The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Structural basis for human coronavirus attachment to sialic acid receptors
Open accessAbstract
Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein, which binds to host receptors and fuses the viral and cellular membranes. To understand the molecular basis of coronavirus attachment to oligosaccharide receptors, we determined cryo-EM structures of coronavirus OC43 S glycoprotein trimer in isolation and in complex with a 9-O-acetylated sialic acid. We show that the ligand binds with fast kinetics to a surface-exposed groove and that interactions at the identified site are essential for S-mediated viral entry into host cells, but free monosaccharide does not trigger fusogenic conformational changes. The receptor-interacting site is conserved in all coronavirus S glycoproteins that engage 9-O-acetyl-sialogycans, with an architecture similar to those of the ligand-binding pockets of coronavirus hemagglutinin esterases and influenza virus C/D hemagglutinin-esterase fusion glycoproteins. Our results demonstrate these viruses evolved similar strategies to engage sialoglycans at the surface of target cells. Structural and functional analyses reveal how 9-O-acetyl sialic acid is recognized by the human coronavirus OC43 S glycoprotein and how this interaction promotes viral entry.
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Metadata
- Authors
- Tortorici, M. A., Walls, A. C., Lang, Y., Wang, C., Li, Z., Koerhuis, D., Boons, G.-J., Bosch, B.-J., Rey, F. A., de Groot, R. J., & Veesler, D.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2019-06
- Volume
- 26
- Issue
- 6
- Pages
- 481-489
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2948622157
- Cited by
- 569
- References
- 9
- FWCI
- 74.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tortorici, M. A., Walls, A. C., Lang, Y., Wang, C., Li, Z., Koerhuis, D., Boons, G.-J., Bosch, B.-J., Rey, F. A., de Groot, R. J., & Veesler, D. (2019). Structural basis for human coronavirus attachment to sialic acid receptors. Nature Structural & Molecular Biology. https://doi.org/10.1038/s41594-019-0233-y
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