SARS-like WIV1-CoV poised for human emergence

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

Ge, X.-Y., Li, J.-L., Yang, X.-L., Chmura, A. A., Zhu, G., Epstein, J. H., Mazet, J. K., Hu, B., Zhang, W., Peng, C., et al. (2013) · Nature · doi:10.1038/nature12711 · Cited by 1,778 · see citing works

Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2

Netland, J., Meyerholz, D. K., Moore, S., Cassell, M., & Perlman, S. (2008) · Journal of Virology · doi:10.1128/jvi.00737-08 · Cited by 1,293 · see citing works

Severe acute respiratory syndrome

Peiris, M. J. S., Guan, Y., & Yuen, K. (2004) · Nature Medicine · doi:10.1038/nm1143 · Cited by 1,135 · see citing works

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

Qiu, X., Wong, G., Audet, J., Bello, A., Fernando, L., Alimonti, J. B., Fausther‐Bovendo, H., Wei, H., Aviles, J., Hiatt, E., et al. (2014) · Nature · doi:10.1038/nature13777 · Cited by 984 · see citing works

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission

Graham, R. L., & Baric, R. S. (2009) · Journal of Virology · doi:10.1128/jvi.01394-09 · Cited by 738 · see citing works

An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

Traggiai, E., Becker, S., Subbarao, K., Kolesnikova, L., Uematsu, Y., Gismondo, M. R., Murphy, B. R., Rappuoli, R., & Lanzavecchia, A. (2004) · Nature Medicine · doi:10.1038/nm1080 · Cited by 697 · see citing works

A decade after SARS: strategies for controlling emerging coronaviruses

Graham, R. L., Donaldson, E., & Baric, R. S. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3143 · Cited by 676 · see citing works

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

Bolles, M., Deming, D., Long, K., Agnihothram, S., Whitmore, A., Ferris, M., Funkhouser, W., Gralinski, L., Totura, A., Heise, M., et al. (2011) · Journal of Virology · doi:10.1128/jvi.06048-11 · Cited by 477 · see citing works

A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice

Roberts, A., Deming, D., Paddock, C. D., Cheng, A., Yount, B. L., Vogel, L., Herman, B. D., Sheahan, T., Heise, M. T., Genrich, G. L., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030005 · Cited by 447 · see citing works

Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

Yount, B., Curtis, K. M., Fritz, E. A., Hensley, L. E., Jahrling, P., Prentice, E., Denison, M., Geisbert, T., & Baric, R. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1735582100 · Cited by 394 · see citing works

Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies

Zhu, Z., Chakraborti, S., He, Y., Roberts, A., Sheahan, T., Xiao, X., Hensley, L. E., Prabakaran, P., Rockx, B., Sidorov, I. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701000104 · Cited by 284 · see citing works

Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression

Narayanan, K., Ramirez, S. I., Lokugamage, K. G., & Makino, S. (2014) · Virus Research · doi:10.1016/j.virusres.2014.11.019 · Cited by 185 · see citing works

Coronavirus virulence genes with main focus on SARS-CoV envelope gene

DeDiego, M. L., Nieto-Torres, J. L., Jiménez-Guardeño, J. M., Regla-Nava, J. Á., Castaño-Rodríguez, C., Fernández‐Delgado, R., Usera, F., & Enjuanes, L. (2014) · Virus Research · doi:10.1016/j.virusres.2014.07.024 · Cited by 174 · see citing works

SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission

Deming, M. E., Donaldson, E., & Baric, R. S. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.10.012 · Cited by 166 · see citing works

Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells

Sims, A. M., Tilton, S. C., Menachery, V. D., Gralinski, L. E., Schäfer, A., Matzke, M. M., Webb‐Robertson, B., Chang, J., Luna, M. L., Long, C., et al. (2013) · Journal of Virology · doi:10.1128/jvi.02520-12 · Cited by 156 · see citing works

Identification of Diverse Alphacoronaviruses and Genomic Characterization of a Novel Severe Acute Respiratory Syndrome-Like Coronavirus from Bats in China

He, B., Zhang, Y., Xu, L., Yang, W., Yang, F., Feng, Y., Xia, L., Zhou, J., Zhen, W., Feng, Y., et al. (2014) · Journal of Virology · doi:10.1128/jvi.00631-14 · Cited by 142 · see citing works

Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease

Frieman, M. B., Yount, B. L., Agnihothram, S., Page, C., Donaldson, E., Roberts, A., Vogel, L., Woodruff, B., Scorpio, D. G., Subbarao, K., et al. (2011) · Journal of Virology · doi:10.1128/jvi.05957-11 · Cited by 141 · see citing works

Surveillance for emerging respiratory viruses

Al‐Tawfiq, J. A., Zumla, A. I., Gautret, P., Gray, G. C., Hui, D. S. C., Al-Rabeeah, A. A., & Memish, Z. A. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70840-0 · Cited by 139 · see citing works

A double-inactivated whole virus candidate SARS coronavirus vaccine stimulates neutralising and protective antibody responses

Spruth, M., Kistner, O., Savidis-Dacho, H., Hitter, E., Crowe, B. A., Gerenčer, M., Brühl, P., Grillberger, L., Reiter, M., Tauer, C., et al. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.08.055 · Cited by 121 · see citing works

Targeting expression of a transgene to the airway surface epithelium using a ciliated cell-specific promoter

Ostrowski, L. E., Hutchins, J. R., Zakel, K. L., & O’Neal, W. K. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00221-1 · Cited by 120 · see citing works

Escape from Human Monoclonal Antibody Neutralization Affects In Vitro and In Vivo Fitness of Severe Acute Respiratory Syndrome Coronavirus

Rockx, B., Donaldson, E., Frieman, M. B., Sheahan, T. P., Corti, D., Lanzavecchia, A., & Baric, R. S. (2010) · The Journal of Infectious Diseases · doi:10.1086/651022 · Cited by 83 · see citing works

Broadening of Neutralization Activity to Directly Block a Dominant Antibody-Driven SARS-Coronavirus Evolution Pathway

Sui, J., Aird, D. R., Tamin, A., Murakami, A., Yan, M., Yammanuru, A., Jing, H., Kan, B., Liu, X., Zhu, Q. K., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000197 · Cited by 82 · see citing works

Discovery of Novel Human and Animal Cells Infected by the Severe Acute Respiratory Syndrome Coronavirus by Replication-Specific Multiplex Reverse Transcription-PCR

Gillim-Ross, L., Taylor, J., Scholl, D. R., Ridenour, J., Masters, P. S., & Wentworth, D. E. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.7.3196-3206.2004 · Cited by 81 · see citing works

Effects of Human Anti-Spike Protein Receptor Binding Domain Antibodies on Severe Acute Respiratory Syndrome Coronavirus Neutralization Escape and Fitness

Sui, J., Deming, M. E., Rockx, B., Liddington, R., Zhu, Q. K., Baric, R. S., & Marasco, W. A. (2014) · Journal of Virology · doi:10.1128/jvi.02232-14 · Cited by 68 · see citing works

Pathways of Cross-Species Transmission of Synthetically Reconstructed Zoonotic Severe Acute Respiratory Syndrome Coronavirus

Sheahan, T. P., Rockx, B., Donaldson, E., Corti, D., & Baric, R. S. (2008) · Journal of Virology · doi:10.1128/jvi.00818-08 · Cited by 68 · see citing works

A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

Agnihothram, S., Yount, B. L., Donaldson, E., Huynh, J., Menachery, V. D., Gralinski, L. E., Graham, R. L., Becker, M. M., Tomar, S., Scobey, T., et al. (2014) · mBio · doi:10.1128/mbio.00047-14 · Cited by 56 · see citing works

Amino Acid Substitutions in the S2 Subunit of Mouse Hepatitis Virus Variant V51 Encode Determinants of Host Range Expansion

McRoy, W. C., & Baric, R. S. (2007) · Journal of Virology · doi:10.1128/jvi.01674-07 · Cited by 49 · see citing works

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969 · see citing works

Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein

Walls, A. C., Park, Y.-J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020) · doi:10.1101/2020.02.19.956581 · Cited by 8,586 · see citing works

Origin and evolution of pathogenic coronaviruses

Cui, J., Li, F., & Shi, Z. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0118-9 · Cited by 5,539 · see citing works

SARS and MERS: recent insights into emerging coronaviruses

de Wit, E., van Doremalen, N., Falzarano, D., & Munster, V. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.81 · Cited by 3,510 · see citing works

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Ou, X., Liu, Y., Lei, X., Li, P., Mi, D., Ren, L., Guo, L., Guo, R., Chen, T., Hu, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15562-9 · Cited by 3,097 · see citing works

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

Starr, T. N., Greaney, A. J., Hilton, S. K., Ellis, D., Crawford, K. H. D., Dingens, A. S., Navarro, M. J., Bowen, J. E., Tortorici, M. A., Walls, A. C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.012 · Cited by 1,956 · see citing works

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

Pinto, D., Park, Y.-J., Beltramello, M., Walls, A. C., Tortorici, M. A., Bianchi, S., Jaconi, S., Culap, K., Zatta, F., De Marco, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2349-y · Cited by 1,885 · see citing works

SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness

Corbett, K. S., Edwards, D. K., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., et al. (2020) · Nature · doi:10.1038/s41586-020-2622-0 · Cited by 1,615 · see citing works

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Sheahan, T. P., Sims, A. M., Graham, R. L., Menachery, V. D., Gralinski, L. E., Case, J. B., Leist, S. R., Pyrć, K., Feng, J. Y., Trantcheva, I., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3653 · Cited by 1,575 · see citing works

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

Yuan, M., Wu, N. C., Zhu, X., Lee, C.-C. D., So, R. T. Y., Lv, H., Mok, C. K. P., & Wilson, I. A. (2020) · Science · doi:10.1126/science.abb7269 · Cited by 1,405 · see citing works

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Agostini, M. L., Andres, E. L., Sims, A. M., Graham, R. L., Sheahan, T. P., Lu, X., Smith, E. C., Case, J. B., Feng, J. Y., Jordan, R., et al. (2018) · mBio · doi:10.1128/mbio.00221-18 · Cited by 1,418 · see citing works

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Sia, S. F., Yan, L.-M., Chin, A. W. H., Fung, K., Choy, K.-T., Wong, A. Y. L., Kaewpreedee, P., Perera, R. A. P. M., Poon, L. L. M., Nicholls, J. M., et al. (2020) · Nature · doi:10.1038/s41586-020-2342-5 · Cited by 1,303 · see citing works

Return of the Coronavirus: 2019-nCoV

Gralinski, L. E., & Menachery, V. D. (2020) · Viruses · doi:10.3390/v12020135 · Cited by 1,348 · see citing works

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Sheahan, T. P., Sims, A. M., Zhou, S., Graham, R. L., Pruijssers, A. J. P., Agostini, M. L., Leist, S. R., Schäfer, A., Dinnon, K. H., Stevens, L. J., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abb5883 · Cited by 1,069 · see citing works

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

Boni, M. F., Lemey, P., Jiang, X., Lam, T. T.-Y., Perry, B. W., Castoe, T. A., Rambaut, A., & Robertson, D. L. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0771-4 · Cited by 1,014 · see citing works

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

Hu, B., Zeng, L., Yang, X., Ge, X.-Y., Zhang, W., Li, B., Xie, J., Shen, X.-R., Zhang, Y.-Z., Wang, N., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006698 · Cited by 956 · see citing works

Animal models for COVID-19

Muñoz-Fontela, C., Dowling, W. E., Funnell, S. G. P., Gsell, P.-S., Riveros-Balta, A. X., Albrecht, R. A., Andersen, H., Baric, R. S., Carroll, M. W., Cavaleri, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2787-6 · Cited by 798 · see citing works

Structural insights into coronavirus entry

(2019) · Advances in Virus Research · doi:10.1016/bs.aivir.2019.08.002 · Cited by 769 · see citing works

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays

Crawford, K. H. D., Eguia, R. T., Dingens, A. S., Loes, A. N., Malone, K. D., Wolf, C. R., Chu, H. Y., Tortorici, M. A., Veesler, D., Murphy, M., et al. (2020) · Viruses · doi:10.3390/v12050513 · Cited by 727 · see citing works

An Infectious cDNA Clone of SARS-CoV-2

Xie, X., Muruato, A., Lokugamage, K. G., Narayanan, K., Zhang, X., Zou, J., Liu, J., Schindewolf, C., Bopp, N. E., Aguilar, P. V., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.004 · Cited by 647 · see citing works

Coronavirus membrane fusion mechanism offers a potential target for antiviral development

Tang, T., Bidon, M. K., Jaimes, J. A., Whittaker, G. R., & Daniel, S. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104792 · Cited by 750 · see citing works

Molecular Evolution of Human Coronavirus Genomes

Forni, D., Cagliani, R., Clerici, M., & Sironi, M. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.09.001 · Cited by 741 · see citing works

COVID-19 neutralizing antibodies predict disease severity and survival

Garcia-Beltran, W., Lam, E., Astudillo, M., Yang, D., Miller, T., Feldman, J., Hauser, B., Caradonna, T. M., Clayton, K., Nitido, A. D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.12.015 · Cited by 56 · see citing works

Emerging Pandemic Diseases: How We Got to COVID-19

Morens, D. M., & Fauci, A. S. (2020) · Cell · doi:10.1016/j.cell.2020.08.021 · Cited by 720 · see citing works

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

Leist, S. R., Dinnon, K. H., Schäfer, A., Tse, L. V., Okuda, K., Hou, Y. J., West, A., Edwards, C. E., Sanders, W., Fritch, E. J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.050 · Cited by 613 · see citing works

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

Dinnon, K. H., Leist, S. R., Schäfer, A., Edwards, C. E., Martinez, D. R., Montgomery, S. A., West, A., Yount, B. L., Hou, Y. J., Adams, L. E., et al. (2020) · Nature · doi:10.1038/s41586-020-2708-8 · Cited by 675 · see citing works

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

Sun, S.-H., Chen, Q., Gu, H.-J., Yang, G., Wang, Y.-X., Huang, X.-Y., Liu, S.-S., Zhang, N.-N., Li, X.-F., Xiong, R., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.020 · Cited by 617 · see citing works

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

Walls, A. C., Xiong, X., Park, Y.-J., Tortorici, M. A., Snijder, J., Quispe, J., Cameroni, E., Gopal, R., Dai, M., Lanzavecchia, A., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.028 · Cited by 582 · see citing works

Structural basis for human coronavirus attachment to sialic acid receptors

Tortorici, M. A., Walls, A. C., Lang, Y., Wang, C., Li, Z., Koerhuis, D., Boons, G., Bosch, B., Rey, F. A., de Groot, R. J., et al. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0233-y · Cited by 573 · see citing works

Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2

Jiang, R.-D., Liu, M.-Q., Chen, Y., Shan, C., Zhou, Y.-W., Shen, X.-R., Li, Q., Zhang, L., Zhu, Y., Si, H.-R., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.027 · Cited by 541 · see citing works

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Wec, A. Z., Wrapp, D., Herbert, A. S., Maurer, D. P., Haslwanter, D., Sakharkar, M., Jangra, R. K., Dieterle, M. E., Lilov, A., Huang, D., et al. (2020) · Science · doi:10.1126/science.abc7424 · Cited by 520 · see citing works

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

Walls, A. C., Fiala, B., Schäfer, A., Wrenn, S., Pham, M. N., Murphy, M., Tse, L. V., Shehata, L., O’Connor, M. A., Chen, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.043 · Cited by 532 · see citing works

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

Pruijssers, A. J. P., George, A. S., Schäfer, A., Leist, S. R., Gralinski, L. E., Dinnon, K. H., Yount, B. L., Agostini, M. L., Stevens, L. J., Chappell, J. D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107940 · Cited by 516 · see citing works

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

Brown, A. J., Won, J. J., Graham, R. L., Dinnon, K. H., Sims, A. M., Feng, J. Y., Cihlář, T., Denison, M. R., Baric, R. S., & Sheahan, T. P. (2019) · Antiviral Research · doi:10.1016/j.antiviral.2019.104541 · Cited by 514 · see citing works

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

Xia, S., Yan, L., Xu, W., Agrawal, A. S., Algaissi, A. A., Tseng, C.-T. K., Wang, Q., Du, L., Tan, W., Wilson, I. A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav4580 · Cited by 505 · see citing works

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L. B., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.011 · Cited by 477 · see citing works

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

Jaimes, J. A., André, N. M., Chappie, J. S., Millet, J. K., & Whittaker, G. R. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.04.009 · Cited by 485 · see citing works

Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

Kirchdoerfer, R. N., Wang, N., Pallesen, J., Wrapp, D., Turner, H. L., Cottrell, C. A., Corbett, K. S., Graham, B. S., McLellan, J. S., & Ward, A. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-34171-7 · Cited by 466 · see citing works

Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection

Wu, Q., Zhou, L., Sun, X., Yan, Z., Hu, C., Wu, J., Xu, L., Li, X., Liu, H., Yin, P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09536-z · Cited by 439 · see citing works

Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

Cohen, A. A., Gnanapragasam, P. N. P., Lee, Y., Hoffman, P. R., Ou, S., Kakutani, L. M., Keeffe, J., Wu, H.-J., Howarth, M., West, A. P., et al. (2021) · Science · doi:10.1126/science.abf6840 · Cited by 60 · see citing works

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

Wahl, A. R., Gralinski, L. E., Johnson, C. E., Yao, W., Kovářová, M., Dinnon, K. H., Liu, H., Madden, V. J., Krzystek, H. M., De, C., et al. (2021) · Nature · doi:10.1038/s41586-021-03312-w · Cited by 402 · see citing works

Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections

Lv, H., Wu, N. C., Tsang, O. T.-Y., Yuan, M., Perera, R. A. P. M., Leung, W.-S., So, R. T. Y., Chan, J. M. C., Yip, G. K., Chik, T. S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107725 · Cited by 401 · see citing works

From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans – Call for a One Health approach

Zowalaty, M. E. E., & Järhult, J. D. (2020) · One Health · doi:10.1016/j.onehlt.2020.100124 · Cited by 409 · see citing works

Emergence of SARS-CoV-2 through recombination and strong purifying selection

Li, X., Giorgi, E. E., Marichannegowda, M. H., Foley, B. T., Xiao, C., Kong, X., Chen, Y., Gnanakaran, S., Korber, B., & Gao, F. (2020) · Science Advances · doi:10.1126/sciadv.abb9153 · Cited by 392 · see citing works

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Yuan, M., Huang, D., Lee, C.-C. D., Wu, N. C., Jackson, A. M., Zhu, X., Liu, H., Peng, L., van Gils, M. J., Sanders, R. W., et al. (2021) · doi:10.1101/2021.02.16.430500 · Cited by 364 · see citing works

Global Epidemiology of Bat Coronaviruses

Wong, A. C. P., Li, X., Lau, S. K. P., & Woo, P. C. Y. (2019) · Viruses · doi:10.3390/v11020174 · Cited by 368 · see citing works

Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus

Anthony, S. J., Gilardi, K. V. K., Menachery, V. D., Goldstein, T., Ssebide, B., Mbabazi, R., Navarrete‐Macias, I., Liang, E., Wells, H., Hicks, A. L., et al. (2017) · mBio · doi:10.1128/mbio.00373-17 · Cited by 351 · see citing works

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

White, K. M., Rosales, R., Yildiz, S., Kehrer, T., Miorin, L., Moreno, E., Jangra, S., Uccellini, M. B., Rathnasinghe, R., Coughlan, L., et al. (2021) · Science · doi:10.1126/science.abf4058 · Cited by 348 · see citing works

Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection

Butowt, R., & von Bartheld, C. S. (2021) · The Neuroscientist · doi:10.1177/1073858420956905 · Cited by 345 · see citing works

Small-Molecule Antiviral β- d - N 4 -Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

Agostini, M. L., Pruijssers, A. J. P., Chappell, J. D., Gribble, J., Lu, X., Andres, E. L., Bluemling, G. R., Lockwood, M. A., Sheahan, T. P., Sims, A. M., et al. (2019) · Journal of Virology · doi:10.1128/jvi.01348-19 · Cited by 328 · see citing works

Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody

Rappazzo, C. G., Tse, L. V., Kaku, C. I., Wrapp, D., Sakharkar, M., Huang, D., Deveau, L. M., Yockachonis, T. J., Herbert, A. S., Battles, M. B., et al. (2021) · Science · doi:10.1126/science.abf4830 · Cited by 304 · see citing works

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis

Castaño-Rodríguez, C., Honrubia, J. M., Gutierrez-Alvarez, F. J., DeDiego, M. L., Nieto-Torres, J. L., Jiménez-Guardeño, J. M., Regla-Nava, J. Á., Fernández‐Delgado, R., Verdiá-Báguena, C., Queralt-Martín, M., et al. (2018) · mBio · doi:10.1128/mbio.02325-17 · Cited by 311 · see citing works

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

Li, D., Edwards, R. J., Manne, K., Martinez, D. R., Schäfer, A., Alam, S. M., Wiehe, K. J., Lu, X., Parks, R., Sutherland, L. L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.021 · Cited by 330 · see citing works

Viruses in bats and potential spillover to animals and humans

Wang, L., & Anderson, D. E. (2019) · Current Opinion in Virology · doi:10.1016/j.coviro.2018.12.007 · Cited by 285 · see citing works

Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats

Hu, D., Zhu, C.-Q., Ai, L.-L., He, T., Wang, Y., Ye, F., Yang, L., Ding, C., Zhu, X.-H., Lv, R., et al. (2018) · Emerging Microbes and Infections · doi:10.1038/s41426-018-0155-5 · Cited by 281 · see citing works

Molecular epidemiology, evolution and phylogeny of SARS coronavirus

Luk, H. K. H., Li, X., Fung, J., Lau, S. K. P., & Woo, P. C. Y. (2019) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2019.03.001 · Cited by 281 · see citing works

Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China

Wang, N., Li, S., Yang, X., Huang, H., Zhang, Y., Guo, H., Luo, C., Miller, M., Zhu, G., Chmura, A. A., et al. (2018) · Virologica Sinica · doi:10.1007/s12250-018-0012-7 · Cited by 276 · see citing works

Broad sarbecovirus neutralization by a human monoclonal antibody

Tortorici, M. A., Czudnochowski, N., Starr, T. N., Marzi, R., Walls, A. C., Zatta, F., Bowen, J. E., Jaconi, S., di Iulio, J., Wang, Z., et al. (2021) · Nature · doi:10.1038/s41586-021-03817-4 · Cited by 251 · see citing works

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors

Park, Y.-J., Walls, A. C., Wang, Z., Sauer, M. M., Li, W., Tortorici, M. A., Bosch, B.-J., DiMaio, F., & Veesler, D. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0334-7 · Cited by 260 · see citing works

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Saunders, K. O., Lee, E., Parks, R., Martinez, D. R., Li, D., Chen, H., Edwards, R. J., Gobeil, S., Barr, M., Mansouri, K., et al. (2021) · Nature · doi:10.1038/s41586-021-03594-0 · Cited by 253 · see citing works

Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases

Meganck, R. M., & Baric, R. S. (2021) · Nature Medicine · doi:10.1038/s41591-021-01282-0 · Cited by 253 · see citing works

Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes

Lin, M.-H., Moses, D. C., Hsieh, C.-H., Cheng, S.-C., Chen, Y., Sun, C., & Chou, C. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.12.015 · Cited by 251 · see citing works

An <i>Alphavirus</i> -derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

Erasmus, J. H., Khandhar, A. P., O’Connor, M. A., Walls, A. C., Hemann, E. A., Murapa, P., Archer, J., Leventhal, S., Fuller, J. T., Lewis, T. B., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abc9396 · Cited by 241 · see citing works

Evolutionary Trajectory for the Emergence of Novel Coronavirus SARS-CoV-2

Rehman, S. U., Shafique, L., Ihsan, A., & Liu, Q. (2020) · Pathogens · doi:10.3390/pathogens9030240 · Cited by 237 · see citing works

2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness

Ralph, R., Lew, J. M., Zeng, T., Francis, M. E., Xue, B., Roux, M., Ostadgavahi, A. T., Rubino, S., Dawe, N. J., Al‐Ahdal, M. N., et al. (2020) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.12425 · Cited by 227 · see citing works

Broad-spectrum coronavirus antiviral drug discovery

Totura, A. L., & Bavari, S. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1581171 · Cited by 219 · see citing works

Is SARS-CoV-2 Also an Enteric Pathogen With Potential Fecal–Oral Transmission? A COVID-19 Virological and Clinical Review

Ding, S., & Liang, T. J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.04.052 · Cited by 218 · see citing works

The Origin of COVID-19 and Why It Matters

Morens, D. M., Breman, J. G., Calisher, C. H., Doherty, P. C., Hahn, B. H., Keusch, G. T., Kramer, L. D., LeDuc, J. W., Monath, T. P. C., & Taubenberger, J. K. (2020) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.20-0849 · Cited by 213 · see citing works

Evidence for SARS-CoV-2 Infection of Animal Hosts

Abdel-Moneim, A. S., & Abdelwhab, E. M. (2020) · Pathogens · doi:10.3390/pathogens9070529 · Cited by 205 · see citing works

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

Golden, J. W., Cline, C. R., Zeng, X., Garrison, A. R., Carey, B. D., Mucker, E. M., White, L. E., Shamblin, J. D., Brocato, R. L., Liu, J., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.142032 · Cited by 195 · see citing works

ACE2 binding is an ancestral and evolvable trait of sarbecoviruses

Starr, T. N., Zepeda, S. K., Walls, A. C., Greaney, A. J., Alkhovsky, S. V., Veesler, D., & Bloom, J. D. (2022) · Nature · doi:10.1038/s41586-022-04464-z · Cited by 199 · see citing works

Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection

Menachery, V. D., Dinnon, K. H., Yount, B. L., McAnarney, E. T., Gralinski, L. E., Hale, A., Graham, R. L., Scobey, T., Anthony, S. J., Wang, L., et al. (2020) · Journal of Virology · doi:10.1128/jvi.01774-19 · Cited by 205 · see citing works

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

Zhou, P.-P., Yuan, M., Song, G., Beutler, N., Shaabani, N., Huang, D.-L., He, W.-T., Zhu, X.-Y., Callaghan, S., Yong, P., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abi9215 · Cited by 132 · see citing works

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection

Rathnasinghe, R., Strohmeier, S., Amanat, F., Gillespie, V., Krammer, F., García‐Sastre, A., Coughlan, L., Schotsaert, M., & Uccellini, M. B. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1838955 · Cited by 197 · see citing works

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

Martinez, D. R., Schäfer, A., Leist, S. R., la Cruz, G. D., West, A., Atochina‐Vasserman, E. N., Lindesmith, L. C., Pardi, N., Parks, R., Barr, M., et al. (2021) · Science · doi:10.1126/science.abi4506 · Cited by 189 · see citing works

Structural basis for broad coronavirus neutralization

Sauer, M. M., Tortorici, M., Park, Y.-J., Walls, A., Homad, L. J., Acton, O., Bowen, J., Wang, C., Xiong, X., de van der Schueren, W. J., et al. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00596-4 · Cited by 199 · see citing works

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

Walls, A. C., Miranda, M. C., Schäfer, A., Pham, M. N., Greaney, A., Arunachalam, P. S., Navarro, M.-J., Tortorici, M. A., Rogers, K., O’Connor, M. A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.09.015 · Cited by 185 · see citing works

COVID-19: Knowns, Unknowns, and Questions

Weston, S. M., & Frieman, M. B. (2020) · mSphere · doi:10.1128/msphere.00203-20 · Cited by 183 · see citing works

Engineering SARS-CoV-2 using a reverse genetic system

Xie, X.-P., Lokugamage, K. G., Zhang, X.-W., Vu, M., Muruato, A. E., Menachery, V., & Shi, P.-Y. (2021) · Nature Protocols · doi:10.1038/s41596-021-00491-8 · Cited by 173 · see citing works

Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection

Moreau, G. B., Burgess, S. L., Sturek, J. M., Donlan, A. N., Petri, W. A., & Mann, B. J. (2020) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.20-0762 · Cited by 180 · see citing works

Animal and translational models of SARS-CoV-2 infection and COVID-19

Johansen, M. D., Irving, A. T., Montagutelli, X., Tate, M. D., Rudloff, I., Nold, M. F., Hansbro, N. G., Kim, R., Donovan, C., Liu, G., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00340-z · Cited by 169 · see citing works

Advances in respiratory virus therapeutics – A meeting report from the 6th isirv Antiviral Group conference

Beigel, J. H., Nam, H. H., Adams, P. L., Krafft, A. E., Ince, W. L., El‐Kamary, S. S., & Sims, A. M. (2019) · Antiviral Research · doi:10.1016/j.antiviral.2019.04.006 · Cited by 168 · see citing works

Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection

Edwards, C. E., Yount, B. L., Graham, R. L., Leist, S. R., Hou, Y. J., Dinnon, K. H., Sims, A. M., Swanstrom, J., Gully, K. L., Scobey, T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2001046117 · Cited by 161 · see citing works

Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections

Xiong, X., Tortorici, M. A., Snijder, J., Yoshioka, C., Walls, A. C., Li, W., McGuire, A. T., Rey, F. A., Bosch, B., & Veesler, D. (2017) · Journal of Virology · doi:10.1128/jvi.01628-17 · Cited by 155 · see citing works

Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome)

Hui, D. S. C. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.11.007 · Cited by 155 · see citing works

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

Zhou, P.-P., Song, G., Liu, H., Yuan, M., He, W., Beutler, N., Zhu, X., Tse, L. V., Martinez, D. R., Schäfer, A., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.02.005 · Cited by 151 · see citing works

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

Menachery, V. D., Mitchell, H. D., Cockrell, A. S., Gralinski, L. E., Yount, B. L., Graham, R. L., McAnarney, E. T., Douglas, M. G., Scobey, T., Beall, A. E., et al. (2017) · mBio · doi:10.1128/mbio.00665-17 · Cited by 148 · see citing works

Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China

Li, H., Mendelsohn, E., Zong, C., Zhang, W., Hagan, E. A., Wang, N., Li, S., Yan, H., Huang, H., Zhu, G., et al. (2019) · Biosafety and Health · doi:10.1016/j.bsheal.2019.10.004 · Cited by 143 · see citing works

Jumping species—a mechanism for coronavirus persistence and survival

Menachery, V. D., Graham, R. L., & Baric, R. S. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.01.002 · Cited by 135 · see citing works

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

Li, W., Chen, Y., Prévost, J., Ullah, I., Lu, M., Gong, S. Y., Tauzin, A., Gasser, R., Vézina, D., Anand, S. P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110210 · Cited by 125 · see citing works

Epigenetic Landscape during Coronavirus Infection

Schäfer, A., & Baric, R. S. (2017) · Pathogens · doi:10.3390/pathogens6010008 · Cited by 118 · see citing works

COVID19: an announced pandemic

Platto, S., Xue, T., & Carafoli, E. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02995-9 · Cited by 120 · see citing works

The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin

Segreto, R., & Deigin, Y. (2020) · BioEssays · doi:10.1002/bies.202000240 · Cited by 118 · see citing works

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

Martinez, D. R., Schäfer, A., Gobeil, S., Li, D., la Cruz, G. D., Parks, R., Lu, X., Barr, M., Stalls, V., Janowska, K., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7125 · Cited by 135 · see citing works

Animal models for COVID-19: advances, gaps and perspectives

Fan, C., Wu, Y., Xiong, R., Yang, Y., Ling, C., Liu, S., Liu, S., & Wang, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01087-8 · Cited by 104 · see citing works

SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13

Morrison, C. B., Edwards, C. E., Shaffer, K. M., Araba, K. C., Wykoff, J. A., Williams, D. R., Asakura, T., Dang, H., Morton, L. C., Gilmore, R. C., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119680119 · Cited by 100 · see citing works

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

Menachery, V. D., Gralinski, L. E., Mitchell, H. D., Dinnon, K. H., Leist, S. R., Yount, B. L., Graham, R. L., McAnarney, E. T., Stratton, K. G., Cockrell, A. S., et al. (2017) · mSphere · doi:10.1128/msphere.00346-17 · Cited by 101 · see citing works

The Current and Future State of Vaccines, Antivirals and Gene Therapies Against Emerging Coronaviruses

Tse, L. V., Meganck, R. M., Graham, R. L., & Baric, R. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00658 · Cited by 99 · see citing works

The Remarkable Evolutionary Plasticity of Coronaviruses by Mutation and Recombination: Insights for the COVID-19 Pandemic and the Future Evolutionary Paths of SARS-CoV-2

Amoutzias, G. D., Nikolaidis, M., Tryfonopoulou, E., Chlichlia, K., Markoulatos, P., & Oliver, S. G. (2022) · Viruses · doi:10.3390/v14010078 · Cited by 97 · see citing works

The search for a COVID-19 animal model

Lakdawala, S. S., & Menachery, V. D. (2020) · Science · doi:10.1126/science.abc6141 · Cited by 97 · see citing works

Understanding bat SARS-like coronaviruses for the preparation of future coronavirus outbreaks—implications for coronavirus vaccine development

Ng, O.-W., & Tan, Y.-J. (2017) · Human Vaccines &amp; Immunotherapeutics · doi:10.1080/21645515.2016.1228500 · Cited by 51 · see citing works

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

Becker, M. M., Graham, R. L., Donaldson, E., Rockx, B., Sims, A. M., Sheahan, T. P., Pickles, R. J., Corti, D., Johnston, R. E., Baric, R. S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808116105 · Cited by 257 · see citing works

Strategy To Assess Zoonotic Potential Reveals Low Risk Posed by SARS-Related Coronaviruses from Bat and Pangolin

Yang, Y., Shen, X.-R., Zhang, Y., Jiang, R.-D., Wang, X., Guan, Z., Li, Q., Yao, Y., Gong, Q.-C., Geng, R., et al. (2023) · mBio · doi:10.1128/mbio.03285-22 · Cited by 9 · see citing works

Emergence of SARS and COVID-19 and preparedness for the next emerging disease X

Hu, B., Guo, H., Si, H., & Shi, Z. (2024) · Frontiers in Medicine · doi:10.1007/s11684-024-1066-6 · Cited by 10 · see citing works

Engineering Coronaviruses to Evaluate Emergence and Pathogenic Potential

Lau, S. K. P., & Woo, P. C. Y. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.04.001 · Cited by 5 · see citing works