Serological response predicts normalization of cerebrospinal fluid abnormalities at six months after treatment in HIV-negative neurosyphilis patients.
Open accessAbstract
This study aimed to determine whether a serological response could predict the normalization of cerebrospinal fluid (CSF) abnormalities at 6 months after treatment in human immunodeficiency virus (HIV)-negative neurosyphilis patients. A total of 123 neurosyphilis patients were recruited at baseline, 58 of these patients undergoing treatment, repeated CSF examinations and serological tests for syphilis at 6 months after treatment were included in the follow-up study. Before treatment, the CSF rapid plasma reagin (RPR) titer, CSF Treponema pallidum particle agglutination (TPPA) titer, CSF leukocyte count, and CSF protein concentration were correlated with both serum RPR and TPPA titers. At 6 months after treatment, 28 and nine patients achieved serological responses of RPR and TPPA tests, respectively. The sensitivities of the serological response of RPR and TPPA tests for identifying the normalization of CSF abnormalities were 60.0∼83.3% and 17.1~22.2%, respectively; and 75.0∼91.3% of patients showing serological response of RPR test also achieved CSF normalization, suggesting that the serological response could predict CSF normalization to some degree. Particularly, in patients with ≥8-fold decreases in the serum RPR titer, the CSF RPR, CSF leukocyte count, and CSF protein concentration had normalized, and follow-up lumbar puncture could be reduced considering the resolution of neurological symptoms.
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Among immunocompetent persons and persons with HIV infection on effective ART, normalization of serum RPR titer predicts normalization of abnormal CSF parameters after neurosyphilis treatment.
“Data from two studies indicate that, among immunocompetent persons and persons with HIV infection who are on effective ART, normalization of the serum RPR titer predicts normalization of abnormal CSF parameters after neurosyphilis treatment (614,615).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [615]
The Discussion reports that a serum RPR response predicted normalization of CSF abnormalities after treatment in HIV-negative patients, especially those with a ≥8-fold titer decrease. It also describes a prior study involving HIV-infected patients, but does not establish that those patients were on effective ART. This source therefore supports the HIV-negative finding, not the claim’s ART-qualified finding. (LLM, conf=0.88)
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Cites
Sexually transmitted diseases treatment guidelines (2015)
Workowski, K., & BOLAN, G. A. (2015) · Reproductive Endocrinology · doi:10.18370/2309-4117.2015.24.51-56 · Cited by 2,689 · see citing works
Sexually Transmitted Diseases Treatment Guidelines, 2010
Workowski, K., & BOLAN, G. A. (2011) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2011.04.006 · Cited by 2,074 · see citing works
Laboratory diagnosis and interpretation of tests for syphilis
Larsen, S. A., Steiner, B. M., & Rudolph, A. H. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.1.1 · Cited by 779 · see citing works
Clinical Framework and Medical Countermeasure Use During an Anthrax Mass-Casualty Incident
by, P., Bower, W. A., Hendricks, K. A., Pillai, S. K., Guarnizo, J. T., & Meaney‐Delman, D. M. (2015) · MMWR Recommendations and Reports · doi:10.15585/mmwr.rr6404a1 · Cited by 585 · see citing works
Marra, C. M., Maxwell, C. L., Smith, S. L., Lukehart, S. A., Rompalo, A. M., Eaton, M., Stoner, B. P., Augenbraun, M., Barker, D. E., Corbett, J. J., et al. (2004) · The Journal of Infectious Diseases · doi:10.1086/381227 · Cited by 491 · see citing works
2014 European guideline on the management of syphilis
Janier, M., Hegyi, V., Dupin, N., Unemo, M., Tiplica, G. S., Potočnik, M., French, P., & Patel, R. (2014) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12734 · Cited by 360 · see citing works
IUSTI: 2008 European Guidelines on the Management of Syphilis
French, P., Gomberg, M. A., Janier, M., Schmidt, B. L., Vader, P. V. V., & Young, H.-K. (2009) · International Journal of STD & AIDS · doi:10.1258/ijsa.2008.008510 · Cited by 291 · see citing works
Marra, C. M., Maxwell, C. L., Tantalo, L. C., Sahi, S. K., & Lukehart, S. A. (2008) · Clinical Infectious Diseases · doi:10.1086/591534 · Cited by 159 · see citing works
Marra, C. M., Maxwell, C. L., Tantalo, L. C., Eaton, M. E., Rompalo, A. M., Raines, C. P., Stoner, B. P., Corbett, J. J., Augenbraun, M. H., Zajackowski, M., et al. (2004) · Clinical Infectious Diseases · doi:10.1086/382532 · Cited by 143 · see citing works
Serological Response to Treatment of Syphilis According to Disease Stage and HIV Status
Knaute, D. F., Graf, N., Lautenschlager, S., Weber, R. K., & Bosshard, P. P. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis757 · Cited by 108 · see citing works
Marra, C. M. (2015) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000250 · Cited by 86 · see citing works
Shi, M., Peng, R. ‐., Gao, Z., Zhang, S., Lu, H., Guan, Z., Gao, Y., Wang, C., & Zhou, P. (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13514 · Cited by 46 · see citing works
Xiao, Y., Tong, M.-L., Liu, L., Lin, L., Chen, M., Zhang, H., Zheng, W., Li, S., Lin, H., Lin, Z., et al. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2339-3 · Cited by 39 · see citing works
Liu, F., Liu, L., Guo, X., Xi, Y., Lin, L., Zhang, H., Huang, S.-J., Chen, Y., Zhang, Y., Zhang, Q., et al. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.03.011 · Cited by 37 · see citing works
Lin, L., Zheng, W., Tong, M.-L., Fu, Z.-G., Liu, G.-L., Fu, J., Zhang, D.-W., Yang, T., & Liu, L. (2011) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2011.07.005 · Cited by 32 · see citing works
Factors associated with syphilis infection: a comprehensive analysis based on a case-control study
Xiao, Y., LI, S.-L., Lin, H.-Q., LIN, Z.-F., Zhu, X., Fan, J.-Y., Gao, K., Zhang, H.-L., Lin, L., LIU, L.-L., et al. (2015) · Epidemiology and Infection · doi:10.1017/s0950268815002344 · Cited by 20 · see citing works
Liu, L., Zhang, H., Huang, S.-J., Liu, L., Tong, M.-L., Lin, L., Chen, Y., Xi, Y., Guo, X., Zhang, Y., et al. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.10.008 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 2,759 · see citing works
The Modern Epidemic of Syphilis
Ghanem, K. G., Ram, S., & Rice, P. A. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1901593 · Cited by 532 · see citing works
State-of-the-Art Review: Neurosyphilis
Hamill, M. M., Ghanem, K. G., & Tuddenham, S. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad437 · Cited by 139 · see citing works
Laboratory Diagnostic Tools for Syphilis: Current Status and Future Prospects
Luo, Y., Xie, Y., & Xiao, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.574806 · Cited by 111 · see citing works
The Intersection of HIV and Syphilis: Update on the Key Considerations in Testing and Management
Ren, M., Dashwood, T., & Walmsley, S. L. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00564-z · Cited by 68 · see citing works
Centers for Disease Control and Prevention’s Sexually Transmitted Diseases Infection Guidelines
Workowski, K., & Bachmann, L. H. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciab1055 · Cited by 75 · see citing works
Neurosyphilis: insights into its pathogenesis, susceptibility, diagnosis, treatment, and prevention
Wu, S., Ye, F., Wang, Y.-F., & Li, D. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1340321 · Cited by 51 · see citing works
Tuddenham, S., & Ghanem, K. G. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac060 · Cited by 39 · see citing works
Tsan, G. L., & Claiborne, R. T. (2021) · Clinical and Experimental Optometry · doi:10.1080/08164622.2021.1906848 · Cited by 32 · see citing works
Liu, L., Lin, Y., Chen, W., Tong, M.-L., Luo, X., Lin, L., Zhang, H., Yan, J., Niu, J., & Yang, T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00150 · Cited by 28 · see citing works
Diagnostic role of CXCL13 and CSF serology in patients with neurosyphilis
Li, D., Huang, X., Shi, M.-Q., Luo, L., & Tao, C. (2021) · Sexually Transmitted Infections · doi:10.1136/sextrans-2020-054778 · Cited by 23 · see citing works
Predicting asymptomatic neurosyphilis using peripheral blood indicators
Li, W., Han, J., Zhao, P., Wang, D., Sun, T., Guo, J. F., He, Y., Qu, P., Liu, Y., Shen, C., et al. (2021) · BMC Infectious Diseases · doi:10.1186/s12879-021-06846-6 · Cited by 21 · see citing works
Sadoghi, B., Stary, G., & Wolf, P. (2023) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.14999 · Cited by 21 · see citing works
Du, F., Wu, M., Zhang, X., Zhang, R., & Wang, Q. (2022) · Trials · doi:10.1186/s13063-022-06769-w · Cited by 13 · see citing works
Xiao, Y., Chen, M., Shen, X., Lin, L., Liu, L., Yang, T., & Niu, J. (2019) · European Neurology · doi:10.1159/000503626 · Cited by 10 · see citing works
Neurosyphilis and Lyme neuroborreliosis
Dersch, R. S., & Singh, A. E. (2021) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000923 · Cited by 9 · see citing works
Syphilis for dermatologists: Current concepts
Navarrete, J., & Saavedra-Portales, S. (2023) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2023.12.009 · Cited by 6 · see citing works
A Review of Syphilis Infection in Pediatric Patients
Labudde, E. J., & Lee, J. (2024) · Pediatrics in Review · doi:10.1542/pir.2023-006309 · Cited by 6 · see citing works
Intrathecal immunoglobin synthesis and its role in patients with neurosyphilis
Huang, X., Ying, S., Luo, L., Li, L., Li, D., & Xie, Y. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.1008595 · Cited by 6 · see citing works
Sífilis congénita resultado de una Neurosífilis materna no diagnosticada. Reporte de caso
Yolanda Cifuentes, C., Ángel‐Müller, E., & Moreno, R. C. D. (2020) · Revista Médicas UIS · doi:10.18273/revmed.v33n1-2020009 · Cited by 5 · see citing works
Analysis of Neurosyphilis Imaging Methods and Treatment: A Focused Review
Patel, S. S., Blum, A. L., Morgan, R. T., Piper, B. J., Rodriguez, A. J., & VanVarick, R. E. (2024) · Cureus · doi:10.7759/cureus.72976 · Cited by 4 · see citing works
Liu, D., Chen, R., He, Y., Wang, Y., Lin, L., Liu, L., Yang, T., & Tong, M.-L. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01067-23 · Cited by 3 · see citing works
Sadoghi, B., Stary, G., & Wolf, P. (2023) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.14999_g · Cited by 2 · see citing works
Guan, H., Di, X., Li, M., Yu, N., Cai, R., Chen, C., Peng, J., Xia, Z., & Wei, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-94927-w · Cited by 2 · see citing works
(2021) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001086 · Cited by 2 · see citing works
Martín-Aspas, A., Gómez, A. S., Cuevas, M. C., & Selma, O. C. (2022) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2022.04.001 · Cited by 1 · see citing works
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Saylor, D. R., & Marra, C. M. (2020) · Current clinical neurology · doi:10.1007/978-3-030-56084-3_6
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Schmidt, W. M., Perera, N. D., Fortes, B. H., Nelson, B. A., Smith, W. M., & Nordhues, H. C. (2023) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.90a.22038
Neurosyphilis in patients at a university hospital in the central west region of Brazil
Rosa, P. W., Borges, M. A. S. B., Coutinho, J. V. S. C., Filho, R. V. T., & Guilarde, A. O. (2023) · Revista de Patologia Tropical / Journal of Tropical Pathology · doi:10.5216/rpt.v52i2.75654
Syphilitic Meningoencephalitis Presenting as Status Epilepticus in a Patient With HIV
Irizarry‐Caro, J. A., Egge, S. L., Alsheikh-Kassim, M., Chandra, S., Nguyen, E., Chijioke, J., & Arduino, R. C. (2023) · Annals of Internal Medicine Clinical Cases · doi:10.7326/aimcc.2023.0040
Guan, H., Di, X., Li, M., Yu, N., Cai, R., Chen, C., Peng, J., Xia, Z., & Wei, H. (2024) · Research Square · doi:10.21203/rs.3.rs-4605969/v1
(2025) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2025.07.009
- Authors
- Xiao, Y., Tong, M.-L., Lin, L.-R., Liu, L.-L., Gao, K., Chen, M.-J., Zhang, H.-L., Zheng, W.-H., Li, S.-L., Lin, H.-L., Lin, Z.-F., Yang, T.-C., & Niu, J.-J.
- Affiliations
- Fujian Medical University (CN)
- Xiamen University (CN)
- Corresponding author
- Yang, Tian-Ci
- Venue
- Scientific Reports
- Published
- 2017-08-30
- Volume
- 7
- Issue
- 1
- Pages
- 9911-9911
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5577126
- OpenAlex
- W2748955003
- Cited by
- 32
- References
- 17
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (2014D001)
- Fujian Provincial Health and Family Planning Commission
- Natural Science Foundation of Fujian Province (2014D001, 2016 J01628)
- National Science Fund for Distinguished Young Scholars (2014D001)
- Topics
- Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- neurosyphilis, HIV-negative, serological response, cerebrospinal fluid abnormalities, RPR, TPPA, treatment response prediction, cerebrospinal fluid protein, CSF leukocyte count
- MeSH terms
- Adult, Anti-Bacterial Agents, Ceftriaxone, Inclusion Bodies, Doxycycline, Female, Humans, Male, Middle Aged, Neurosyphilis, Penicillins, Serologic Tests, Syphilis Serodiagnosis, Time Factors, Treponema pallidum, Treatment Outcome
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