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The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder

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Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains

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Retroviral integrase: Structure, mechanism, and inhibition

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Enzymology of Mammalian DNA Methyltransferases

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Significance of targeting DNMT3A mutations in AML

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Structural basis of SIRT7 nucleosome engagement and substrate specificity

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Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex

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Structures of chromatin modulators in complex with nucleosome

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Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells

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Rational fragment-based design of compounds targeting the PWWP domain of the HRP family

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Molecular Mechanism of LEDGF/p75 Dimerization

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DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics

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Beyond the Usual Suspects: Examining the Role of Understudied Histone Variants in Breast Cancer

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Catching Nucleosome by Its Decorated Tails Determines Its Functional States

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Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma

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Approaches to Study Native Chromatin-Modifying Complex Activities and Functions

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Advances in inhibitor development targeting the PWWP domain

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Loss of function in NSD2 causes DNA methylation signature similar to that in Wolf-Hirschhorn syndrome

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HDGF Knockout Suppresses Colorectal Cancer Progression and Drug Resistance by Modulating the DNA Damage Response

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H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function

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Structure and function of IWS1 in transcription elongation

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Inhibitors targeting the PWWP domain-containing proteins

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Facile preparation of sulfonium peptide and protein probes for selective crosslinking of methyllysine readers

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Beyond the mono-nucleosome

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The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function

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Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

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MeCP2 requires interactions with nucleosome linker DNA to read chromatin DNA methylation

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LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

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The role of chromatin in retroviral preintegration complex function

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PWWP3A deficiency accelerates testicular senescence in aged mice

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Structure of the complete S. cerevisiae Rpd3S-nucleosome complexPreprint

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The structural basis for de novo DNA methylation in chromatinPreprint

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Chromatin Regulatory Targets for Anticancer Therapeutics

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Mimicking the Nucleosomal Context in Peptide-Based Binders of a H3K36me Reader Increases Binding Affinity While Altering the Binding Mode

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PWWP2A/B: Prominent players in the proteomic landscape

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NDF/GLYR1 Promotes RNA Polymerase II Processivity via Pol II Binding and Nucleosome Destabilization

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Crystal engineering of the hepatoma-derived growth factor-related protein 2 PWWP domain towards crystallographic fragment screening

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Decoding gene responsiveness to synthetic chromatin reader-actuators with multi-modal epigenomic profiling

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The NPAC-LSD2 complex in nucleosome demethylation

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Recognition of histone methylation and DNA by the PWWP domain: Mechanism and function

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Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain

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Intact Nucleosomal Context Enables Chromodomain Reader MRG15 to Distinguish H3K36me3 from - Me2Preprint

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HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modificationPreprint

Sapp, N., Burge, N. L., Cox, K. L., Thapa, S., Prakash, P., Balasubramaniam, M., Christenson, D., Li, M., Linderberger, J., Kvaratskhelia, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.16.480507 · Cited by 1 · see citing works

DNA methylation signature in NSD2 loss-of-function variants appeared similar to that in Wolf-Hirschhorn syndromePreprint

Kawai, T., Kinoshita, S., Takayama, Y., Onishi, E., Kamura, H., Kojima, K., Kikuchi, H., Terao, M., Sugawara, T., Migita, O., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.06.522834 · Cited by 1 · see citing works

The role of LEDGF in transcription is exploited by HIV-1 to position integrationPreprint

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H3.3 De Novo Mutations Alter Lysine 36 Methylation via Distinct MechanismsPreprint

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H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeller functionPreprint

Li, J., Bergmann, L., de Almeida, A. R., Webb, K. M., Gogol, M., Voigt, P., Liu, Y., Liang, H., & Smolle, M. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.26.432832

Structural and biochemical studies on chromatin-protein complexes in transcription initiation

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Toward Understanding Pharmacological Modulation of DNA Methylation

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Drug Discovery for Chromatin Readers, Writers, Erasers, Remodelers and Epitranscriptomic Targets

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Why do histone monomethylation and dimethylation cause a significant difference in binding to LEDGF?

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Association of the PWWP ‐domain protein HUA2 and the H3K36 methylation in flowering time control

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Genome-wide identification and characterization of SET domain family genes in Neopyropia yezoensis

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Relationship between the distribution of LEDGF along genes and positions of HIV-1 DNA integration

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Identification of specific phylogenetic properties of HIV-1 M and O integrases

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High-Affinity Nanobody Against the LEDGF PWWP Domain Inhibits Chromatin Binding In Vitro

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De novo design of proteinaceous binders targeting the LEDGF PWWP domain

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DPF3a couples H3K36me2-dependent chromatin remodeling to genome architecture during myogenesisPreprint

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BindingDB Entry 50022700: Inhibitors targeting the PWWP domain-containing proteins.

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BindingDB Entry 50022853: Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.

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Multivalency of nucleosome recognition by LEDGF

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Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain

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