Microbiota–Plasma Metabolome Axis in Myeloproliferative Neoplasm Pathogenesis: A Mendelian Randomization and Mediation Analysis

Kan, H., Zhang, K., Mao, A., & Geng, L. (2025) · Metabolites · doi:10.3390/metabo15080501 · Cited by 2

Association between neurodevelopmental disorders in congenital heart disease and changes in circulatory metabolites and gut microbiota composition

An, J., Wang, Q., Bai, Z., Ma, S., Yang, Z., Yu, D., & Mo, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1639057 · Cited by 2

Quinic Acid Suppresses on High-fat diet-induced Brain Oxidative Stress and Neuroinflammation via Regulating Gut Microbes Lactobacillus and Akkermansia

Li, S., Wang, S., Liang, T., Zhang, Y., Huang, K., & Xiao, G. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.09.015 · Cited by 2

Antimicrobial proteins regulating neuroinflammation

Bhusal, A., Lee, W., & Suk, K. (2026) · Annals of Medicine · doi:10.1080/07853890.2025.2610072 · Cited by 2

The dual-sensitive period gut-brain crosstalk, neuroinflammation, and the biological roots of adolescent depression

Shi, Y., & Ma, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1821502 · Cited by 3

Lycopene regulates microglial M1/M2 polarization by inhibiting MAPK/NF-κB signaling and alleviates neuroinflammation

Jifu, C., Lü, L., Li, Y., Gao, X., Pei, B., Liu, L., Xu, Z., Xia, J., & Wang, J. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116940 · Cited by 2

Reversal of protein chemical aging by enzymatic deglycation

Trabosh, N., Smith, J., Hsu, M. Y.-H., Panja, S., Nagaraj, R. H., Olsson, N., McAllister, F. E., & Cravens, A. (2026) · Nature Communications · doi:10.1038/s41467-026-75141-2 · Cited by 2

Positive Association Between Serum Concentration of 4-Tertiary-octylphenol and Oxidation of DNA and Lipid in Adolescents and Young Adults

Lin, C., Lee, H., Wang, C., Sung, F., & Su, T. (2024) · Exposure and Health · doi:10.1007/s12403-024-00628-6 · Cited by 2

Alkali-extracted polysaccharides from mung bean skin possess protective effect on H 2O 2-induced IEC-6 cells: the role of NF-κB and MAPK signaling pathways

Chen, D., Xie, L., Wen, P., Yu, Q., Chen, Y., Lu, H., Chen, T., Tao, X., & Xie, J. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250006 · Cited by 2

Identification of ubiquitination-related key biomarkers and immune infiltration in Crohn’s disease by bioinformatics analysis and machine learning

Chen, W., Xu, Z., Sun, H., Feng, W., & Huang, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-88148-4 · Cited by 1

Effect of High Glucose and Carboxymethyl-Lysine on Osteocyte Gene Expression

Vaidya, R., Conlon, L., Duclos, O. T., Behzad, R., Aaronson, J., & Karim, L. (2025) · American Journal of Molecular Biology · doi:10.4236/ajmb.2025.152012 · Cited by 1

Intestinal microbiota improves inflammation and cognitive function in the brain of a7nAChR deficient rat through the gut brain axis

Cao, C., Li, S., Wang, W., Shi, L., Ma, R., Zhang, B., & Tian, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-02627-2 · Cited by 1

The prevention effect of prebiotics and probiotics on bisphenol A caused neurotoxicity and mood disorders from the perspective of regulating gut microbiota

Cai, Y., Chen, Y., Gong, X., Chen, Y., Qin, W., & Zhang, X. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70007 · Cited by 1

Simultaneously Monitoring and Reducing Nε-Carboxymethyl-Lysine and 5-Hydroxymethylfurfural Contents During Soy Sauce Production and Consumption

Wu, Y., Hu, B., Wen, Y., Xiao, Z., Li, L., Zhang, X., Zhang, Z., & Li, B. (2025) · Foods · doi:10.3390/foods14142437 · Cited by 1

Age‐Related Differences in Gut Microbiome and Fecal Metabolome of Captive African Penguins (Spheniscus demersus)

Jiang, J., Hu, D., Hu, S., Huang, K., Zheng, J., & Pei, E. (2025) · Zoo Biology · doi:10.1002/zoo.70014 · Cited by 1

Akkermansia muciniphila: A double-edged sword in life-stage-specific nutritional modulation of Parkinson’s disease via the gut-brain axis

Chen, N., Pang, D., & Shang, H. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128436 · Cited by 3

Peripheral to central: Exploring the neural, endocrine, and immune pathways of the gut-brain axis in postoperative neurocognitive dysfunction

Cao, R., Shi, Z., Ou, W., & Liu, Z. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111975 · Cited by 1

Gut microbiota-epigenetic interactions in systemic aging: mechanistic drivers for endocrine and reproductive network remodeling and therapeutic modulation

Birigwa, C., Tong, Q., Qu, B., Zuo, T., Yuan, W., Xiong, J., & Luo, J. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1826382 · Cited by 2

Deciphering underground decarboxylase activity towards Nε-modified lysine derivatives in enterobacteria

Aveta, E. F., Vougioukas, P., Qi, F., Mehler, J., Behringer, K. I., Gericke, N., Walczak, M., Vallejo-Janeta, A. P., Blank, T., Hellwig, M., et al. (2026) · Food Chemistry · doi:10.1016/j.foodchem.2026.150234 · Cited by 1

Exercise alleviates neuroinflammation and cognitive decline in aged mice via hepatic FGF21-driven microglial mitophagy

Li, P., Wu, T., Chen, M., Wang, N., Jia, X., Chen, Z., & Duan, R. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106935 · Cited by 1

Microbiota and Methylglyoxal-Derived AGEs: Implications in Ageing and Age-Related Disease

Tombolesi, N., Francini, E., Pazmay, G. V. B., Fortunato, C., Marchegiani, F., Olivieri, F., Fumarola, S., Maniscalco, R., & Matacchione, G. (2026) · Life · doi:10.3390/life16081265 · Cited by 1

Diet–gut microbiota–immune–brain interactions in aging: mechanistic pathways and clinical implications

Jarfan, M. A., Vimaleswaran, K. S., & Wijeyesekera, A. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1847644 · Cited by 1

Brain aging by gut AGE

Ferrarelli, L. K. (2022) · Science Signaling · doi:10.1126/scisignal.abq3005 · Cited by 1

Molecular Interplay of Oxidative Stress and Gut Microbiome in Aging

Bari, A. B. A., Krishnan, M., & Babu, S. (2024) · Springer eBooks · doi:10.1007/978-981-99-8803-7_7 · Cited by 1

DNA Damage, Transposable Element Expression and Their Associated Factors in Aging

Mitiku, T., Abebe, B., Birhane, N., & Getie, B. (2024) · Biochemistry and Molecular Biology · doi:10.11648/j.bmb.20240904.11 · Cited by 2

Gut–brain axis in ageing

Hofer, U. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00762-5 · Cited by 6

Impaired gut barrier affects microglia health

Bostick, J. W., & Mazmanian, S. K. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01028-2 · Cited by 12

Targeting the gut microbiome to reverse microglia activation and stress-induced immune priming in ageing

Boehme, M., van de Wouw, M., Sandhu, K. V., Lyons, K., Fouhy, F., Ramirez, L. O., van Leuven, L., Golubeva, A. V., Scott, K. A., Stanton, C., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.12.038 · Cited by 6

Gut microbiota and sex-differences influence distinct processes of microglial aging

Nabavi, L. S. (2022) · FreiDok plus (Universitätsbibliothek Freiburg) · doi:10.6094/unifr/232422

Aging

Rommy von Bernhardi, M., Flores, B., & Nakanishi, H. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1429-6_13