The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles
Open accessAbstract
Gold nanomaterials have attracted considerable interest as vehicles for intracellular drug delivery. In our study, we synthesized three different shapes of methylpolyethylene glycol coated-anisotropic gold nanoparticles: stars, rods, and triangles. The cellular internalization of these nanoparticles by RAW264.7 cells was analyzed, providing a parametric evaluation of the effect of shape. The efficiency of cellular uptake of the gold nanoparticles was found to rank in the following order from lowest to highest: stars, rods, and triangles. The possible mechanisms of cellular uptake for the three types of gold nanoparticles were examined, and it was found that different shapes tended to use the various endocytosis pathways in different proportions. Our study, which has demonstrated that shape can modulate the uptake of nanoparticles into RAW264.7 cells and that triangles were the shape with the most efficient cellular uptake, provides useful guidance toward the design of nanomaterials for drug delivery.
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Cites
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Cited by
Engineering precision nanoparticles for drug delivery
Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0090-8 · Cited by 7,933
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Engineered nanoparticles for imaging and drug delivery in colorectal cancer
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Metadata
- Authors
- Xie, X., Liao, J., Shao, X., Li, Q., & Lin, Y.
- Venue
- Scientific Reports
- Published
- 2017-06-19
- Volume
- 7
- Issue
- 1
- Pages
- 3827-3827
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2625047539
- Cited by
- 462
- References
- 55
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xie, X., Liao, J., Shao, X., Li, Q., & Lin, Y. (2017). The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles. Scientific Reports. https://doi.org/10.1038/s41598-017-04229-z
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
